DT-Web: DB08860

Identification

Name

Pitavastatin

Accession Number

DB08860

Type

small molecule

Description

Pitavastatin a lipid-lowering agent that belongs to the statin class of medications for treatment of dyslipidemia. It is also used for primary and secondary prevention of cardiovascular disease. FDA approved in Aug 3, 2009.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antilipemic Agents

Molecular Weight

421.4608

Groups

approved

Monoisotopic Weight

421.168936466

Pharmacology

Indication

Pitavastatin is used to lower serum levels of total cholesterol, LDL-C, apolipoprotein B, and triglycerides, and raise levels of HDL-C for the treatment of dyslipidemia.

Mechanism of action

Pitavastatin is lipid-lowering agent that works to control the synthesis of cholesterol via competitive inhibition of the liver enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. As a result, a compensatory increase in LDL-receptor expression can be observed which facilitates an increase LDL catabolism.

Absorption

Bioavailability = 51%; Time to peak, plasma = 1 hour; Pitavastatin was absorbed in the small intestine but very little in the colon. Cmax decreases by 43% if pitavastatin is taken with a fatty meal but there are no significant changes to AUC or baseline LDL levels compared to fasting state. The Cmax and AUC of pitavastatin did not differ following evening or morning drug administration.

Protein binding

>99% protein bound in human plasma, mainly to albumin and alpha 1-acid glycoprotein.

Biotransformation

Pitavastatin is mainly metabolized by liver. It undergoes glucuronidation by uridine 5-diphosphate glucuronosyl transferases (UGT1A3 and UGT2B7) to form the major circulating metabolite, pitavastatin lactone. The cytochrome P450 system has little involvement with the metabolism of pitavastatin. There is some metabolism by CYP2C9 and to a lesser extent, CYP2C8. Studies suggest that concomitant therapy with drugs that are involved with the cytochrome P450 system will not effect the pharmacokinetics of pitavastatin.

Route of elimination

79% in feces and 15% excreted in urine.

Toxicity

The most frequent adverse reactions (rate >=2.0% in at least one marketed dose) were myalgia, back pain, diarrhea, constipation and pain in extremity.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Increases serum concentration of pitavastatin and the potential for adverse drug reactions. Avoid concomitant drug therapy.
Colchicine	Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both colchicine and pitavastatin via pharmacodynamic synergism.
Cyclosporine	Cyclosporine decreases metabolism of pitavastatin thus increasing serum concentration. Avoid concomitant drug therapy.
Erythromycin	Erythromycin decreases metabolism of pitavastatin. Do not exceed 1 mg per day of pitavastatin or use alternative therapy.
Fenofibrate	Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both fenofibrate and pitavastatin via pharmacodynamic synergism. Use alternative therapy.
Gemfibrozil	Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both gemfibrozil and pitavastatin via pharmacodynamic synergism. Use alternative therapy.
Lopinavir	Lopinavir decreases metabolism of pitavastatin thus increasing serum concentration. Avoid concomitant drug therapy.
Niacin	Increased incidence of adverse drug reactions (ie. rhabdomyolysis) of both niacin and pitavastatin via pharmacodynamic synergism. Use alternative therapy.
Rifampin	Rifampin significantly increased pitavastatin exposure. In patients taking rifampin, a dose of LIVALO 2 mg once daily should not be exceeded.
Rifampin	Rifampin significantly increased pitavastatin exposure. In patients taking rifampin, a dose of LIVALO 2 mg once daily should not be exceeded.

Food Interactions

Avoid taking pitavastatin with red yeast rice. May increase risk of myopathy of pitavastatin via pharmacodynamic synergism. Red yeast rice contain monocolin K (similar to lovastatin)
Take with or without food

3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name	3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name	HMGCR
Pharmacological action	yes
Actions	inhibitor
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.439

UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.2928
UDP-glucuronosyltransferase 1-3
Name	UDP-glucuronosyltransferase 1-3
Gene Name	UGT1A3
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.2795
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.5468
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.4735

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate
References	Hirano M, Maeda K, Shitara Y, Sugiyama Y: Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. Epub 2004 May 24. - Pubmed
DTHybrid score	0.4749
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Hirano M, Maeda K, Shitara Y, Sugiyama Y: Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. Epub 2004 May 24. - Pubmed
DTHybrid score	0.337
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.3067
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.1941
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.3779
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.6193
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Morgan RE, Campbell SE, Yu CY, Sponseller CA, Muster HA: Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. doi: 10.1097/FJC.0b013e318256cdf0. - Pubmed
DTHybrid score	0.3704

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.4749
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions
References	Not Available
DTHybrid score	0.337
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions
References	Not Available
DTHybrid score	0.3067
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions
References	Not Available
DTHybrid score	0.1941
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.3779
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.6193
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.3704

