DT-Web: DB00717

Identification

Name

Norethindrone

Accession Number

DB00717 (APRD00679)

Type

small molecule

Description

A synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

298.4192

Groups

approved

Monoisotopic Weight

298.193280076

Pharmacology

Indication

Norethindrone acetate is indicated for the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.

Mechanism of action

Progestins diffuse freely into target cells and bind to the progesterone receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

Absorption

Norethindrone acetate is completely and rapidly deacetylated to norethindrone (NET) after oral administration, and the disposition of norethindrone acetate is indistinguishable from that of orally administered norethindrone. Norethindrone is rapidly absorbed from norethindrone acetate, in which maximum plasma concentration occur 2 hours post-dose (Tmax). When a single dose is given to healthy women, the Cmax is 26.19 ? 6.19 hours. The AUC (0-inf) is 166.90 ? 56.28 ng/mL*h. Absolute oral bioavailability is approximately 64%. The effect of food on the pharmacokinetics of norethindrone acetate is unknown.

Protein binding

Norethindrone is 36% bound to sex hormone-binding globulin and 61% bound to albumin.

Biotransformation

Hepatic. Norethindrone is extensively metabolized, primarily via reduction. It also undergoes sulfate and glucuronide conjugation. The majority of metabolites in the circulation are sulfates, with glucuronides accounting for most of the urinary metabolites.

Route of elimination

Norethindrone is excreted in both urine and feces, primarily as metabolites.

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acitretin	Acitretine may cause a loss of contraceptive effect
Amobarbital	This product may cause a slight decrease of contraceptive effect
Aprobarbital	This product may cause a slight decrease of contraceptive effect
Artemether	Artemether may decrease the effectiveness of norethindrone by increasing its metabolism via CYP3A4. Consider an alternate non-hormonal means of contraception during artemether therapy.
Bexarotene	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of norethindrone, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Bosentan	Bosentan may decrease the contraceptive effect of norethindrone. Hormonal contraception should not be relied on alone during concomitant therapy with bosentan.
Butabarbital	This product may cause a slight decrease of contraceptive effect
Butalbital	This product may cause a slight decrease of contraceptive effect
Butethal	This product may cause a slight decrease of contraceptive effect
Carbamazepine	This product may cause a slight decrease of contraceptive effect
Colesevelam	Bile Acid Sequestrants may decrease the serum concentration of Contraceptives (Progestins). Administer oral progestin-containing contraceptives at least 1-4 hours prior to or 4-6 hours after administration of a bile acid sequestrant. Consider alternatives in order to avoid this combination when possible, due to the risk for impaired contraceptive effectiveness.
Ethotoin	This product may cause a slight decrease of contraceptive effect
Fosphenytoin	This product may cause a slight decrease of contraceptive effect
Griseofulvin	This product may cause a slight decrease of contraceptive effect
Heptabarbital	This product may cause a slight decrease of contraceptive effect
Hexobarbital	This product may cause a slight decrease of contraceptive effect
Lamotrigine	The oral contraceptive decreases the effect of lamotrigine
Mephenytoin	This product may cause a slight decrease of contraceptive effect
Methohexital	This product may cause a slight decrease of contraceptive effect
Methylphenobarbital	This product may cause a slight decrease of contraceptive effect
Pentobarbital	This product may cause a slight decrease of contraceptive effect
Phenobarbital	This product may cause a slight decrease of contraceptive effect
Phenytoin	This product may cause a slight decrease of contraceptive effect
Pioglitazone	Possible loss of contraceptive effect
Primidone	This product may cause a slight decrease of contraceptive effect
Rifabutin	Rifabutin may decrease the contraceptive effect of norethindrone. Hormonal contraception should not be solely relied on alone during concomitant therapy with rifabutin.
Rifampin	This product may cause a slight decrease of contraceptive effect
Rifapentine	This product may cause a slight decrease of contraceptive effect
Rufinamide	Rufinamide decreases plasma concentrations of norethindrone, thus consider therapy modification
Secobarbital	This product may cause a slight decrease of contraceptive effect
St. John's Wort	St. John's Wort could reduce the contraceptive effect
Talbutal	This product may cause a slight decrease of contraceptive effect
Thiopental	Thiopental may decrease the effect of Norethindrone. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy.
Tizanidine	The contraceptive increases the effect of tizanidine
Tretinoin	Oral Tretinoin may decrease the effect of oral contraceptive, Norethindrone. An alternate form of contraception should be used during concomitant therapy.
Troglitazone	Possible loss of contraceptive effect
Warfarin	Norethindrone may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if norethindrone is initiated, discontinued or dose changed.

