DT-Web

DB00622 - Nicardipine


Identification
Name Nicardipine
Accession Number DB00622 (APRD00088)
Type small molecule
Description A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 479.525
Groups approved
Monoisotopic Weight 479.205635675
Pharmacology
Indication Used for the management of patients with chronic stable angina and for the treatment of hypertension.
Mechanism of action By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, nicardipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Absorption While nicardipine is completely absorbed, it is subject to saturable first pass metabolism and the systemic bioavailability is about 35% following a 30 mg oral dose at steady state.
Protein binding >95%
Biotransformation Nicardipine HCl is metabolized extensively by the liver.
Route of elimination Nicardipine has been shown to be rapidly and extensively metabolized by the liver.
Toxicity Oral LD50 Rat = 184 mg/kg, Oral LD50 Mouse = 322 mg/kg
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bromazepam Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nicardipine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Cyclosporine Nicardipine increases the effect and toxicity of cyclosporine
Dantrolene Nicardipine may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if nicardipine is initiated, discontinued or dose changed.
Quinupristin This combination presents an increased risk of toxicity
Tacrolimus The calcium channel blocker, Nicardipine, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Nicardipine therapy is initiated, discontinued or altered.
Tadalafil Nicardipine may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Nicardipine may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Nicardipine may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Nicardipine is initiated, discontinued or dose changed.
Tamsulosin Nicardipine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nicardipine is initiated, discontinued, or dose changed.
Telithromycin Co-administration may result in altered plasma concentrations of Nicardipine and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus Nicardipine may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Nicardipine, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Nicardipine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiopental The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nicardipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nicardipine if Thiopental is initiated, discontinued or dose changed.
Tiagabine The strong CYP3A4 inhibitor, Nicardipine, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Nicardipine is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may alter the concentration of Nicardipine. Monitor for efficacy and adverse/toxic effects of Nicardipine.
Tolbutamide Nicardipine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Nicardipine is initiated, discontinued or dose changed.
Tolterodine Nicardipine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The p-glycoprotein inhibitor, Nicardipine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Torasemide Nicardipine, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Nicardipine is initiated, discontinued or dose changed.
Tramadol Nicardipine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Nicardipine may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Nicardipine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Nicardipine is initiated, discontinued or dose changed.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trimethoprim The strong CYP2C9 inhibitor, Nicardipine, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Nicardipine is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4 inhibitor, Nicardipine, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Nicardipine is initiated, discontinued or dose changed.
Vardenafil Nicardipine, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Nicardipine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Nicardipine is initiated, discontinued, or dose changed.
Verapamil Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nicardipine is initiated, discontinued or dose changed.
Vinblastine Nicardipine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nicardipine is initiated, discontinued or dose changed.
Vincristine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nicardipine is initiated, discontinued or dose changed.
Vinorelbine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Nicardipine is initiated, discontinued or dose changed.
Voriconazole Nicardipine, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of nicardipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole and nicardipine if concomitant therapy is initiated, discontinued or doses are changed.
Warfarin Nicardipine, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if nicardipine is initiated, discontinued or dose changed.
Zafirlukast Nicardipine, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if nicardipine is initiated, discontinued or dose changed.
Zolpidem Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nicardipine is initiated, discontinued or dose changed.
Zonisamide Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if nicardipine is initiated, discontinued or dose changed.
Zopiclone Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nicardipine is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Grapefruit and grapefruit juice should be avoided throughout treatment. Grapefruit can increase serum levels of this product.

