DT-Web

DB07947 - ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE


Identification
Name ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
Accession Number DB07947
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 419.925
Groups experimental
Monoisotopic Weight 419.107039982
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


cAMP-dependent protein kinase catalytic subunit alpha
Name cAMP-dependent protein kinase catalytic subunit alpha
Gene Name PRKACA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9091
cAMP-dependent protein kinase inhibitor alpha
Name cAMP-dependent protein kinase inhibitor alpha
Gene Name PKIA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6213
RAC-beta serine/threonine-protein kinase
Name RAC-beta serine/threonine-protein kinase
Gene Name AKT2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8796
Glycogen synthase kinase-3 beta
Name Glycogen synthase kinase-3 beta
Gene Name GSK3B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4756

Predictions


Id Partner name Gene Name Score
1531 Rho-associated protein kinase 1 ROCK1 0.1721
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0943
6697 Rho-associated protein kinase 2 ROCK2 0.0847
6545 Calcium/calmodulin-dependent protein kinase type IV CAMK4 0.0661
6296 Serine/threonine-protein kinase haspin GSG2 0.0492
1742 D-HSCDK2 CDK2deltaT 0.0443
1771 Cell division control protein 2 homolog CDK1 0.0443
3321 Cell division control protein 2 homolog CRK2 0.0443
1058 Cell division protein kinase 5 CDK5 0.043
6882 Iodotyrosine dehalogenase 1 IYD 0.0325
6881 Nickel-binding periplasmic protein nikA 0.0325
6880 Alpha-amylase G-6 BH0413 0.0324
2026 Inositol monophosphatase IMPA1 0.0272
1387 Inositol monophosphatase 2 IMPA2 0.0244
3428 H(+)/Cl(-) exchange transporter clcA clcA 0.0239
923 Glutamate receptor 3 GRIA3 0.0231
6321 Cyclin-dependent kinase 5 activator 1 CDK5R1 0.022
2530 Protein kinase C theta type PRKCQ 0.0204
3382 Glycolipid transfer protein GLTP 0.0192
2240 Cell division protein kinase 2 CDK2 0.0139
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0134
3176 Trypsin-1 PRSS1 0.0129
2473 Tyrosine-protein kinase CSK CSK 0.0117
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0117
2408 Tyrosine-protein kinase SYK SYK 0.011
4751 Mitogen-activated protein kinase 12 MAPK12 0.0109
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0102
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0095
4750 Protein S100-A11 S100A11 0.0092
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0087
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0087
3482 Cell division protein kinase 7 CDK7 0.008
3005 Threonine-phosphate decarboxylase cobD 0.008
2207 Rhodopsin RHO 0.0077
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0071
1422 Serine/threonine-protein kinase 6 AURKA 0.0066
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.006
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0055
3361 Serpin B5 SERPINB5 0.0055
5694 Transcription antiterminator licT licT 0.0055
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0054
1176 Mitogen-activated protein kinase 1 MAPK1 0.0051
2514 Phosphocarrier protein HPr ptsH 0.0046
5689 Phosphocarrier protein HPr ptsH 0.0046
3602 Anti-sigma F factor antagonist spoIIAA 0.0046
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0046
56 Delta-aminolevulinic acid dehydratase ALAD 0.0044
2356 Delta-aminolevulinic acid dehydratase hemB 0.0044
3613 Delta-aminolevulinic acid dehydratase hemB 0.0044
3674 Delta-aminolevulinic acid dehydratase hemB 0.0044
394 Calcineurin subunit B isoform 1 PPP3R1 0.0042
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0042
2528 Fatty acid metabolism regulator protein fadR 0.0042
6740 Fatty acid metabolism regulator protein fadR 0.0042
6753 Apolipoprotein M APOM 0.0042
6743 Non-fluorescent flavoprotein luxF 0.0042
6742 Recoverin RCVRN 0.0042
6747 Chalcone/stilbene synthase family protein MT1417 0.0042
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0042
6751 Gag polyprotein gag 0.0042
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0042
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0042
6749 Polyprotein Not Available 0.0042
2286 Isocitrate dehydrogenase [NADP] icd 0.0042
2302 Isocitrate dehydrogenase [NADP] icd 0.0042
2771 Isocitrate dehydrogenase [NADP] icd 0.0042
5646 Galactokinase GALK1 0.0042
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0042
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0042
5302 TrwB trwB 0.0042
5265 FtsH ftsH 0.0042
1130 Lithostathine 1 alpha REG1A 0.004
4542 Glutaminase 1 glsA1 0.004
4544 Glutaminase 1 glsA1 0.004
4534 Cytohesin-2 CYTH2 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.0039
3668 Maltose-binding periplasmic protein precursor malE 0.0038
