DT-Web

DB01241 - Gemfibrozil


Identification
Name Gemfibrozil
Accession Number DB01241 (APRD00293)
Type small molecule
Description A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 250.3334
Groups approved
Monoisotopic Weight 250.15689457
Pharmacology
Indication For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Mechanism of action Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPAR?) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.
Absorption Well absorbed from gastrointestinal tract (within 1-2 hours).
Protein binding 95%
Biotransformation Hepatic. Gemfibrozil mainly undergoes oxidation of a ring methyl group to successively form a hydroxymethyl and a carboxyl metabolite.
Route of elimination Approximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil.
Toxicity Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Gemfibrozil may increase the anticoagulant effect of acenocoumarol.
Anisindione Gemfibrozil may increase the anticoagulant effect of anisindione.
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Bexarotene Gemfibrozil may increase the serum concentration of bexarotene. This combination should be avoided.
Carisoprodol Strong CYP2C19 inhibitors such as gemfibrozil may decrease the metabolism of CYP2C19 substrates such as carisoprodol. Consider an alternative for one of the interacting drugs in order to avoid toxicity of the substrate. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of the CYP substrate if a CYP inhibitor is initiated/dose increased, and decreased effects if a CYP inhibitor is discontinued/dose decreased.
Cerivastatin Increased risk of myopathy/rhabdomyolysis
Dabrafenib Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Dicumarol Gemfibrozil may increase the anticoagulant effect of dicumarol.
Fluvastatin Increased risk of myopathy/rhabdomyolysis
Glimepiride Gemfibrozil increases the effect and toxicity of rosiglitazone/pioglitazone
Lovastatin Increased risk of myopathy/rhabdomyolysis
Pioglitazone Gemfibrozil may increase the effect and toxicity of pioglitazone.
Pitavastatin Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both gemfibrozil and pitavastatin via pharmacodynamic synergism. Use alternative therapy.
Pravastatin Increased risk of myopathy/rhabdomyolysis
Repaglinide Gemfibrozil may increase the effect and toxicity of repaglinide.
Rosiglitazone Increases the effect and toxicity of rosiglitazone/pioglitazone
Rosuvastatin Gemfibrozil may increase the therapeutic and toxic effects of rosuvastatin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of rosuvastatin if gemfibrozil is initiated, discontinued or dose changed.
Simvastatin Increased risk of myopathy/rhabdomyolysis
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Gemfibrozil, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Gemfibrozil is initiated, discontinued or if the dose is changed.
Tamoxifen Gemfibrozil may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Gemfibrozil is initiated, discontinued or dose changed.
Tizanidine Gemfibrozil may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolbutamide Gemfibrozil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Gemfibrozil is initiated, discontinued or dose changed.
Torasemide Gemfibrozil, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Gemfibrozil is initiated, discontinued or dose changed.
Tretinoin The strong CYP2C8 inhibitor, Gemfibrozil, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Gemfibrozil is initiated, discontinued to dose changed.
Trimethoprim The strong CYP2C9 inhibitor, Gemfibrozil, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Gemfibrozil is initiated, discontinued or dose changed.
Trimipramine The strong CYP2C19 inhibitor, Gemfibrozil, may decrease the metabolism and clearance of Trimipramine, a CYP2C19 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Gemfibrozil is initiated, discontinued or dose changed.
Ursodeoxycholic acid The fibric acid derivative decreases the effect of ursodiol
Voriconazole Gemfibrozil, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if gemfibrozil is initiated, discontinued or dose changed.
Warfarin Gemfibrozil, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if gemfibrozil is initiated, discontinued or dose changed.
Zafirlukast Gemfibrozil, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if gemfibrozil is initiated, discontinued or dose changed.
Food Interactions
  • Take 30 minutes before meals.

