DT-Web: DB00412

Identification

Name

Rosiglitazone

Accession Number

DB00412 (APRD00403)

Type

small molecule

Description

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPAR?. Rosiglitazone is a selective ligand of PPAR?, and has no PPAR?-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NF?B) levels fall and inhibitor (I?B) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

357.427

Groups

approved

Monoisotopic Weight

357.114712179

Pharmacology

Indication

Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Mechanism of action

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

Absorption

The absolute bioavailability of rosiglitazone is 99%. Peak plasma concentrations are observed about 1 hour after dosing. Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), but there was an approximately 28% decrease in C_max and a delay in T_max (1.75 hours). These changes are not likely to be clinically significant; therefore, rosiglitazone may be administered with or without food. Maximum plasma concentration (Cmax) and the area under the curve (AUC) of rosiglitazone increase in a dose-proportional manner over the therapeutic dose range.

Protein binding

99.8% bound to plasma proteins, primarily albumin.

Biotransformation

Hepatic. Rosiglitazone is extensively metabolized in the liver to inactive metabolites via N-demethylation, hydroxylation, and conjugation with sulfate and glucuronic acid. In vitro data have shown that Cytochrome (CYP) P450 isoenzyme 2C8 (CYP2C8) and to a minor extent CYP2C9 are involved in the hepatic metabolism of rosiglitazone.

Route of elimination

Following oral or intravenous administration of [14C]rosiglitazone maleate, approximately 64% and 23% of the dose was eliminated in the urine and in the feces, respectively.

Toxicity

Side effects include fluid retention, congestive heart failure (CHF), liver disease

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Avanafil	Co-administration with avanafil resulted in an approximate 2.0% increase in AUC0-inf and 14% decrease in Cmax of rosiglitazone.
Colesevelam	Bile Acid Sequestrants may decrease the absorption of Antidiabetic Agents (Thiazolidinedione). Separate the dosing of bile acid sequestrants and thiazolidinediones by at least 2 hours. Monitor for reduced effects of the antidiabetic agents.
Gemfibrozil	Increases the effect and toxicity of rosiglitazone/pioglitazone
Ketoconazole	Ketoconazole increases the effect of rosiglitazone
Rifampin	Rifampin reduces levels and efficacy of rosiglitazone
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of rosiglitazone. Monitor for changes in fasting and postprandial blood sugars.
Tretinoin	The moderate CYP2C8 inhibitor, Rosiglitazone, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Rosiglitazone is initiated, discontinued to dose changed.

Food Interactions

Not Available

Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	yes
Actions	agonist
References	Su JL, Winegar DA, Wisely GB, Sigel CS, Hull-Ryde EA: Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro. Hybridoma. 1999 Jun;18(3):273-80. - Pubmed Rieusset J, Auwerx J, Vidal H: Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes. Biochem Biophys Res Commun. 1999 Nov;265(1):265-71. - Pubmed Kameda N, Okuya S, Oka Y: [Rosiglitazone (BRL-49653)] Nippon Rinsho. 2000 Feb;58(2):401-4. - Pubmed Johnson BA, Wilson EM, Li Y, Moller DE, Smith RG, Zhou G: Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation. J Mol Biol. 2000 Apr 28;298(2):187-94. - Pubmed Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen X, Vanbogelen R, Leff T: Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone. Diabetes. 2000 Apr;49(4):539-47. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	1.0204
Long-chain-fatty-acid--CoA ligase 4
Name	Long-chain-fatty-acid--CoA ligase 4
Gene Name	ACSL4
Pharmacological action	unknown
Actions	inhibitor
References	Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE: Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages. Diabetes. 2007 Apr;56(4):1143-52. Epub 2007 Jan 26. - Pubmed
DTHybrid score	0.1491

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4432
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6303
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.5604
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4821
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3404
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5027
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5084

