DT-Web

DB00661 - Verapamil


Identification
Name Verapamil
Accession Number DB00661 (APRD00335)
Type small molecule
Description A calcium channel blocker that is a class IV anti-arrhythmia agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 454.6016
Groups approved
Monoisotopic Weight 454.283157714
Pharmacology
Indication For the treatment of hypertension, angina, and cluster headache prophylaxis.
Mechanism of action Verapamil inhibits voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thuis reducing heart rate and blood pressure. Verapamil's mechanism of effect in cluster headache is thought to be linked to its calcium-channel blocker effect, but which channel subtypes are involved is presently not known.
Absorption 90%
Protein binding 90%
Biotransformation Not Available
Route of elimination Approximately 70% of an administered dose is excreted as metabolites in the urine and 16% or more in the feces within 5 days. About 3% to 4% is excreted in the urine as unchanged drug.
Toxicity LD50=8 mg/kg (i.v. in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Increased effect of both drugs
Amifostine Verapamil may enhance the hypotensive effect of Amifostine. At chemotherapeutic doses of Amifostine, Verapamil should be withheld for 24 hours prior to Amifostine administration. Caution should be used at lower Amifostine doses used during radiotherapy, but routine interruption of Verapamil therapy is not recommended.
Aminophylline Verapamil increases the effect of theophylline
Amiodarone Additive bradycardic effects may occur. One case report of sinus arrest has been reported. Monitor for changes in the therapeutic effect and signs of Verapamil toxicity if Amiodarone is initiated, discontinued or dose changed.
Amobarbital Amobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Amobarbital is initiated, discontinued or dose changed.
Amprenavir Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Amprenavir is initiated, discontinued or dose changed.
Atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Atazanavir is initiated, discontinued or dose changed.
Atenolol Increased effect of both drugs
Atorvastatin Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Atorvastatin by decreasing its metabolism. Avoid concurrent use if possible or reduce lovastatin dose during concomitant therapy. Monitor for changes in the therapeutic/adverse effects of Atorvastatin if Verapamil is initiated, discontinued or dose changed.
Bisoprolol Increased effect of both drugs
Bromazepam Verapamil may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or a reductin in the bromazepam dose. Monitor for changes in the therapeutic and adverse effects of bromazepam if verapamil is initiated, discontinued or dose changed.
Buspirone Verapamil may increase the serum concentration of Buspirone. The likely occurs via Verapamil-mediated CYP3A4 inhibition resulting in decreased Buspirone metabolism. Monitor for changes in the therapeutic/adverse effects of Buspirone if Verpamil is initiated, discontinued or dose changed.
Butabarbital Butabarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Butabarbital is initiated, discontinued or dose changed.
Butalbital Butalbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Butalbital is initiated, discontinued or dose changed.
Carbamazepine Verapamil may increase the serum concentration of Carbamazepine by decreasing its metabolism. Monitor for changes in the therapeutic/adverse effects of Carbamazepine if Verapamil is initiated, discontinued or dose changed.
Carvedilol Increased effect of both drugs
Clarithromycin Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Clarithromycin is initiated, discontinued or dose changed.
Colchicine Verapamil may increase the serum concentration of Colchicine. This likely occurs via Verapamil-mediated inhibition of CYP3A4 and p-glycoprotein-mediated transport. Monitor for changes in the therapeutic/adverse effects of Colchicine if Verapamil is initiated, discontinued or dose changed.
Conivaptan Conivaptan, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Conivaptan is initiated, discontinued or dose changed.
Cyclosporine Verapamil may increase the serum concentration of cyclosporine by inhibiting CYP3A4-mediated metabolism of cyclosporine. Monitor for changes in the therapeutic/adverse effects of cyclosporine if verapamil is initiated, discontinued or dose changed.
Dabigatran etexilate Verapamil may increase serum concentrations of the active metabolite(s) of dabigatran etexilate, resulting in an increased risk of bleeding. It is also a strong p-glycoprotein inhibitor. Therapy modification should be considered.
Darunavir Darunavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Darunavir is initiated, discontinued or dose changed.
Delavirdine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Delavirdine is initiated, discontinued or dose changed.
Digitoxin Verapamil may increase the serum concentration of Digitoxin by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of Digitoxin if Verpamail is initiated, discontinued or dose changed.