Food Interactions

Take without regard to meals.

Progesterone receptor
Name	Progesterone receptor
Gene Name	PGR
Pharmacological action	unknown
Actions	agonist
References	Mendoza-Rodriguez CA, Camacho-Arroyo I, Garcia GA, Cerbon MA: Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites. Contraception. 1999 May;59(5):339-43. - Pubmed Madauss KP, Deng SJ, Austin RJ, Lambert MH, McLay I, Pritchard J, Short SA, Stewart EL, Uings IJ, Williams SP: Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. J Med Chem. 2004 Jun 17;47(13):3381-7. - Pubmed Garcia-Becerra R, Cooney AJ, Borja-Cacho E, Lemus AE, Perez-Palacios G, Larrea F: Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins. J Steroid Biochem Mol Biol. 2004 Jun;91(1-2):21-7. - Pubmed Mirkin S, Wong BC, Archer DF: Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells. Fertil Steril. 2005 Aug;84(2):485-91. - Pubmed Pasapera AM, Cerbon MA, Castro I, Gutierrez R, Camacho-Arroyo I, Garcia GA, Perez-Palacios G: Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits. Biol Reprod. 1995 Feb;52(2):426-32. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6153

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6751
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.412
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3268
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.342

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inducer
References	Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. - Pubmed
DTHybrid score	0.4437