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed
DTHybrid score	0.2697

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.2697

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.5193
1588	Multidrug resistance protein 1	ABCB1	0.2656
290	Prostaglandin G/H synthase 2	PTGS2	0.2387
6030	Cytochrome P450 2B6	CYP2B6	0.219
4118	Cytochrome P450 3A5	CYP3A5	0.2131
6013	Cytochrome P450 2E1	CYP2E1	0.1897
6024	Cytochrome P450 1A1	CYP1A1	0.1617
6107	Cytochrome P450 3A7	CYP3A7	0.1553
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1194
1729	Solute carrier family 22 member 6	SLC22A6	0.1181
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0973
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0959
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0931
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0874
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0822
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0821
6106	Cytochrome P450 2C18	CYP2C18	0.0799
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0788
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0779
492	Histamine H1 receptor	HRH1	0.0706
6142	Solute carrier family 22 member 8	SLC22A8	0.065
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0621
824	Sodium-dependent serotonin transporter	SLC6A4	0.0594
862	Multidrug resistance-associated protein 1	ABCC1	0.0591
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0573
275	Arachidonate 5-lipoxygenase	ALOX5	0.0571
3811	Cytochrome P450 19A1	CYP19A1	0.0571
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0569
6145	Solute carrier family 22 member 1	SLC22A1	0.0565
2164	Multidrug resistance-associated protein 4	ABCC4	0.0554
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0551
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0548
759	Free fatty acid receptor 1	FFAR1	0.0546
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0521
831	D(2) dopamine receptor	DRD2	0.049
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.048
6228	Nuclear receptor coactivator 1	NCOA1	0.0472
776	Bile salt export pump	ABCB11	0.0464
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0464
3312	Fatty acid-binding protein, brain	FABP7	0.0453
1053	BC269730_2	FADS1	0.045
1395	Sodium/calcium exchanger 1	SLC8A1	0.045
1898	Cytochrome P450 1B1	CYP1B1	0.0444
891	Dihydropteroate synthase	folP	0.0439
5359	Dihydropteroate synthase	folP	0.0439
7175	Dihydropteroate synthase	sulI	0.0439
118	Organic cation/carnitine transporter 2	SLC22A5	0.043
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0425
1024	Solute carrier family 22 member 11	SLC22A11	0.0422
556	Alpha-1A adrenergic receptor	ADRA1A	0.042
6143	Solute carrier family 22 member 7	SLC22A7	0.0418
766	Beta-2 adrenergic receptor	ADRB2	0.0414
6144	Solute carrier family 22 member 2	SLC22A2	0.0412
70	Type-1 angiotensin II receptor	AGTR1	0.0411
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.041
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0391
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0379
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0378
3941	Amine oxidase [flavin-containing] A	MAOA	0.037
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0368
459	Retinoic acid receptor RXR-alpha	RXRA	0.0362
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0361
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0351
713	Sodium-dependent dopamine transporter	SLC6A3	0.0349
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0341
23	D(1A) dopamine receptor	DRD1	0.0339
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0329
36	Insulin receptor	INSR	0.0325
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0318
136	Estrogen receptor	ESR1	0.0311
193	Beta-1 adrenergic receptor	ADRB1	0.0304
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0303
318	Alpha-2A adrenergic receptor	ADRA2A	0.0302
731	HIV-1 protease	HIV-1 protease	0.0295
6241	Nuclear receptor coactivator 2	NCOA2	0.0287
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0287
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0287
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0287
632	Alpha-1B adrenergic receptor	ADRA1B	0.0287
1757	Myeloperoxidase	MPO	0.0283
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0281
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0279
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0278
847	Mu-type opioid receptor	OPRM1	0.0271
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.027
3939	Amine oxidase [flavin-containing] B	MAOB	0.0262
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0262
468	Cytochrome P450 4A11	CYP4A11	0.0261
267	Plasminogen activator inhibitor 1	SERPINE1	0.0254
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0253
696	Kappa-type opioid receptor	OPRK1	0.0251
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0247
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0247
6141	Sodium/bile acid cotransporter	SLC10A1	0.0246
373	Transthyretin	TTR	0.0244
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0243
6221	Steroid hormone receptor ERR1	ESRRA	0.0238
467	Delta-type opioid receptor	OPRD1	0.0238
6102	Arylamine N-acetyltransferase 2	NAT2	0.0237
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0236
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0234
