DT-Web: DB00307

Identification

Name

Bexarotene

Accession Number

DB00307 (APRD00114)

Type

small molecule

Description

Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. [Wikipedia]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Anticarcinogenic Agents

Molecular Weight

348.4779

Groups

approved

Monoisotopic Weight

348.20893014

Pharmacology

Indication

Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.

Mechanism of action

Bexarotene selectively binds with and activates retinoid X receptor subtypes. There are three subtypes in total: RXR_?, RXR_?, RXR_?. The exact mechanism of action of bexarotene in the treatment of CTCL is unknown but the drug has activity in all clinical stages of CTCL.

Absorption

Not Available

Protein binding

>99%

Biotransformation

Not Available

Route of elimination

Urinary elimination of bexarotene and its known metabolites is a minor excretory pathway (<1% of administered dose).

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Conivaptan	Conivaptan may increase the serum concentration of CYP3A4 substrates such as bexarotene. Upon completion/discontinuation of conivaptan, allow at least 7 days before initiating therapy with drugs that are CYP3A4 substrates. Consider therapy modification.
Demeclocycline	Tetracycline derivatives like demeclocycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Desogestrel	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of desogestrel, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Doxycycline	Tetracycline derivatives like doxycycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Drospirenone	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of drospirenone, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Ethynodiol Diacetate	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of ethynodiol diacetate it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Etonogestrel	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of etonogestrel, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Gemfibrozil	Gemfibrozil may increase the serum concentration of bexarotene. This combination should be avoided.
Levonorgestrel	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of levonorgestrel, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Medroxyprogesterone	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of medroxyprogesterone, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Minocycline	Tetracycline derivatives like minocycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Norelgestromin	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of norelgestromin, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Norethindrone	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of norethindrone, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Norgestimate	Bexarotene may decrease the serum concentration of Contraceptives (Progestins). Since bexarotene is teratogenic and can lower serum concentrations of norgestimate, it is advised that women of childbearing potential use two forms of contraception (including at least one non-hormonal form).
Tetracycline	Tetracycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Tigecycline	Tigecycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. The development of pseudotumor cerebri (intracranial hypertension) is of particular concern. Avoid this combination.
Vitamin A	Bexarotene increases the risk of vitamin A toxicity. Avoid vitamin A supplementation while taking bexarotene.

