DT-Web

DB00599 - Thiopental


Identification
Name Thiopental
Accession Number DB00599 (APRD00660)
Type small molecule
Description A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 242.338
Groups approved
Monoisotopic Weight 242.10889852
Pharmacology
Indication For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders.
Mechanism of action Thiopental binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Absorption Rapidly absorbed.
Protein binding Approximately 80% of the drug in the blood is bound to plasma protein.
Biotransformation Primarily hepatic. Biotransformation products of thiopental are pharmacologically inactive and mostly excreted in the urine.
Route of elimination Not Available
Toxicity Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by an alarming fall in blood pressure even to shock levels. Apnea, occasional laryngospasm, coughing and other respiratory difficulties with excessive or too rapid injections may occur. Lethal blood levels may be as low as 1 mg/100 mL for short-acting barbiturates; less if other depressant drugs or alcohol are also present.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Thiopental may increase the metabolism of the Vitamin K antagonist, Acenocoumarol. Acenocoumarol dose adjustment may be required.
Amlodipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Amlodipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Amlodipine if Thiopental is initiated, discontinued or dose changed.
Chloramphenicol Chloramphenicol may increase the serum concentration of Thiopental by decreasing Thiopental metabolism. Thiopental may decrease the serum concentration of Chloramphenicol by increasing Chloramphenicol metabolism. Monitor for changes in therapeutic effects of both agents if concomitant therapy is initiated, discontinued or doses are adjusted.
Cyclosporine Thiopental may increase the metabolism and clearance of Cyclosporine. Monitor for changes in the therapeutic/adverse effects of Cyclosporine if Thiopental is initiated, discontinued or dose changed.
Desogestrel Thiopental may decrease the effect of Desogestrel. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Diltiazem The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Diltiazem, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Diltiazem if Thiopental is initiated, discontinued or dose changed.
Disopyramide Thiopental may increase the metabolism and clearance of Disopyramide. Monitor for changes in therapeutic/adverse effects of Disopyramide if Thiopental is inititaed, discontinued or dose changed.
Doxycycline Thiopental may decrease the serum levels of Doxycycline. A reduction in antimicrobial effects may occur. An alternative antibiotic may be considered.
Drospirenone Thiopental may decrease the effect of Drospirenone. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Ethinyl Estradiol Thiopental may decrease the effect of Ethinyl estradiol. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Ethynodiol Diacetate Thiopental may decrease the effect of Ethynodiol diacetate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Etonogestrel Thiopental may decrease the effect of Etonogestrel. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Felodipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Felodipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Felodipine if Thiopental is initiated, discontinued or dose changed.
Isradipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Isradipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Isradipine if Thiopental is initiated, discontinued or dose changed.
Lamotrigine Thiopental may increase the metabolism and clearance of Lamotrigine. Monitor for decreased therapeutic effect of Lamotrigine if Thiopental is initiated.
Levonorgestrel Thiopental may decrease the effect of Levonorgestrel. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Medroxyprogesterone Thiopental may decrease the effect of Medroxyprogesterone. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Mestranol Thiopental may decrease the effect of Mestranol. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Methadone Thiopental may decrease the effect of Methadone by increasing Methadone metabolism. Methadone withdrawal may occur.
Nicardipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nicardipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nicardipine if Thiopental is initiated, discontinued or dose changed.
Nifedipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nifedipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nifedipine if Thiopental is initiated, discontinued or dose changed.
Nimodipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nimodipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nimodipine if Thiopental is initiated, discontinued or dose changed.
Nisoldipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nisoldipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nisoldipine if Thiopental is initiated, discontinued or dose changed.
Nitrendipine The CYP3A4 inducer, Thiopental, may increase the metabolism and clearance of Nitrendipine, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Nitrendipine if Thiopental is initiated, discontinued or dose changed.
Norethindrone Thiopental may decrease the effect of Norethindrone. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Norgestimate Thiopental may decrease the effect of Norgestimate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Propafenone Thiopental may increase the metabolism and clearance of Propafenone. Monitor for decreased therapeutic effect of Propafenone if Thiopental is initiated.