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.509
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.439
6016	Cytochrome P450 2C19	CYP2C19	0.3294
4119	Cytochrome P450 2D6	CYP2D6	0.2885
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.2754
4118	Cytochrome P450 3A5	CYP3A5	0.2662
4200	Cytochrome P450 1A2	CYP1A2	0.2448
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.2064
862	Multidrug resistance-associated protein 1	ABCC1	0.1832
6030	Cytochrome P450 2B6	CYP2B6	0.1813
6107	Cytochrome P450 3A7	CYP3A7	0.1748
1729	Solute carrier family 22 member 6	SLC22A6	0.1621
20	Prostaglandin G/H synthase 1	PTGS1	0.1521
776	Bile salt export pump	ABCB11	0.1517
6142	Solute carrier family 22 member 8	SLC22A8	0.1446
2164	Multidrug resistance-associated protein 4	ABCC4	0.1427
6024	Cytochrome P450 1A1	CYP1A1	0.1163
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1136
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1086
6013	Cytochrome P450 2E1	CYP2E1	0.1073
290	Prostaglandin G/H synthase 2	PTGS2	0.0994
6145	Solute carrier family 22 member 1	SLC22A1	0.0956
70	Type-1 angiotensin II receptor	AGTR1	0.0924
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0866
5718	Cytochrome P450 2A6	CYP2A6	0.0843
1024	Solute carrier family 22 member 11	SLC22A11	0.0837
738	Monocarboxylate transporter 1	SLC16A1	0.081
6143	Solute carrier family 22 member 7	SLC22A7	0.0793
4604	Liver carboxylesterase 1	CES1	0.0792
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0777
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0753
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0747
1898	Cytochrome P450 1B1	CYP1B1	0.0628
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0598
136	Estrogen receptor	ESR1	0.0587
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0577
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0575
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0575
6144	Solute carrier family 22 member 2	SLC22A2	0.0574
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0563
6106	Cytochrome P450 2C18	CYP2C18	0.0544
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.054
6148	Multidrug resistance-associated protein 7	ABCC10	0.0519
556	Alpha-1A adrenergic receptor	ADRA1A	0.0501
118	Organic cation/carnitine transporter 2	SLC22A5	0.0499
492	Histamine H1 receptor	HRH1	0.0496
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0483
3587	Gastrotropin	FABP6	0.0473
6136	Multidrug resistance-associated protein 5	ABCC5	0.0472
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0449
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0424
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.042
4589	3-hydroxy-3-methylglutaryl CoA synthase	mvaS	0.0417
824	Sodium-dependent serotonin transporter	SLC6A4	0.0407
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0404
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0398
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0385
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0378
844	Epidermal growth factor receptor	EGFR	0.0376
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0374
758	Thyroid hormone receptor alpha	THRA	0.0373
6167	Organic solute transporter subunit beta	OSTB	0.0372
6166	Organic solute transporter subunit alpha	OSTA	0.0371
817	DNA topoisomerase 2-alpha	TOP2A	0.0371
3811	Cytochrome P450 19A1	CYP19A1	0.037
6137	Multidrug resistance-associated protein 6	ABCC6	0.0362
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0359
594	Thyroxine-binding globulin	SERPINA7	0.0359
33	Cystine/glutamate transporter	SLC7A11	0.0357
6147	Solute carrier family 22 member 3	SLC22A3	0.0349
891	Dihydropteroate synthase	folP	0.0341
5359	Dihydropteroate synthase	folP	0.0341
7175	Dihydropteroate synthase	sulI	0.0341
346	Thyroid hormone receptor beta-1	THRB	0.0335
847	Mu-type opioid receptor	OPRM1	0.0332
696	Kappa-type opioid receptor	OPRK1	0.0329
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0327
373	Transthyretin	TTR	0.0321
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0317
632	Alpha-1B adrenergic receptor	ADRA1B	0.0312
789	Alpha-1D adrenergic receptor	ADRA1D	0.0304
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0303
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0298
731	HIV-1 protease	HIV-1 protease	0.0297
5880	Thrombopoietin receptor	MPL	0.0297
467	Delta-type opioid receptor	OPRD1	0.0297
29	Tubulin beta-1 chain	TUBB1	0.0293
617	Muscarinic acetylcholine receptor M2	CHRM2	0.029
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0287
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0284
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0283
117	Sterol O-acyltransferase 1	SOAT1	0.0277
833	Organic cation/carnitine transporter 1	SLC22A4	0.0276
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0268
6085	Fatty acid-binding protein, intestinal	FABP2	0.0265
468	Cytochrome P450 4A11	CYP4A11	0.0264
6149	Solute carrier family 22 member 10	SLC22A10	0.0262
504	Mast/stem cell growth factor receptor	KIT	0.0259
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0257
831	D(2) dopamine receptor	DRD2	0.0254
275	Arachidonate 5-lipoxygenase	ALOX5	0.025
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0242
1630	Integrin beta-2	ITGB2	0.0241
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0241
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0241
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.024
6220	Aryl hydrocarbon receptor	AHR	0.0235
273	Apoptosis regulator Bcl-2	BCL2	0.0231
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0229
318	Alpha-2A adrenergic receptor	ADRA2A	0.0228
3941	Amine oxidase [flavin-containing] A	MAOA	0.0227
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0226
1353	DNA topoisomerase 1	TOP1	0.0226
3552	DNA topoisomerase 1	topA	0.0226
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0222
756	Sex hormone-binding globulin	SHBG	0.022
1760	Aminopeptidase N	ANPEP	0.0215
6843	Aminopeptidase N	pepN	0.0215
6031	Cytochrome P450 3A43	CYP3A43	0.0214
6151	Monocarboxylate transporter 10	SLC16A10	0.0212
193	Beta-1 adrenergic receptor	ADRB1	0.0212
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0211
766	Beta-2 adrenergic receptor	ADRB2	0.0211
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0209
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0208
465	Calmodulin	CALM1	0.0206
380	Cytochrome P450 17A1	CYP17A1	0.0205
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0205
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0203
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0203
26	Vascular endothelial growth factor receptor 3	FLT4	0.0195
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0194
2539	Tubulin alpha-1 chain	TUBA4A	0.0194
6044	Serum paraoxonase/lactonase 3	PON3	0.0193
869	Estrogen receptor beta	ESR2	0.019
3923	Cholinesterase	BCHE	0.019
199	Monocarboxylate transporter 8	SLC16A2	0.0189
871	Glucocorticoid receptor	NR3C1	0.0189
32	Vascular endothelial growth factor receptor 1	FLT1	0.0187
614	Progesterone receptor	PGR	0.0186
407	Vascular endothelial growth factor receptor 2	KDR	0.0185
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0184
23	D(1A) dopamine receptor	DRD1	0.0184
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0183
146	Androgen receptor	AR	0.018
1757	Myeloperoxidase	MPO	0.018
572	Integrin alpha-L	ITGAL	0.0179
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0178
952	Dipeptidyl peptidase 4	DPP4	0.0177
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0177
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0177
4122	Histone deacetylase 2	HDAC2	0.0176
3809	Estrogen-related receptor gamma	ESRRG	0.0174
