DT-Web

DB08705 - 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE


Identification
Name 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE
Accession Number DB08705
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 367.196
Groups experimental
Monoisotopic Weight 366.000390253
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene serine/threonine-protein kinase Pim-1
Name Proto-oncogene serine/threonine-protein kinase Pim-1
Gene Name PIM1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2654

Predictions


Id Partner name Gene Name Score
6290 Death-associated protein kinase 3 DAPK3 0.0588
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0561
6391 Protein kinase C iota type PRKCI 0.0488
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0398
2530 Protein kinase C theta type PRKCQ 0.0156
2473 Tyrosine-protein kinase CSK CSK 0.0113
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0113
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0098
3361 Serpin B5 SERPINB5 0.0097
5694 Transcription antiterminator licT licT 0.0097
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0097
10 Glycogen phosphorylase, liver form PYGL 0.0095
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0084
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0084
3602 Anti-sigma F factor antagonist spoIIAA 0.0082
2514 Phosphocarrier protein HPr ptsH 0.0082
5689 Phosphocarrier protein HPr ptsH 0.0082
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0082
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0079
2408 Tyrosine-protein kinase SYK SYK 0.0079
56 Delta-aminolevulinic acid dehydratase ALAD 0.0078
2356 Delta-aminolevulinic acid dehydratase hemB 0.0078
3613 Delta-aminolevulinic acid dehydratase hemB 0.0078
3674 Delta-aminolevulinic acid dehydratase hemB 0.0078
1721 Glycogen synthase kinase-3 beta GSK3B 0.0078
6837 Serine/threonine-protein kinase 17B STK17B 0.0077
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0077
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0074
2286 Isocitrate dehydrogenase [NADP] icd 0.0074
2302 Isocitrate dehydrogenase [NADP] icd 0.0074
2771 Isocitrate dehydrogenase [NADP] icd 0.0074
1130 Lithostathine 1 alpha REG1A 0.0071
4542 Glutaminase 1 glsA1 0.0071
4544 Glutaminase 1 glsA1 0.0071
4534 Cytohesin-2 CYTH2 0.0071
3668 Maltose-binding periplasmic protein precursor malE 0.0068
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0067
4318 Siroheme synthase cysG 0.0066
3119 Fimbrial protein pilE1 0.0065
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0065
6599 HTH-type transcriptional regulator ttgR ttgR 0.0062
3453 Alkaline phosphatase phoA 0.0062
2592 Beta-galactosidase lacZ 0.0061
2503 Phosphomannomutase/phosphoglucomutase algC 0.0059
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0059
5150 Endo-1,4-beta-xylanase Y xynY 0.0059
2599 Tyrosine-protein kinase HCK HCK 0.0058
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0058
388 AMP deaminase 1 AMPD1 0.0058
315 Arginase-1 ARG1 0.0057
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0056
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0056
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0056
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0054
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0054
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.005
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.005
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.005
297 Adenylate cyclase type 1 ADCY1 0.005
128 Adenine phosphoribosyltransferase APRT 0.0049
1291 cAMP response element-binding protein CREB1 0.0049
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0049
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0048
6021 Adenosine kinase ADK 0.0046
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0046
2207 Rhodopsin RHO 0.0045
1588 Multidrug resistance protein 1 ABCB1 0.0043
489 Monocarboxylate transporter 2 SLC16A7 0.0043
24 Thymidylate synthase TMP1 0.0043
359 Thymidylate synthase TYMS 0.0043
2626 Thymidylate synthase thyA 0.0043
2729 Thymidylate synthase thyA 0.0043
5352 Thymidylate synthase THYA 0.0043
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0043
2240 Cell division protein kinase 2 CDK2 0.0042
1152 Glycogen phosphorylase, muscle form PYGM 0.0037
738 Monocarboxylate transporter 1 SLC16A1 0.0033
3794 Osmolarity sensor protein envZ envZ 0.0032
5641 Rod shape-determining protein MreB TM_0588 0.0032
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0032
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0032
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0032
5645 DNA topoisomerase 4 subunit B parE 0.0032
6227 DNA topoisomerase 4 subunit B parE 0.0032
5643 General secretion pathway protein E epsE 0.0032
5644 Sensor protein phoQ phoQ 0.0032
5642 Chaperone clpB clpB 0.0032
5649 Potassium-transporting ATPase B chain kdpB 0.0032
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0029
2282 Protein recA recA 0.0028
2315 Protein recA recA 0.0028
2332 Protein recA recA 0.0028
5263 Protein recA recA 0.0028
5646 Galactokinase GALK1 0.0028
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0028
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0028
5302 TrwB trwB 0.0028
5265 FtsH ftsH 0.0028
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0028
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0028
4751 Mitogen-activated protein kinase 12 MAPK12 0.0028
2397 Dihydroxyacetone kinase dhaK 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
2852 DNA mismatch repair protein mutL mutL 0.0028
5312 Kinesin-like protein KIF1A KIF1A 0.0026
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0026
3231 Death-associated protein kinase 1 DAPK1 0.0026
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0026
862 Multidrug resistance-associated protein 1 ABCC1 0.0025
2615 Chemotaxis protein cheA cheA 0.0024
1881 Hexokinase-1 HK1 0.0024
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0024
2371 Pantothenate kinase coaA 0.0024
2892 Acetylglutamate kinase argB 0.0024
3550 Acetylglutamate kinase argB 0.0024
825 Arsenical pump-driving ATPase ASNA1 0.0024
3435 Arsenical pump-driving ATPase arsA 0.0024
2727 S-adenosylmethionine synthetase metK 0.0023
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0023
887 DNA gyrase subunit B gyrB 0.0023
4150 DNA gyrase subunit B gyrB 0.0023
6225 DNA gyrase subunit B gyrB 0.0023
936 Ephrin type-A receptor 2 EPHA2 0.0023
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0022
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0022
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0022
958 Insulin-like growth factor 1 receptor IGF1R 0.0021
2251 Thymidylate kinase tmk 0.002
2254 Thymidylate kinase DTYMK 0.002
3522 Thymidylate kinase tmk 0.002
4924 Cytochrome P450 2C8 CYP2C8 0.0019
3822 Actin, alpha skeletal muscle ACTA1 0.0019
207 Glutathione synthetase GSS 0.0018
5269 Glutathione synthetase gshB 0.0018
1836 Mitogen-activated protein kinase 10 MAPK10 0.0018
4192 DNA topoisomerase 2-beta TOP2B 0.0018
2236 Casein kinase II subunit alpha CSNK2A1 0.0017
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