Targets


Voltage-dependent L-type calcium channel subunit alpha-1C
Name Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score 0.5305
Voltage-dependent L-type calcium channel subunit beta-2
Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name CACNB2
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score 0.4391
Voltage-dependent L-type calcium channel subunit alpha-1D
Name Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name CACNA1D
Pharmacological action yes
Actions inhibitor
References
  • Bell DC, Butcher AJ, Berrow NS, Page KM, Brust PF, Nesterova A, Stauderman KA, Seabrook GR, Nurnberg B, Dolphin AC: Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents. J Neurophysiol. 2001 Feb;85(2):816-27. - Pubmed
DTHybrid score 0.4264
Voltage-dependent calcium channel subunit alpha-2/delta-1
Name Voltage-dependent calcium channel subunit alpha-2/delta-1
Gene Name CACNA2D1
Pharmacological action yes
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Striessnig, J. (2004). Ca ^2+^ channel blockers. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 201-207). Berlin, Germany: Springer. -
DTHybrid score 0.4881
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Gene Name PDE1A
Pharmacological action unknown
Actions inhibitor
References
  • Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. - Pubmed
DTHybrid score Not Available
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Name Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Gene Name PDE1B
Pharmacological action unknown
Actions inhibitor
References
  • Sharma RK, Wang JH, Wu Z: Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists. J Neurochem. 1997 Aug;69(2):845-50. - Pubmed
DTHybrid score Not Available
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.6527
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.4873
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.3802
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.9865
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.8606
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.87
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.647
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action unknown
Actions antagonist
References
  • Thayer SA, Welcome M, Chhabra A, Fairhurst AS: Effects of dihydropyridine calcium channel blocking drugs on rat brain muscarinic and alpha-adrenergic receptors. Biochem Pharmacol. 1985 Jan 15;34(2):175-80. - Pubmed
DTHybrid score 0.5496
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions other/unknown
References
  • Thayer SA, Fairhurst AS: The interaction of dihydropyridine calcium channel blockers with calmodulin and calmodulin inhibitors. Mol Pharmacol. 1983 Jul;24(1):6-9. - Pubmed
DTHybrid score 0.5624

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.1726
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9402
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7707
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6595
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5648
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5033
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4714
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5716

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharm Res. 2000 Oct;17(10):1189-97. - Pubmed
  • Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE: Influence of passive permeability on apparent P-glycoprotein kinetics. Pharm Res. 2000 Dec;17(12):1456-60. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Takara K, Sakaeda T, Tanigawara Y, Nishiguchi K, Ohmoto N, Horinouchi M, Komada F, Ohnishi N, Yokoyama T, Okumura K: Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. Eur J Pharm Sci. 2002 Aug;16(3):159-65. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
DTHybrid score 0.7785

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.5521
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.3953
6107 Cytochrome P450 3A7 CYP3A7 0.3875
492 Histamine H1 receptor HRH1 0.3041
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.2551
502 5-hydroxytryptamine 2A receptor HTR2A 0.2505
831 D(2) dopamine receptor DRD2 0.2445
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.2432
318 Alpha-2A adrenergic receptor ADRA2A 0.2255
5718 Cytochrome P450 2A6 CYP2A6 0.2226
6024 Cytochrome P450 1A1 CYP1A1 0.2156
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1924
23 D(1A) dopamine receptor DRD1 0.1825
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1748
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.1688
587 Serum albumin ALB 0.165
590 5-hydroxytryptamine 2C receptor HTR2C 0.1603
824 Sodium-dependent serotonin transporter SLC6A4 0.1579
629 Alpha-2B adrenergic receptor ADRA2B 0.1421
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.141
3923 Cholinesterase BCHE 0.1349
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.1328
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1327
320 5-hydroxytryptamine 1A receptor HTR1A 0.1298
378 Alpha-2C adrenergic receptor ADRA2C 0.127
20 Prostaglandin G/H synthase 1 PTGS1 0.1241
6145 Solute carrier family 22 member 1 SLC22A1 0.1191
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.1182
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.1136
6106 Cytochrome P450 2C18 CYP2C18 0.1077
432 D(4) dopamine receptor DRD4 0.1041
6048 Troponin C, skeletal muscle TNNC2 0.1039
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1035
638 D(3) dopamine receptor DRD3 0.0975
6144 Solute carrier family 22 member 2 SLC22A2 0.0959