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0174
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0173
24	Thymidylate synthase	TMP1	0.0173
359	Thymidylate synthase	TYMS	0.0173
2626	Thymidylate synthase	thyA	0.0173
2729	Thymidylate synthase	thyA	0.0173
5352	Thymidylate synthase	THYA	0.0173
4120	NADPH--cytochrome P450 reductase	POR	0.0172
672	Prostaglandin F2-alpha receptor	PTGFR	0.0171
489	Monocarboxylate transporter 2	SLC16A7	0.0171
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0168
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0168
459	Retinoic acid receptor RXR-alpha	RXRA	0.0167
713	Sodium-dependent dopamine transporter	SLC6A3	0.0166
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0165
1629	Transcription factor AP-1	JUN	0.0164
3810	Catechol O-methyltransferase	COMT	0.0164
1852	Microtubule-associated protein 2	MAP2	0.0164
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0164
811	Translocator protein	TSPO	0.0163
6102	Arylamine N-acetyltransferase 2	NAT2	0.0161
13	Aminomethyltransferase, mitochondrial	AMT	0.0161
122	P2Y purinoceptor 12	P2RY12	0.0161
5923	Microtubule-associated protein tau	MAPT	0.016
5924	Microtubule-associated protein 4	MAP4	0.016
558	Solute carrier family 12 member 1	SLC12A1	0.0156
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0156
3233	Bile acid receptor	NR1H4	0.0156
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
1792	Tissue-type plasminogen activator	PLAT	0.0149
183	Vascular endothelial growth factor A	VEGFA	0.0149
477	DNA topoisomerase 4 subunit A	parC	0.0149
886	DNA topoisomerase 4 subunit A	parC	0.0149
6226	DNA topoisomerase 4 subunit A	parC	0.0149
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0148
404	DNA gyrase subunit A	gyrA	0.0146
6224	DNA gyrase subunit A	gyrA	0.0146
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0146
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0145
6138	Multidrug resistance protein 3	ABCB4	0.0145
6182	Cytochrome P450 2J2	CYP2J2	0.0144
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0141
5787	Angiopoietin-1 receptor	TEK	0.014
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0139
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0138
3939	Amine oxidase [flavin-containing] B	MAOB	0.0137
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0136
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0136
2021	Thrombomodulin	THBD	0.0136
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0136
365	Dihydrofolate reductase	DHFR	0.0133
2381	Dihydrofolate reductase	DFR1	0.0133
2833	Dihydrofolate reductase	Not Available	0.0133
2931	Dihydrofolate reductase	folA	0.0133
3544	Dihydrofolate reductase	folA	0.0133
3682	Dihydrofolate reductase	folA	0.0133
6642	Dihydrofolate reductase	folA	0.0133
6756	Dihydrofolate reductase	dfrA	0.0133
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0131
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0131
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0128
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0128
908	Glutathione S-transferase theta-1	GSTT1	0.0126
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0125
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0125
737	Mineralocorticoid receptor	NR3C2	0.0125
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0124
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0122
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0122
3947	Xanthine dehydrogenase/oxidase	XDH	0.0122
1650	Heme carrier protein 1	SLC46A1	0.0121
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.012
904	Glutathione S-transferase P	GSTP1	0.012
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0119
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0117
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0117
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0117
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0116
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0115
4773	Deoxycytidine kinase	DCK	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
260	Cytochrome P450 51	ERG11	0.0114
761	Cytochrome P450 51	ERG11	0.0114
3163	Cytochrome P450 51	cyp51	0.0114
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
500	Monocarboxylate transporter 4	SLC16A3	0.0111
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.011
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0109
768	FK506-binding protein 1A	FKBP1A	0.0109
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0109
2443	Azurin	azu	0.0108
161	Tubulin beta chain	TUBB	0.0108
312	Tubulin beta chain	TUB2	0.0108
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0107
1517	Beta-3 adrenergic receptor	ADRB3	0.0107
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0107
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0107
6146	High affinity copper uptake protein 1	SLC31A1	0.0106
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0106
723	Cytosolic phospholipase A2	PLA2G4A	0.0105
1050	Bile salt sulfotransferase	SULT2A1	0.0104
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0104
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0104
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0104
6043	Putative G-protein coupled receptor 44	GPR44	0.0102
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0102
165	FL cytokine receptor	FLT3	0.01
267	Plasminogen activator inhibitor 1	SERPINE1	0.01
1618	High affinity nerve growth factor receptor	NTRK1	0.01
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.01
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0098
5650	NimA-related protein	DR_0842	0.0098
1192	Sulfotransferase 1A1	SULT1A1	0.0097
527	Prostacyclin receptor	PTGIR	0.0097
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0097
6837	Serine/threonine-protein kinase 17B	STK17B	0.0096
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0096
185	Vasopressin V1a receptor	AVPR1A	0.0096
2391	Ferrochelatase	hemH	0.0095
6502	Ferrochelatase	DKFZp686P18130	0.0095
1591	Ferrochelatase, mitochondrial	FECH	0.0095
6163	Copper-transporting ATPase 2	ATP7B	0.0095
6165	Copper-transporting ATPase 1	ATP7A	0.0095
566	Serotransferrin	TF	0.0094
322	Vasopressin V2 receptor	AVPR2	0.0093
992	Protein tyrosine kinase 2 beta	PTK2B	0.0092
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0092
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0092
6042	Prostaglandin reductase 2	PTGR2	0.0092
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0092
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0092
6221	Steroid hormone receptor ERR1	ESRRA	0.0091
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0091
6501	Fatty acid-binding protein, liver	FABP1	0.009
4217	Telomerase reverse transcriptase	TERT	0.009
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0089
777	Tumor necrosis factor	TNF	0.0089
3856	Fibroblast growth factor receptor 3	FGFR3	0.0089
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0088
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0088
54	Prothrombin	F2	0.0088
4116	Dihydropteroate synthetase	Not Available	0.0087
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0086
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0085
482	Glycine receptor subunit alpha-1	GLRA1	0.0085
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0084
293	Gamma-glutamyl hydrolase	GGH	0.0084
2599	Tyrosine-protein kinase HCK	HCK	0.0084
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0084
663	Solute carrier family 12 member 4	SLC12A4	0.0084
53	Solute carrier family 12 member 5	SLC12A5	0.0084
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0083