465	Calmodulin	CALM1	0.0233
833	Organic cation/carnitine transporter 1	SLC22A4	0.0233
260	Cytochrome P450 51	ERG11	0.0233
761	Cytochrome P450 51	ERG11	0.0233
3163	Cytochrome P450 51	cyp51	0.0233
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.023
6147	Solute carrier family 22 member 3	SLC22A3	0.0226
6014	Cytochrome P450 2A13	CYP2A13	0.0225
3809	Estrogen-related receptor gamma	ESRRG	0.0223
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.022
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.022
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0219
738	Monocarboxylate transporter 1	SLC16A1	0.0218
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0218
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0216
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0214
817	DNA topoisomerase 2-alpha	TOP2A	0.0212
6031	Cytochrome P450 3A43	CYP3A43	0.0209
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0209
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0206
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0204
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0204
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0204
4604	Liver carboxylesterase 1	CES1	0.0201
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0199
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0197
146	Androgen receptor	AR	0.0197
3923	Cholinesterase	BCHE	0.0195
122	P2Y purinoceptor 12	P2RY12	0.0188
638	D(3) dopamine receptor	DRD3	0.0183
6085	Fatty acid-binding protein, intestinal	FABP2	0.018
703	NADPH azoreductase	azr	0.0178
6136	Multidrug resistance-associated protein 5	ABCC5	0.0176
789	Alpha-1D adrenergic receptor	ADRA1D	0.0171
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0167
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0166
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0165
629	Alpha-2B adrenergic receptor	ADRA2B	0.0164
811	Translocator protein	TSPO	0.0164
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0163
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0163
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.016
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0156
844	Epidermal growth factor receptor	EGFR	0.0156
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0153
380	Cytochrome P450 17A1	CYP17A1	0.0153
482	Glycine receptor subunit alpha-1	GLRA1	0.0153
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0152
871	Glucocorticoid receptor	NR3C1	0.0152
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.015
477	DNA topoisomerase 4 subunit A	parC	0.0147
886	DNA topoisomerase 4 subunit A	parC	0.0147
6226	DNA topoisomerase 4 subunit A	parC	0.0147
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0145
6148	Multidrug resistance-associated protein 7	ABCC10	0.0145
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0144
6182	Cytochrome P450 2J2	CYP2J2	0.0144
758	Thyroid hormone receptor alpha	THRA	0.0143
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.014
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0139
5880	Thrombopoietin receptor	MPL	0.0139
432	D(4) dopamine receptor	DRD4	0.0138
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0137
504	Mast/stem cell growth factor receptor	KIT	0.0136
26	Vascular endothelial growth factor receptor 3	FLT4	0.0136
378	Alpha-2C adrenergic receptor	ADRA2C	0.0133
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0133
777	Tumor necrosis factor	TNF	0.0131
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0131
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0131
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0131
94	5-hydroxytryptamine 4 receptor	HTR4	0.013
32	Vascular endothelial growth factor receptor 1	FLT1	0.013
756	Sex hormone-binding globulin	SHBG	0.013
558	Solute carrier family 12 member 1	SLC12A1	0.0128
407	Vascular endothelial growth factor receptor 2	KDR	0.0128
33	Cystine/glutamate transporter	SLC7A11	0.0128
346	Thyroid hormone receptor beta-1	THRB	0.0128
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0127
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0125
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0124
869	Estrogen receptor beta	ESR2	0.0123
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0123
183	Vascular endothelial growth factor A	VEGFA	0.0122
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0121
6137	Multidrug resistance-associated protein 6	ABCC6	0.012
6220	Aryl hydrocarbon receptor	AHR	0.012
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0119
3587	Gastrotropin	FABP6	0.0118
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0118
705	Glutamate receptor 1	GRIA1	0.0117
1507	Cytochrome c	CYCS	0.0116
365	Dihydrofolate reductase	DHFR	0.0116
2381	Dihydrofolate reductase	DFR1	0.0116
2833	Dihydrofolate reductase	Not Available	0.0116
2931	Dihydrofolate reductase	folA	0.0116
3544	Dihydrofolate reductase	folA	0.0116
3682	Dihydrofolate reductase	folA	0.0116
6642	Dihydrofolate reductase	folA	0.0116
6756	Dihydrofolate reductase	dfrA	0.0116
594	Thyroxine-binding globulin	SERPINA7	0.0112
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0112
716	5-hydroxytryptamine 7 receptor	HTR7	0.0111
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0111
563	Thyroid peroxidase	TPO	0.011
571	Melatonin receptor type 1A	MTNR1A	0.011