Digoxin Verapamil may increase the serum concentration of Digoxin by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of Digoxin if Verpamail is initiated, discontinued or dose changed.
Dofetilide Verapamil may increase the plamsa levels of Dofetilide. Increased risk of torsade de pointes. Concomitant therapy is contraindicated.
Dronedarone Verapamil is a moderate CYP3A4 inhibitor and will increase dronedarone levels 1.4-1.7 fold. Decrease doses of non-dihyropyridinic calcium-channel blocker.
Eplerenone This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Erythromycin Erythromycin, a moderate CYP3A4 inhibitor, may increase the serum concentration of veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Monitor for changes in the therapeutic/adverse effects of verapamil if erythromycin is initiated, discontinued or dose changed.
Esmolol Increased effect of both drugs
Everolimus Concomitant administration may increase the serum concentrations of both agents. Concurrent use should be avoided.
Fluconazole Fluconazole may increase the serum concentration of Verapamil by decreasing Verapamil metabolism. This likely occurs via Fluconazole-mediated CYP3A4 inhibition. Monitor for changes in the therapeutic/adverse effects of Verapamil if Fluconazole is initiated, discontinued, or dose changed.
Fosamprenavir Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Fosamprenavir is initiated, discontinued or dose changed.
Halofantrine Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Halofantrine by decreasing its metabolism. Extreme caution with increased cardiac status monitoring should be used during concomitant therapy.
Imatinib Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Imatinib is initiated, discontinued or dose changed.
Indacaterol Strong inhibitors of CYP3A4 may increase levels of indacaterol. Monitor closely for adverse events.
Indinavir Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Indinavir is initiated, discontinued or dose changed.
Isoniazid Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Isoniazid is initiated, discontinued or dose changed.
Itraconazole Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Itraconazole is initiated, discontinued or dose changed.
Ketoconazole Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Ketoconazole is initiated, discontinued or dose changed.
Labetalol Increased effect of both drugs
Lithium Signs of lithium toxicity
Lopinavir Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Lopinavir is initiated, discontinued or dose changed.
Lovastatin Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Lovastatin by decreasing its metabolism. Avoid concurrent use if possible or reduce lovastatin dose during concomitant therapy. Monitor for changes in the therapeutic/adverse effects of Lovastatin if Verapamil is initiated, discontinued or dose changed.
Methohexital Methohexital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Methohexital is initiated, discontinued or dose changed.
Methylphenobarbital Methylphenobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Methylphenobarbital is initiated, discontinued or dose changed.
Metoprolol Increased effect of both drugs
Miconazole Miconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Miconazole is initiated, discontinued or dose changed.
Midazolam Verapamil may increase the serum concentration of Midazolam by decreasing its metabolism. Avoid concomitant therapy if possible or consider a dose reduction in the initial dose of Midazolam.
Nadolol Increased effect of both drugs
Nafcillin Nafcillin may decrease the serum concentration of Verapamil by increasing its metabolism via CYP3A4. Monitor for changes in the therapeutic/adverse effects of Verapamil if Nafcillin is initiated, discontinued or dose changed.
Nefazodone Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nefazodone is initiated, discontinued or dose changed.
Nelfinavir Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nelfinavir is initiated, discontinued or dose changed.
Nicardipine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nicardipine is initiated, discontinued or dose changed.
Oxprenolol Increased effect of both drugs
Oxtriphylline Verapamil increases the effect of theophylline
Pentobarbital Pentobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Pentobarbital is initiated, discontinued or dose changed.
Phenobarbital Phenobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Phenobarbital is initiated, discontinued or dose changed.
Phenytoin Verapamil may increase the serum concentration of Phenytoin by decreasing its metabolism. Monitor for changes in the therapeutic/adverse effects of Phenytoin if Verapamil is initiated, discontinued or dose changed.
Pindolol Increased effect of both drugs
Posaconazole Posaconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Posaconazole is initiated, discontinued or dose changed.
Prazosin Risk of hypotension at the beginning of therapy
Primidone The barbiturate, primidone, decreases the effect of the calcium channel blocker, verapamil.
Propranolol Increased effect of both drugs
Quinidine Concurrent therapy may result in increased serum levels of both agents. Both agents are CYP3A4 inhibitors and substrates. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of the agent if the other is initiated, discontinued or dose changed.
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Verapamil, a CYP3A4 inhibitor, may increase the serum concentration of Ranolazine. Concomitant therapy is contraindicated.