Food Interactions

Not Available

Retinoic acid receptor RXR-alpha
Name	Retinoic acid receptor RXR-alpha
Gene Name	RXRA
Pharmacological action	yes
Actions	agonist
References	Lowe MN, Plosker GL: Bexarotene. Am J Clin Dermatol. 2000 Jul-Aug;1(4):245-50; discussion 251-2. - Pubmed Tsai DE, Luger SM, Andreadis C, Vogl DT, Kemner A, Potuzak M, Goradia A, Loren AW, Perl AE, Schuster SJ, Porter DL, Stadtmauer EA, Goldstein SC, Thompson JE, Swider C, Bagg A, Mato AR, Carroll M: A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. Clin Cancer Res. 2008 Sep 1;14(17):5619-25. - Pubmed Tooker P, Yen WC, Ng SC, Negro-Vilar A, Hermann TW: Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res. 2007 May 1;67(9):4425-33. - Pubmed Lalloyer F, Fievet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A: The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. Epub 2006 Sep 28. - Pubmed Yen WC, Lamph WW: The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma. Mol Cancer Ther. 2005 May;4(5):824-34. - Pubmed Yen WC, Prudente RY, Corpuz MR, Negro-Vilar A, Lamph WW: A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours. Br J Cancer. 2006 Mar 13;94(5):654-60. - Pubmed Rizvi N, Hawkins MJ, Eisenberg PD, Yocum RC, Reich SD: Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer. Clin Lung Cancer. 2001 Feb;2(3):210-5. - Pubmed Rigas JR, Dragnev KH: Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene. Oncologist. 2005 Jan;10(1):22-33. - Pubmed Farol LT, Hymes KB: Bexarotene: a clinical review. Expert Rev Anticancer Ther. 2004 Apr;4(2):180-8. - Pubmed
DTHybrid score	0.6023
Retinoic acid receptor RXR-beta
Name	Retinoic acid receptor RXR-beta
Gene Name	RXRB
Pharmacological action	yes
Actions	agonist
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Tsai DE, Luger SM, Andreadis C, Vogl DT, Kemner A, Potuzak M, Goradia A, Loren AW, Perl AE, Schuster SJ, Porter DL, Stadtmauer EA, Goldstein SC, Thompson JE, Swider C, Bagg A, Mato AR, Carroll M: A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. Clin Cancer Res. 2008 Sep 1;14(17):5619-25. - Pubmed Tooker P, Yen WC, Ng SC, Negro-Vilar A, Hermann TW: Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res. 2007 May 1;67(9):4425-33. - Pubmed Lalloyer F, Fievet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A: The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. Epub 2006 Sep 28. - Pubmed Yen WC, Lamph WW: The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma. Mol Cancer Ther. 2005 May;4(5):824-34. - Pubmed Yen WC, Prudente RY, Corpuz MR, Negro-Vilar A, Lamph WW: A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours. Br J Cancer. 2006 Mar 13;94(5):654-60. - Pubmed Rizvi N, Hawkins MJ, Eisenberg PD, Yocum RC, Reich SD: Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer. Clin Lung Cancer. 2001 Feb;2(3):210-5. - Pubmed Rigas JR, Dragnev KH: Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene. Oncologist. 2005 Jan;10(1):22-33. - Pubmed Farol LT, Hymes KB: Bexarotene: a clinical review. Expert Rev Anticancer Ther. 2004 Apr;4(2):180-8. - Pubmed Lowe MN, Plosker GL: Bexarotene. Am J Clin Dermatol. 2000 Jul-Aug;1(4):245-50; discussion 251-2. - Pubmed
DTHybrid score	0.6413
Retinoic acid receptor RXR-gamma
Name	Retinoic acid receptor RXR-gamma
Gene Name	RXRG
Pharmacological action	yes
Actions	agonist
References	Lowe MN, Plosker GL: Bexarotene. Am J Clin Dermatol. 2000 Jul-Aug;1(4):245-50; discussion 251-2. - Pubmed Tsai DE, Luger SM, Andreadis C, Vogl DT, Kemner A, Potuzak M, Goradia A, Loren AW, Perl AE, Schuster SJ, Porter DL, Stadtmauer EA, Goldstein SC, Thompson JE, Swider C, Bagg A, Mato AR, Carroll M: A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. Clin Cancer Res. 2008 Sep 1;14(17):5619-25. - Pubmed Tooker P, Yen WC, Ng SC, Negro-Vilar A, Hermann TW: Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. Cancer Res. 2007 May 1;67(9):4425-33. - Pubmed Lalloyer F, Fievet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A: The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. Epub 2006 Sep 28. - Pubmed Yen WC, Lamph WW: The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma. Mol Cancer Ther. 2005 May;4(5):824-34. - Pubmed Yen WC, Prudente RY, Corpuz MR, Negro-Vilar A, Lamph WW: A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours. Br J Cancer. 2006 Mar 13;94(5):654-60. - Pubmed Rizvi N, Hawkins MJ, Eisenberg PD, Yocum RC, Reich SD: Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer. Clin Lung Cancer. 2001 Feb;2(3):210-5. - Pubmed Rigas JR, Dragnev KH: Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene. Oncologist. 2005 Jan;10(1):22-33. - Pubmed Farol LT, Hymes KB: Bexarotene: a clinical review. Expert Rev Anticancer Ther. 2004 Apr;4(2):180-8. - Pubmed
DTHybrid score	0.3909

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.347
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2817