362	Melatonin receptor type 1B	MTNR1B	0.011
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0108
2211	Fatty acid-binding protein, heart	FABP3	0.0108
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0107
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0107
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0106
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0106
2853	14 kDa fatty acid-binding protein	Not Available	0.0105
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0105
124	Histamine H2 receptor	HRH2	0.0104
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0102
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0101
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
427	Substance-P receptor	TACR1	0.01
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.01
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0099
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0099
16	Adenosine A1 receptor	ADORA1	0.0098
921	Glutamate receptor 2	GRIA2	0.0098
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0097
518	Peroxidase/catalase T	katG	0.0097
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0097
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0097
6043	Putative G-protein coupled receptor 44	GPR44	0.0096
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0096
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0095
3810	Catechol O-methyltransferase	COMT	0.0095
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0095
566	Serotransferrin	TF	0.0094
163	D(1B) dopamine receptor	DRD5	0.0094
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0094
1178	Adenosine A2a receptor	ADORA2A	0.0094
1010	Cytochrome P450 51A1	CYP51A1	0.0094
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0093
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0093
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0093
273	Apoptosis regulator Bcl-2	BCL2	0.0092
1050	Bile salt sulfotransferase	SULT2A1	0.0091
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0091
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.009
3947	Xanthine dehydrogenase/oxidase	XDH	0.009
1648	Elastin	ELN	0.0089
4122	Histone deacetylase 2	HDAC2	0.0088
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0088
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0087
4116	Dihydropteroate synthetase	Not Available	0.0087
614	Progesterone receptor	PGR	0.0086
1656	CYP2B protein	CYP2B	0.0084
24	Thymidylate synthase	TMP1	0.0083
359	Thymidylate synthase	TYMS	0.0083
2626	Thymidylate synthase	thyA	0.0083
2729	Thymidylate synthase	thyA	0.0083
5352	Thymidylate synthase	THYA	0.0083
1192	Sulfotransferase 1A1	SULT1A1	0.0082
131	Synaptic vesicular amine transporter	SLC18A2	0.0081
88	Retinoic acid receptor RXR-beta	RXRB	0.0081
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0081
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0081
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0081
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0081
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0081
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0081
1650	Heme carrier protein 1	SLC46A1	0.008
6103	Arylamine N-acetyltransferase 1	NAT1	0.008
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.008
474	Acetylcholinesterase	ACHE	0.008
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
3932	Glutathione S-transferase A2	GSTA2	0.008
106	Cannabinoid receptor 2	CNR2	0.0079
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
1275	Estrogen sulfotransferase	SULT1E1	0.0078
7	Nitric oxide synthase, inducible	NOS2	0.0077
6149	Solute carrier family 22 member 10	SLC22A10	0.0077
1629	Transcription factor AP-1	JUN	0.0077
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0075
634	Squalene monooxygenase	SQLE	0.0075
7196	Squalene monooxygenase	ERG1	0.0075
68	Cannabinoid receptor 1	CNR1	0.0075
823	Fibroblast growth factor receptor 2	FGFR2	0.0074
4120	NADPH--cytochrome P450 reductase	POR	0.0074
29	Tubulin beta-1 chain	TUBB1	0.0074
295	Carbonic anhydrase 1	CA1	0.0074
6044	Serum paraoxonase/lactonase 3	PON3	0.0073
2230	Catalase	CAT	0.0073
3249	Catalase	katA	0.0073
3625	Catalase	katA	0.0073
4539	Catalase	katA	0.0073
4941	Catalase	katB	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1618	High affinity nerve growth factor receptor	NTRK1	0.0072
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0071
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
2539	Tubulin alpha-1 chain	TUBA4A	0.0071
645	Penicillin-binding protein 1A	mrcA	0.0071
5805	Penicillin-binding protein 1A	ponA	0.0071
6185	Penicillin-binding protein 1A	mrcA	0.0071
6799	Penicillin-binding protein 1A	pbpA	0.0071
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0071
4238	50S ribosomal protein L4	rplD	0.007
5578	50S ribosomal protein L4	rplD	0.007
6173	50S ribosomal protein L4	rplD	0.007
6219	50S ribosomal protein L4	rplD	0.007
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.007
49	Endothelin B receptor	EDNRB	0.007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.007
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0069
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0069
2021	Thrombomodulin	THBD	0.0069
6174	50S ribosomal protein L32	rpmF	0.0069
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0069
6167	Organic solute transporter subunit beta	OSTB	0.0069