Quinidine Thiopental may increase the metabolism and clearance of Quinidine. Monitor for decreased therapeutic effect of Quinidine if Thiopental is initiated.
Trimipramine The barbiturate, Thiopental, may increase the metabolism and clearance of Trimipramine. Monitor for changes in the therapeutics and adverse effects of Trimipramine if Thiopental is initiated, discontinued or dose changed. Dose adjustments of Trimipramine may be required.
Triprolidine The CNS depressants, Triprolidine and Thiopental, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Verapamil Thiopental, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Thiopental is initiated, discontinued or dose changed.
Warfarin Thiopental may decrease the serum concentration of warfarin by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of warfarin if thiopental is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
  • Grasshoff C, Netzhammer N, Schweizer J, Antkowiak B, Hentschke H: Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition. Neuropharmacology. 2008 Oct;55(5):793-802. Epub 2008 Jun 21. - Pubmed
DTHybrid score 0.8648
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.8062
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7943
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.7542
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
DTHybrid score 0.8041
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. - Pubmed
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
DTHybrid score 0.7538
Neuronal acetylcholine receptor subunit alpha-4
Name Neuronal acetylcholine receptor subunit alpha-4
Gene Name CHRNA4
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.7057
Neuronal acetylcholine receptor subunit alpha-7
Name Neuronal acetylcholine receptor subunit alpha-7
Gene Name CHRNA7
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.7059
Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 1.3205
Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions antagonist
References
  • Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. - Pubmed
  • Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. - Pubmed
DTHybrid score 0.8505
Fatty-acid amide hydrolase
Name Fatty-acid amide hydrolase
Gene Name FAAH
Pharmacological action unknown
Actions inhibitor
References
  • Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ: The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0538

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3096
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.468

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.2176
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.1953
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.1951
4757 Cytochrome P450 2C9 CYP2C9 0.1942
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1906
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1878
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1758
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1746
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1745
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1744
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1743
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1739
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1737
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1735
4200 Cytochrome P450 1A2 CYP1A2 0.1646
6245 SDS hydrolase SdsA1 sdsA1 0.1544
6030 Cytochrome P450 2B6 CYP2B6 0.1414
4924 Cytochrome P450 2C8 CYP2C8 0.1366
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.1286
4119 Cytochrome P450 2D6 CYP2D6 0.128
811 Translocator protein TSPO 0.1101
1588 Multidrug resistance protein 1 ABCB1 0.1089
5718 Cytochrome P450 2A6 CYP2A6 0.1017
4118 Cytochrome P450 3A5 CYP3A5 0.1004
6107 Cytochrome P450 3A7 CYP3A7 0.0833
20 Prostaglandin G/H synthase 1 PTGS1 0.0616
6024 Cytochrome P450 1A1 CYP1A1 0.0607
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0577
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.051
6106 Cytochrome P450 2C18 CYP2C18 0.0448
587 Serum albumin ALB 0.0432
1898 Cytochrome P450 1B1 CYP1B1 0.0299
3811 Cytochrome P450 19A1 CYP19A1 0.026
482 Glycine receptor subunit alpha-1 GLRA1 0.0249
172 Potassium channel subfamily K member 1 KCNK1 0.0249
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0243
468 Cytochrome P450 4A11 CYP4A11 0.0242
862 Multidrug resistance-associated protein 1 ABCC1 0.0234
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0229
502 5-hydroxytryptamine 2A receptor HTR2A 0.0228
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0227
705 Glutamate receptor 1 GRIA1 0.0223
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0221
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0218
776 Bile salt export pump ABCB11 0.0213
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0211
831 D(2) dopamine receptor DRD2 0.0206
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0202
492 Histamine H1 receptor HRH1 0.0201
537 ATP synthase delta chain, mitochondrial ATP5D 0.02
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0197
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0196