5312 Kinesin-like protein KIF1A KIF1A 0.0038
5961 Insulin INS 0.0037
6527 Lymphocyte antigen 96 LY96 0.0037
6755 Poliovirus receptor PVR 0.0037
3119 Fimbrial protein pilE1 0.0037
4318 Siroheme synthase cysG 0.0037
2892 Acetylglutamate kinase argB 0.0036
3550 Acetylglutamate kinase argB 0.0036
2371 Pantothenate kinase coaA 0.0036
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0036
825 Arsenical pump-driving ATPase ASNA1 0.0036
3435 Arsenical pump-driving ATPase arsA 0.0036
2615 Chemotaxis protein cheA cheA 0.0036
1881 Hexokinase-1 HK1 0.0036
3453 Alkaline phosphatase phoA 0.0035
2727 S-adenosylmethionine synthetase metK 0.0034
2592 Beta-galactosidase lacZ 0.0034
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0034
6524 Protein tonB tonB 0.0034
2503 Phosphomannomutase/phosphoglucomutase algC 0.0033
5150 Endo-1,4-beta-xylanase Y xynY 0.0033
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0033
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0033
5641 Rod shape-determining protein MreB TM_0588 0.0033
5645 DNA topoisomerase 4 subunit B parE 0.0033
6227 DNA topoisomerase 4 subunit B parE 0.0033
5644 Sensor protein phoQ phoQ 0.0033
5643 General secretion pathway protein E epsE 0.0033
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0033
5649 Potassium-transporting ATPase B chain kdpB 0.0033
3794 Osmolarity sensor protein envZ envZ 0.0033
5642 Chaperone clpB clpB 0.0033
315 Arginase-1 ARG1 0.0032
2616 Ganglioside GM2 activator GM2A 0.0032
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0031
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0031
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.003
4210 Toll-like receptor 4 TLR4 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
2251 Thymidylate kinase tmk 0.0029
2254 Thymidylate kinase DTYMK 0.0029
3522 Thymidylate kinase tmk 0.0029
997 Protein kinase C beta type PRKCB 0.0029
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0029
740 Argininosuccinate synthase ASS1 0.0029
865 Argininosuccinate synthase ASS1 0.0029
2680 Argininosuccinate synthase argG 0.0029
3194 Argininosuccinate synthase argG 0.0029
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0029
2397 Dihydroxyacetone kinase dhaK 0.0029
2852 DNA mismatch repair protein mutL mutL 0.0029
6316 ADP-ribosylation factor 1 ARF1 0.0029
2297 Genome polyprotein Not Available 0.0029
2322 Genome polyprotein Not Available 0.0029
2694 Genome polyprotein Not Available 0.0029
2719 Genome polyprotein Not Available 0.0029
2860 Genome polyprotein Not Available 0.0029
2928 Genome polyprotein Not Available 0.0029
3160 Genome polyprotein Not Available 0.0029
3260 Genome polyprotein Not Available 0.0029
4783 Genome polyprotein Not Available 0.0029
5726 Genome polyprotein Not Available 0.0029
5779 Genome polyprotein Not Available 0.0029
5867 Genome polyprotein Not Available 0.0029
6253 Genome polyprotein Not Available 0.0029
6301 Genome polyprotein Not Available 0.0029
6380 Genome polyprotein Not Available 0.0029
6381 Genome polyprotein Not Available 0.0029
6437 Genome polyprotein Not Available 0.0029
6520 Genome polyprotein Not Available 0.0029
6521 Genome polyprotein Not Available 0.0029
6652 Genome polyprotein Not Available 0.0029
6734 Genome polyprotein Not Available 0.0029
6735 Genome polyprotein Not Available 0.0029
6736 Genome polyprotein Not Available 0.0029
6737 Genome polyprotein Not Available 0.0029
6738 Genome polyprotein Not Available 0.0029
6739 Genome polyprotein Not Available 0.0029
6744 Genome polyprotein Not Available 0.0029
6748 Genome polyprotein Not Available 0.0029
6894 Genome polyprotein Not Available 0.0029
6898 Genome polyprotein Not Available 0.0029
3822 Actin, alpha skeletal muscle ACTA1 0.0028
1588 Multidrug resistance protein 1 ABCB1 0.0027
864 Gag-Pol polyprotein gag-pol 0.0027
2237 Gag-Pol polyprotein gag-pol 0.0027
2326 Gag-Pol polyprotein gag-pol 0.0027
2451 Gag-Pol polyprotein gag-pol 0.0027
2901 Gag-Pol polyprotein gag-pol 0.0027
3165 Gag-Pol polyprotein gag-pol 0.0027
3722 Gag-Pol polyprotein gag-pol 0.0027
6306 Gag-Pol polyprotein gag-pol 0.0027
6624 Gag-Pol polyprotein gag-pol 0.0027
207 Glutathione synthetase GSS 0.0027
5269 Glutathione synthetase gshB 0.0027
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0027
3231 Death-associated protein kinase 1 DAPK1 0.0026
10 Glycogen phosphorylase, liver form PYGL 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0026
6131 Carbonic anhydrase 14 CA14 0.0025
1970 Protein kinase C alpha type PRKCA 0.0025
6122 Carbonic anhydrase 3 CA3 0.0025
6085 Fatty acid-binding protein, intestinal FABP2 0.0024
24 Thymidylate synthase TMP1 0.0024
359 Thymidylate synthase TYMS 0.0024
2626 Thymidylate synthase thyA 0.0024
2729 Thymidylate synthase thyA 0.0024
5352 Thymidylate synthase THYA 0.0024