Id	Partner name	Gene Name	Score
229	Retinoic acid receptor beta	RARB	0.2424
730	Retinoic acid receptor alpha	RARA	0.2413
162	Retinoic acid receptor gamma-1	RARG	0.2307
6283	Oxysterols receptor LXR-alpha	NR1H3	0.2212
6241	Nuclear receptor coactivator 2	NCOA2	0.1746
564	Cellular retinoic acid-binding protein 1	CRABP1	0.1261
4924	Cytochrome P450 2C8	CYP2C8	0.115
6016	Cytochrome P450 2C19	CYP2C19	0.1137
5934	Cytochrome P450 26A1	CYP26A1	0.1084
4119	Cytochrome P450 2D6	CYP2D6	0.1066
4200	Cytochrome P450 1A2	CYP1A2	0.1038
1588	Multidrug resistance protein 1	ABCB1	0.097
4118	Cytochrome P450 3A5	CYP3A5	0.0826
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0675
587	Serum albumin	ALB	0.0672
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.066
6030	Cytochrome P450 2B6	CYP2B6	0.0657
331	Retinol-binding protein I, cellular	RBP1	0.0637
6107	Cytochrome P450 3A7	CYP3A7	0.0601
6013	Cytochrome P450 2E1	CYP2E1	0.0516
3811	Cytochrome P450 19A1	CYP19A1	0.0502
20	Prostaglandin G/H synthase 1	PTGS1	0.0499
6228	Nuclear receptor coactivator 1	NCOA1	0.0442
6350	Nuclear receptor subfamily 1 group I member 3	NR1I3	0.0432
5718	Cytochrome P450 2A6	CYP2A6	0.043
6024	Cytochrome P450 1A1	CYP1A1	0.0386
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0342
290	Prostaglandin G/H synthase 2	PTGS2	0.0322
6106	Cytochrome P450 2C18	CYP2C18	0.0295
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0263
719	Retinoic acid receptor responder protein 1	RARRES1	0.0258
770	Retinoic acid-induced protein 3	GPRC5A	0.0258
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0247
1729	Solute carrier family 22 member 6	SLC22A6	0.0243
2907	Oxysterols receptor LXR-beta	NR1H2	0.0242
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.022
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0217
492	Histamine H1 receptor	HRH1	0.0217
84	Nuclear receptor 0B1	NR0B1	0.0212
569	Retinal dehydrogenase 2	ALDH1A2	0.0199
468	Cytochrome P450 4A11	CYP4A11	0.0197
1181	Alpha-1-acid glycoprotein 1	ORM1	0.019
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0185
611	Retinal dehydrogenase 1	ALDH1A1	0.0185
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0183
136	Estrogen receptor	ESR1	0.0175
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0174
862	Multidrug resistance-associated protein 1	ABCC1	0.0168
871	Glucocorticoid receptor	NR3C1	0.0166
824	Sodium-dependent serotonin transporter	SLC6A4	0.0159
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0151
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0151
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0149
731	HIV-1 protease	HIV-1 protease	0.014
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0139
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0136
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0133
556	Alpha-1A adrenergic receptor	ADRA1A	0.0123
1898	Cytochrome P450 1B1	CYP1B1	0.0118
847	Mu-type opioid receptor	OPRM1	0.0117
891	Dihydropteroate synthase	folP	0.0116
5359	Dihydropteroate synthase	folP	0.0116
7175	Dihydropteroate synthase	sulI	0.0116
6145	Solute carrier family 22 member 1	SLC22A1	0.0115
831	D(2) dopamine receptor	DRD2	0.0115
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0113
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0111
122	P2Y purinoceptor 12	P2RY12	0.011
318	Alpha-2A adrenergic receptor	ADRA2A	0.0109
776	Bile salt export pump	ABCB11	0.0109
6142	Solute carrier family 22 member 8	SLC22A8	0.0108
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0108
260	Cytochrome P450 51	ERG11	0.0106
761	Cytochrome P450 51	ERG11	0.0106
3163	Cytochrome P450 51	cyp51	0.0106
2164	Multidrug resistance-associated protein 4	ABCC4	0.0105
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0103
467	Delta-type opioid receptor	OPRD1	0.0101
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0099
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0098
6144	Solute carrier family 22 member 2	SLC22A2	0.0096
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0096
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0095
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0094
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0093
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0091
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0091
713	Sodium-dependent dopamine transporter	SLC6A3	0.009
70	Type-1 angiotensin II receptor	AGTR1	0.0089
632	Alpha-1B adrenergic receptor	ADRA1B	0.0089
696	Kappa-type opioid receptor	OPRK1	0.0088
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0088
6143	Solute carrier family 22 member 7	SLC22A7	0.0085
23	D(1A) dopamine receptor	DRD1	0.0083
232	Corticosteroid-binding globulin	SERPINA6	0.008
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.008
766	Beta-2 adrenergic receptor	ADRB2	0.0079
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0078
118	Organic cation/carnitine transporter 2	SLC22A5	0.0078
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0078
614	Progesterone receptor	PGR	0.0076
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0076
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0076
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0075