6166	Organic solute transporter subunit alpha	OSTA	0.0069
199	Monocarboxylate transporter 8	SLC16A2	0.0069
6033	High affinity interleukin-8 receptor A	CXCR1	0.0068
1636	Trace amine-associated receptor 1	TAAR1	0.0067
578	Endothelin-1 receptor	EDNRA	0.0066
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0066
251	Alcohol dehydrogenase 1A	ADH1A	0.0065
780	Retinoic acid receptor RXR-gamma	RXRG	0.0065
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0065
4237	50S ribosomal protein L22	rplV	0.0065
162	Retinoic acid receptor gamma-1	RARG	0.0065
130	Prostacyclin synthase	PTGIS	0.0065
6432	Transporter	snf	0.0065
592	Carbonic anhydrase 4	CA4	0.0065
1517	Beta-3 adrenergic receptor	ADRB3	0.0065
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0064
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
173	Toll-like receptor 7	TLR7	0.0063
161	Tubulin beta chain	TUBB	0.0063
312	Tubulin beta chain	TUB2	0.0063
133	Dihydropterate synthase	sulI	0.0063
952	Dipeptidyl peptidase 4	DPP4	0.0063
565	Extracellular calcium-sensing receptor	CASR	0.0062
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
3856	Fibroblast growth factor receptor 3	FGFR3	0.0062
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0061
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0061
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0061
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0061
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0061
2112	Toll-like receptor 9	TLR9	0.0061
4203	Histamine N-methyltransferase	HNMT	0.006
6020	Aldehyde oxidase	AOX1	0.006
117	Sterol O-acyltransferase 1	SOAT1	0.006
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.006
1541	Metalloproteinase	mmp20	0.006
6146	High affinity copper uptake protein 1	SLC31A1	0.0059
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0059
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0059
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0058
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0058
444	Alcohol dehydrogenase 1B	ADH1B	0.0058
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0058
517	Alcohol dehydrogenase 1C	ADH1C	0.0058
357	Carbonic anhydrase 2	CA2	0.0058
5934	Cytochrome P450 26A1	CYP26A1	0.0057
737	Mineralocorticoid receptor	NR3C2	0.0056
84	Nuclear receptor 0B1	NR0B1	0.0056
1630	Integrin beta-2	ITGB2	0.0056
2207	Rhodopsin	RHO	0.0056
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0056
1525	Heparin-binding growth factor 2	FGF2	0.0055
4217	Telomerase reverse transcriptase	TERT	0.0055
4103	Proteasome subunit beta type 2	PSMB2	0.0055
4102	Proteasome subunit beta type 5	PSMB5	0.0055
4101	Proteasome subunit beta type 1	PSMB1	0.0055
4226	Uridine phosphorylase 2	UPP2	0.0055
284	DNA-directed RNA polymerase beta chain	rpoB	0.0054
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0054
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0053
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0053
1992	Vitamin D-binding protein	GC	0.0053
850	Vasopressin V1b receptor	AVPR1B	0.0053
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0053
3639	Thymidine phosphorylase	deoA	0.0053
3936	Thymidine phosphorylase	TYMP	0.0053
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0052
4311	tRNA	TRDMT1	0.0051
4325	tRNA	trmD	0.0051
4328	tRNA	trmD	0.0051
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0051
904	Glutathione S-transferase P	GSTP1	0.0051
4225	Uridine phosphorylase 1	UPP1	0.005
229	Retinoic acid receptor beta	RARB	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
1792	Tissue-type plasminogen activator	PLAT	0.0049
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0049
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0049
1714	Mitogen-activated protein kinase 3	MAPK3	0.0049
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
3808	Dihydropteroate synthase 2	folP2	0.0049
3601	Dihydropteroate synthase 1	folP1	0.0049
3807	Dihydropteroate synthase 1	folP1	0.0049
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0049
768	FK506-binding protein 1A	FKBP1A	0.0049
730	Retinoic acid receptor alpha	RARA	0.0049
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0049
6151	Monocarboxylate transporter 10	SLC16A10	0.0049
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0049
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0048
6042	Prostaglandin reductase 2	PTGR2	0.0048
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
6126	Carbonic anhydrase 7	CA7	0.0047
413	Amidophosphoribosyltransferase	PPAT	0.0047
2515	Amidophosphoribosyltransferase	purF	0.0047
3714	Amidophosphoribosyltransferase	purF	0.0047
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0047
185	Vasopressin V1a receptor	AVPR1A	0.0046
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0046
3382	Glycolipid transfer protein	GLTP	0.0046
322	Vasopressin V2 receptor	AVPR2	0.0046
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
992	Protein tyrosine kinase 2 beta	PTK2B	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0045
489	Monocarboxylate transporter 2	SLC16A7	0.0045
5300	Antigen peptide transporter 1	TAP1	0.0045
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0045
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0044
1039	Histone deacetylase 9	HDAC9	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