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0948
713 Sodium-dependent dopamine transporter SLC6A3 0.0946
766 Beta-2 adrenergic receptor ADRB2 0.0933
193 Beta-1 adrenergic receptor ADRB1 0.0926
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0892
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0887
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0851
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0846
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0836
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0804
737 Mineralocorticoid receptor NR3C2 0.0796
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0794
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0791
862 Multidrug resistance-associated protein 1 ABCC1 0.078
118 Organic cation/carnitine transporter 2 SLC22A5 0.0713
341 5-hydroxytryptamine 3 receptor HTR3A 0.0712
725 5-hydroxytryptamine 1D receptor HTR1D 0.0707
885 5-hydroxytryptamine 1B receptor HTR1B 0.0695
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0662
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0662
3811 Cytochrome P450 19A1 CYP19A1 0.0649
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0636
4604 Liver carboxylesterase 1 CES1 0.0634
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0628
1898 Cytochrome P450 1B1 CYP1B1 0.0621
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0619
163 D(1B) dopamine receptor DRD5 0.0612
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.061
1256 5-hydroxytryptamine 6 receptor HTR6 0.0604
3941 Amine oxidase [flavin-containing] A MAOA 0.0598
833 Organic cation/carnitine transporter 1 SLC22A4 0.0594
290 Prostaglandin G/H synthase 2 PTGS2 0.0585
6147 Solute carrier family 22 member 3 SLC22A3 0.0585
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0579
716 5-hydroxytryptamine 7 receptor HTR7 0.0576
1729 Solute carrier family 22 member 6 SLC22A6 0.0575
776 Bile salt export pump ABCB11 0.0569
436 5-hydroxytryptamine 2B receptor HTR2B 0.056
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0558
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0549
847 Mu-type opioid receptor OPRM1 0.0526
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.052
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0516
467 Delta-type opioid receptor OPRD1 0.0501
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0489
528 5-hydroxytryptamine 1E receptor HTR1E 0.0486
696 Kappa-type opioid receptor OPRK1 0.0481
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.048
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0466
136 Estrogen receptor ESR1 0.045
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0441
260 Cytochrome P450 51 ERG11 0.0438
761 Cytochrome P450 51 ERG11 0.0438
3163 Cytochrome P450 51 cyp51 0.0438
731 HIV-1 protease HIV-1 protease 0.0435
6220 Aryl hydrocarbon receptor AHR 0.0434
871 Glucocorticoid receptor NR3C1 0.0414
124 Histamine H2 receptor HRH2 0.0413
2164 Multidrug resistance-associated protein 4 ABCC4 0.0413
131 Synaptic vesicular amine transporter SLC18A2 0.0401
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0399
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0399
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0398
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0386
6142 Solute carrier family 22 member 8 SLC22A8 0.0385
1089 Cartilage oligomeric matrix protein COMP 0.0378
1108 Calpastatin CAST 0.0378
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0373
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0372
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0371
6031 Cytochrome P450 3A43 CYP3A43 0.0369
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0369
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0367
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0365
1507 Cytochrome c CYCS 0.0364
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.036
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0348
722 Troponin I, cardiac muscle TNNI3 0.0347
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0346
468 Cytochrome P450 4A11 CYP4A11 0.0341
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0332
2129 Sucrase-isomaltase, intestinal SI 0.0331
6182 Cytochrome P450 2J2 CYP2J2 0.0328
6143 Solute carrier family 22 member 7 SLC22A7 0.0325
6138 Multidrug resistance protein 3 ABCB4 0.0324
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0324
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0317
16 Adenosine A1 receptor ADORA1 0.0317
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0305
122 P2Y purinoceptor 12 P2RY12 0.0303
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0299
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0295
3939 Amine oxidase [flavin-containing] B MAOB 0.0288
1656 CYP2B protein CYP2B 0.0279
751 Potassium channel subfamily K member 6 KCNK6 0.027
817 DNA topoisomerase 2-alpha TOP2A 0.0269
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0265
295 Carbonic anhydrase 1 CA1 0.0264
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0262
5694 Transcription antiterminator licT licT 0.0262
3361 Serpin B5 SERPINB5 0.0262
6148 Multidrug resistance-associated protein 7 ABCC10 0.0261
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.026
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0259
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0259
233 Potassium channel subfamily K member 2 KCNK2 0.0256
474 Acetylcholinesterase ACHE 0.0247
146 Androgen receptor AR 0.0246
6432 Transporter snf 0.0246