Rifabutin Rifabutin, a CYP3A4 inducer, may decrease the serum concentration of Verapamil by increasing its metabolism (particularly in the intestinal mucosa) and decreasing its absorption. Monitor for changes in the therapeutic/adverse effects of Verapamil if Rifabutin is initiated, discontinued or dose changed.
Rifampin Rifampin, a CYP3A4 inducer, may decrease the serum concentration of Verapamil by increasing its metabolism (particularly in the intestinal mucosa) and decreasing its absorption. Monitor for changes in the therapeutic/adverse effects of Verapamil if Rifampin is initiated, discontinued or dose changed.
Rifapentine Rifapentine, a CYP3A4 inducer, may decrease the serum concentration of Verapamil by increasing its metabolism (particularly in the intestinal mucosa) and decreasing its absorption. Monitor for changes in the therapeutic/adverse effects of Verapamil if Rifapentine is initiated, discontinued or dose changed.
Ritonavir Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Ritonavir is initiated, discontinued or dose changed.
Rituximab Verapamil may increase the hypotensive effects of Rituximab. Consider withholding Verapamil therapy for 12 hours prior to Rituximab infusion.
Saquinavir Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Saquinavir is initiated, discontinued or dose changed.
Secobarbital Secobarbital, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Secobarbital is initiated, discontinued or dose changed.
Silodosin Verapamil is a moderate inhibitor of CYP3A4 and inhibits P-glycoprotein thus increasing the potential for adverse effects
Simvastatin Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Simvastatin by decreasing its metabolism. Avoid concurrent use if possible or reduce Simvastatin dose during concomitant therapy. Monitor for changes in the therapeutic/adverse effects of Simvastatin if Verapamil is initiated, discontinued or dose changed.
Tacrolimus The calcium channel blocker, Verapamil, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Verapamil therapy is initiated, discontinued or altered.
Tamsulosin Verapamil, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Verapamil is initiated, discontinued, or dose changed.
Telithromycin Telithromycin, a CYP3A4 and p-glycoprotein inhibitor, may increase the Vinblastine serum concentration and distribution in certain cells. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Telithromycin is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Verapamil increases the effect of theophylline
Thiopental Thiopental, a CYP3A4 inducer, may increase the serum concentration of Verapamil, a CYP3A4 substrate. Monitor for changes in the therapeutic/adverse effects of Verapamil if Thiopental is initiated, discontinued or dose changed.
Timolol Additive effects of decreased heart rate and contractility may occur. Increased risk of heart block.
Tipranavir Tipranavir, co-administered with Ritonavir, may alter the concentration of Verapamil. Monitor for efficacy and adverse/toxic effects of Verapamil.
Tolterodine Verapamil may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Verapamil, a moderate CYP3A4 inhibitor, may increase the serum concentration of Tolvaptan. Concomitant therapy is contraindicated.
Topotecan The p-glycoprotein inhibitor, Verapamil, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol Verapamil may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Verapamil, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Verapamil is initiated, discontinued or dose changed.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triazolam Verapamil may increase the serum concentration of Triazolam by decreasing its metabolism. Avoid concomitant therapy if possible or consider a dose reduction in the initial dose of Triazolam.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of verapamil by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of verapamil if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.
  • Avoid natural licorice.

