DT-Web

DB04465 - Lactose


Identification
Name Lactose
Accession Number DB04465 (EXPT02005)
Type small molecule
Description A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 342.2965
Groups experimental
Monoisotopic Weight 342.116211546
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glycosyltransferase 6 domain-containing protein 1
Name Glycosyltransferase 6 domain-containing protein 1
Gene Name GLT6D1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Glycolipid transfer protein
Name Glycolipid transfer protein
Gene Name GLTP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.805
Enterotoxin type B
Name Enterotoxin type B
Gene Name entB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5985
Sialidase
Name Sialidase
Gene Name nedA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8987
Hydrolase
Name Hydrolase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.6414
Trans-sialidase
Name Trans-sialidase
Gene Name TCTS-154
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8099
Endo-1,4-beta-xylanase A
Name Endo-1,4-beta-xylanase A
Gene Name xlnA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.1107
Beta-galactosidase
Name Beta-galactosidase
Gene Name lacZ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.826
Tetanus toxin
Name Tetanus toxin
Gene Name tetX
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3613

Predictions


Id Partner name Gene Name Score
2942 Sialidase nanH 0.8987
4335 Trans-sialidase Not Available 0.8099
4819 Hydrolase Not Available 0.6414
5436 Hydrolase Not Available 0.6414
3140 Hemagglutinin-neuraminidase HN 0.4
3609 Hemagglutinin-neuraminidase HN 0.4
3629 Endo-N-acetylneuraminidase Not Available 0.2751
64 Neuraminidase NA 0.2012
641 Neuraminidase NA 0.2012
2676 Neuraminidase NA 0.2012
3026 Neuraminidase NA 0.2012
3519 Neuraminidase NA 0.2012
6007 Neuraminidase NA 0.2012
5482 Sialidase-2 NEU2 0.1684
2560 Galactoside O-acetyltransferase lacA 0.1673
2914 Triosephosphate isomerase, glycosomal Not Available 0.1179
3428 H(+)/Cl(-) exchange transporter clcA clcA 0.1179
5247 Endo-1,4-beta-xylanase Not Available 0.1109
5248 Endo-1,4-beta-xylanase xlnA 0.1109
5250 Endo-1,4-beta-xylanase xyl 0.1109
4669 Endo-1,4-beta-xylanase A xynA 0.1107
5560 Endo-1,4-beta-xylanase A xynA 0.1107
5245 Endo-beta-1,4-xylanase Not Available 0.1055
5246 Xylanase Y BH2105 0.1053
4830 Aldose 1-epimerase galM 0.0964
3365 Beta-amylase spoII 0.0964
4808 Endoxylanase xynC 0.0918
5023 Glycoside hydrolase Not Available 0.0917
5024 Glycoside hydrolase Not Available 0.0917
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0892
5416 Coat protein VP1 Not Available 0.0837
2430 Chondroitinase B cslB 0.082
2324 Botulinum neurotoxin type B botB 0.0772
5414 Fiber protein L5 0.0742
5418 Fiber protein L5 0.0742
1756 E-selectin SELE 0.0742
4389 Lactose operon repressor lacI 0.0725
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0714
6508 Putative uncharacterized protein srtB 0.0677
6543 Putative uncharacterized protein tcp14 0.0677
6615 Putative uncharacterized protein MT0785 0.0677
6623 Putative uncharacterized protein Not Available 0.0677
6806 Putative uncharacterized protein AGR_C_2535 0.0677
6813 Putative uncharacterized protein SAV4671 0.0677
6815 Putative uncharacterized protein AFE_1514 0.0677
6819 Putative uncharacterized protein RUMGNA_03254 0.0677
6825 Putative uncharacterized protein CV_3270 0.0677
4161 Furin FURIN 0.0677
2581 Chondroitinase AC cslA 0.0664
1130 Lithostathine 1 alpha REG1A 0.0646
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0646
6847 Lactase-phlorizin hydrolase LCT 0.0639
6541 Peptostreptococcal albumin-binding protein pab 0.059
2723 Cholera enterotoxin subunit B ctxB 0.0568
3176 Trypsin-1 PRSS1 0.0538
2058 P-selectin SELP 0.0513
6755 Poliovirus receptor PVR 0.0505
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0434
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0434
2853 14 kDa fatty acid-binding protein Not Available 0.0393
2297 Genome polyprotein Not Available 0.0393
2322 Genome polyprotein Not Available 0.0393
2694 Genome polyprotein Not Available 0.0393
2719 Genome polyprotein Not Available 0.0393
2860 Genome polyprotein Not Available 0.0393
2928 Genome polyprotein Not Available 0.0393
3160 Genome polyprotein Not Available 0.0393
3260 Genome polyprotein Not Available 0.0393
4783 Genome polyprotein Not Available 0.0393
5726 Genome polyprotein Not Available 0.0393
5779 Genome polyprotein Not Available 0.0393
5867 Genome polyprotein Not Available 0.0393
6253 Genome polyprotein Not Available 0.0393