Targets


Peroxisome proliferator-activated receptor alpha
Name Peroxisome proliferator-activated receptor alpha
Gene Name PPARA
Pharmacological action yes
Actions agonist
References
  • Clavey V, Copin C, Mariotte MC, Bauge E, Chinetti G, Fruchart J, Fruchart JC, Dallongeville J, Staels B: Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells. Cell Physiol Biochem. 1999;9(3):139-49. - Pubmed
  • Bosse Y, Pascot A, Dumont M, Brochu M, Prud'homme D, Bergeron J, Despres JP, Vohl MC: Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil. Genet Med. 2002 Jul-Aug;4(4):311-5. - Pubmed
  • Pahan K, Jana M, Liu X, Taylor BS, Wood C, Fischer SM: Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277(48):45984-91. Epub 2002 Sep 18. - Pubmed
  • Shoji Y, Sanekata A, Sato M, Imaizumi K: Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil, a ligand for peroxisome proliferator-activated receptor alpha. Biosci Biotechnol Biochem. 2003 May;67(5):1177-8. - Pubmed
  • Rizvi F, Iftikhar M, George JP: Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant rats. J Med Food. 2003 Summer;6(2):123-8. - Pubmed
DTHybrid score 0.4653

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor,inducer
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Honkalammi J, Niemi M, Neuvonen PJ, Backman JT: Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses. Clin Pharmacol Ther. 2012 May;91(5):846-55. doi: 10.1038/clpt.2011.313. - Pubmed
DTHybrid score 0.3717
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3965
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5831
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3999
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4889

Transporters


Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. - Pubmed
DTHybrid score 0.2411

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2677
1588 Multidrug resistance protein 1 ABCB1 0.2173
4118 Cytochrome P450 3A5 CYP3A5 0.1847
6030 Cytochrome P450 2B6 CYP2B6 0.1692
6228 Nuclear receptor coactivator 1 NCOA1 0.1552
6013 Cytochrome P450 2E1 CYP2E1 0.1473
6024 Cytochrome P450 1A1 CYP1A1 0.1315
6107 Cytochrome P450 3A7 CYP3A7 0.1297
238 Peroxisome proliferator-activated receptor gamma PPARG 0.1159
5841 Insulin-like growth factor IB IGF1 0.1126
587 Serum albumin ALB 0.1008
20 Prostaglandin G/H synthase 1 PTGS1 0.1001
5718 Cytochrome P450 2A6 CYP2A6 0.0998
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0964
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0863
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0745
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0744
1502 Peroxisome proliferator-activated receptor delta PPARD 0.073
1729 Solute carrier family 22 member 6 SLC22A6 0.0622
6106 Cytochrome P450 2C18 CYP2C18 0.0576
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0556
1541 Metalloproteinase mmp20 0.0542
290 Prostaglandin G/H synthase 2 PTGS2 0.0506
492 Histamine H1 receptor HRH1 0.0492
862 Multidrug resistance-associated protein 1 ABCC1 0.0483
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0455
3811 Cytochrome P450 19A1 CYP19A1 0.0423
6142 Solute carrier family 22 member 8 SLC22A8 0.0415
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0404
6145 Solute carrier family 22 member 1 SLC22A1 0.0403
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0401
824 Sodium-dependent serotonin transporter SLC6A4 0.0395
468 Cytochrome P450 4A11 CYP4A11 0.0369
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0369
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0366
1898 Cytochrome P450 1B1 CYP1B1 0.0357
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0353
2164 Multidrug resistance-associated protein 4 ABCC4 0.0345
502 5-hydroxytryptamine 2A receptor HTR2A 0.0333
136 Estrogen receptor ESR1 0.0333
776 Bile salt export pump ABCB11 0.0326
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0324
731 HIV-1 protease HIV-1 protease 0.0323
6144 Solute carrier family 22 member 2 SLC22A2 0.0303
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0294
831 D(2) dopamine receptor DRD2 0.0293
70 Type-1 angiotensin II receptor AGTR1 0.028
556 Alpha-1A adrenergic receptor ADRA1A 0.0277
3941 Amine oxidase [flavin-containing] A MAOA 0.0277
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0273
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0272
6143 Solute carrier family 22 member 7 SLC22A7 0.0267
318 Alpha-2A adrenergic receptor ADRA2A 0.0265
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0262
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0262
36 Insulin receptor INSR 0.0258
118 Organic cation/carnitine transporter 2 SLC22A5 0.0258
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0254
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0254
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.025
871 Glucocorticoid receptor NR3C1 0.0248
260 Cytochrome P450 51 ERG11 0.0242
761 Cytochrome P450 51 ERG11 0.0242
3163 Cytochrome P450 51 cyp51 0.0242
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0238
23 D(1A) dopamine receptor DRD1 0.023
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0228
590 5-hydroxytryptamine 2C receptor HTR2C 0.0228
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0227
320 5-hydroxytryptamine 1A receptor HTR1A 0.0223
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0222
341 5-hydroxytryptamine 3 receptor HTR3A 0.0219
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0219
713 Sodium-dependent dopamine transporter SLC6A3 0.0218
1024 Solute carrier family 22 member 11 SLC22A11 0.0217
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0211
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0209
3932 Glutathione S-transferase A2 GSTA2 0.0209