Targets


Voltage-dependent L-type calcium channel subunit alpha-1C
Name Voltage-dependent L-type calcium channel subunit alpha-1C
Gene Name CACNA1C
Pharmacological action yes
Actions inhibitor
References
  • Dilmac N, Hilliard N, Hockerman GH: Molecular determinants of frequency dependence and Ca2+ potentiation of verapamil block in the pore region of Cav1.2. Mol Pharmacol. 2004 Nov;66(5):1236-47. Epub 2004 Jul 30. - Pubmed
  • Morel N, Buryi V, Feron O, Gomez JP, Christen MO, Godfraind T: The action of calcium channel blockers on recombinant L-type calcium channel alpha1-subunits. Br J Pharmacol. 1998 Nov;125(5):1005-12. - Pubmed
  • Patel MK, Clunn GF, Lymn JS, Austin O, Hughes AD: Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells. Br J Pharmacol. 2005 Jul;145(6):811-7. - Pubmed
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.8049
Voltage-dependent L-type calcium channel subunit alpha-1D
Name Voltage-dependent L-type calcium channel subunit alpha-1D
Gene Name CACNA1D
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.6661
Voltage-dependent L-type calcium channel subunit alpha-1F
Name Voltage-dependent L-type calcium channel subunit alpha-1F
Gene Name CACNA1F
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.4817
Voltage-dependent L-type calcium channel subunit alpha-1S
Name Voltage-dependent L-type calcium channel subunit alpha-1S
Gene Name CACNA1S
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.7152
Voltage-dependent L-type calcium channel subunit beta-1
Name Voltage-dependent L-type calcium channel subunit beta-1
Gene Name CACNB1
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.5038
Voltage-dependent L-type calcium channel subunit beta-2
Name Voltage-dependent L-type calcium channel subunit beta-2
Gene Name CACNB2
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.6462
Voltage-dependent L-type calcium channel subunit beta-3
Name Voltage-dependent L-type calcium channel subunit beta-3
Gene Name CACNB3
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.4031
Voltage-dependent L-type calcium channel subunit beta-4
Name Voltage-dependent L-type calcium channel subunit beta-4
Gene Name CACNB4
Pharmacological action yes
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.4042
Voltage-dependent T-type calcium channel subunit alpha-1I
Name Voltage-dependent T-type calcium channel subunit alpha-1I
Gene Name CACNA1I
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3388
Voltage-dependent T-type calcium channel subunit alpha-1G
Name Voltage-dependent T-type calcium channel subunit alpha-1G
Gene Name CACNA1G
Pharmacological action unknown
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Freeze BS, McNulty MM, Hanck DA: State-dependent verapamil block of the cloned human Ca(v)3.1 T-type Ca(2+) channel. Mol Pharmacol. 2006 Aug;70(2):718-26. Epub 2006 May 12. - Pubmed
DTHybrid score 0.4365
Voltage-dependent N-type calcium channel subunit alpha-1B
Name Voltage-dependent N-type calcium channel subunit alpha-1B
Gene Name CACNA1B
Pharmacological action unknown
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.3022
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Name Voltage-dependent P/Q-type calcium channel subunit alpha-1A
Gene Name CACNA1A
Pharmacological action unknown
Actions inhibitor
References
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.3518
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions inhibitor
References
  • Duan JJ, Ma JH, Zhang PH, Wang XP, Zou AR, Tu DN: Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain. Acta Pharmacol Sin. 2007 Jul;28(7):959-67. - Pubmed
  • Cheng HC, Incardona J, McCullough B: Isolated perfused and paced guinea pig heart to test for drug-induced changes of the QT interval. J Pharmacol Toxicol Methods. 2006 Nov-Dec;54(3):278-87. Epub 2006 Feb 28. - Pubmed
  • Schneider J, Hauser R, Andreas JO, Linz K, Jahnel U: Differential effects of human ether-a-go-go-related gene (HERG) blocking agents on QT duration variability in conscious dogs. Eur J Pharmacol. 2005 Apr 4;512(1):53-60. - Pubmed
  • Ridley JM, Dooley PC, Milnes JT, Witchel HJ, Hancox JC: Lidoflazine is a high affinity blocker of the HERG K(+)channel. J Mol Cell Cardiol. 2004 May;36(5):701-5. - Pubmed
  • Shimizu W, Aiba T, Antzelevitch C: Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. Long QT syndrome and Brugada syndrome. Curr Pharm Des. 2005;11(12):1561-72. - Pubmed
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 0.3697
Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action unknown
Actions other
References
  • Milberg P, Reinsch N, Osada N, Wasmer K, Monnig G, Stypmann J, Breithardt G, Haverkamp W, Eckardt L: Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3. Basic Res Cardiol. 2005 Jul;100(4):365-71. Epub 2005 Jun 10. - Pubmed
DTHybrid score 0.6143
ATP-sensitive inward rectifier potassium channel 11
Name ATP-sensitive inward rectifier potassium channel 11
Gene Name KCNJ11
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S, Terzic A: Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J Physiol. 2006 Dec 15;577(Pt 3):1053-65. Epub 2006 Oct 12. - Pubmed