232	Corticosteroid-binding globulin	SERPINA6	0.0044
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0044
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0044
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0044
5787	Angiopoietin-1 receptor	TEK	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
3937	Fatty-acid amide hydrolase	FAAH	0.0044
818	50S ribosomal protein L10	rplJ	0.0043
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0043
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0043
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0043
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0043
2320	Thymidine kinase, cytosolic	TK1	0.0043
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0043
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0043
239	Coagulation factor X	F10	0.0043
572	Integrin alpha-L	ITGAL	0.0042
174	Sigma 1-type opioid receptor	SIGMAR1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0042
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0042
1864	RET proto-oncogene	RET	0.0042
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0042
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0042
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0042
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0042
65	Matrix metalloproteinase-9	Not Available	0.0041
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0041
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
6677	Myelin P2 protein	PMP2	0.0041
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0041
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
164	Histamine H4 receptor	HRH4	0.004
633	Penicillin-binding proteins 1A/1B	pbpA	0.004
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.004
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0039
976	Platelet glycoprotein IX	GP9	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0039
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0039
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0039
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0039
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
469	Annexin A1	ANXA1	0.0038
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0038
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1196	Complement decay-accelerating factor	CD55	0.0038
1313	Lactoylglutathione lyase	GLO1	0.0038
54	Prothrombin	F2	0.0037
1374	Natriuretic peptides B	NPPB	0.0036
1827	Gap junction alpha-1 protein	GJA1	0.0036
1908	Vascular cell adhesion protein 1	VCAM1	0.0036
3086	Plasmepsin-2	Not Available	0.0036
4228	Keratin, type II cytoskeletal 7	KRT7	0.0036
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0036
581	Cytochrome P450 2R1	CYP2R1	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
2298	Cytochrome P450-cam	camC	0.0036
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0036
3957	Adenosine deaminase	ADA	0.0036
153	Dopamine beta-hydroxylase	DBH	0.0035
751	Potassium channel subfamily K member 6	KCNK6	0.0035
822	Aldose reductase	AKR1B1	0.0035
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0035
6500	Phospholipase A2	PLA2G1B	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0035
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0035
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0034
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0034
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0034
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0034
712	Tubulin alpha chain	TUB1	0.0034
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0034
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0034
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0034
4210	Toll-like receptor 4	TLR4	0.0034
165	FL cytokine receptor	FLT3	0.0034
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0033
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0033
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0033
6506	Stathmin-4	STMN4	0.0033
760	Fibroblast growth factor 1	FGF1	0.0033
319	Opioid receptor, sigma 1	OPRS1	0.0033
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0033
2808	Chloramphenicol acetyltransferase 3	cat3	0.0033
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0033
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0033
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0033
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0033
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
172	Potassium channel subfamily K member 1	KCNK1	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0032
1760	Aminopeptidase N	ANPEP	0.0032
6843	Aminopeptidase N	pepN	0.0032
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0032
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0032
1268	Neuropeptide S receptor	NPSR1	0.0032
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0032
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0032
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0031
3426	Glutamine synthetase	glnA	0.0031
3987	Glutamine synthetase	GLUL	0.0031
719	Retinoic acid receptor responder protein 1	RARRES1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
770	Retinoic acid-induced protein 3	GPRC5A	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0031
1291	cAMP response element-binding protein	CREB1	0.0031
