DT-Web

DB01601 - Lopinavir


Identification
Name Lopinavir
Accession Number DB01601 (EXPT00388)
Type small molecule
Description Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. It is marketed by Abbott as Kaletra, a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 628.8008
Groups approved
Monoisotopic Weight 628.362470666
Pharmacology
Indication Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.
Mechanism of action Lopinavir inhibits the HIV viral protease enzyme. This prevents cleavage of the gag-pol polyprotein and, therefore, improper viral assembly results. This subsequently results in non-infectious, immature viral particles.
Absorption Administered alone, lopinavir has insufficient bioavailability; however, like several HIV protease inhibitors, its blood levels are greatly increased by low doses of ritonavir, a potent inhibitor of cytochrome P450 3A4.
Protein binding Lopinavir is highly bound to plasma proteins (98-99%).
Biotransformation Hepatic. Lopinavir is extensively metabolized by the hepatic cytochrome P450 system, almost exclusively by the CYP3A isozyme.
Route of elimination Not Available
Toxicity Although human experience of acute overdosage with lopinavir is limited, accidental ingestion of the product by a young child could result in significant alcohol-related toxicity and could approach the potential lethal dose of alcohol.
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Abacavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Lopinavir. The antiviral response should be closely monitored.
Bromazepam Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if lopinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Dantrolene Lopinavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if lopinavir is initiated, discontinued or dose changed.
Darunavir Decreased levels of darunavir
Etravirine Etravirine, when used concomitantly with protease inhibitors, may experience a decrease in serum concentration. Protease inhibitors, when used concomitantly with etravirine, may experience an increase in serum concentration. Ritonavir boosting of etravirine therapy is a requirement to concurrent therapy. In addition, it is recommended to monitor serum concentrations of the antiretrovirals, as well as to monitor antiretroviral therapy for efficacy.
Fosphenytoin Levels of both drugs are affected
Phenytoin Levels of both drugs are affected
Pitavastatin Lopinavir decreases metabolism of pitavastatin thus increasing serum concentration. Avoid concomitant drug therapy.
Ponatinib Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Roflumilast Affects CYP1A2 metabolism; decreases level or effect of roflumilast.
Tacrolimus The protease inhibitor, Lopinavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Lopinavir therapy is initiated, discontinued or altered.
Tadalafil Lopinavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Lopinavir may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Lopinavir, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lopinavir is initiated, discontinued, or dose changed.
Telithromycin Lopinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Lopinavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Lopinavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Lopinavir is initiated, discontinued or dose changed.
Tiagabine The strong CYP3A4 inhibitor, Lopinavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Lopinavir is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may decrease the plasma concentration of Lopinavir. Consider alternate therapy.
Tolterodine Lopinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The p-glycoprotein inhibitor, Lopinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol Lopinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Lopinavir may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The protease inhibitor, Lopinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lopinavir is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4/CYP2D6 inhibitor, Lopinavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4/CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Lopinavir is initiated, discontinued or dose changed.
Vardenafil Lopinavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Lopinavir, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Lopinavir is initiated, discontinued, or dose changed.
Verapamil Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Lopinavir is initiated, discontinued or dose changed.
Vinblastine Lopinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Lopinavir is initiated, discontinued or dose changed.
Vincristine Lopinavir, a strong CYP3A4 and p-glycoprotein inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism and/or increasing its efflux. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Lopinavir is initiated, discontinued or dose changed.
Vinorelbine Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Lopinavir is initiated, discontinued or dose changed.
Voriconazole Lopinavir may reduce serum concentration and efficacy of voriconazole. This combination should be avoided unless the potential benefits outweigh the risk of reduced voriconazole efficacy.
Zolpidem Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if lopinavir is initiated, discontinued or dose changed.
Zonisamide Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if lopinavir is initiated, discontinued or dose changed.
Zopiclone Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if lopinavir is initiated, discontinued or dose changed.
Zuclopenthixol Lopinavir, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if lopinavir is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid St.John's Wort.