6301 Genome polyprotein Not Available 0.0393
6380 Genome polyprotein Not Available 0.0393
6381 Genome polyprotein Not Available 0.0393
6437 Genome polyprotein Not Available 0.0393
6520 Genome polyprotein Not Available 0.0393
6521 Genome polyprotein Not Available 0.0393
6652 Genome polyprotein Not Available 0.0393
6734 Genome polyprotein Not Available 0.0393
6735 Genome polyprotein Not Available 0.0393
6736 Genome polyprotein Not Available 0.0393
6737 Genome polyprotein Not Available 0.0393
6738 Genome polyprotein Not Available 0.0393
6739 Genome polyprotein Not Available 0.0393
6744 Genome polyprotein Not Available 0.0393
6748 Genome polyprotein Not Available 0.0393
6894 Genome polyprotein Not Available 0.0393
6898 Genome polyprotein Not Available 0.0393
2211 Fatty acid-binding protein, heart FABP3 0.0363
6501 Fatty acid-binding protein, liver FABP1 0.0343
6677 Myelin P2 protein PMP2 0.0342
4604 Liver carboxylesterase 1 CES1 0.0318
587 Serum albumin ALB 0.0298
1992 Vitamin D-binding protein GC 0.0277
2183 Fatty acid-binding protein, adipocyte FABP4 0.0271
3668 Maltose-binding periplasmic protein precursor malE 0.027
3312 Fatty acid-binding protein, brain FABP7 0.0263
3689 Endoglucanase A celA 0.022
5411 Slt-IIvB stxB2e 0.022
5563 Galectin-2 LGALS2 0.022
5046 Ecotin eco 0.0219
3009 Beta-glucanase Not Available 0.0219
5554 D-galactose-binding periplasmic protein mglB 0.0219
3741 D-galactose-binding periplasmic protein precursor mglB 0.0219
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0219
5568 Endoglucanase C307 celC307 0.0219
1875 Pulmonary surfactant-associated protein D SFTPD 0.0219
5569 Endo-1,4-beta glucanase EngF engF 0.0219
5562 Hexokinase Not Available 0.0219
5559 Neopullulanase nplT 0.0219
3793 Aspartate ammonia-lyase aspA 0.0219
4668 Laminarinase TM_0024 0.0219
4670 Cellulase B celB 0.0219
3744 Endoglucanase SS precursor celS 0.0219
5570 Endoglucanase E-4 celD 0.0219
5553 Endoglucanase E1 Acel_0614 0.0219
4667 BH0236 protein BH0236 0.0219
4671 Endoglucanase C cenC 0.0219
2286 Isocitrate dehydrogenase [NADP] icd 0.0193
2302 Isocitrate dehydrogenase [NADP] icd 0.0193
2771 Isocitrate dehydrogenase [NADP] icd 0.0193
1503 Galectin-7 LGALS7 0.0191
1184 Interferon beta IFNB1 0.0191
4509 Acetoin(diacetyl) reductase budC 0.0191
5176 YtnJ moxC 0.0191
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0191
5498 Maltoporin lamB 0.0191
5561 Maltoporin lamB 0.0191
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0191
4622 Amylase Not Available 0.0191
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0191
2705 Dimethyl sulfoxide reductase dmsA 0.0191
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0176
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0176
3747 Cellulase B precursor celB 0.0176
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0176
2531 Alpha-amylase amyE 0.0176
2948 Alpha-amylase amy 0.0176
3169 Alpha-amylase Not Available 0.0176
2541 Neopullulanase 1 tvaI 0.0176
3091 Maltodextrin phosphorylase malP 0.0176
2606 Neopullulanase 2 tvaII 0.0176
4811 Amylosucrase ams 0.0176
5694 Transcription antiterminator licT licT 0.0167
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0167
3361 Serpin B5 SERPINB5 0.0167
4666 Fucose-binding lectin PA-IIL lecB 0.0166
3225 Shiga toxin B-chain stxB 0.0166
2826 Glucose--fructose oxidoreductase gfo 0.0166
2372 Bifunctional tail protein 9 0.0166
1881 Hexokinase-1 HK1 0.0166
6614 Lactase-like protein LCTL 0.0159
3030 Salivary alpha-amylase AMY1A 0.0159
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0159
2508 Cyclomaltodextrin glucanotransferase cgt 0.0159
2523 Cyclomaltodextrin glucanotransferase cgt 0.0159
3207 Cyclomaltodextrin glucanotransferase amyA 0.0159
1675 Glucokinase GCK 0.0159
4662 Glucokinase glk 0.0159
4272 POSSIBLE CELLULASE CELA1 celA1 0.0153
2802 Endoglucanase G celCCG 0.0153
4692 A/G-specific adenine glycosylase mutY 0.0152
2440 Endoglucanase F celCCF 0.0145
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0138
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0138
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0138
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0138
2252 Endoglucanase 5A cel5A 0.0134
2245 Xylose isomerase xylA 0.0134
2253 Xylose isomerase xylA 0.0134
2260 Xylose isomerase xylA 0.0134
2431 Xylose isomerase xylA 0.0134
56 Delta-aminolevulinic acid dehydratase ALAD 0.0134
2356 Delta-aminolevulinic acid dehydratase hemB 0.0134
3613 Delta-aminolevulinic acid dehydratase hemB 0.0134
3674 Delta-aminolevulinic acid dehydratase hemB 0.0134