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0031
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.003
6501	Fatty acid-binding protein, liver	FABP1	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
2417	Chloramphenicol acetyltransferase	cat	0.003
3278	Chloramphenicol acetyltransferase	cat	0.003
908	Glutathione S-transferase theta-1	GSTT1	0.003
2810	Dr hemagglutinin structural subunit	draA	0.003
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.003
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
6168	Solute carrier family 22 member 16	SLC22A16	0.0029
814	Ryanodine receptor 1	RYR1	0.0029
6073	Potassium channel subfamily K member 9	KCNK9	0.0028
6072	Potassium channel subfamily K member 3	KCNK3	0.0028
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0028
4192	DNA topoisomerase 2-beta	TOP2B	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0028
5431	Lipid binding protein	Not Available	0.0028
3616	Fatty acid-binding protein, epidermal	FABP5	0.0028
5433	UPF0230 protein TM_1468	TM_1468	0.0028
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
400	Coagulation factor IX	F9	0.0027
5461	Coagulation factor IX	F9	0.0027
1353	DNA topoisomerase 1	TOP1	0.0027
3552	DNA topoisomerase 1	topA	0.0027
569	Retinal dehydrogenase 2	ALDH1A2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2236	Casein kinase II subunit alpha	CSNK2A1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0026
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
268	Adenosine A2b receptor	ADORA2B	0.0025
611	Retinal dehydrogenase 1	ALDH1A1	0.0025
551	Carnitine O-acetyltransferase	CRAT	0.0025
85	Growth hormone receptor	GHR	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0025
604	Vitamin K-dependent protein Z	PROZ	0.0025
6218	Pannexin-1	PANX1	0.0025
3830	Calreticulin	CALR	0.0025
856	Vitamin D3 receptor	VDR	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
1867	Major prion protein	PRNP	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
6138	Multidrug resistance protein 3	ABCB4	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
244	Angiotensin-converting enzyme	ACE	0.0024
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
283	SEC14-like protein 2	SEC14L2	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1245	Vitamin K-dependent protein S	PROS1	0.0023
422	Vitamin K-dependent protein C	PROC	0.0023
723	Cytosolic phospholipase A2	PLA2G4A	0.0023
6131	Carbonic anhydrase 14	CA14	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
6459	Glycodelin	PAEP	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
1262	Corticotropin-lipotropin	POMC	0.0021
5818	Folate receptor alpha	FOLR1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
6209	30S ribosomal protein S19	rpsS	0.0021
6712	30S ribosomal protein S19	rpsS	0.0021
6726	30S ribosomal protein S19	rpsS	0.0021
6207	30S ribosomal protein S14	rpsN	0.0021
936	Ephrin type-A receptor 2	EPHA2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3913	Glutamic acid decarboxylase	GAD65	0.0021
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6048	Troponin C, skeletal muscle	TNNC2	0.002
1820	Beta-nerve growth factor	NGF	0.002
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.002
1243	Cathepsin D	CTSD	0.0019
2449	Tubulin alpha-3 chain	TUBA1A	0.0019
820	Glycine receptor subunit alpha-2	GLRA2	0.0019
1483	Membrane copper amine oxidase	AOC3	0.0019
5798	Mitogen-activated protein kinase 11	MAPK11	0.0019
798	Osteocalcin	BGLAP	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
293	Gamma-glutamyl hydrolase	GGH	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0018
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0018
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1341	Histamine H3 receptor	HRH3	0.0018
735	Alanine aminotransferase 1	GPT	0.0017
3904	Alanine aminotransferase 2	GPT2	0.0017
828	Phenylalanine-4-hydroxylase	PAH	0.0017
3109	Phenylalanine-4-hydroxylase	phhA	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
369	Coagulation factor VII	F7	0.0017
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0017
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0016
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
3611	Cytidine deaminase	cdd	0.0014
3707	Cytidine deaminase	cdd	0.0014
4211	Cytidine deaminase	CDA	0.0014
4773	Deoxycytidine kinase	DCK	0.0014
4948	Cytochrome c-553	Not Available	0.0014
4923	Cytochrome c3	DvMF_2499	0.0014
4945	Cytochrome c3	Not Available	0.0014
4949	Cytochrome c3	DVU_3171	0.0014
4968	Cytochrome c3	cytc3	0.0014
4997	Cytochrome c3	SO_2727	0.0014
5219	Cytochrome c3	cyd	0.0014
4902	Nine-heme cytochrome c	Ddes_2038	0.0014
3189	High-molecular-weight cytochrome c	hmcA	0.0014
233	Potassium channel subfamily K member 2	KCNK2	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
3404	Exotoxin A	eta	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
5923	Microtubule-associated protein tau	MAPT	0.0013
5924	Microtubule-associated protein 4	MAP4	0.0013
4386	Hemoglobin-like protein HbN	glbN	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0012
1852	Microtubule-associated protein 2	MAP2	0.0012
6824	Tyrosine-protein kinase Lyn	LYN	0.0012
473	L-lactate dehydrogenase A chain	LDHA	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
3221	Cytochrome c4	cc4	0.0011
4943	Cytochrome c6	petJ	0.0011
4954	Soluble cytochrome b558	Not Available	0.0011