6031	Cytochrome P450 3A43	CYP3A43	0.0075
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0074
4116	Dihydropteroate synthetase	Not Available	0.0072
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0072
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.007
49	Endothelin B receptor	EDNRB	0.0069
1024	Solute carrier family 22 member 11	SLC22A11	0.0069
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0068
592	Carbonic anhydrase 4	CA4	0.0067
811	Translocator protein	TSPO	0.0066
789	Alpha-1D adrenergic receptor	ADRA1D	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0065
3941	Amine oxidase [flavin-containing] A	MAOA	0.0063
817	DNA topoisomerase 2-alpha	TOP2A	0.0063
146	Androgen receptor	AR	0.0063
295	Carbonic anhydrase 1	CA1	0.0063
133	Dihydropterate synthase	sulI	0.0063
629	Alpha-2B adrenergic receptor	ADRA2B	0.006
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
6182	Cytochrome P450 2J2	CYP2J2	0.0059
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0059
3923	Cholinesterase	BCHE	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0056
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0056
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0056
3939	Amine oxidase [flavin-containing] B	MAOB	0.0056
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0055
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0055
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0055
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0054
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0054
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0054
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0054
6147	Solute carrier family 22 member 3	SLC22A3	0.0054
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0052
29	Tubulin beta-1 chain	TUBB1	0.0052
638	D(3) dopamine receptor	DRD3	0.0051
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0051
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0051
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0051
3810	Catechol O-methyltransferase	COMT	0.005
465	Calmodulin	CALM1	0.005
357	Carbonic anhydrase 2	CA2	0.005
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.005
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.005
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.005
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.005
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0048
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0048
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0048
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0048
378	Alpha-2C adrenergic receptor	ADRA2C	0.0048
4604	Liver carboxylesterase 1	CES1	0.0048
6137	Multidrug resistance-associated protein 6	ABCC6	0.0048
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
407	Vascular endothelial growth factor receptor 2	KDR	0.0047
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0046
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0046
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0046
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0046
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0046
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0046
193	Beta-1 adrenergic receptor	ADRB1	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
6102	Arylamine N-acetyltransferase 2	NAT2	0.0045
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0045
474	Acetylcholinesterase	ACHE	0.0045
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
833	Organic cation/carnitine transporter 1	SLC22A4	0.0044
365	Dihydrofolate reductase	DHFR	0.0043
2381	Dihydrofolate reductase	DFR1	0.0043
2833	Dihydrofolate reductase	Not Available	0.0043
2931	Dihydrofolate reductase	folA	0.0043
3544	Dihydrofolate reductase	folA	0.0043
3682	Dihydrofolate reductase	folA	0.0043
6642	Dihydrofolate reductase	folA	0.0043
6756	Dihydrofolate reductase	dfrA	0.0043
756	Sex hormone-binding globulin	SHBG	0.0043
6136	Multidrug resistance-associated protein 5	ABCC5	0.0043
952	Dipeptidyl peptidase 4	DPP4	0.0043
432	D(4) dopamine receptor	DRD4	0.0042
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0042
6148	Multidrug resistance-associated protein 7	ABCC10	0.0042
6220	Aryl hydrocarbon receptor	AHR	0.0042
777	Tumor necrosis factor	TNF	0.0041
161	Tubulin beta chain	TUBB	0.0041
312	Tubulin beta chain	TUB2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
856	Vitamin D3 receptor	VDR	0.0041
504	Mast/stem cell growth factor receptor	KIT	0.0041
869	Estrogen receptor beta	ESR2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
427	Substance-P receptor	TACR1	0.004
275	Arachidonate 5-lipoxygenase	ALOX5	0.004
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.004
814	Ryanodine receptor 1	RYR1	0.0039
1541	Metalloproteinase	mmp20	0.0039
716	5-hydroxytryptamine 7 receptor	HTR7	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1275	Estrogen sulfotransferase	SULT1E1	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0038
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0038
54	Prothrombin	F2	0.0037
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0037
844	Epidermal growth factor receptor	EGFR	0.0036
1656	CYP2B protein	CYP2B	0.0036