1588 Multidrug resistance protein 1 ABCB1 0.0127
10 Glycogen phosphorylase, liver form PYGL 0.0124
2427 Ferrichrome-iron receptor fhuA 0.0123
4513 Pancreatic alpha-amylase AMY2A 0.0123
4534 Cytohesin-2 CYTH2 0.0121
1152 Glycogen phosphorylase, muscle form PYGM 0.0099
315 Arginase-1 ARG1 0.0098
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0089
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0089
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0088
5591 Complement component C8 gamma chain C8G 0.0088
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0088
5582 Regulator of transcription; stringent starvation protein A sspA 0.0088
5590 N utilization substance protein B homolog nusB 0.0088
4695 UPF0124 protein yfiH yfiH 0.0088
5588 Cell division protein FtsY TM_0570 0.0088
5587 Iron(III)-binding periplasmic protein fbpA 0.0088
2838 Ribose-5-phosphate isomerase A rpiA 0.0088
2952 Ribose-5-phosphate isomerase A rpiA 0.0088
5595 Ribose-5-phosphate isomerase A rpiA 0.0088
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0088
5581 Beta-fructosidase bfrA 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
4375 Glutamine synthetase 1 glnA1 0.0088
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0088
2300 Lysozyme E 0.0088
3633 Lysozyme R 0.0088
5597 Lysozyme 17 0.0088
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0088
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0088
5593 Transferase Not Available 0.0088
5060 Intron-associated endonuclease 1 ITEVIR 0.0088
5574 Invasin YPTB1668 0.0088
5575 Short tail fiber protein 12 0.0088
5600 Pyruvate decarboxylase pdc 0.0088
5580 Hexon protein PII 0.0088
4533 Glyoxalase family protein BC_1747 0.0076
3132 Tryptophan synthase alpha chain trpA 0.0076
6568 Tryptophan synthase alpha chain trpA 0.0076
4992 Cytochrome c peroxidase Not Available 0.0076
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0076
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0076
3729 Citrate synthase gltA 0.0076
4575 Citrate synthase cit 0.0076
4580 Citrate synthase gltA 0.0076
5006 RNASE4 protein RNASE4 0.0076
5328 Prostaglandin F synthase Tb11.02.2310 0.0076
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0076
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0076
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0076
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0076
2555 Pol polyprotein pol 0.0076
3242 Pol polyprotein gag-pol 0.0076
3471 Pol polyprotein gag-pro-pol 0.0076
5256 Pol polyprotein pol 0.0076
6469 Pol polyprotein gag-pol 0.0076
6565 Pol polyprotein Not Available 0.0076
24 Thymidylate synthase TMP1 0.0073
359 Thymidylate synthase TYMS 0.0073
2626 Thymidylate synthase thyA 0.0073
2729 Thymidylate synthase thyA 0.0073
5352 Thymidylate synthase THYA 0.0073
2603 Beta-lactamase II blm 0.007
3583 6-phosphogluconolactonase pgl 0.007
2149 Angiogenin ANG 0.007
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.007
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.007
2521 Cell division protein ftsZ ftsZ 0.007
3301 Cell division protein ftsZ ftsZ 0.007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.007
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0067
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0066
3486 Fumarate hydratase class II fumC 0.0066
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0064
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0062
857 Malate dehydrogenase, mitochondrial MDH2 0.0062
332 Beta-lactamase blaZ 0.0061
2478 Beta-lactamase ampC 0.0061
2613 Beta-lactamase ampC 0.0061
2635 Beta-lactamase ampC 0.0061
2700 Beta-lactamase penP 0.0061
5445 Beta-lactamase blaB 0.0061
6019 Beta-lactamase SHV-7 0.0061
6701 Beta-lactamase cphA 0.0061
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0061
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0061
2697 Uridine-cytidine kinase 2 UCK2 0.0061
1123 Eosinophil cationic protein RNASE3 0.0061
20 Prostaglandin G/H synthase 1 PTGS1 0.0061
2452 Tryptophanyl-tRNA synthetase trpS 0.006
5579 Carboxypeptidase B CPB1 0.0058
3384 Macrophage migration inhibitory factor MIF 0.0057
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0056
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0056
411 Glycine N-methyltransferase GNMT 0.0054
128 Adenine phosphoribosyltransferase APRT 0.0049
5682 Ribonuclease pancreatic RNASE1 0.0044
822 Aldose reductase AKR1B1 0.0044
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0043
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0033
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