Targets


HIV-1 protease
Name HIV-1 protease
Gene Name HIV-1 protease
Pharmacological action yes
Actions inhibitor
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Garriga C, Perez-Elias MJ, Delgado R, Ruiz L, Najera R, Pumarola T, Alonso-Socas Mdel M, Garcia-Bujalance S, Menendez-Arias L: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol. 2007 Nov;79(11):1617-28. - Pubmed
  • Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana TM: Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres. J Med Chem. 2007 Sep 6;50(18):4316-28. Epub 2007 Aug 16. - Pubmed
  • Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3291

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7586
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5471
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4809
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4625
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.354
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5216

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Vishnuvardhan D, Moltke LL, Richert C, Greenblatt DJ: Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein. AIDS. 2003 May 2;17(7):1092-4. - Pubmed
DTHybrid score 0.4467

Predictions


Id Partner name Gene Name Score
4924 Cytochrome P450 2C8 CYP2C8 0.2739
4118 Cytochrome P450 3A5 CYP3A5 0.2449
6013 Cytochrome P450 2E1 CYP2E1 0.1767
6107 Cytochrome P450 3A7 CYP3A7 0.1759
6024 Cytochrome P450 1A1 CYP1A1 0.1328
5718 Cytochrome P450 2A6 CYP2A6 0.1191
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1119
587 Serum albumin ALB 0.1058
862 Multidrug resistance-associated protein 1 ABCC1 0.0933
20 Prostaglandin G/H synthase 1 PTGS1 0.0927
492 Histamine H1 receptor HRH1 0.0867
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0831
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0777
824 Sodium-dependent serotonin transporter SLC6A4 0.0769
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0753
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0685
6106 Cytochrome P450 2C18 CYP2C18 0.0668
6145 Solute carrier family 22 member 1 SLC22A1 0.0665
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0662
556 Alpha-1A adrenergic receptor ADRA1A 0.0594
502 5-hydroxytryptamine 2A receptor HTR2A 0.0589
831 D(2) dopamine receptor DRD2 0.0583
220 Sodium channel protein type 5 subunit alpha SCN5A 0.053
3811 Cytochrome P450 19A1 CYP19A1 0.0511
290 Prostaglandin G/H synthase 2 PTGS2 0.048
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0479
1729 Solute carrier family 22 member 6 SLC22A6 0.0475
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0465
6144 Solute carrier family 22 member 2 SLC22A2 0.0444
318 Alpha-2A adrenergic receptor ADRA2A 0.044
713 Sodium-dependent dopamine transporter SLC6A3 0.044
766 Beta-2 adrenergic receptor ADRB2 0.0439
1898 Cytochrome P450 1B1 CYP1B1 0.0418
193 Beta-1 adrenergic receptor ADRB1 0.0411
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0389
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0382
590 5-hydroxytryptamine 2C receptor HTR2C 0.0382
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0379
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0376
136 Estrogen receptor ESR1 0.0373
23 D(1A) dopamine receptor DRD1 0.0373
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0369
320 5-hydroxytryptamine 1A receptor HTR1A 0.0368
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0367
632 Alpha-1B adrenergic receptor ADRA1B 0.0363
118 Organic cation/carnitine transporter 2 SLC22A5 0.0361
3941 Amine oxidase [flavin-containing] A MAOA 0.0354
847 Mu-type opioid receptor OPRM1 0.0353
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0338
776 Bile salt export pump ABCB11 0.0337
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0325
871 Glucocorticoid receptor NR3C1 0.032
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0317
260 Cytochrome P450 51 ERG11 0.0316
761 Cytochrome P450 51 ERG11 0.0316
3163 Cytochrome P450 51 cyp51 0.0316
341 5-hydroxytryptamine 3 receptor HTR3A 0.0306
465 Calmodulin CALM1 0.0296
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0294
467 Delta-type opioid receptor OPRD1 0.0292
6142 Solute carrier family 22 member 8 SLC22A8 0.0291
3923 Cholinesterase BCHE 0.029
817 DNA topoisomerase 2-alpha TOP2A 0.0289
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0285
696 Kappa-type opioid receptor OPRK1 0.0278
3939 Amine oxidase [flavin-containing] B MAOB 0.0276
122 P2Y purinoceptor 12 P2RY12 0.027
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0269
885 5-hydroxytryptamine 1B receptor HTR1B 0.0267
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0261
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.026
36 Insulin receptor INSR 0.0258
2164 Multidrug resistance-associated protein 4 ABCC4 0.0258
789 Alpha-1D adrenergic receptor ADRA1D 0.0254
6143 Solute carrier family 22 member 7 SLC22A7 0.0251
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0251
638 D(3) dopamine receptor DRD3 0.0247
468 Cytochrome P450 4A11 CYP4A11 0.0246
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0239
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0236
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0236
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0232
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0229
6147 Solute carrier family 22 member 3 SLC22A3 0.0226
725 5-hydroxytryptamine 1D receptor HTR1D 0.0225
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0224
629 Alpha-2B adrenergic receptor ADRA2B 0.0223
833 Organic cation/carnitine transporter 1 SLC22A4 0.0217
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0215
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0208
6182 Cytochrome P450 2J2 CYP2J2 0.0198
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0194