4916	Cyanoglobin	glbN	0.0011
4947	Bacterial hemoglobin	vhb	0.0011
4934	Cytochrome c-551	nirM	0.0011
5218	Cytochrome c-551	nirM	0.0011
4905	Cytochrome c2	Not Available	0.0011
4939	Cytochrome c2	cycA	0.0011
4964	Cytochrome c2	cycA	0.0011
4979	Cytochrome c2	cycA	0.0011
6673	Cytochrome c2	cycA	0.0011
4915	Cytochrome c-550	psbV	0.0011
4959	Cytochrome c-550	psbV	0.0011
5216	Cytochrome c-550	psbV	0.0011
4925	Cytochrome c-type protein SHP	shp	0.0011
4975	Cytochrome c-556	RPA3973	0.0011
4994	Hemoglobin-like protein HbO	glbO	0.0011
4942	Diheme cytochrome c napB	napB	0.0011
4984	Neuroglobin	NGB	0.0011
5000	HemO	hemO	0.0011
4936	Cytochrome c2 iso-2	Not Available	0.0011
4981	Iron-starvation protein PigA	pigA	0.0011
4961	Hemophore HasA	hasA	0.0011
4998	Hemoglobin-like protein yjbI	yjbI	0.0011
4909	CooA protein	cooA	0.0011
644	Heme oxygenase 2	HMOX2	0.0011
4982	Heme oxygenase 2	pbsA2	0.0011
4935	Cytochrome c-554	cycA1	0.0011
4910	Cytoglobin	CYGB	0.0011
3116	Bacterioferritin	bfr	0.0011
4906	Bacterioferritin	bfr	0.0011
4965	Bacterioferritin	bfr	0.0011
4907	Cytochrome c-L	moxG	0.0011
6865	Cytochrome c-L	moxG	0.0011
4976	Apocytochrome f	petA	0.0011
6407	Apocytochrome f	petA	0.0011
4937	Cytochrome oxidase subunit II	rcoxA	0.0011
4971	Nonaheme cytochrome c	hmcA	0.0011
4904	Cytochrome c family protein	GSU1996	0.0011
4989	Cytochrome c551 peroxidase	ccp	0.0011
5222	Cytochrome c551 peroxidase	ccpA	0.0011
4931	Cytochrome P450 167A1	CYP167A1	0.0011
4999	Cytochrome P450 165B3	CYP165B3	0.0011
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0011
4764	Cytochrome P450 165C4	CYP165C4	0.0011
4960	Putative cytochrome P450-family protein	SCO7417	0.0011
4903	Methyl-accepting chemotaxis protein	Tar4	0.0011
4972	P450cin	cinA	0.0011
4922	Cytochrome c, putative	SO_4144	0.0011
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0011
4993	Hydroxylamine oxidoreductase	hao1	0.0011
4952	Catalase/peroxidase	katA	0.0011
3093	Catalase HPII	katE	0.0011
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0011
2290	ADP-ribosyl cyclase 2	BST1	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
6163	Copper-transporting ATPase 2	ATP7B	0.001
6165	Copper-transporting ATPase 1	ATP7A	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0009
76	Nitric-oxide synthase, brain	NOS1	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
1184	Interferon beta	IFNB1	0.0008
4920	Peroxidase/catalase	katG	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
896	Glutathione S-transferase Mu 1	GSTM1	0.0008
2119	Cytochrome b5	CYB5A	0.0008
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0008
4990	PpcA	ppcA	0.0008
4037	Hypothetical protein	GPX1	0.0008
4297	Hypothetical protein	SP_1951	0.0008
4521	Hypothetical protein	BC_2969	0.0008
4540	Hypothetical protein	TM_1070	0.0008
4555	Hypothetical protein	MT1739	0.0008
4569	Hypothetical protein	mshD	0.0008
4578	Hypothetical protein	PA3270	0.0008
4747	Hypothetical protein	PA3967	0.0008
5177	Hypothetical protein	TM_0096	0.0008
5194	Hypothetical protein	PA1204	0.0008
5240	Hypothetical protein	Rv2991	0.0008
5370	Hypothetical protein	TM_1158	0.0008
5710	Hypothetical protein	Tb927.5.1360	0.0008
4988	Sulfite oxidase, mitochondrial	SUOX	0.0008
3375	Acidic cytochrome c3	Not Available	0.0008
3570	Cytochrome P450 152A1	cypC	0.0008
2915	Sensor protein fixL	fixL	0.0008
4944	Sensor protein fixL	fixL	0.0008
4289	Cytochrome P450	TT_P0059	0.0008
6262	Cytochrome P450	staP	0.0008
4992	Cytochrome c peroxidase	Not Available	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
4385	Cytochrome c'	Not Available	0.0008
4967	Cytochrome c'	cycA	0.0008
5038	Cytochrome c'	Not Available	0.0008
5223	Cytochrome c'	cycP	0.0008
4813	Heme oxygenase	hmuO	0.0008
5769	Heme oxygenase	Not Available	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
3670	Soluble cytochrome b562 precursor	cybC	0.0007
3411	Cytochrome P450 121	cyp121	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
2617	Nitric oxide synthase oxygenase	nos	0.0007
2701	Nitric oxide synthase oxygenase	nos	0.0007
3291	Cytochrome c-552	cycA	0.0007
4927	Cytochrome c-552	nrfA	0.0007
4938	Cytochrome c-552	cycA	0.0007
4953	Cytochrome c-552	nrfA	0.0007
5217	Cytochrome c-552	cycM	0.0007
3102	Flavohemoprotein	hmp	0.0007
4969	Flavohemoprotein	hmp	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
4608	Putative cytochrome P450	SCO1207	0.0006
4963	Putative cytochrome P450	SCO2884	0.0006
6254	Putative cytochrome P450	SCO6998	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
358	Cystathionine beta-synthase	CBS	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
693	Hemoglobin subunit beta	HBB	0.0005
6268	Hydroxyacid oxidase 1	HAO1	0.0005
2427	Ferrichrome-iron receptor	fhuA	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
810	Heme oxygenase 1	HMOX1	0.0005
3391	Heme oxygenase 1	pbsA1	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
5961	Insulin	INS	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
6755	Poliovirus receptor	PVR	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
6122	Carbonic anhydrase 3	CA3	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0003
3007	Carbonic anhydrase 12	CA12	0.0003
4205	Carbonic anhydrase 9	CA9	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00412 - Rosiglitazone

Targets

Enzymes

Transporters

Carriers

Predictions