  • Shigeto M, Katsura M, Matsuda M, Ohkuma S, Kaku K: Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. J Pharmacol Exp Ther. 2007 Jul;322(1):1-7. Epub 2007 Apr 4. - Pubmed
DTHybrid score 0.3414
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action unknown
Actions other/unknown
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
  • Brown NL, Sirugue O, Worcel M: The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes. Eur J Pharmacol. 1986 Apr 9;123(1):161-5. - Pubmed
DTHybrid score 0.3705

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score 1.6297
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9678
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7535
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9859
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.1422
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8666
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9535
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3384
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.696
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.2108

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor,inducer
References
  • Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. - Pubmed
  • Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed
  • Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed
  • Kawahara I, Kato Y, Suzuki H, Achira M, Ito K, Crespi CL, Sugiyama Y: Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems. Drug Metab Dispos. 2000 Oct;28(10):1238-43. - Pubmed
  • Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K: Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):281-4. - Pubmed
  • Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Leonessa F, Kim JH, Ghiorghis A, Kulawiec RJ, Hammer C, Talebian A, Clarke R: C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. J Med Chem. 2002 Jan 17;45(2):390-8. - Pubmed
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed
  • Zhang S, Morris ME: Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther. 2003 Mar;304(3):1258-67. - Pubmed
  • Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD: Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000 Sep;11(3):207-14. - Pubmed
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos. 2001 Aug;29(8):1080-3. - Pubmed
  • Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
  • Wils P, Phung-Ba V, Warnery A, Lechardeur D, Raeissi S, Hidalgo IJ, Scherman D: Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol. 1994 Oct 7;48(7):1528-30. - Pubmed
  • Hait WN, Gesmonde JF, Murren JR, Yang JM, Chen HX, Reiss M: Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells. Biochem Pharmacol. 1993 Jan 26;45(2):401-6. - Pubmed
  • Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E: Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol. 1997 Jan 10;53(1):17-25. - Pubmed
  • Kuhnel JM, Perrot JY, Faussat AM, Marie JP, Schwaller MA: Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe. Leukemia. 1997 Jul;11(7):1147-55. - Pubmed
  • Kim AE, Dintaman JM, Waddell DS, Silverman JA: Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J Pharmacol Exp Ther. 1998 Sep;286(3):1439-45. - Pubmed
  • Bebawy M, Morris MB, Roufogalis BD: A continuous fluorescence assay for the study of P-glycoprotein-mediated drug efflux using inside-out membrane vesicles. Anal Biochem. 1999 Mar 15;268(2):270-7. - Pubmed
  • Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R: P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999 Apr;437(5):652-60. - Pubmed
  • Jonsson O, Behnam-Motlagh P, Persson M, Henriksson R, Grankvist K: Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity. Biochem Pharmacol. 1999 Dec 1;58(11):1801-6. - Pubmed
  • Eagling VA, Profit L, Back DJ: Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999 Oct;48(4):543-52. - Pubmed
  • Choi CH, Kim JH, Kim SH: Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR. Biochem Biophys Res Commun. 2004 Jul 30;320(3):672-9. - Pubmed
  • Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25. - Pubmed
  • Hu K, Morris ME: Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanates on P-glycoprotein- and MRP1-mediated transport. J Pharm Sci. 2004 Jul;93(7):1901-11. - Pubmed
  • Lee BH, Lee CO, Kwon MJ, Yi KY, Yoo SE, Choi SU: Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity. Anticancer Drugs. 2003 Feb;14(2):175-81. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Petri N, Tannergren C, Rungstad D, Lennernas H: Transport characteristics of fexofenadine in the Caco-2 cell model. Pharm Res. 2004 Aug;21(8):1398-404. - Pubmed
  • Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed
  • Santoni-Rugiu E, Silverman JA: Functional characterization of the rat mdr1b encoded P-glycoprotein: not all inducing agents are substrates. Carcinogenesis. 1997 Nov;18(11):2255-63. - Pubmed
  • Sieczkowski E, Lehner C, Ambros PF, Hohenegger M: Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells. Int J Cancer. 2010 May 1;126(9):2025-35. - Pubmed
  • Chiu LY, Ko JL, Lee YJ, Yang TY, Tee YT, Sheu GT: L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18. Epub 2009 Nov 26. - Pubmed