146 Androgen receptor AR 0.019
6031 Cytochrome P450 3A43 CYP3A43 0.0188
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0186
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0185
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0182
891 Dihydropteroate synthase folP 0.0182
5359 Dihydropteroate synthase folP 0.0182
7175 Dihydropteroate synthase sulI 0.0182
477 DNA topoisomerase 4 subunit A parC 0.0181
886 DNA topoisomerase 4 subunit A parC 0.0181
6226 DNA topoisomerase 4 subunit A parC 0.0181
378 Alpha-2C adrenergic receptor ADRA2C 0.0181
436 5-hydroxytryptamine 2B receptor HTR2B 0.0179
404 DNA gyrase subunit A gyrA 0.0178
6224 DNA gyrase subunit A gyrA 0.0178
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0176
124 Histamine H2 receptor HRH2 0.0176
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0176
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0174
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0174
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0174
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0173
432 D(4) dopamine receptor DRD4 0.017
4604 Liver carboxylesterase 1 CES1 0.0165
4120 NADPH--cytochrome P450 reductase POR 0.0165
70 Type-1 angiotensin II receptor AGTR1 0.0162
818 50S ribosomal protein L10 rplJ 0.016
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.016
6220 Aryl hydrocarbon receptor AHR 0.0159
504 Mast/stem cell growth factor receptor KIT 0.0158
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0155
474 Acetylcholinesterase ACHE 0.0153
6137 Multidrug resistance-associated protein 6 ABCC6 0.0153
844 Epidermal growth factor receptor EGFR 0.015
777 Tumor necrosis factor TNF 0.0148
1656 CYP2B protein CYP2B 0.0145
614 Progesterone receptor PGR 0.0145
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0143
1024 Solute carrier family 22 member 11 SLC22A11 0.0142
6148 Multidrug resistance-associated protein 7 ABCC10 0.0141
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.014
158 Sodium channel protein type 1 subunit alpha SCN1A 0.014
161 Tubulin beta chain TUBB 0.0139
312 Tubulin beta chain TUB2 0.0139
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0139
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0138
6136 Multidrug resistance-associated protein 5 ABCC5 0.0138
716 5-hydroxytryptamine 7 receptor HTR7 0.0137
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0137
869 Estrogen receptor beta ESR2 0.0134
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0131
380 Cytochrome P450 17A1 CYP17A1 0.0129
407 Vascular endothelial growth factor receptor 2 KDR 0.0128
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0128
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0128
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0128
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0128
756 Sex hormone-binding globulin SHBG 0.0127
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0124
26 Vascular endothelial growth factor receptor 3 FLT4 0.0124
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0124
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0119
163 D(1B) dopamine receptor DRD5 0.0119
32 Vascular endothelial growth factor receptor 1 FLT1 0.0118
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0118
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0118
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0118
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0118
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0118
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0118
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0117
6014 Cytochrome P450 2A13 CYP2A13 0.0117
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0117
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0115
811 Translocator protein TSPO 0.0115
1757 Myeloperoxidase MPO 0.0114
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0114
174 Sigma 1-type opioid receptor SIGMAR1 0.0113
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0113
1010 Cytochrome P450 51A1 CYP51A1 0.0113
482 Glycine receptor subunit alpha-1 GLRA1 0.0113
228 Beta platelet-derived growth factor receptor PDGFRB 0.0112
6141 Sodium/bile acid cotransporter SLC10A1 0.0111
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0111
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.011
94 5-hydroxytryptamine 4 receptor HTR4 0.011
3947 Xanthine dehydrogenase/oxidase XDH 0.011
952 Dipeptidyl peptidase 4 DPP4 0.0108
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
1178 Adenosine A2a receptor ADORA2A 0.0106
427 Substance-P receptor TACR1 0.0106
373 Transthyretin TTR 0.0104
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0104
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0103
232 Corticosteroid-binding globulin SERPINA6 0.0103
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0102
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0102
16 Adenosine A1 receptor ADORA1 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.01
1192 Sulfotransferase 1A1 SULT1A1 0.0099
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
592 Carbonic anhydrase 4 CA4 0.0097
49 Endothelin B receptor EDNRB 0.0096
295 Carbonic anhydrase 1 CA1 0.0096
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0095
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0094
365 Dihydrofolate reductase DHFR 0.0094
2381 Dihydrofolate reductase DFR1 0.0094
2833 Dihydrofolate reductase Not Available 0.0094
2931 Dihydrofolate reductase folA 0.0094
3544 Dihydrofolate reductase folA 0.0094
3682 Dihydrofolate reductase folA 0.0094
6642 Dihydrofolate reductase folA 0.0094
6756 Dihydrofolate reductase dfrA 0.0094
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0094
6102 Arylamine N-acetyltransferase 2 NAT2 0.0092
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0092
29 Tubulin beta-1 chain TUBB1 0.0092