172 Potassium channel subfamily K member 1 KCNK1 0.0246
828 Phenylalanine-4-hydroxylase PAH 0.0244
3109 Phenylalanine-4-hydroxylase phhA 0.0244
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0238
891 Dihydropteroate synthase folP 0.0238
5359 Dihydropteroate synthase folP 0.0238
7175 Dihydropteroate synthase sulI 0.0238
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0235
705 Glutamate receptor 1 GRIA1 0.023
2132 Protein S100-B S100B 0.0222
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0219
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0218
4120 NADPH--cytochrome P450 reductase POR 0.0218
482 Glycine receptor subunit alpha-1 GLRA1 0.0216
844 Epidermal growth factor receptor EGFR 0.0214
24 Thymidylate synthase TMP1 0.0214
359 Thymidylate synthase TYMS 0.0214
2626 Thymidylate synthase thyA 0.0214
2729 Thymidylate synthase thyA 0.0214
5352 Thymidylate synthase THYA 0.0214
1517 Beta-3 adrenergic receptor ADRB3 0.0213
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0212
723 Cytosolic phospholipase A2 PLA2G4A 0.0211
56 Delta-aminolevulinic acid dehydratase ALAD 0.0209
2356 Delta-aminolevulinic acid dehydratase hemB 0.0209
3613 Delta-aminolevulinic acid dehydratase hemB 0.0209
3674 Delta-aminolevulinic acid dehydratase hemB 0.0209
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0206
811 Translocator protein TSPO 0.0206
504 Mast/stem cell growth factor receptor KIT 0.0205
614 Progesterone receptor PGR 0.0204
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0202
380 Cytochrome P450 17A1 CYP17A1 0.02
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.02
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0199
6137 Multidrug resistance-associated protein 6 ABCC6 0.0198
2286 Isocitrate dehydrogenase [NADP] icd 0.0198
2302 Isocitrate dehydrogenase [NADP] icd 0.0198
2771 Isocitrate dehydrogenase [NADP] icd 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
1024 Solute carrier family 22 member 11 SLC22A11 0.0197
94 5-hydroxytryptamine 4 receptor HTR4 0.0195
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0194
70 Type-1 angiotensin II receptor AGTR1 0.0191
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0191
4534 Cytohesin-2 CYTH2 0.0188
6136 Multidrug resistance-associated protein 5 ABCC5 0.0188
777 Tumor necrosis factor TNF 0.0187
3947 Xanthine dehydrogenase/oxidase XDH 0.0187
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0183
537 ATP synthase delta chain, mitochondrial ATP5D 0.0182
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0182
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0182
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0182
3668 Maltose-binding periplasmic protein precursor malE 0.0182
1618 High affinity nerve growth factor receptor NTRK1 0.0181
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0181
3876 Aromatic-L-amino-acid decarboxylase DDC 0.018
6141 Sodium/bile acid cotransporter SLC10A1 0.0177
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0176
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0175
161 Tubulin beta chain TUBB 0.0174
312 Tubulin beta chain TUB2 0.0174
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0173
1010 Cytochrome P450 51A1 CYP51A1 0.0173
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0173
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0173
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0173
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0173
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0171
80 Peroxisome proliferator-activated receptor alpha PPARA 0.017
6102 Arylamine N-acetyltransferase 2 NAT2 0.0168
29 Tubulin beta-1 chain TUBB1 0.0163
2592 Beta-galactosidase lacZ 0.0163
869 Estrogen receptor beta ESR2 0.0162
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0162
756 Sex hormone-binding globulin SHBG 0.0161
407 Vascular endothelial growth factor receptor 2 KDR 0.0161
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.016
315 Arginase-1 ARG1 0.0158
1757 Myeloperoxidase MPO 0.0157
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0153
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0153
26 Vascular endothelial growth factor receptor 3 FLT4 0.0152
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0152
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0151
952 Dipeptidyl peptidase 4 DPP4 0.0151
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0148
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0146
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0146
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
818 50S ribosomal protein L10 rplJ 0.0146
32 Vascular endothelial growth factor receptor 1 FLT1 0.0146
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0145
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0143
174 Sigma 1-type opioid receptor SIGMAR1 0.0142
6859 Protein S100-A4 S100A4 0.014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0139
1360 Sphingomyelin phosphodiesterase SMPD1 0.0138
228 Beta platelet-derived growth factor receptor PDGFRB 0.0137
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0136
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0136
365 Dihydrofolate reductase DHFR 0.0135
2381 Dihydrofolate reductase DFR1 0.0135
2833 Dihydrofolate reductase Not Available 0.0135
2931 Dihydrofolate reductase folA 0.0135
3544 Dihydrofolate reductase folA 0.0135
3682 Dihydrofolate reductase folA 0.0135
6642 Dihydrofolate reductase folA 0.0135
6756 Dihydrofolate reductase dfrA 0.0135
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