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.4437

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.271
4119	Cytochrome P450 2D6	CYP2D6	0.252
4924	Cytochrome P450 2C8	CYP2C8	0.2054
4200	Cytochrome P450 1A2	CYP1A2	0.2008
136	Estrogen receptor	ESR1	0.1907
146	Androgen receptor	AR	0.1432
6030	Cytochrome P450 2B6	CYP2B6	0.1392
3811	Cytochrome P450 19A1	CYP19A1	0.1081
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1013
6013	Cytochrome P450 2E1	CYP2E1	0.1009
871	Glucocorticoid receptor	NR3C1	0.0975
6024	Cytochrome P450 1A1	CYP1A1	0.0874
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0839
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0814
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0748
5718	Cytochrome P450 2A6	CYP2A6	0.0662
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0662
862	Multidrug resistance-associated protein 1	ABCC1	0.066
869	Estrogen receptor beta	ESR2	0.0658
20	Prostaglandin G/H synthase 1	PTGS1	0.0638
6145	Solute carrier family 22 member 1	SLC22A1	0.0618
1729	Solute carrier family 22 member 6	SLC22A6	0.0568
2202	Steryl-sulfatase	STS	0.0552
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.052
6106	Cytochrome P450 2C18	CYP2C18	0.0484
232	Corticosteroid-binding globulin	SERPINA6	0.0471
290	Prostaglandin G/H synthase 2	PTGS2	0.0468
737	Mineralocorticoid receptor	NR3C2	0.0466
6142	Solute carrier family 22 member 8	SLC22A8	0.0466
492	Histamine H1 receptor	HRH1	0.044
824	Sodium-dependent serotonin transporter	SLC6A4	0.0428
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0421
1898	Cytochrome P450 1B1	CYP1B1	0.0413
6144	Solute carrier family 22 member 2	SLC22A2	0.0394
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0391
847	Mu-type opioid receptor	OPRM1	0.0388
831	D(2) dopamine receptor	DRD2	0.0379
776	Bile salt export pump	ABCB11	0.0375
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0375
556	Alpha-1A adrenergic receptor	ADRA1A	0.0374
6031	Cytochrome P450 3A43	CYP3A43	0.0368
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0359
6143	Solute carrier family 22 member 7	SLC22A7	0.0355
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0354
269	Adrenodoxin, mitochondrial	FDX1	0.0348
381	Prolactin receptor	PRLR	0.0347
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0346
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0339
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0338
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0337
380	Cytochrome P450 17A1	CYP17A1	0.0311
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0306
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0304
1649	Small inducible cytokine A2	CCL2	0.0301
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0298
731	HIV-1 protease	HIV-1 protease	0.0295
260	Cytochrome P450 51	ERG11	0.0285
761	Cytochrome P450 51	ERG11	0.0285
3163	Cytochrome P450 51	cyp51	0.0285
3923	Cholinesterase	BCHE	0.0282
467	Delta-type opioid receptor	OPRD1	0.0274
23	D(1A) dopamine receptor	DRD1	0.0265
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0264
2164	Multidrug resistance-associated protein 4	ABCC4	0.0263
632	Alpha-1B adrenergic receptor	ADRA1B	0.0262
6147	Solute carrier family 22 member 3	SLC22A3	0.0257
696	Kappa-type opioid receptor	OPRK1	0.0253
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0246
1024	Solute carrier family 22 member 11	SLC22A11	0.0239
891	Dihydropteroate synthase	folP	0.0236
5359	Dihydropteroate synthase	folP	0.0236
7175	Dihydropteroate synthase	sulI	0.0236
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0236
318	Alpha-2A adrenergic receptor	ADRA2A	0.0233
118	Organic cation/carnitine transporter 2	SLC22A5	0.0233
766	Beta-2 adrenergic receptor	ADRB2	0.0232
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0232
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0229
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0227
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0221
6182	Cytochrome P450 2J2	CYP2J2	0.022
6148	Multidrug resistance-associated protein 7	ABCC10	0.0218
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0216
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0214
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0212
6241	Nuclear receptor coactivator 2	NCOA2	0.0212
6141	Sodium/bile acid cotransporter	SLC10A1	0.021
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0209
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0206
817	DNA topoisomerase 2-alpha	TOP2A	0.0204
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0203
638	D(3) dopamine receptor	DRD3	0.0203
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0201
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.02
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.02
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0198
193	Beta-1 adrenergic receptor	ADRB1	0.0197
713	Sodium-dependent dopamine transporter	SLC6A3	0.0193
844	Epidermal growth factor receptor	EGFR	0.0193
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0183
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0182
723	Cytosolic phospholipase A2	PLA2G4A	0.0178
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0178
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0177
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0176
469	Annexin A1	ANXA1	0.0175
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0174
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0174
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0174
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0174
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0173
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0171
468	Cytochrome P450 4A11	CYP4A11	0.017
4604	Liver carboxylesterase 1	CES1	0.017
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0169
3941	Amine oxidase [flavin-containing] A	MAOA	0.0167
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0167