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0208
885 5-hydroxytryptamine 1B receptor HTR1B 0.0206
632 Alpha-1B adrenergic receptor ADRA1B 0.0206
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0204
766 Beta-2 adrenergic receptor ADRB2 0.0202
817 DNA topoisomerase 2-alpha TOP2A 0.0192
122 P2Y purinoceptor 12 P2RY12 0.019
847 Mu-type opioid receptor OPRM1 0.0189
833 Organic cation/carnitine transporter 1 SLC22A4 0.0188
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0187
3939 Amine oxidase [flavin-containing] B MAOB 0.0187
6141 Sodium/bile acid cotransporter SLC10A1 0.0185
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0182
725 5-hydroxytryptamine 1D receptor HTR1D 0.0182
6031 Cytochrome P450 3A43 CYP3A43 0.0182
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0179
467 Delta-type opioid receptor OPRD1 0.0178
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0172
696 Kappa-type opioid receptor OPRK1 0.0171
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0168
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0165
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0164
891 Dihydropteroate synthase folP 0.0162
5359 Dihydropteroate synthase folP 0.0162
7175 Dihydropteroate synthase sulI 0.0162
146 Androgen receptor AR 0.016
6147 Solute carrier family 22 member 3 SLC22A3 0.0155
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0154
789 Alpha-1D adrenergic receptor ADRA1D 0.0153
193 Beta-1 adrenergic receptor ADRB1 0.0152
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0152
465 Calmodulin CALM1 0.0148
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0148
6182 Cytochrome P450 2J2 CYP2J2 0.0147
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0147
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
26 Vascular endothelial growth factor receptor 3 FLT4 0.0145
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
407 Vascular endothelial growth factor receptor 2 KDR 0.0143
6148 Multidrug resistance-associated protein 7 ABCC10 0.0143
4604 Liver carboxylesterase 1 CES1 0.0142
5880 Thrombopoietin receptor MPL 0.0139
32 Vascular endothelial growth factor receptor 1 FLT1 0.0138
629 Alpha-2B adrenergic receptor ADRA2B 0.0138
638 D(3) dopamine receptor DRD3 0.0137
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0136
6136 Multidrug resistance-associated protein 5 ABCC5 0.0134
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0133
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0131
275 Arachidonate 5-lipoxygenase ALOX5 0.013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0129
3923 Cholinesterase BCHE 0.0128
777 Tumor necrosis factor TNF 0.0126
6220 Aryl hydrocarbon receptor AHR 0.0126
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0125
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0123
373 Transthyretin TTR 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
504 Mast/stem cell growth factor receptor KIT 0.0122
811 Translocator protein TSPO 0.012
1757 Myeloperoxidase MPO 0.012
3587 Gastrotropin FABP6 0.0118
758 Thyroid hormone receptor alpha THRA 0.0116
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0116
6102 Arylamine N-acetyltransferase 2 NAT2 0.0115
29 Tubulin beta-1 chain TUBB1 0.0114
614 Progesterone receptor PGR 0.0114
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0111
378 Alpha-2C adrenergic receptor ADRA2C 0.011
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0108
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0106
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0106
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0104
844 Epidermal growth factor receptor EGFR 0.0104
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0104
365 Dihydrofolate reductase DHFR 0.0103
2381 Dihydrofolate reductase DFR1 0.0103
2833 Dihydrofolate reductase Not Available 0.0103
2931 Dihydrofolate reductase folA 0.0103
3544 Dihydrofolate reductase folA 0.0103
3682 Dihydrofolate reductase folA 0.0103
6642 Dihydrofolate reductase folA 0.0103
6756 Dihydrofolate reductase dfrA 0.0103
346 Thyroid hormone receptor beta-1 THRB 0.0103
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0103
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0102
869 Estrogen receptor beta ESR2 0.0102
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0102
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0102
818 50S ribosomal protein L10 rplJ 0.0102
16 Adenosine A1 receptor ADORA1 0.0101
432 D(4) dopamine receptor DRD4 0.01
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.01
6014 Cytochrome P450 2A13 CYP2A13 0.0099
756 Sex hormone-binding globulin SHBG 0.0098
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
380 Cytochrome P450 17A1 CYP17A1 0.0096
228 Beta platelet-derived growth factor receptor PDGFRB 0.0096
49 Endothelin B receptor EDNRB 0.0096
6137 Multidrug resistance-associated protein 6 ABCC6 0.0096
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0095
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0095
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0095
436 5-hydroxytryptamine 2B receptor HTR2B 0.0095
738 Monocarboxylate transporter 1 SLC16A1 0.0095
4148 Serine/threonine-protein kinase mTOR MTOR 0.0094
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0094
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0094
124 Histamine H2 receptor HRH2 0.0093
4122 Histone deacetylase 2 HDAC2 0.0092
2539 Tubulin alpha-1 chain TUBA4A 0.0092
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0092
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0092
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0092
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
427 Substance-P receptor TACR1 0.0089