  • Karlsson JE, Heddle C, Rozkov A, Rotticci-Mulder J, Tuvesson O, Hilgendorf C, Andersson TB: High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human embryonic kidney 293-epstein-barr virus nuclear antigen cells. Drug Metab Dispos. 2010 Apr;38(4):705-14. Epub 2010 Jan 13. - Pubmed
  • Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. Epub 2009 Jul 21. - Pubmed
  • Kugawa F, Suzuki T, Miyata M, Tomono K, Tamanoi F: Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Pharmazie. 2009 May;64(5):296-300. - Pubmed
  • Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
  • Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed
  • Pauli-Magnus C, von Richter O, Burk O, Ziegler A, Mettang T, Eichelbaum M, Fromm MF: Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. - Pubmed
  • Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
  • Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
  • Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
  • Dagenais C, Graff CL, Pollack GM: Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol. 2004 Jan 15;67(2):269-76. - Pubmed
  • Borgnia MJ, Eytan GD, Assaraf YG: Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. - Pubmed
  • Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed
  • Tfelt-Hansen P, Tfelt-Hansen J: Verapamil for cluster headache. Clinical pharmacology and possible mode of action. Headache. 2009 Jan;49(1):117-25. - Pubmed
DTHybrid score 1.213
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
DTHybrid score 0.4796
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions inhibitor
References
  • Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
DTHybrid score 0.3346
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Chen ZS, Lee K, Walther S, Raftogianis RB, Kuwano M, Zeng H, Kruh GD: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. - Pubmed
  • Bai J, Lai L, Yeo HC, Goh BC, Tan TM: Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. - Pubmed
DTHybrid score 0.3469
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score 0.4217
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score 0.3682
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Lespine A, Dupuy J, Orlowski S, Nagy T, Glavinas H, Krajcsi P, Alvinerie M: Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chem Biol Interact. 2006 Feb 25;159(3):169-79. Epub 2005 Dec 27. - Pubmed
DTHybrid score 0.4734
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
  • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score 0.4657
Multidrug resistance-associated protein 7
Name Multidrug resistance-associated protein 7
Gene Name ABCC10
Actions inhibitor
References
  • Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score 0.2481
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed
DTHybrid score 0.6266
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
  • Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta. 2000 Jun 1;1466(1-2):315-27. - Pubmed
DTHybrid score 0.3161
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol Pharmacol. 2004 Jun;65(6):1485-95. - Pubmed
DTHybrid score 0.5577
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH, Schellens JH: Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors. Drug Metab Dispos. 2009 Apr;37(4):917-23. Epub 2009 Jan 12. - Pubmed
DTHybrid score 0.4816

Predictions


Id Partner name Gene Name Score
6013 Cytochrome P450 2E1 CYP2E1 0.4464
6024 Cytochrome P450 1A1 CYP1A1 0.4219
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.399
587 Serum albumin ALB 0.3365
5718 Cytochrome P450 2A6 CYP2A6 0.3323
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.3319
6144 Solute carrier family 22 member 2 SLC22A2 0.286
1729 Solute carrier family 22 member 6 SLC22A6 0.2621
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.2301
6142 Solute carrier family 22 member 8 SLC22A8 0.2236
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2183
492 Histamine H1 receptor HRH1 0.2156
1181 Alpha-1-acid glycoprotein 1 ORM1 0.192
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.1902
20 Prostaglandin G/H synthase 1 PTGS1 0.1899
6147 Solute carrier family 22 member 3 SLC22A3 0.1863
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.184
556 Alpha-1A adrenergic receptor ADRA1A 0.1753
465 Calmodulin CALM1 0.1736
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1557
6220 Aryl hydrocarbon receptor AHR 0.1547
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1486
1671 Excitatory amino acid transporter 3 SLC1A1 0.1482
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.1474
737 Mineralocorticoid receptor NR3C2 0.147
1898 Cytochrome P450 1B1 CYP1B1 0.1459
6143 Solute carrier family 22 member 7 SLC22A7 0.1423
831 D(2) dopamine receptor DRD2 0.141
6141 Sodium/bile acid cotransporter SLC10A1 0.1399
713 Sodium-dependent dopamine transporter SLC6A3 0.1392
632 Alpha-1B adrenergic receptor ADRA1B 0.1341
817 DNA topoisomerase 2-alpha TOP2A 0.1318
502 5-hydroxytryptamine 2A receptor HTR2A 0.1271
193 Beta-1 adrenergic receptor ADRB1 0.126
318 Alpha-2A adrenergic receptor ADRA2A 0.1238
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1198
789 Alpha-1D adrenergic receptor ADRA1D 0.1193
1024 Solute carrier family 22 member 11 SLC22A11 0.1134
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.1126