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0167
789	Alpha-1D adrenergic receptor	ADRA1D	0.0164
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0164
833	Organic cation/carnitine transporter 1	SLC22A4	0.0164
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0163
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0159
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0158
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0157
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0153
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0153
811	Translocator protein	TSPO	0.0153
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0152
122	P2Y purinoceptor 12	P2RY12	0.0149
465	Calmodulin	CALM1	0.0148
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0146
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0146
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0146
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0142
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0142
629	Alpha-2B adrenergic receptor	ADRA2B	0.0141
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0141
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.014
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0139
378	Alpha-2C adrenergic receptor	ADRA2C	0.0139
818	50S ribosomal protein L10	rplJ	0.0135
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0134
504	Mast/stem cell growth factor receptor	KIT	0.0132
6085	Fatty acid-binding protein, intestinal	FABP2	0.0128
705	Glutamate receptor 1	GRIA1	0.0128
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0127
6137	Multidrug resistance-associated protein 6	ABCC6	0.0125
124	Histamine H2 receptor	HRH2	0.0125
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0124
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0123
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0123
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0123
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0123
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0122
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0122
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0121
26	Vascular endothelial growth factor receptor 3	FLT4	0.0121
768	FK506-binding protein 1A	FKBP1A	0.012
6136	Multidrug resistance-associated protein 5	ABCC5	0.0118
70	Type-1 angiotensin II receptor	AGTR1	0.0117
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0116
32	Vascular endothelial growth factor receptor 1	FLT1	0.0115
432	D(4) dopamine receptor	DRD4	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
161	Tubulin beta chain	TUBB	0.0115
312	Tubulin beta chain	TUB2	0.0115
407	Vascular endothelial growth factor receptor 2	KDR	0.0112
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
4120	NADPH--cytochrome P450 reductase	POR	0.0111
29	Tubulin beta-1 chain	TUBB1	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.011
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.011
3939	Amine oxidase [flavin-containing] B	MAOB	0.011
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
716	5-hydroxytryptamine 7 receptor	HTR7	0.0109
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0108
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0108
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0108
6014	Cytochrome P450 2A13	CYP2A13	0.0108
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
373	Transthyretin	TTR	0.0107
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0105
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0105
1656	CYP2B protein	CYP2B	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
777	Tumor necrosis factor	TNF	0.0104
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0104
952	Dipeptidyl peptidase 4	DPP4	0.0103
738	Monocarboxylate transporter 1	SLC16A1	0.0099
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0099
2539	Tubulin alpha-1 chain	TUBA4A	0.0098
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0097
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0097
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0096
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0096
4237	50S ribosomal protein L22	rplV	0.0095
566	Serotransferrin	TF	0.0094
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0093
427	Substance-P receptor	TACR1	0.0092
1010	Cytochrome P450 51A1	CYP51A1	0.0091
1353	DNA topoisomerase 1	TOP1	0.0089
3552	DNA topoisomerase 1	topA	0.0089
183	Vascular endothelial growth factor A	VEGFA	0.0089
6220	Aryl hydrocarbon receptor	AHR	0.0088
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0087
6020	Aldehyde oxidase	AOX1	0.0084
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0084
244	Angiotensin-converting enzyme	ACE	0.0084
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0084
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
6102	Arylamine N-acetyltransferase 2	NAT2	0.0082
1256	5-hydroxytryptamine 6 receptor	HTR6	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
1852	Microtubule-associated protein 2	MAP2	0.0079
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0078
482	Glycine receptor subunit alpha-1	GLRA1	0.0078
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
1192	Sulfotransferase 1A1	SULT1A1	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0078
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0075
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0075
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0074
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
474	Acetylcholinesterase	ACHE	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
5300	Antigen peptide transporter 1	TAP1	0.0072
165	FL cytokine receptor	FLT3	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0071
3932	Glutathione S-transferase A2	GSTA2	0.0071
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0069
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0069
1525	Heparin-binding growth factor 2	FGF2	0.0069
