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H(+)/Cl(-) exchange transporter clcA


Partner ID 3428
Name H(+)/Cl(-) exchange transporter clcA
Synonyms 5478
Gene name clcA
General function Inorganic ion transport and metabolism
Specific function Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
Gene sequence + ...

ATGAAAACAGACACTTCCACCTTTTTAGCTCAGCAAATTGTGCGTTTACGGCGCAGAGATCAGATTCGCCGGTTAATGCAGCGGGATAAAACGCCGCTGGCCATCCTGTTCATGGCGGCCGTTGTCGGCACGCTTACCGGACTGGTTGGCGTCGCCTTTGAAAAGGCGGTTTCCTGGGTACAAAACATGCGCATTGGCGCGCTGGTTCAGGTCGCGGACCATGCGTTTTTGCTTTGGCCGCTGGCCTTTATCCTTTCGGCGTTACTGGCGATGGTCGGCTACTTTTTGGTGCGAAAATTTGCGCCGGAAGCCGGCGGCTCGGGTATCCCGGAAATTGAAGGTGCGCTGGAGGAGTTACGTCCGGTGCGCTGGTGGCGCGTGTTGCCGGTGAAGTTTATCGGCGGGATGGGAACGTTGGGCGCAGGAATGGTATTAGGGCGCGAAGGGCCAACGGTGCAAATCGGGGGCAACCTGGGGCGCATGGTGCTGGATGTTTTTCGTATGCGCAGCGCCGAAGCGCGGCATACGTTGCTGGCGACCGGCGCGGCGGCGGGGCTCTCTGCGGCGTTTAACGCGCCGCTGGCGGGTATCCTGTTTATTATTGAAGAGATGCGCCCGCAGTTTCGCTACAACCTGATTTCGATTAAAGCGGTGTTTACCGGCGTCATCATGTCGAGCATTGTGTTCCGCATATTTAACGGCGAAGCGCCGATTATTGAAGTCGGCAAACTGTCTGATGCGCCGGTTAACACGCTGTGGTTATACCTTATCCTCGGTATTATTTTTGGCTGCGTCGGGCCGGTATTTAATTCGCTGGTGCTGCGTACCCAGGATATGTTTCAGCGCTTTCATGGCGGCGAAATTAAAAAATGGGTGCTTATGGGCGGCGCGATCGGCGGCCTGTGCGGTATTCTGGGGTTGATTGAGCCGGCCGCGGCAGGCGGCGGATTTAACCTTATTCCTATCGCCGCGGCAGGTAATTTTAGCGTCGGGCTACTGCTGTTCATCTTTATTACCCGGGTTGTCACGACGCTGCTTTGCTTTTCTTCCGGCGCGCCGGGGGGCATTTTCGCCCCGATGCTGGCGCTGGGAACGCTGCTTGGTACGGCCTTCGGTATGGCGGCGGCAGTGCTTTTCCCGCAGTATCACCTGGAGGCCGGTACCTTTGCGATTGCCGGGATGGGGGCGCTGATGGCGGCGTCGGTGCGCGCCCCGTTGACAGGGATTGTGCTGGTGCTGGAGATGACCGATAACTATCAGCTCATTTTGCCAATGATTATCACCTGTCTTGGCGCGACACTATTAGCCCAGTTTTTGGGCGGGAAACCGTTATACTCAACCATCCTGGCGCGCACTCTGGCGAAGCAGGATGCGGAACAGGCGGAGAAAAACCAGAATGCGCCTGCGGACGAGAATACTTGA
Protein sequence + ...

MKTDTSTFLAQQIVRLRRRDQIRRLMQRDKTPLAILFMAAVVGTLTGLVGVAFEKAVSWVQNMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPAAAGGGFNLIPIAAAGNFSVGLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHLEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQAEKNQNAPADENT
GO Classification
component
membrane
cell
function
voltage-gated chloride channel activity
transporter activity
ion transporter activity
ion channel activity
voltage-gated ion channel activity
process
ion transport
anion transport
inorganic anion transport
chloride transport
physiological process
cellular physiological process
transport
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02440 N-Octane
DB03715 Pentadecane

Associated as Prediction

Id Name
DB01919 Pentanal
DB01940 Balanol Analog 2
DB02155 Balanol Analog 8
DB02440 N-Octane
DB02482 Phosphonothreonine
DB02611 Balanol Analog 1
DB02764 Hexane
DB03203 Sphingosine
DB03374 3,5-Diiodotyrosine
DB03600 Decanoic Acid
DB03715 Pentadecane
DB04098 Balanol
DB04224 Oleic Acid
DB04465 Lactose
DB04522 Phosphonoserine
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04707 HYDROXYFASUDIL
DB06959 (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE
DB06977 (2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE
DB07107 (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
DB07124 (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
DB07204 (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
DB07235 N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
DB07458 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE
DB07583 (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
DB07854 N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
DB07855 (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
DB07856 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
DB07857 (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB07858 (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
DB07860 (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
DB07876 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
DB07995 N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
DB07996 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
DB07997 N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
DB08070 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
DB08113 3-pyridin-4-yl-1H-indazole
DB08114 5-benzyl-1,3-thiazol-2-amine
DB08148 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
DB08149 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
DB08150 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
DB08162 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE
DB08231 MYRISTIC ACID
DB08568 (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE
DB08569 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
DB08756 (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
DB08846 Ellagic Acid
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