131 Synaptic vesicular amine transporter SLC18A2 0.0091
578 Endothelin-1 receptor EDNRA 0.009
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0089
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0089
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
921 Glutamate receptor 2 GRIA2 0.0087
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0086
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0086
705 Glutamate receptor 1 GRIA1 0.0082
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0081
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0081
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
1256 5-hydroxytryptamine 6 receptor HTR6 0.008
173 Toll-like receptor 7 TLR7 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6020 Aldehyde oxidase AOX1 0.0078
528 5-hydroxytryptamine 1E receptor HTR1E 0.0078
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
511 5-hydroxytryptamine 1F receptor HTR1F 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
6085 Fatty acid-binding protein, intestinal FABP2 0.0076
6432 Transporter snf 0.0076
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0076
4122 Histone deacetylase 2 HDAC2 0.0075
738 Monocarboxylate transporter 1 SLC16A1 0.0075
3810 Catechol O-methyltransferase COMT 0.0074
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0074
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0073
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
4116 Dihydropteroate synthetase Not Available 0.0072
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0072
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0072
183 Vascular endothelial growth factor A VEGFA 0.0072
357 Carbonic anhydrase 2 CA2 0.0072
6138 Multidrug resistance protein 3 ABCB4 0.0072
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0071
737 Mineralocorticoid receptor NR3C2 0.0071
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0071
1618 High affinity nerve growth factor receptor NTRK1 0.007
1517 Beta-3 adrenergic receptor ADRB3 0.007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.007
275 Arachidonate 5-lipoxygenase ALOX5 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0069
68 Cannabinoid receptor 1 CNR1 0.0068
563 Thyroid peroxidase TPO 0.0067
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0067
1629 Transcription factor AP-1 JUN 0.0067
273 Apoptosis regulator Bcl-2 BCL2 0.0067
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0067
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0067
284 DNA-directed RNA polymerase beta chain rpoB 0.0065
5773 DNA-directed RNA polymerase beta chain rpoB 0.0065
2499 Tubulin beta-2C chain TUBB2C 0.0065
319 Opioid receptor, sigma 1 OPRS1 0.0065
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
856 Vitamin D3 receptor VDR 0.0063
823 Fibroblast growth factor receptor 2 FGFR2 0.0063
133 Dihydropterate synthase sulI 0.0063
2112 Toll-like receptor 9 TLR9 0.0062
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0061
4203 Histamine N-methyltransferase HNMT 0.0061
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6126 Carbonic anhydrase 7 CA7 0.006
904 Glutathione S-transferase P GSTP1 0.0059
2539 Tubulin alpha-1 chain TUBA4A 0.0059
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
814 Ryanodine receptor 1 RYR1 0.0059
780 Retinoic acid receptor RXR-gamma RXRG 0.0059
24 Thymidylate synthase TMP1 0.0058
359 Thymidylate synthase TYMS 0.0058
2626 Thymidylate synthase thyA 0.0058
2729 Thymidylate synthase thyA 0.0058
5352 Thymidylate synthase THYA 0.0058
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0058
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0058
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
4103 Proteasome subunit beta type 2 PSMB2 0.0057
4102 Proteasome subunit beta type 5 PSMB5 0.0056
4101 Proteasome subunit beta type 1 PSMB1 0.0056
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0056
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0056
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0056
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0056
3932 Glutathione S-transferase A2 GSTA2 0.0055
518 Peroxidase/catalase T katG 0.0055
6506 Stathmin-4 STMN4 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
239 Coagulation factor X F10 0.0054
581 Cytochrome P450 2R1 CYP2R1 0.0054
6044 Serum paraoxonase/lactonase 3 PON3 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
88 Retinoic acid receptor RXR-beta RXRB 0.0053
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0053
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0053
1275 Estrogen sulfotransferase SULT1E1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
165 FL cytokine receptor FLT3 0.0053
6043 Putative G-protein coupled receptor 44 GPR44 0.0053
712 Tubulin alpha chain TUB1 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0051
6146 High affinity copper uptake protein 1 SLC31A1 0.0051
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0051
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0051
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0051
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.005
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.005
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0049
54 Prothrombin F2 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0048
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
5300 Antigen peptide transporter 1 TAP1 0.0047
4311 tRNA TRDMT1 0.0047
4325 tRNA trmD 0.0047
4328 tRNA trmD 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
7 Nitric oxide synthase, inducible NOS2 0.0047
683 Potassium transporter GK0582 0.0047
1852 Microtubule-associated protein 2 MAP2 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
634 Squalene monooxygenase SQLE 0.0046
7196 Squalene monooxygenase ERG1 0.0046