1517	Beta-3 adrenergic receptor	ADRB3	0.0069
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0068
273	Apoptosis regulator Bcl-2	BCL2	0.0067
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0067
36	Insulin receptor	INSR	0.0066
1050	Bile salt sulfotransferase	SULT2A1	0.0066
239	Coagulation factor X	F10	0.0066
163	D(1B) dopamine receptor	DRD5	0.0065
94	5-hydroxytryptamine 4 receptor	HTR4	0.0064
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0064
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1618	High affinity nerve growth factor receptor	NTRK1	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0063
6043	Putative G-protein coupled receptor 44	GPR44	0.0063
319	Opioid receptor, sigma 1	OPRS1	0.0062
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
814	Ryanodine receptor 1	RYR1	0.0061
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0061
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
558	Solute carrier family 12 member 1	SLC12A1	0.0058
3382	Glycolipid transfer protein	GLTP	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
1483	Membrane copper amine oxidase	AOC3	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
6432	Transporter	snf	0.0055
592	Carbonic anhydrase 4	CA4	0.0055
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0055
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0055
1196	Complement decay-accelerating factor	CD55	0.0055
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0052
49	Endothelin B receptor	EDNRB	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
295	Carbonic anhydrase 1	CA1	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
357	Carbonic anhydrase 2	CA2	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.005
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.005
5787	Angiopoietin-1 receptor	TEK	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
3947	Xanthine dehydrogenase/oxidase	XDH	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0049
758	Thyroid hormone receptor alpha	THRA	0.0049
284	DNA-directed RNA polymerase beta chain	rpoB	0.0049
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0049
823	Fibroblast growth factor receptor 2	FGFR2	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
4773	Deoxycytidine kinase	DCK	0.0048
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0048
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0048
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0048
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0048
2808	Chloramphenicol acetyltransferase 3	cat3	0.0047
88	Retinoic acid receptor RXR-beta	RXRB	0.0047
904	Glutathione S-transferase P	GSTP1	0.0047
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0047
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0047
5934	Cytochrome P450 26A1	CYP26A1	0.0047
459	Retinoic acid receptor RXR-alpha	RXRA	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0046
84	Nuclear receptor 0B1	NR0B1	0.0046
6174	50S ribosomal protein L32	rpmF	0.0045
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0045
54	Prothrombin	F2	0.0045
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
571	Melatonin receptor type 1A	MTNR1A	0.0044
362	Melatonin receptor type 1B	MTNR1B	0.0044
6149	Solute carrier family 22 member 10	SLC22A10	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
1178	Adenosine A2a receptor	ADORA2A	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
921	Glutamate receptor 2	GRIA2	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
1630	Integrin beta-2	ITGB2	0.0043
3601	Dihydropteroate synthase 1	folP1	0.0043
3807	Dihydropteroate synthase 1	folP1	0.0043
3808	Dihydropteroate synthase 2	folP2	0.0043
2417	Chloramphenicol acetyltransferase	cat	0.0043
3278	Chloramphenicol acetyltransferase	cat	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
976	Platelet glycoprotein IX	GP9	0.0043
1757	Myeloperoxidase	MPO	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0043
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0043
2810	Dr hemagglutinin structural subunit	draA	0.0043
33	Cystine/glutamate transporter	SLC7A11	0.0042
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0042
856	Vitamin D3 receptor	VDR	0.0042
65	Matrix metalloproteinase-9	Not Available	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
3913	Glutamic acid decarboxylase	GAD65	0.0041
4311	tRNA	TRDMT1	0.0041
4325	tRNA	trmD	0.0041
4328	tRNA	trmD	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
1864	RET proto-oncogene	RET	0.004
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.004
4122	Histone deacetylase 2	HDAC2	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0039
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
24	Thymidylate synthase	TMP1	0.0039
359	Thymidylate synthase	TYMS	0.0039
2626	Thymidylate synthase	thyA	0.0039
2729	Thymidylate synthase	thyA	0.0039
5352	Thymidylate synthase	THYA	0.0039
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
174	Sigma 1-type opioid receptor	SIGMAR1	0.0038
365	Dihydrofolate reductase	DHFR	0.0038
2381	Dihydrofolate reductase	DFR1	0.0038
2833	Dihydrofolate reductase	Not Available	0.0038
2931	Dihydrofolate reductase	folA	0.0038
3544	Dihydrofolate reductase	folA	0.0038
3682	Dihydrofolate reductase	folA	0.0038
6642	Dihydrofolate reductase	folA	0.0038
6756	Dihydrofolate reductase	dfrA	0.0038
162	Retinoic acid receptor gamma-1	RARG	0.0038
85	Growth hormone receptor	GHR	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0037
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0037
275	Arachidonate 5-lipoxygenase	ALOX5	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0037
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
4203	Histamine N-methyltransferase	HNMT	0.0036
4103	Proteasome subunit beta type 2	PSMB2	0.0036
4102	Proteasome subunit beta type 5	PSMB5	0.0036
4101	Proteasome subunit beta type 1	PSMB1	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
4210	Toll-like receptor 4	TLR4	0.0035