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0083
896	Glutathione S-transferase Mu 1	GSTM1	0.0083
1656	CYP2B protein	CYP2B	0.0083
2808	Chloramphenicol acetyltransferase 3	cat3	0.0082
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0082
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0082
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0082
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0082
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0082
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0082
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0082
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0082
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0082
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0082
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0082
6559	Cytochrome c oxidase subunit 2	ctaC	0.0082
6669	Cytochrome c oxidase subunit 2	ctaC	0.0082
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0082
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0082
6558	Cytochrome c oxidase subunit 1	ctaD	0.0082
6014	Cytochrome P450 2A13	CYP2A13	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0081
6218	Pannexin-1	PANX1	0.0081
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0081
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0081
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0081
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
2636	Shikimate dehydrogenase	aroE	0.0079
3515	Shikimate dehydrogenase	aroE	0.0079
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0079
244	Angiotensin-converting enzyme	ACE	0.0079
461	Glycine receptor subunit alpha-3	GLRA3	0.0079
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0078
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0078
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0078
310	Solute carrier family 12 member 2	SLC12A2	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
1313	Lactoylglutathione lyase	GLO1	0.0076
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0076
2540	Choloylglycine hydrolase	cbh	0.0075
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0075
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0075
284	DNA-directed RNA polymerase beta chain	rpoB	0.0075
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0075
1039	Histone deacetylase 9	HDAC9	0.0075
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0073
124	Histamine H2 receptor	HRH2	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
629	Alpha-2B adrenergic receptor	ADRA2B	0.0072
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0071
2320	Thymidine kinase, cytosolic	TK1	0.0071
645	Penicillin-binding protein 1A	mrcA	0.0071
5805	Penicillin-binding protein 1A	ponA	0.0071
6185	Penicillin-binding protein 1A	mrcA	0.0071
6799	Penicillin-binding protein 1A	pbpA	0.0071
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0071
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0071
469	Annexin A1	ANXA1	0.0071
5818	Folate receptor alpha	FOLR1	0.0071
4192	DNA topoisomerase 2-beta	TOP2B	0.007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0069
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0069
88	Retinoic acid receptor RXR-beta	RXRB	0.0069
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0069
5626	Nucleoside diphosphate kinase B	NME2	0.0068
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0068
705	Glutamate receptor 1	GRIA1	0.0067
36	Insulin receptor	INSR	0.0066
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0066
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0066
5669	50S ribosomal protein L27	rpmA	0.0066
5675	Chaperone protein torD	torD	0.0065
5670	Organic hydroperoxide resistance protein	ohr	0.0065
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0065
5410	Unsaturated glucuronyl hydrolase	ugl	0.0065
5676	Axin-1	AXIN1	0.0065
5673	C protein alpha-antigen	bca	0.0065
638	D(3) dopamine receptor	DRD3	0.0065
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0065
1525	Heparin-binding growth factor 2	FGF2	0.0064
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0064
5294	Nucleoside diphosphate kinase A	NME1	0.0064
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0064
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
751	Potassium channel subfamily K member 6	KCNK6	0.0063
133	Dihydropterate synthase	sulI	0.0063
611	Retinal dehydrogenase 1	ALDH1A1	0.0062
3270	Elongation factor G	fusA	0.0062
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0062
6020	Aldehyde oxidase	AOX1	0.0061
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0061
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0061
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0061
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0061
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0061
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0061
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0061
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0061
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0061
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0061
517	Alcohol dehydrogenase 1C	ADH1C	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
1541	Metalloproteinase	mmp20	0.006
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
909	Maleylacetoacetate isomerase	GSTZ1	0.0058
6500	Phospholipase A2	PLA2G1B	0.0058
172	Potassium channel subfamily K member 1	KCNK1	0.0058
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0057
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0057
3191	Histidinol dehydrogenase	hisD	0.0057
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
378	Alpha-2C adrenergic receptor	ADRA2C	0.0056
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0056
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0056
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0056
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0056
3932	Glutathione S-transferase A2	GSTA2	0.0055
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0055
6432	Transporter	snf	0.0055
823	Fibroblast growth factor receptor 2	FGFR2	0.0055
702	UMP-CMP kinase	CMPK1	0.0055
1864	RET proto-oncogene	RET	0.0055
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0055
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0055
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0055
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0055
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0055
162	Retinoic acid receptor gamma-1	RARG	0.0053
4811	Amylosucrase	ams	0.0053
2280	Listeriolysin regulatory protein	prfA	0.0052
2449	Tubulin alpha-3 chain	TUBA1A	0.0052
551	Carnitine O-acetyltransferase	CRAT	0.0052
6103	Arylamine N-acetyltransferase 1	NAT1	0.0052
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0052
191	Peptide methionine sulfoxide reductase	MSRA	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0052
427	Substance-P receptor	TACR1	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
1123	Eosinophil cationic protein	RNASE3	0.0052
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0051
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
2232	Interleukin-5	IL5	0.0051
474	Acetylcholinesterase	ACHE	0.0051
1593	Mucin-2	MUC2	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
239	Coagulation factor X	F10	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
357	Carbonic anhydrase 2	CA2	0.005
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.005
6168	Solute carrier family 22 member 16	SLC22A16	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0049
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0049