1636 Trace amine-associated receptor 1 TAAR1 0.0134
4116 Dihydropteroate synthetase Not Available 0.0131
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.013
427 Substance-P receptor TACR1 0.0127
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0125
1192 Sulfotransferase 1A1 SULT1A1 0.0125
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
1178 Adenosine A2a receptor ADORA2A 0.0123
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0123
373 Transthyretin TTR 0.0121
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0121
6014 Cytochrome P450 2A13 CYP2A13 0.0121
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.012
164 Histamine H4 receptor HRH4 0.012
6085 Fatty acid-binding protein, intestinal FABP2 0.0119
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0118
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0117
2795 Methionine aminopeptidase 2 METAP2 0.0117
1262 Corticotropin-lipotropin POMC 0.0117
592 Carbonic anhydrase 4 CA4 0.0116
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
362 Melatonin receptor type 1B MTNR1B 0.0113
571 Melatonin receptor type 1A MTNR1A 0.0113
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0113
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.011
921 Glutamate receptor 2 GRIA2 0.0108
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0107
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0106
5682 Ribonuclease pancreatic RNASE1 0.0104
738 Monocarboxylate transporter 1 SLC16A1 0.0104
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0102
3810 Catechol O-methyltransferase COMT 0.0102
823 Fibroblast growth factor receptor 2 FGFR2 0.0102
3932 Glutathione S-transferase A2 GSTA2 0.0101
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.01
319 Opioid receptor, sigma 1 OPRS1 0.01
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0098
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0098
6020 Aldehyde oxidase AOX1 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
4122 Histone deacetylase 2 HDAC2 0.0096
4203 Histamine N-methyltransferase HNMT 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
49 Endothelin B receptor EDNRB 0.0096
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
183 Vascular endothelial growth factor A VEGFA 0.0091
578 Endothelin-1 receptor EDNRA 0.009
153 Dopamine beta-hydroxylase DBH 0.009
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
239 Coagulation factor X F10 0.0087
357 Carbonic anhydrase 2 CA2 0.0087
275 Arachidonate 5-lipoxygenase ALOX5 0.0086
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
6126 Carbonic anhydrase 7 CA7 0.0084
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
165 FL cytokine receptor FLT3 0.0083
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
814 Ryanodine receptor 1 RYR1 0.0083
208 DNA-directed RNA polymerase beta' chain rpoC 0.008
5774 DNA-directed RNA polymerase beta' chain rpoC 0.008
6151 Monocarboxylate transporter 10 SLC16A10 0.008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
518 Peroxidase/catalase T katG 0.008
768 FK506-binding protein 1A FKBP1A 0.0079
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
477 DNA topoisomerase 4 subunit A parC 0.0078
886 DNA topoisomerase 4 subunit A parC 0.0078
6226 DNA topoisomerase 4 subunit A parC 0.0078
88 Retinoic acid receptor RXR-beta RXRB 0.0078
84 Nuclear receptor 0B1 NR0B1 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
469 Annexin A1 ANXA1 0.0077
404 DNA gyrase subunit A gyrA 0.0077
6224 DNA gyrase subunit A gyrA 0.0077
4237 50S ribosomal protein L22 rplV 0.0076
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
54 Prothrombin F2 0.0076
563 Thyroid peroxidase TPO 0.0075
904 Glutathione S-transferase P GSTP1 0.0075
4311 tRNA TRDMT1 0.0075
4325 tRNA trmD 0.0075
4328 tRNA trmD 0.0075
1541 Metalloproteinase mmp20 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
444 Alcohol dehydrogenase 1B ADH1B 0.0073
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0072
1050 Bile salt sulfotransferase SULT2A1 0.0071
6174 50S ribosomal protein L32 rpmF 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0071
1629 Transcription factor AP-1 JUN 0.007
3830 Calreticulin CALR 0.007
251 Alcohol dehydrogenase 1A ADH1A 0.007
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.007
3809 Estrogen-related receptor gamma ESRRG 0.007
1852 Microtubule-associated protein 2 MAP2 0.007
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
68 Cannabinoid receptor 1 CNR1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
6035 Nuclear receptor ROR-beta RORB 0.0066
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0066
6034 Hydroxyindole O-methyltransferase ASMT 0.0066
6036 Eosinophil peroxidase EPX 0.0066
1630 Integrin beta-2 ITGB2 0.0066
976 Platelet glycoprotein IX GP9 0.0065
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0065
1275 Estrogen sulfotransferase SULT1E1 0.0064
284 DNA-directed RNA polymerase beta chain rpoB 0.0063
5773 DNA-directed RNA polymerase beta chain rpoB 0.0063
2616 Ganglioside GM2 activator GM2A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
133 Dihydropterate synthase sulI 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
2449 Tubulin alpha-3 chain TUBA1A 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0062
780 Retinoic acid receptor RXR-gamma RXRG 0.0062
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
7 Nitric oxide synthase, inducible NOS2 0.0061
273 Apoptosis regulator Bcl-2 BCL2 0.006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1196 Complement decay-accelerating factor CD55 0.006