2427 Ferrichrome-iron receptor fhuA 0.0024
887 DNA gyrase subunit B gyrB 0.0024
4150 DNA gyrase subunit B gyrB 0.0024
6225 DNA gyrase subunit B gyrB 0.0024
936 Ephrin type-A receptor 2 EPHA2 0.0024
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0023
634 Squalene monooxygenase SQLE 0.0023
7196 Squalene monooxygenase ERG1 0.0023
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0023
768 FK506-binding protein 1A FKBP1A 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
958 Insulin-like growth factor 1 receptor IGF1R 0.0022
3007 Carbonic anhydrase 12 CA12 0.0021
4205 Carbonic anhydrase 9 CA9 0.0021
1152 Glycogen phosphorylase, muscle form PYGM 0.0021
6126 Carbonic anhydrase 7 CA7 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.0019
1836 Mitogen-activated protein kinase 10 MAPK10 0.0019
465 Calmodulin CALM1 0.0017
592 Carbonic anhydrase 4 CA4 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
295 Carbonic anhydrase 1 CA1 0.0015
5304 UPF0166 protein TM_0021 TM_0021 0.0015
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0015
5293 Shikimate kinase 2 aroL 0.0015
5288 Shikimate kinase aroK 0.0015
5259 Transcriptional regulator ntrC1 0.0015
6699 Transcriptional regulator Cgl2612 0.0015
5287 Signaling protein Not Available 0.0015
5266 Activator of hgdC 0.0015
3199 Phosphopantetheine adenylyltransferase coaD 0.0015
3543 Phosphopantetheine adenylyltransferase coaD 0.0015
3567 Phosphopantetheine adenylyltransferase coaD 0.0015
5289 Phosphopantetheine adenylyltransferase coaD 0.0015
5283 D-alanine--D-alanine ligase B ddlB 0.0015
5299 D-alanine--D-alanine ligase ddl 0.0015
6598 D-alanine--D-alanine ligase ddl 0.0015
5276 Chromosomal replication initiator protein dnaA dnaA 0.0015
5292 Putative partitioning protein TT_C1605 0.0015
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0015
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0015
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0015
5291 Glycogen synthase 1 glgA1 0.0015
2874 Nitrogenase iron protein 1 nifH1 0.0015
4346 Polynucleotide kinase pseT 0.0015
5264 DNA replication protein REP 0.0015
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0015
5281 Plasmid segregation protein parM parM 0.0015
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0015
5308 Preprotein translocase secA 1 subunit secA1 0.0015
5285 Kinesin heavy chain KIF5B 0.0015
5315 Chaperone protein htpG htpG 0.0015
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0015
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0015
5284 Large T antigen Not Available 0.0015
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0015
5277 Preprotein translocase subunit secA secA 0.0015
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0015
5261 Phosphoribosylformylglycinamidine synthase purL 0.0015
1024 Solute carrier family 22 member 11 SLC22A11 0.0014
4774 NTPase P4 Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
4837 Cag-alfa cag-alfa 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
413 Amidophosphoribosyltransferase PPAT 0.0013
2515 Amidophosphoribosyltransferase purF 0.0013
3714 Amidophosphoribosyltransferase purF 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
2683 Mono-ADP-ribosyltransferase C3 C3 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
587 Serum albumin ALB 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
6024 Cytochrome P450 1A1 CYP1A1 0.0011
3669 Ribokinase rbsK 0.0011
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0011
1729 Solute carrier family 22 member 6 SLC22A6 0.0011
6013 Cytochrome P450 2E1 CYP2E1 0.0011
5300 Antigen peptide transporter 1 TAP1 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
408 Riboflavin kinase RFK 0.001
2282 Protein recA recA 0.001
2315 Protein recA recA 0.001
2332 Protein recA recA 0.001
5263 Protein recA recA 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2697 Uridine-cytidine kinase 2 UCK2 0.001
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.001
788 Creatine kinase M-type CKM 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
6395 Myosin-14 MYH14 0.0009
2091 Endoplasmin HSP90B1 0.0009
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0009
48 Pyridoxal kinase PDXK 0.0009
702 UMP-CMP kinase CMPK1 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0009
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0009
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
5294 Nucleoside diphosphate kinase A NME1 0.0008
5682 Ribonuclease pancreatic RNASE1 0.0007
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0007
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0007
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0007
4773 Deoxycytidine kinase DCK 0.0006
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