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0049
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0049
563	Thyroid peroxidase	TPO	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0048
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0048
106	Cannabinoid receptor 2	CNR2	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
1010	Cytochrome P450 51A1	CYP51A1	0.0048
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0047
716	5-hydroxytryptamine 7 receptor	HTR7	0.0047
6677	Myelin P2 protein	PMP2	0.0047
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0047
1275	Estrogen sulfotransferase	SULT1E1	0.0047
2159	Quinone oxidoreductase	CRYZ	0.0047
1714	Mitogen-activated protein kinase 3	MAPK3	0.0047
84	Nuclear receptor 0B1	NR0B1	0.0046
3014	Ribonuclease UK114	HRSP12	0.0046
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0046
5428	Replication protein	repA	0.0046
3617	Non-heme chloroperoxidase	cpo	0.0046
5426	Non-heme chloroperoxidase	cpo	0.0046
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0046
3639	Thymidine phosphorylase	deoA	0.0046
3936	Thymidine phosphorylase	TYMP	0.0046
3018	HTH-type transcriptional regulator malT	malT	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0045
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0045
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0045
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0045
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0045
94	5-hydroxytryptamine 4 receptor	HTR4	0.0045
4226	Uridine phosphorylase 2	UPP2	0.0045
936	Ephrin type-A receptor 2	EPHA2	0.0045
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
295	Carbonic anhydrase 1	CA1	0.0044
49	Endothelin B receptor	EDNRB	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
6033	High affinity interleukin-8 receptor A	CXCR1	0.0044
7	Nitric oxide synthase, inducible	NOS2	0.0043
4210	Toll-like receptor 4	TLR4	0.0043
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0043
3729	Citrate synthase	gltA	0.0042
4575	Citrate synthase	cit	0.0042
4580	Citrate synthase	gltA	0.0042
4225	Uridine phosphorylase 1	UPP1	0.0042
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0042
319	Opioid receptor, sigma 1	OPRS1	0.0042
131	Synaptic vesicular amine transporter	SLC18A2	0.0041
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0041
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0041
578	Endothelin-1 receptor	EDNRA	0.0041
760	Fibroblast growth factor 1	FGF1	0.0041
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4103	Proteasome subunit beta type 2	PSMB2	0.004
4161	Furin	FURIN	0.004
4102	Proteasome subunit beta type 5	PSMB5	0.004
4101	Proteasome subunit beta type 1	PSMB1	0.004
2314	Triosephosphate isomerase	TPI	0.004
3417	Triosephosphate isomerase	tpiA	0.004
3443	Triosephosphate isomerase	tpiA	0.004
6346	Triosephosphate isomerase	TPI1	0.004
1291	cAMP response element-binding protein	CREB1	0.004
2958	Probable tautomerase ydcE	pptA	0.004
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.004
2573	Cocaine esterase	cocE	0.004
7263	Cocaine esterase	Not Available	0.004
2371	Pantothenate kinase	coaA	0.0039
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0039
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0039
3115	Ras-related protein Rab-9	RAB9A	0.0039
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0039
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0039
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
413	Amidophosphoribosyltransferase	PPAT	0.0038
2515	Amidophosphoribosyltransferase	purF	0.0038
3714	Amidophosphoribosyltransferase	purF	0.0038
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0038
1178	Adenosine A2a receptor	ADORA2A	0.0038
1992	Vitamin D-binding protein	GC	0.0037
1648	Elastin	ELN	0.0037
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0037
432	D(4) dopamine receptor	DRD4	0.0037
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0037
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0037
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0037
130	Prostacyclin synthase	PTGIS	0.0037
6824	Tyrosine-protein kinase Lyn	LYN	0.0037
822	Aldose reductase	AKR1B1	0.0036
921	Glutamate receptor 2	GRIA2	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
4564	YvbK protein	yvbK	0.0036
4567	Putative acyl-CoA thioester hydrolase HI0827	HI_0827	0.0036
4566	Acyl-CoA hydrolase	BC_2038	0.0036
4572	Acyl-CoA hydrolase	BH0798	0.0036
4576	Aac(6')-Ii protein	aac(6')-Ii	0.0036
4577	4'-phosphopantetheinyl transferase sfp	sfp	0.0036
2528	Fatty acid metabolism regulator protein	fadR	0.0036
6740	Fatty acid metabolism regulator protein	fadR	0.0036
4579	Serine acetyltransferase	cysE	0.0036
6807	Serine acetyltransferase	cysE	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0036
1569	G1/S-specific cyclin-D1	CCND1	0.0036
6174	50S ribosomal protein L32	rpmF	0.0036
592	Carbonic anhydrase 4	CA4	0.0035
5934	Cytochrome P450 26A1	CYP26A1	0.0033
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0033
2178	Metabotropic glutamate receptor 5	GRM5	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
2216	Fibroblast growth factor receptor 4	FGFR4	0.0033
5328	Prostaglandin F synthase	Tb11.02.2310	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0032
6211	Tubulin epsilon chain	TUBE1	0.0032
6210	Tubulin delta chain	TUBD1	0.0032
6212	Tubulin gamma-1 chain	TUBG1	0.0032
76	Nitric-oxide synthase, brain	NOS1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
2207	Rhodopsin	RHO	0.0032
5798	Mitogen-activated protein kinase 11	MAPK11	0.0032
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0031
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0031
2499	Tubulin beta-2C chain	TUBB2C	0.0031
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0031
3489	Acetyl-coenzyme A synthetase	acs	0.0031
2396	Formyl-coenzyme A transferase	frc	0.0031
3457	Formyl-coenzyme A transferase	frc	0.0031
4574	PROBABLE NAPHTHOATE SYNTHASE MENB	menB	0.0031
3024	Crotonobetainyl-CoA:carnitine CoA-transferase	caiB	0.0031
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0031
4563	Acetyl transferase	rimL	0.0031
4565	Aminoglycoside 6'-N-acetyltransferase	aac(6')-Iy	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0031
484	Tyrosine-protein kinase ABL2	ABL2	0.003
5251	Carbonyl reductase [NADPH] 1	CBR1	0.003
2693	Heat-labile enterotoxin B chain	eltB	0.003
283	SEC14-like protein 2	SEC14L2	0.003
444	Alcohol dehydrogenase 1B	ADH1B	0.003
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.003
518	Peroxidase/catalase T	katG	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
6645	D-amino-acid oxidase	DAO	0.0029
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0029
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0029
683	Potassium transporter	GK0582	0.0029
4573	Histone acetyltransferase PCAF	KAT2B	0.0029
2377	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex	Not Available	0.0029
2560	Galactoside O-acetyltransferase	lacA	0.0029
3199	Phosphopantetheine adenylyltransferase	coaD	0.0029
3543	Phosphopantetheine adenylyltransferase	coaD	0.0029
3567	Phosphopantetheine adenylyltransferase	coaD	0.0029
5289	Phosphopantetheine adenylyltransferase	coaD	0.0029
2248	Malate synthase G	glcB	0.0028
3190	Malate synthase G	glcB	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
2285	Streptogramin A acetyltransferase	vatD	0.0028
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0028
16	Adenosine A1 receptor	ADORA1	0.0028
3178	Formate acetyltransferase 1	pflB	0.0028
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0028
666	NADP-dependent malic enzyme	ME1	0.0028
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