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0036
482	Glycine receptor subunit alpha-1	GLRA1	0.0036
6014	Cytochrome P450 2A13	CYP2A13	0.0036
1757	Myeloperoxidase	MPO	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0034
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0034
24	Thymidylate synthase	TMP1	0.0034
359	Thymidylate synthase	TYMS	0.0034
2626	Thymidylate synthase	thyA	0.0034
2729	Thymidylate synthase	thyA	0.0034
5352	Thymidylate synthase	THYA	0.0034
6020	Aldehyde oxidase	AOX1	0.0033
4120	NADPH--cytochrome P450 reductase	POR	0.0033
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6141	Sodium/bile acid cotransporter	SLC10A1	0.0033
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0033
183	Vascular endothelial growth factor A	VEGFA	0.0033
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0033
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
6085	Fatty acid-binding protein, intestinal	FABP2	0.0032
3947	Xanthine dehydrogenase/oxidase	XDH	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
94	5-hydroxytryptamine 4 receptor	HTR4	0.0031
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0031
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0031
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
705	Glutamate receptor 1	GRIA1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
124	Histamine H2 receptor	HRH2	0.003
380	Cytochrome P450 17A1	CYP17A1	0.003
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.003
737	Mineralocorticoid receptor	NR3C2	0.0029
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0029
153	Dopamine beta-hydroxylase	DBH	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0029
1010	Cytochrome P450 51A1	CYP51A1	0.0028
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0027
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0027
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0027
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
373	Transthyretin	TTR	0.0026
26	Vascular endothelial growth factor receptor 3	FLT4	0.0026
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0026
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0026
1629	Transcription factor AP-1	JUN	0.0025
921	Glutamate receptor 2	GRIA2	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
32	Vascular endothelial growth factor receptor 1	FLT1	0.0025
738	Monocarboxylate transporter 1	SLC16A1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0025
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
1648	Elastin	ELN	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0023
4122	Histone deacetylase 2	HDAC2	0.0023
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0023
581	Cytochrome P450 2R1	CYP2R1	0.0023
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0022
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0022
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0022
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0022
16	Adenosine A1 receptor	ADORA1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
1050	Bile salt sulfotransferase	SULT2A1	0.0022
2232	Interleukin-5	IL5	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0021
1178	Adenosine A2a receptor	ADORA2A	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
1852	Microtubule-associated protein 2	MAP2	0.0021
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
3932	Glutathione S-transferase A2	GSTA2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0019
3639	Thymidine phosphorylase	deoA	0.0019
3936	Thymidine phosphorylase	TYMP	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
518	Peroxidase/catalase T	katG	0.0018
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0018
164	Histamine H4 receptor	HRH4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1618	High affinity nerve growth factor receptor	NTRK1	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
683	Potassium transporter	GK0582	0.0018
823	Fibroblast growth factor receptor 2	FGFR2	0.0018
239	Coagulation factor X	F10	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
4773	Deoxycytidine kinase	DCK	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
6174	50S ribosomal protein L32	rpmF	0.0017
1196	Complement decay-accelerating factor	CD55	0.0017
3809	Estrogen-related receptor gamma	ESRRG	0.0017
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0016
6149	Solute carrier family 22 member 10	SLC22A10	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0016
563	Thyroid peroxidase	TPO	0.0016
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0015
634	Squalene monooxygenase	SQLE	0.0015
7196	Squalene monooxygenase	ERG1	0.0015
558	Solute carrier family 12 member 1	SLC12A1	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
5787	Angiopoietin-1 receptor	TEK	0.0015
904	Glutathione S-transferase P	GSTP1	0.0015
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0015
273	Apoptosis regulator Bcl-2	BCL2	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
2808	Chloramphenicol acetyltransferase 3	cat3	0.0014
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0014
1192	Sulfotransferase 1A1	SULT1A1	0.0014
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0014
6146	High affinity copper uptake protein 1	SLC31A1	0.0014