556 Alpha-1A adrenergic receptor ADRA1A 0.0192
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0189
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0189
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0189
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0189
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0188
6145 Solute carrier family 22 member 1 SLC22A1 0.018
6144 Solute carrier family 22 member 2 SLC22A2 0.0177
824 Sodium-dependent serotonin transporter SLC6A4 0.0172
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0171
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.017
6031 Cytochrome P450 3A43 CYP3A43 0.0169
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0169
871 Glucocorticoid receptor NR3C1 0.0168
1181 Alpha-1-acid glycoprotein 1 ORM1 0.016
923 Glutamate receptor 3 GRIA3 0.0159
260 Cytochrome P450 51 ERG11 0.0158
761 Cytochrome P450 51 ERG11 0.0158
3163 Cytochrome P450 51 cyp51 0.0158
318 Alpha-2A adrenergic receptor ADRA2A 0.0156
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
23 D(1A) dopamine receptor DRD1 0.0148
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0147
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0141
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0141
6102 Arylamine N-acetyltransferase 2 NAT2 0.0141
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.014
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0136
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0133
136 Estrogen receptor ESR1 0.0133
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0129
290 Prostaglandin G/H synthase 2 PTGS2 0.0127
1729 Solute carrier family 22 member 6 SLC22A6 0.0124
3923 Cholinesterase BCHE 0.0123
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.012
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0116
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0115
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0115
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0113
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.011
617 Muscarinic acetylcholine receptor M2 CHRM2 0.011
320 5-hydroxytryptamine 1A receptor HTR1A 0.0109
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0108
3426 Glutamine synthetase glnA 0.0105
3987 Glutamine synthetase GLUL 0.0105
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0102
3941 Amine oxidase [flavin-containing] A MAOA 0.01
6147 Solute carrier family 22 member 3 SLC22A3 0.0096
731 HIV-1 protease HIV-1 protease 0.0095
118 Organic cation/carnitine transporter 2 SLC22A5 0.0094
6014 Cytochrome P450 2A13 CYP2A13 0.0094
847 Mu-type opioid receptor OPRM1 0.0093
341 5-hydroxytryptamine 3 receptor HTR3A 0.0093
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0092
474 Acetylcholinesterase ACHE 0.0091
833 Organic cation/carnitine transporter 1 SLC22A4 0.0091
465 Calmodulin CALM1 0.009
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0089
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0088
590 5-hydroxytryptamine 2C receptor HTR2C 0.0087
632 Alpha-1B adrenergic receptor ADRA1B 0.0086
629 Alpha-2B adrenergic receptor ADRA2B 0.0085
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0084
3939 Amine oxidase [flavin-containing] B MAOB 0.0083
16 Adenosine A1 receptor ADORA1 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
592 Carbonic anhydrase 4 CA4 0.0082
232 Corticosteroid-binding globulin SERPINA6 0.008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.008
820 Glycine receptor subunit alpha-2 GLRA2 0.0078
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0078
6020 Aldehyde oxidase AOX1 0.0077
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
467 Delta-type opioid receptor OPRD1 0.0073
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0073
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
789 Alpha-1D adrenergic receptor ADRA1D 0.0071
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0071
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.007
2164 Multidrug resistance-associated protein 4 ABCC4 0.0069
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0068
885 5-hydroxytryptamine 1B receptor HTR1B 0.0068
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0067
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0067
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0067
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0067
638 D(3) dopamine receptor DRD3 0.0066
713 Sodium-dependent dopamine transporter SLC6A3 0.0065
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0065
777 Tumor necrosis factor TNF 0.0064
251 Alcohol dehydrogenase 1A ADH1A 0.0063
444 Alcohol dehydrogenase 1B ADH1B 0.0063
614 Progesterone receptor PGR 0.0062
817 DNA topoisomerase 2-alpha TOP2A 0.0062
357 Carbonic anhydrase 2 CA2 0.006
1178 Adenosine A2a receptor ADORA2A 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
696 Kappa-type opioid receptor OPRK1 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
766 Beta-2 adrenergic receptor ADRB2 0.0058
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0057