2112	Toll-like receptor 9	TLR9	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
340	Apoptotic protease-activating factor 1	APAF1	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
4404	FcbC1 protein	fcbC	0.0027
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
818	50S ribosomal protein L10	rplJ	0.0026
571	Melatonin receptor type 1A	MTNR1A	0.0026
362	Melatonin receptor type 1B	MTNR1B	0.0026
6228	Nuclear receptor coactivator 1	NCOA1	0.0026
2376	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	dapD	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6126	Carbonic anhydrase 7	CA7	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
163	D(1B) dopamine receptor	DRD5	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0025
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0025
5322	Oxidoreductase ydhF	ydhF	0.0025
5333	Alcohol dehydrogenase, iron-containing	TM_0920	0.0025
3772	3-oxoacyl-[acyl-carrier-protein] reductase	fabG	0.0025
5342	NADH-dependent butanol dehydrogenase, putative	TM_0820	0.0025
5326	Oxidoreductase, short chain dehydrogenase/reductase family	TM_0441	0.0025
5157	Dehydrogenase/reductase SDR family member 11	DHRS11	0.0025
5346	Oxidoreductase, aldo/keto reductase family	TM_1009	0.0025
5332	MtdA bifunctional protein	mtdA	0.0025
3778	NAD(P) transhydrogenase subunit beta	pntB	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
4403	Protein iolS	iolS	0.0025
5343	NADP-dependent fatty aldehyde dehydrogenase	aldH	0.0025
5330	General stress protein 69	yhdN	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
1196	Complement decay-accelerating factor	CD55	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0024
1867	Major prion protein	PRNP	0.0024
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0024
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
615	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
3138	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
4568	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
6370	3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	0.0024
3611	Cytidine deaminase	cdd	0.0024
3707	Cytidine deaminase	cdd	0.0024
4211	Cytidine deaminase	CDA	0.0024
6231	Pepsin A	PGA3	0.0024
1176	Mitogen-activated protein kinase 1	MAPK1	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
4388	Aminoglycoside 2'-N-acetyltransferase	aac	0.0024
633	Penicillin-binding proteins 1A/1B	pbpA	0.0024
2596	Acetyl-CoA acetyltransferase	phbA	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0023
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
976	Platelet glycoprotein IX	GP9	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
634	Squalene monooxygenase	SQLE	0.0023
7196	Squalene monooxygenase	ERG1	0.0023
654	Flavin reductase	BLVRB	0.0023
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0023
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
2375	ADP-L-glycero-D-manno-heptose-6-epimerase	hldD	0.0022
5073	Ferredoxin--NADP reductase	petH	0.0022
5076	Ferredoxin--NADP reductase	fpr	0.0022
5119	Ferredoxin--NADP reductase	petH	0.0022
5121	Ferredoxin--NADP reductase	fpr	0.0022
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0022
814	Ryanodine receptor 1	RYR1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
2305	Isocitrate dehydrogenase [NADP] cytoplasmic	IDH1	0.0022
3446	NADP-dependent alcohol dehydrogenase	adh	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
2286	Isocitrate dehydrogenase [NADP]	icd	0.0022
2302	Isocitrate dehydrogenase [NADP]	icd	0.0022
2771	Isocitrate dehydrogenase [NADP]	icd	0.0022
4582	Putative pteridine reductase 2	ptr2	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0022
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0022
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0022
3086	Plasmepsin-2	Not Available	0.0022
989	L-xylulose reductase	DCXR	0.0022
1262	Corticotropin-lipotropin	POMC	0.0021
291	Nitric-oxide synthase, endothelial	NOS3	0.0021
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0021
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0021
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0021
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0021
6209	30S ribosomal protein S19	rpsS	0.0021
6712	30S ribosomal protein S19	rpsS	0.0021
6726	30S ribosomal protein S19	rpsS	0.0021
6207	30S ribosomal protein S14	rpsN	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0021
174	Sigma 1-type opioid receptor	SIGMAR1	0.0021
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
6297	Prostaglandin reductase 1	PTGR1	0.002
6862	Aldo-keto reductase family 1 member B10	AKR1B10	0.002
6048	Troponin C, skeletal muscle	TNNC2	0.002
4531	Putative ketoacyl reductase	actIII	0.002
3808	Dihydropteroate synthase 2	folP2	0.002
3601	Dihydropteroate synthase 1	folP1	0.002
3807	Dihydropteroate synthase 1	folP1	0.002
3062	Aspartate-semialdehyde dehydrogenase	asd	0.002
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.002
2417	Chloramphenicol acetyltransferase	cat	0.002
3278	Chloramphenicol acetyltransferase	cat	0.002
564	Cellular retinoic acid-binding protein 1	CRABP1	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
4311	tRNA	TRDMT1	0.002
4325	tRNA	trmD	0.002
4328	tRNA	trmD	0.002
2810	Dr hemagglutinin structural subunit	draA	0.002
153	Dopamine beta-hydroxylase	DBH	0.002
6755	Poliovirus receptor	PVR	0.002
2240	Cell division protein kinase 2	CDK2	0.002
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.002
1058	Cell division protein kinase 5	CDK5	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0019
2675	Pteridine reductase 1	PTR1	0.0019
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0019
569	Retinal dehydrogenase 2	ALDH1A2	0.0019
2697	Uridine-cytidine kinase 2	UCK2	0.0019
1124	Sepiapterin reductase	SPR	0.0019
581	Cytochrome P450 2R1	CYP2R1	0.0019
605	Fumarate reductase flavoprotein subunit	frdA	0.0019
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0019
3673	Fumarate reductase flavoprotein subunit	fccA	0.0019
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0019
6549	Fumarate reductase flavoprotein subunit	frdA	0.0019
3957	Adenosine deaminase	ADA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
3937	Fatty-acid amide hydrolase	FAAH	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
164	Histamine H4 receptor	HRH4	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
857	Malate dehydrogenase, mitochondrial	MDH2	0.0018
4992	Cytochrome c peroxidase	Not Available	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0017
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0017
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
5288	Shikimate kinase	aroK	0.0017
5287	Signaling protein	Not Available	0.0017
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0017
5293	Shikimate kinase 2	aroL	0.0017
5304	UPF0166 protein TM_0021	TM_0021	0.0017
4346	Polynucleotide kinase	pseT	0.0017
5292	Putative partitioning protein	TT_C1605	0.0017
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0017
5266	Activator of	hgdC	0.0017
5259	Transcriptional regulator	ntrC1	0.0017
6699	Transcriptional regulator	Cgl2612	0.0017
2874	Nitrogenase iron protein 1	nifH1	0.0017
5283	D-alanine--D-alanine ligase B	ddlB	0.0017
5281	Plasmid segregation protein parM	parM	0.0017
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0017
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0017
5299	D-alanine--D-alanine ligase	ddl	0.0017
6598	D-alanine--D-alanine ligase	ddl	0.0017
5315	Chaperone protein htpG	htpG	0.0017
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0017
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0017
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0017