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0059
5787 Angiopoietin-1 receptor TEK 0.0059
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
634 Squalene monooxygenase SQLE 0.0057
7196 Squalene monooxygenase ERG1 0.0057
765 Indoleamine 2,3-dioxygenase IDO1 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
6146 High affinity copper uptake protein 1 SLC31A1 0.0057
517 Alcohol dehydrogenase 1C ADH1C 0.0056
3426 Glutamine synthetase glnA 0.0056
3987 Glutamine synthetase GLUL 0.0056
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0056
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0056
1374 Natriuretic peptides B NPPB 0.0055
1827 Gap junction alpha-1 protein GJA1 0.0055
1908 Vascular cell adhesion protein 1 VCAM1 0.0055
6506 Stathmin-4 STMN4 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
3937 Fatty-acid amide hydrolase FAAH 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
162 Retinoic acid receptor gamma-1 RARG 0.0052
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
1992 Vitamin D-binding protein GC 0.0052
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3913 Glutamic acid decarboxylase GAD65 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
908 Glutathione S-transferase theta-1 GSTT1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.005
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.005
3404 Exotoxin A eta 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0048
2230 Catalase CAT 0.0048
3249 Catalase katA 0.0048
3625 Catalase katA 0.0048
4539 Catalase katA 0.0048
4941 Catalase katB 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6766 O-GlcNAcase BT_4395 BT_4395 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
4773 Deoxycytidine kinase DCK 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
1253 Interferon gamma IFNG 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
1648 Elastin ELN 0.0046
936 Ephrin type-A receptor 2 EPHA2 0.0046
4192 DNA topoisomerase 2-beta TOP2B 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0045
527 Prostacyclin receptor PTGIR 0.0045
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0045
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
4210 Toll-like receptor 4 TLR4 0.0044
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0044
130 Prostacyclin synthase PTGIS 0.0044
5934 Cytochrome P450 26A1 CYP26A1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
3904 Alanine aminotransferase 2 GPT2 0.0043
6044 Serum paraoxonase/lactonase 3 PON3 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0041
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.004
572 Integrin alpha-L ITGAL 0.004
3868 Calcineurin subunit B isoform 2 PPP3R2 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0038
820 Glycine receptor subunit alpha-2 GLRA2 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
33 Cystine/glutamate transporter SLC7A11 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
719 Retinoic acid receptor responder protein 1 RARRES1 0.0037
770 Retinoic acid-induced protein 3 GPRC5A 0.0037
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0037
5798 Mitogen-activated protein kinase 11 MAPK11 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0036
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
6221 Steroid hormone receptor ERR1 ESRRA 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
6755 Poliovirus receptor PVR 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
1039 Histone deacetylase 9 HDAC9 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0034
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0034
268 Adenosine A2b receptor ADORA2B 0.0033
2207 Rhodopsin RHO 0.0033
5880 Thrombopoietin receptor MPL 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0033
3917 Methylenetetrahydrofolate reductase MTHFR 0.0032
291 Nitric-oxide synthase, endothelial NOS3 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
3957 Adenosine deaminase ADA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1864 RET proto-oncogene RET 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0031
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0031
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1650 Heme carrier protein 1 SLC46A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
1268 Neuropeptide S receptor NPSR1 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
2298 Cytochrome P450-cam camC 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
6459 Glycodelin PAEP 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
896 Glutathione S-transferase Mu 1 GSTM1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
358 Cystathionine beta-synthase CBS 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
2320 Thymidine kinase, cytosolic TK1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
6316 ADP-ribosylation factor 1 ARF1 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
2021 Thrombomodulin THBD 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6163 Copper-transporting ATPase 2 ATP7B 0.0025
6165 Copper-transporting ATPase 1 ATP7A 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6218 Pannexin-1 PANX1 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
3221 Cytochrome c4 cc4 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
5961 Insulin INS 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
6228 Nuclear receptor coactivator 1 NCOA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
2802 Endoglucanase G celCCG 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
↑