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0057
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0056
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0056
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0056
725 5-hydroxytryptamine 1D receptor HTR1D 0.0055
29 Tubulin beta-1 chain TUBB1 0.0054
3947 Xanthine dehydrogenase/oxidase XDH 0.0054
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0053
461 Glycine receptor subunit alpha-3 GLRA3 0.0053
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
4604 Liver carboxylesterase 1 CES1 0.0051
122 P2Y purinoceptor 12 P2RY12 0.005
6143 Solute carrier family 22 member 7 SLC22A7 0.005
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.005
1010 Cytochrome P450 51A1 CYP51A1 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0048
517 Alcohol dehydrogenase 1C ADH1C 0.0048
161 Tubulin beta chain TUBB 0.0048
312 Tubulin beta chain TUB2 0.0048
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0048
432 D(4) dopamine receptor DRD4 0.0047
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0047
6220 Aryl hydrocarbon receptor AHR 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
4122 Histone deacetylase 2 HDAC2 0.0046
295 Carbonic anhydrase 1 CA1 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
193 Beta-1 adrenergic receptor ADRB1 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.004
2981 Phospholipase A2, membrane associated PLA2G2A 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3932 Glutathione S-transferase A2 GSTA2 0.0039
1024 Solute carrier family 22 member 11 SLC22A11 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
891 Dihydropteroate synthase folP 0.0038
5359 Dihydropteroate synthase folP 0.0038
7175 Dihydropteroate synthase sulI 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
153 Dopamine beta-hydroxylase DBH 0.0037
869 Estrogen receptor beta ESR2 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6126 Carbonic anhydrase 7 CA7 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0036
3404 Exotoxin A eta 0.0036
856 Vitamin D3 receptor VDR 0.0035
284 DNA-directed RNA polymerase beta chain rpoB 0.0035
5773 DNA-directed RNA polymerase beta chain rpoB 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
1757 Myeloperoxidase MPO 0.0034
6138 Multidrug resistance protein 3 ABCB4 0.0034
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
3810 Catechol O-methyltransferase COMT 0.0033
735 Alanine aminotransferase 1 GPT 0.0032
3904 Alanine aminotransferase 2 GPT2 0.0032
373 Transthyretin TTR 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
146 Androgen receptor AR 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
904 Glutathione S-transferase P GSTP1 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0031
6141 Sodium/bile acid cotransporter SLC10A1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.003
1256 5-hydroxytryptamine 6 receptor HTR6 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0029
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0029
756 Sex hormone-binding globulin SHBG 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0028
6136 Multidrug resistance-associated protein 5 ABCC5 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0027
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0027
1268 Neuropeptide S receptor NPSR1 0.0027
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0027
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0027
2298 Cytochrome P450-cam camC 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
518 Peroxidase/catalase T katG 0.0027
163 D(1B) dopamine receptor DRD5 0.0027
365 Dihydrofolate reductase DHFR 0.0027
2381 Dihydrofolate reductase DFR1 0.0027
2833 Dihydrofolate reductase Not Available 0.0027
2931 Dihydrofolate reductase folA 0.0027
3544 Dihydrofolate reductase folA 0.0027
3682 Dihydrofolate reductase folA 0.0027
6642 Dihydrofolate reductase folA 0.0027
6756 Dihydrofolate reductase dfrA 0.0027
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
1050 Bile salt sulfotransferase SULT2A1 0.0026
49 Endothelin B receptor EDNRB 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
563 Thyroid peroxidase TPO 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
6073 Potassium channel subfamily K member 9 KCNK9 0.0024
6072 Potassium channel subfamily K member 3 KCNK3 0.0024
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
124 Histamine H2 receptor HRH2 0.0024
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
358 Cystathionine beta-synthase CBS 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0023
922 Glutamate receptor 4 GRIA4 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
737 Mineralocorticoid receptor NR3C2 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0022
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0022
4027 Glutamate receptor delta-1 subunit GRID1 0.0022
4018 Glutamate receptor delta-2 subunit GRID2 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0022
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0022
1912 Excitatory amino acid transporter 1 SLC1A3 0.0022
664 Glutamate decarboxylase 2 GAD2 0.0022