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0046
1630 Integrin beta-2 ITGB2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
153 Dopamine beta-hydroxylase DBH 0.0044
130 Prostacyclin synthase PTGIS 0.0044
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0044
84 Nuclear receptor 0B1 NR0B1 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0042
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
3957 Adenosine deaminase ADA 0.0042
1992 Vitamin D-binding protein GC 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
1648 Elastin ELN 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
976 Platelet glycoprotein IX GP9 0.004
5787 Angiopoietin-1 receptor TEK 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
6174 50S ribosomal protein L32 rpmF 0.004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.004
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.004
6149 Solute carrier family 22 member 10 SLC22A10 0.004
1262 Corticotropin-lipotropin POMC 0.004
3856 Fibroblast growth factor receptor 3 FGFR3 0.0039
2981 Phospholipase A2, membrane associated PLA2G2A 0.0039
1541 Metalloproteinase mmp20 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
936 Ephrin type-A receptor 2 EPHA2 0.0038
85 Growth hormone receptor GHR 0.0038
164 Histamine H4 receptor HRH4 0.0038
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
208 DNA-directed RNA polymerase beta' chain rpoC 0.0037
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0037
3809 Estrogen-related receptor gamma ESRRG 0.0037
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0037
33 Cystine/glutamate transporter SLC7A11 0.0037
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0037
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0036
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0036
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0036
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0036
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0036
469 Annexin A1 ANXA1 0.0036
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0036
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0036
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0036
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0036
4773 Deoxycytidine kinase DCK 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
5934 Cytochrome P450 26A1 CYP26A1 0.0035
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0033
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0032
3937 Fatty-acid amide hydrolase FAAH 0.0032
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
908 Glutathione S-transferase theta-1 GSTT1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6824 Tyrosine-protein kinase Lyn LYN 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.003
291 Nitric-oxide synthase, endothelial NOS3 0.003
5798 Mitogen-activated protein kinase 11 MAPK11 0.003
517 Alcohol dehydrogenase 1C ADH1C 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
1196 Complement decay-accelerating factor CD55 0.0029
1864 RET proto-oncogene RET 0.0029
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0029
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0029
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
1360 Sphingomyelin phosphodiesterase SMPD1 0.0029
162 Retinoic acid receptor gamma-1 RARG 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1039 Histone deacetylase 9 HDAC9 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0025
6859 Protein S100-A4 S100A4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3830 Calreticulin CALR 0.0025
4217 Telomerase reverse transcriptase TERT 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0025
572 Integrin alpha-L ITGAL 0.0025
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0025
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
267 Plasminogen activator inhibitor 1 SERPINE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3808 Dihydropteroate synthase 2 folP2 0.0023
3601 Dihydropteroate synthase 1 folP1 0.0023
3807 Dihydropteroate synthase 1 folP1 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
3086 Plasmepsin-2 Not Available 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
5923 Microtubule-associated protein tau MAPT 0.0023
5924 Microtubule-associated protein 4 MAP4 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
1341 Histamine H3 receptor HRH3 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
6221 Steroid hormone receptor ERR1 ESRRA 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6048 Troponin C, skeletal muscle TNNC2 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
2207 Rhodopsin RHO 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0019
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2021 Thrombomodulin THBD 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
6218 Pannexin-1 PANX1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
229 Retinoic acid receptor beta RARB 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6168 Solute carrier family 22 member 16 SLC22A16 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1243 Cathepsin D CTSD 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
3917 Methylenetetrahydrofolate reductase MTHFR 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4210 Toll-like receptor 4 TLR4 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3221 Cytochrome c4 cc4 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
1792 Tissue-type plasminogen activator PLAT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
2298 Cytochrome P450-cam camC 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4920 Peroxidase/catalase katG 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
358 Cystathionine beta-synthase CBS 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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