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0017
5291	Glycogen synthase 1	glgA1	0.0017
5264	DNA replication protein	REP	0.0017
5277	Preprotein translocase subunit secA	secA	0.0017
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0017
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0017
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0017
5284	Large T antigen	Not Available	0.0017
5308	Preprotein translocase secA 1 subunit	secA1	0.0017
5285	Kinesin heavy chain	KIF5B	0.0017
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0016
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0016
207	Glutathione synthetase	GSS	0.0015
5269	Glutathione synthetase	gshB	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0014
719	Retinoic acid receptor responder protein 1	RARRES1	0.0014
770	Retinoic acid-induced protein 3	GPRC5A	0.0014
233	Potassium channel subfamily K member 2	KCNK2	0.0014
268	Adenosine A2b receptor	ADORA2B	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0013
1268	Neuropeptide S receptor	NPSR1	0.0013
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0013
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0013
4106	Guanylate kinase	GUK1	0.0013
4516	Guanylate kinase	gmk	0.0013
4837	Cag-alfa	cag-alfa	0.0013
5682	Ribonuclease pancreatic	RNASE1	0.0013
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0013
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0013
5646	Galactokinase	GALK1	0.0013
4838	PMS1 protein homolog 2	PMS2	0.0013
4839	DNA polymerase III subunit tau	dnaX	0.0013
5302	TrwB	trwB	0.0013
5265	FtsH	ftsH	0.0013
5189	Trimethylamine dehydrogenase	tmd	0.0013
1374	Natriuretic peptides B	NPPB	0.0013
4774	NTPase P4	Not Available	0.0013
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0013
1827	Gap junction alpha-1 protein	GJA1	0.0013
2270	Dephospho-CoA kinase	coaE	0.0013
1908	Vascular cell adhesion protein 1	VCAM1	0.0013
856	Vitamin D3 receptor	VDR	0.0013
2284	Adenylate kinase	adk	0.0013
2296	Adenylate kinase	adk	0.0013
2311	Adenylate kinase	adk	0.0013
2312	Adenylate kinase	Not Available	0.0013
3470	Hypothetical protein MG245 homolog	MPN_348	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
3175	Glutamate--cysteine ligase	gshA	0.0013
3426	Glutamine synthetase	glnA	0.0013
3987	Glutamine synthetase	GLUL	0.0013
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0013
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0013
3221	Cytochrome c4	cc4	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
251	Alcohol dehydrogenase 1A	ADH1A	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
2683	Mono-ADP-ribosyltransferase C3	C3	0.0013
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
694	Matrix protein 2	M	0.0012
6073	Potassium channel subfamily K member 9	KCNK9	0.0012
6072	Potassium channel subfamily K member 3	KCNK3	0.0012
292	Activin receptor type-1	ACVR1	0.0012
2390	Nonsecretory ribonuclease	RNASE2	0.0012
5312	Kinesin-like protein KIF1A	KIF1A	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
2922	Glycerol kinase	glpK	0.0012
5271	Focal adhesion kinase 1	PTK2	0.0012
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0012
6859	Protein S100-A4	S100A4	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
2282	Protein recA	recA	0.0011
2315	Protein recA	recA	0.0011
2332	Protein recA	recA	0.0011
5263	Protein recA	recA	0.0011
408	Riboflavin kinase	RFK	0.0011
4948	Cytochrome c-553	Not Available	0.0011
4923	Cytochrome c3	DvMF_2499	0.0011
4945	Cytochrome c3	Not Available	0.0011
4949	Cytochrome c3	DVU_3171	0.0011
4968	Cytochrome c3	cytc3	0.0011
4997	Cytochrome c3	SO_2727	0.0011
5219	Cytochrome c3	cyd	0.0011
4902	Nine-heme cytochrome c	Ddes_2038	0.0011
3189	High-molecular-weight cytochrome c	hmcA	0.0011
2615	Chemotaxis protein cheA	cheA	0.0011
3913	Glutamic acid decarboxylase	GAD65	0.0011
1881	Hexokinase-1	HK1	0.0011
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
2892	Acetylglutamate kinase	argB	0.0011
3550	Acetylglutamate kinase	argB	0.0011
3669	Ribokinase	rbsK	0.0011
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.001
714	Glutathione reductase, mitochondrial	GSR	0.001
144	Hemoglobin subunit alpha	HBA1	0.001
788	Creatine kinase M-type	CKM	0.001
2727	S-adenosylmethionine synthetase	metK	0.001
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.001
1483	Membrane copper amine oxidase	AOC3	0.001
2334	Dethiobiotin synthetase	bioD	0.001
6555	Dethiobiotin synthetase	bioD	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2149	Angiogenin	ANG	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
3583	6-phosphogluconolactonase	pgl	0.001
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.001
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
48	Pyridoxal kinase	PDXK	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0009
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0009
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0009
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0009
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0009
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0009
810	Heme oxygenase 1	HMOX1	0.0009
3391	Heme oxygenase 1	pbsA1	0.0009
735	Alanine aminotransferase 1	GPT	0.0009
3904	Alanine aminotransferase 2	GPT2	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0009
2091	Endoplasmin	HSP90B1	0.0009
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0009
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0009
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0009
6395	Myosin-14	MYH14	0.0009
2251	Thymidylate kinase	tmk	0.0009
2254	Thymidylate kinase	DTYMK	0.0009
3522	Thymidylate kinase	tmk	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
816	Biliverdin reductase A	BLVRA	0.0009
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0009
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0009
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
1422	Serine/threonine-protein kinase 6	AURKA	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
3379	Kinesin-like protein KIF11	KIF11	0.0008
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0008
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0008
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0008
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0008
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0008
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0008
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0008
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0008
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0008
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0008
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0008
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0008
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0008
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0008
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0008
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0008
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0008
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0008
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0008
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0008
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0008
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0008
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0008
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0008
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0008
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0008
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0008