3890 Glutamate decarboxylase 2 GAD2 0.0022
4016 Excitatory amino acid transporter 5 SLC1A7 0.0022
4019 Excitatory amino acid transporter 4 SLC1A6 0.0022
1047 Excitatory amino acid transporter 2 SLC1A2 0.0022
4026 Aspartyl aminopeptidase DNPEP 0.0022
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0022
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0022
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0022
925 Metabotropic glutamate receptor 4 GRM4 0.0022
926 Metabotropic glutamate receptor 7 GRM7 0.0022
927 Metabotropic glutamate receptor 8 GRM8 0.0022
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0022
4020 Glutamyl aminopeptidase ENPEP 0.0022
4017 5-oxoprolinase OPLAH 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0021
1656 CYP2B protein CYP2B 0.0021
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
380 Cytochrome P450 17A1 CYP17A1 0.0021
3601 Dihydropteroate synthase 1 folP1 0.0021
3807 Dihydropteroate synthase 1 folP1 0.0021
3808 Dihydropteroate synthase 2 folP2 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.002
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
625 Glutamate carboxypeptidase 2 FOLH1 0.002
275 Arachidonate 5-lipoxygenase ALOX5 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
6432 Transporter snf 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.002
738 Monocarboxylate transporter 1 SLC16A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0019
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0019
5 Glutaminase liver isoform, mitochondrial GLS2 0.0019
917 Glutaminase kidney isoform, mitochondrial GLS 0.0019
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0019
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0019
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0019
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0019
5261 Phosphoribosylformylglycinamidine synthase purL 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0019
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0019
183 Vascular endothelial growth factor A VEGFA 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
665 Phosphoserine aminotransferase PSAT1 0.0019
4652 Phosphoserine aminotransferase serC 0.0019
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0019
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0019
420 Glutamate decarboxylase 1 GAD1 0.0019
3900 Glutamate decarboxylase 1 GAD1 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
4120 NADPH--cytochrome P450 reductase POR 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
916 Metabotropic glutamate receptor 1 GRM1 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
2207 Rhodopsin RHO 0.0018
683 Potassium transporter GK0582 0.0018
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
239 Coagulation factor X F10 0.0017
1671 Excitatory amino acid transporter 3 SLC1A1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0017
976 Platelet glycoprotein IX GP9 0.0017
3877 Growth-inhibiting protein 18 GIG18 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0017
1374 Natriuretic peptides B NPPB 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0017
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0017
426 Aspartate aminotransferase, mitochondrial GOT2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
763 Tyrosine aminotransferase TAT 0.0016
5493 Tyrosine aminotransferase Not Available 0.0016
228 Beta platelet-derived growth factor receptor PDGFRB 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0016
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
173 Toll-like receptor 7 TLR7 0.0016
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0016
528 5-hydroxytryptamine 1E receptor HTR1E 0.0015
3233 Bile acid receptor NR1H4 0.0015
54 Prothrombin F2 0.0015
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0015
427 Substance-P receptor TACR1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
4311 tRNA TRDMT1 0.0015
4325 tRNA trmD 0.0015
4328 tRNA trmD 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
4192 DNA topoisomerase 2-beta TOP2B 0.0015
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
1541 Metalloproteinase mmp20 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
469 Annexin A1 ANXA1 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
1618 High affinity nerve growth factor receptor NTRK1 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
164 Histamine H4 receptor HRH4 0.0012
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
2236 Casein kinase II subunit alpha CSNK2A1 0.0011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
6151 Monocarboxylate transporter 10 SLC16A10 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
3957 Adenosine deaminase ADA 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
3221 Cytochrome c4 cc4 0.0009
4773 Deoxycytidine kinase DCK 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0008
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
6085 Fatty acid-binding protein, intestinal FABP2 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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