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0089
511 5-hydroxytryptamine 1F receptor HTR1F 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0088
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0088
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0088
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0088
1178 Adenosine A2a receptor ADORA2A 0.0088
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0087
94 5-hydroxytryptamine 4 receptor HTR4 0.0086
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0086
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0084
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0083
594 Thyroxine-binding globulin SERPINA7 0.0083
1010 Cytochrome P450 51A1 CYP51A1 0.0082
295 Carbonic anhydrase 1 CA1 0.0082
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0081
6085 Fatty acid-binding protein, intestinal FABP2 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
3810 Catechol O-methyltransferase COMT 0.008
952 Dipeptidyl peptidase 4 DPP4 0.008
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0079
6020 Aldehyde oxidase AOX1 0.0079
921 Glutamate receptor 2 GRIA2 0.0079
4120 NADPH--cytochrome P450 reductase POR 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
563 Thyroid peroxidase TPO 0.0078
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0077
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0077
716 5-hydroxytryptamine 7 receptor HTR7 0.0075
6167 Organic solute transporter subunit beta OSTB 0.0074
6166 Organic solute transporter subunit alpha OSTA 0.0074
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0074
284 DNA-directed RNA polymerase beta chain rpoB 0.0073
5773 DNA-directed RNA polymerase beta chain rpoB 0.0073
161 Tubulin beta chain TUBB 0.0072
312 Tubulin beta chain TUB2 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
1656 CYP2B protein CYP2B 0.0072
6044 Serum paraoxonase/lactonase 3 PON3 0.0071
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0071
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0071
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.007
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0068
24 Thymidylate synthase TMP1 0.0067
359 Thymidylate synthase TYMS 0.0067
2626 Thymidylate synthase thyA 0.0067
2729 Thymidylate synthase thyA 0.0067
5352 Thymidylate synthase THYA 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0066
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0066
88 Retinoic acid receptor RXR-beta RXRB 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
117 Sterol O-acyltransferase 1 SOAT1 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
163 D(1B) dopamine receptor DRD5 0.0064
33 Cystine/glutamate transporter SLC7A11 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1648 Elastin ELN 0.0063
133 Dihydropterate synthase sulI 0.0063
737 Mineralocorticoid receptor NR3C2 0.0062
183 Vascular endothelial growth factor A VEGFA 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
474 Acetylcholinesterase ACHE 0.0061
518 Peroxidase/catalase T katG 0.006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0059
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0058
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0058
68 Cannabinoid receptor 1 CNR1 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0058
3809 Estrogen-related receptor gamma ESRRG 0.0058
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0056
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
814 Ryanodine receptor 1 RYR1 0.0056
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
856 Vitamin D3 receptor VDR 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
823 Fibroblast growth factor receptor 2 FGFR2 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0054
482 Glycine receptor subunit alpha-1 GLRA1 0.0054
768 FK506-binding protein 1A FKBP1A 0.0054
1630 Integrin beta-2 ITGB2 0.0054
199 Monocarboxylate transporter 8 SLC16A2 0.0053
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
1629 Transcription factor AP-1 JUN 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0051
1275 Estrogen sulfotransferase SULT1E1 0.0051
634 Squalene monooxygenase SQLE 0.005
7196 Squalene monooxygenase ERG1 0.005
528 5-hydroxytryptamine 1E receptor HTR1E 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.005
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.005
1256 5-hydroxytryptamine 6 receptor HTR6 0.005
1618 High affinity nerve growth factor receptor NTRK1 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
1050 Bile salt sulfotransferase SULT2A1 0.0049
780 Retinoic acid receptor RXR-gamma RXRG 0.0049
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0048
4311 tRNA TRDMT1 0.0048
4325 tRNA trmD 0.0048
4328 tRNA trmD 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0047
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0047
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0046
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
239 Coagulation factor X F10 0.0045
6174 50S ribosomal protein L32 rpmF 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
6149 Solute carrier family 22 member 10 SLC22A10 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
581 Cytochrome P450 2R1 CYP2R1 0.0043
6146 High affinity copper uptake protein 1 SLC31A1 0.0043
1483 Membrane copper amine oxidase AOC3 0.0043
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
1192 Sulfotransferase 1A1 SULT1A1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
162 Retinoic acid receptor gamma-1 RARG 0.0041
572 Integrin alpha-L ITGAL 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1517 Beta-3 adrenergic receptor ADRB3 0.004
3868 Calcineurin subunit B isoform 2 PPP3R2 0.004