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0014
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0014
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0014
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0014
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0014
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
2417	Chloramphenicol acetyltransferase	cat	0.0013
3278	Chloramphenicol acetyltransferase	cat	0.0013
3808	Dihydropteroate synthase 2	folP2	0.0013
3601	Dihydropteroate synthase 1	folP1	0.0013
3807	Dihydropteroate synthase 1	folP1	0.0013
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0013
2810	Dr hemagglutinin structural subunit	draA	0.0013
165	FL cytokine receptor	FLT3	0.0013
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0013
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0012
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
5924	Microtubule-associated protein 4	MAP4	0.0012
5923	Microtubule-associated protein tau	MAPT	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
1992	Vitamin D-binding protein	GC	0.0012
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0012
319	Opioid receptor, sigma 1	OPRS1	0.0012
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
976	Platelet glycoprotein IX	GP9	0.0011
1630	Integrin beta-2	ITGB2	0.0011
4103	Proteasome subunit beta type 2	PSMB2	0.0011
4101	Proteasome subunit beta type 1	PSMB1	0.0011
4102	Proteasome subunit beta type 5	PSMB5	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
1374	Natriuretic peptides B	NPPB	0.0011
1827	Gap junction alpha-1 protein	GJA1	0.0011
1908	Vascular cell adhesion protein 1	VCAM1	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
3937	Fatty-acid amide hydrolase	FAAH	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
4217	Telomerase reverse transcriptase	TERT	0.0011
469	Annexin A1	ANXA1	0.0011
6033	High affinity interleukin-8 receptor A	CXCR1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
5251	Carbonyl reductase [NADPH] 1	CBR1	0.001
511	5-hydroxytryptamine 1F receptor	HTR1F	0.001
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.001
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.001
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.001
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
7	Nitric oxide synthase, inducible	NOS2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.001
174	Sigma 1-type opioid receptor	SIGMAR1	0.001
936	Ephrin type-A receptor 2	EPHA2	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0009
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0009
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
3086	Plasmepsin-2	Not Available	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6044	Serum paraoxonase/lactonase 3	PON3	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
33	Cystine/glutamate transporter	SLC7A11	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
572	Integrin alpha-L	ITGAL	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
267	Plasminogen activator inhibitor 1	SERPINE1	0.0008
1864	RET proto-oncogene	RET	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
1867	Major prion protein	PRNP	0.0008
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6432	Transporter	snf	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
3830	Calreticulin	CALR	0.0008
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0008
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0008
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0008
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0008
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
2298	Cytochrome P450-cam	camC	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
6221	Steroid hormone receptor ERR1	ESRRA	0.0007
6218	Pannexin-1	PANX1	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
751	Potassium channel subfamily K member 6	KCNK6	0.0007
1039	Histone deacetylase 9	HDAC9	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0007
4311	tRNA	TRDMT1	0.0007
4325	tRNA	trmD	0.0007
4328	tRNA	trmD	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
172	Potassium channel subfamily K member 1	KCNK1	0.0007
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
908	Glutathione S-transferase theta-1	GSTT1	0.0006
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0006
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3221	Cytochrome c4	cc4	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
3957	Adenosine deaminase	ADA	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
291	Nitric-oxide synthase, endothelial	NOS3	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
2021	Thrombomodulin	THBD	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0005
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0005
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1507	Cytochrome c	CYCS	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2207	Rhodopsin	RHO	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
489	Monocarboxylate transporter 2	SLC16A7	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
76	Nitric-oxide synthase, brain	NOS1	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00307 - Bexarotene

Targets

Enzymes

Predictions