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0008
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0008
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0008
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0008
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0008
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0008
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0008
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0008
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0008
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0008
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0008
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0008
107	C-4 methylsterol oxidase	SC4MOL	0.0008
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0008
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0008
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0008
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0008
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0008
729	GDP-L-fucose synthetase	TSTA3	0.0008
3463	GDP-L-fucose synthetase	fcl	0.0008
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0008
167	L-lactate dehydrogenase C chain	LDHC	0.0008
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0008
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0008
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0008
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0008
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0008
206	3-keto-steroid reductase	HSD17B7	0.0008
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0008
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0008
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0008
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0008
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0008
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0008
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0008
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0008
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0008
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0008
34	7-dehydrocholesterol reductase	DHCR7	0.0008
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0008
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0008
711	UDP-glucose 6-dehydrogenase	UGDH	0.0008
3672	UDP-glucose 6-dehydrogenase	hasB	0.0008
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0008
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0008
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0008
643	Peroxisomal bifunctional enzyme	EHHADH	0.0008
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0008
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0008
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0008
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
3822	Actin, alpha skeletal muscle	ACTA1	0.0008
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0008
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0008
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0008
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0008
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0008
396	Alcohol dehydrogenase 4	ADH4	0.0008
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0008
328	Sorbitol dehydrogenase	SORD	0.0008
597	Dihydropteridine reductase	QDPR	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
509	Thymidine kinase	TK	0.0008
570	Thymidine kinase	TK	0.0008
2559	Thymidine kinase	TK	0.0008
3430	Thymidine kinase	tdk	0.0008
3518	Thymidine kinase	TK	0.0008
5301	Thymidine kinase	tdk	0.0008
5771	Thymidine kinase	ORF36	0.0008
7009	Thymidine kinase	ORF36	0.0008
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0008
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0008
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0008
12	Alcohol dehydrogenase class 3	ADH5	0.0008
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0008
3830	Calreticulin	CALR	0.0008
77	L-lactate dehydrogenase B chain	LDHB	0.0008
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0007
1507	Cytochrome c	CYCS	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0007
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0007
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6026	Alcohol dehydrogenase 6	ADH6	0.0007
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0007
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0007
626	Cysteine dioxygenase type 1	CDO1	0.0007
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0007
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
627	11-cis retinol dehydrogenase	RDH5	0.0007
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0007
4954	Soluble cytochrome b558	Not Available	0.0007
4943	Cytochrome c6	petJ	0.0007
4916	Cyanoglobin	glbN	0.0007
4947	Bacterial hemoglobin	vhb	0.0007
5000	HemO	hemO	0.0007
4934	Cytochrome c-551	nirM	0.0007
5218	Cytochrome c-551	nirM	0.0007
4975	Cytochrome c-556	RPA3973	0.0007
4915	Cytochrome c-550	psbV	0.0007
4959	Cytochrome c-550	psbV	0.0007
5216	Cytochrome c-550	psbV	0.0007
4925	Cytochrome c-type protein SHP	shp	0.0007
4942	Diheme cytochrome c napB	napB	0.0007
4936	Cytochrome c2 iso-2	Not Available	0.0007
4905	Cytochrome c2	Not Available	0.0007
4939	Cytochrome c2	cycA	0.0007
4964	Cytochrome c2	cycA	0.0007
4979	Cytochrome c2	cycA	0.0007
6673	Cytochrome c2	cycA	0.0007
4994	Hemoglobin-like protein HbO	glbO	0.0007
4984	Neuroglobin	NGB	0.0007
4981	Iron-starvation protein PigA	pigA	0.0007
4998	Hemoglobin-like protein yjbI	yjbI	0.0007
4935	Cytochrome c-554	cycA1	0.0007
4961	Hemophore HasA	hasA	0.0007
4909	CooA protein	cooA	0.0007
4910	Cytoglobin	CYGB	0.0007
4937	Cytochrome oxidase subunit II	rcoxA	0.0007
4971	Nonaheme cytochrome c	hmcA	0.0007
4904	Cytochrome c family protein	GSU1996	0.0007
4907	Cytochrome c-L	moxG	0.0007
6865	Cytochrome c-L	moxG	0.0007
4989	Cytochrome c551 peroxidase	ccp	0.0007
5222	Cytochrome c551 peroxidase	ccpA	0.0007
4976	Apocytochrome f	petA	0.0007
6407	Apocytochrome f	petA	0.0007
4931	Cytochrome P450 167A1	CYP167A1	0.0007
4999	Cytochrome P450 165B3	CYP165B3	0.0007
4903	Methyl-accepting chemotaxis protein	Tar4	0.0007
4764	Cytochrome P450 165C4	CYP165C4	0.0007
4960	Putative cytochrome P450-family protein	SCO7417	0.0007
4922	Cytochrome c, putative	SO_4144	0.0007
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0007
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0007
4972	P450cin	cinA	0.0007
4993	Hydroxylamine oxidoreductase	hao1	0.0007
4952	Catalase/peroxidase	katA	0.0007
3093	Catalase HPII	katE	0.0007
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0007
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0007
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0006
4041	Microsomal glutathione S-transferase 2	MGST2	0.0006
279	Tyrosinase	TYR	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
828	Phenylalanine-4-hydroxylase	PAH	0.0006
3109	Phenylalanine-4-hydroxylase	phhA	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
4920	Peroxidase/catalase	katG	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
4990	PpcA	ppcA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4031	Glutathione S-transferase A1	GSTA1	0.0005
2230	Catalase	CAT	0.0005
3249	Catalase	katA	0.0005
3625	Catalase	katA	0.0005
4539	Catalase	katA	0.0005
4941	Catalase	katB	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
2802	Endoglucanase G	celCCG	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
2298	Cytochrome P450-cam	camC	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08860 - Pitavastatin

Targets

Enzymes

Transporters

Carriers

Predictions