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
904 Glutathione S-transferase P GSTP1 0.004
153 Dopamine beta-hydroxylase DBH 0.004
54 Prothrombin F2 0.004
6138 Multidrug resistance protein 3 ABCB4 0.0039
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1525 Heparin-binding growth factor 2 FGF2 0.0039
6432 Transporter snf 0.0039
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0038
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
85 Growth hormone receptor GHR 0.0038
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0037
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1760 Aminopeptidase N ANPEP 0.0037
6843 Aminopeptidase N pepN 0.0037
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
976 Platelet glycoprotein IX GP9 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0036
4102 Proteasome subunit beta type 5 PSMB5 0.0036
4101 Proteasome subunit beta type 1 PSMB1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6221 Steroid hormone receptor ERR1 ESRRA 0.0036
185 Vasopressin V1a receptor AVPR1A 0.0035
3808 Dihydropteroate synthase 2 folP2 0.0035
3601 Dihydropteroate synthase 1 folP1 0.0035
3807 Dihydropteroate synthase 1 folP1 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
165 FL cytokine receptor FLT3 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
3957 Adenosine deaminase ADA 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0034
751 Potassium channel subfamily K member 6 KCNK6 0.0034
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0034
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0033
229 Retinoic acid receptor beta RARB 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2981 Phospholipase A2, membrane associated PLA2G2A 0.0032
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0032
84 Nuclear receptor 0B1 NR0B1 0.0032
5787 Angiopoietin-1 receptor TEK 0.0032
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0032
760 Fibroblast growth factor 1 FGF1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
469 Annexin A1 ANXA1 0.0031
1992 Vitamin D-binding protein GC 0.0031
1353 DNA topoisomerase 1 TOP1 0.0031
3552 DNA topoisomerase 1 topA 0.0031
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0031
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0031
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0031
172 Potassium channel subfamily K member 1 KCNK1 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0031
6151 Monocarboxylate transporter 10 SLC16A10 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.003
106 Cannabinoid receptor 2 CNR2 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0029
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0029
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0028
3917 Methylenetetrahydrofolate reductase MTHFR 0.0028
164 Histamine H4 receptor HRH4 0.0028
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0028
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
936 Ephrin type-A receptor 2 EPHA2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
3937 Fatty-acid amide hydrolase FAAH 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
517 Alcohol dehydrogenase 1C ADH1C 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0026
551 Carnitine O-acetyltransferase CRAT 0.0025
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
537 ATP synthase delta chain, mitochondrial ATP5D 0.0025
5934 Cytochrome P450 26A1 CYP26A1 0.0024
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0024
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0024
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0024
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
251 Alcohol dehydrogenase 1A ADH1A 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0024
1039 Histone deacetylase 9 HDAC9 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
4192 DNA topoisomerase 2-beta TOP2B 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0023
820 Glycine receptor subunit alpha-2 GLRA2 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
908 Glutathione S-transferase theta-1 GSTT1 0.0023
7 Nitric oxide synthase, inducible NOS2 0.0022
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
444 Alcohol dehydrogenase 1B ADH1B 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3904 Alanine aminotransferase 2 GPT2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0021
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
2021 Thrombomodulin THBD 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.002
1864 RET proto-oncogene RET 0.002
1820 Beta-nerve growth factor NGF 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
6218 Pannexin-1 PANX1 0.0019
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
1253 Interferon gamma IFNG 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0018
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4773 Deoxycytidine kinase DCK 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
1243 Cathepsin D CTSD 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0015
1341 Histamine H3 receptor HRH3 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5818 Folate receptor alpha FOLR1 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
2207 Rhodopsin RHO 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1650 Heme carrier protein 1 SLC46A1 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
2298 Cytochrome P450-cam camC 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3221 Cytochrome c4 cc4 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
1507 Cytochrome c CYCS 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
798 Osteocalcin BGLAP 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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