6044	Serum paraoxonase/lactonase 3	PON3	0.0035
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0035
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3904	Alanine aminotransferase 2	GPT2	0.0034
735	Alanine aminotransferase 1	GPT	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0033
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
1992	Vitamin D-binding protein	GC	0.0033
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0033
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
572	Integrin alpha-L	ITGAL	0.0032
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0032
1867	Major prion protein	PRNP	0.0032
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0032
3809	Estrogen-related receptor gamma	ESRRG	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
3086	Plasmepsin-2	Not Available	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
4217	Telomerase reverse transcriptase	TERT	0.003
4192	DNA topoisomerase 2-beta	TOP2B	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
106	Cannabinoid receptor 2	CNR2	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.003
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0029
1629	Transcription factor AP-1	JUN	0.0029
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
936	Ephrin type-A receptor 2	EPHA2	0.0028
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0028
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0028
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0027
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
267	Plasminogen activator inhibitor 1	SERPINE1	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
7	Nitric oxide synthase, inducible	NOS2	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0025
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0025
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0025
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0025
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0025
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
730	Retinoic acid receptor alpha	RARA	0.0024
581	Cytochrome P450 2R1	CYP2R1	0.0024
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6221	Steroid hormone receptor ERR1	ESRRA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2320	Thymidine kinase, cytosolic	TK1	0.0024
6231	Pepsin A	PGA3	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0024
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
2207	Rhodopsin	RHO	0.0023
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0023
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
2021	Thrombomodulin	THBD	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0022
518	Peroxidase/catalase T	katG	0.0022
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1650	Heme carrier protein 1	SLC46A1	0.0021
6218	Pannexin-1	PANX1	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6151	Monocarboxylate transporter 10	SLC16A10	0.002
283	SEC14-like protein 2	SEC14L2	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
3937	Fatty-acid amide hydrolase	FAAH	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
1253	Interferon gamma	IFNG	0.0018
563	Thyroid peroxidase	TPO	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
3810	Catechol O-methyltransferase	COMT	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
489	Monocarboxylate transporter 2	SLC16A7	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
634	Squalene monooxygenase	SQLE	0.0017
7196	Squalene monooxygenase	ERG1	0.0017
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0017
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6042	Prostaglandin reductase 2	PTGR2	0.0016
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0016
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6146	High affinity copper uptake protein 1	SLC31A1	0.0015
1792	Tissue-type plasminogen activator	PLAT	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
1039	Histone deacetylase 9	HDAC9	0.0015
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0014
1541	Metalloproteinase	mmp20	0.0014
172	Potassium channel subfamily K member 1	KCNK1	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
444	Alcohol dehydrogenase 1B	ADH1B	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0013
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0013
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0013
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0013
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0013
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0013
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0013
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0013
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0013
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
164	Histamine H4 receptor	HRH4	0.0013
1313	Lactoylglutathione lyase	GLO1	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
251	Alcohol dehydrogenase 1A	ADH1A	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0011
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0011
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
517	Alcohol dehydrogenase 1C	ADH1C	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
820	Glycine receptor subunit alpha-2	GLRA2	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
3830	Calreticulin	CALR	0.0009
6228	Nuclear receptor coactivator 1	NCOA1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
6034	Hydroxyindole O-methyltransferase	ASMT	0.0009
6035	Nuclear receptor ROR-beta	RORB	0.0009
6036	Eosinophil peroxidase	EPX	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
3404	Exotoxin A	eta	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
3221	Cytochrome c4	cc4	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0005
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
4920	Peroxidase/catalase	katG	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00717 - Norethindrone

Targets

Enzymes

Transporters

Carriers

Predictions