378 Alpha-2C adrenergic receptor ADRA2C 0.108
290 Prostaglandin G/H synthase 2 PTGS2 0.1073
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1073
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.1039
233 Potassium channel subfamily K member 2 KCNK2 0.1029
6137 Multidrug resistance-associated protein 6 ABCC6 0.1027
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0998
3811 Cytochrome P450 19A1 CYP19A1 0.0994
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0977
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0974
3923 Cholinesterase BCHE 0.0973
6136 Multidrug resistance-associated protein 5 ABCC5 0.0966
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0962
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0959
3941 Amine oxidase [flavin-containing] A MAOA 0.0947
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0936
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0932
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0931
629 Alpha-2B adrenergic receptor ADRA2B 0.0929
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.092
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0915
172 Potassium channel subfamily K member 1 KCNK1 0.0911
1435 Synaptic vesicle glycoprotein 2A SV2A 0.091
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0909
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0906
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0906
847 Mu-type opioid receptor OPRM1 0.0903
136 Estrogen receptor ESR1 0.0886
766 Beta-2 adrenergic receptor ADRB2 0.0886
731 HIV-1 protease HIV-1 protease 0.0884
6031 Cytochrome P450 3A43 CYP3A43 0.0871
751 Potassium channel subfamily K member 6 KCNK6 0.087
320 5-hydroxytryptamine 1A receptor HTR1A 0.0866
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0864
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0852
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0848
590 5-hydroxytryptamine 2C receptor HTR2C 0.0822
467 Delta-type opioid receptor OPRD1 0.0784
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0752
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0751
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0738
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0738
696 Kappa-type opioid receptor OPRK1 0.0733
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0728
468 Cytochrome P450 4A11 CYP4A11 0.0728
23 D(1A) dopamine receptor DRD1 0.0724
3939 Amine oxidase [flavin-containing] B MAOB 0.0715
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0699
477 DNA topoisomerase 4 subunit A parC 0.069
886 DNA topoisomerase 4 subunit A parC 0.069
6226 DNA topoisomerase 4 subunit A parC 0.069
738 Monocarboxylate transporter 1 SLC16A1 0.0688
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0687
404 DNA gyrase subunit A gyrA 0.068
6224 DNA gyrase subunit A gyrA 0.068
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0676
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0676
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0673
33 Cystine/glutamate transporter SLC7A11 0.0647
871 Glucocorticoid receptor NR3C1 0.0623
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0613
341 5-hydroxytryptamine 3 receptor HTR3A 0.0598
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0597
295 Carbonic anhydrase 1 CA1 0.0593
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0575
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0556
6182 Cytochrome P450 2J2 CYP2J2 0.0555
4604 Liver carboxylesterase 1 CES1 0.0554
3947 Xanthine dehydrogenase/oxidase XDH 0.055
24 Thymidylate synthase TMP1 0.0537
359 Thymidylate synthase TYMS 0.0537
2626 Thymidylate synthase thyA 0.0537
2729 Thymidylate synthase thyA 0.0537
5352 Thymidylate synthase THYA 0.0537
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0536
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0535
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0529
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0521
16 Adenosine A1 receptor ADORA1 0.0519
70 Type-1 angiotensin II receptor AGTR1 0.0513
260 Cytochrome P450 51 ERG11 0.0512
761 Cytochrome P450 51 ERG11 0.0512
3163 Cytochrome P450 51 cyp51 0.0512
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0505
844 Epidermal growth factor receptor EGFR 0.0487
131 Synaptic vesicular amine transporter SLC18A2 0.0481
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0478
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0472
161 Tubulin beta chain TUBB 0.0466
312 Tubulin beta chain TUB2 0.0466
6048 Troponin C, skeletal muscle TNNC2 0.0464
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0464
3587 Gastrotropin FABP6 0.0463
380 Cytochrome P450 17A1 CYP17A1 0.0461
504 Mast/stem cell growth factor receptor KIT 0.046
29 Tubulin beta-1 chain TUBB1 0.0456
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0454
4773 Deoxycytidine kinase DCK 0.0454
4120 NADPH--cytochrome P450 reductase POR 0.0452
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0443
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0442
638 D(3) dopamine receptor DRD3 0.044
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0424
6167 Organic solute transporter subunit beta OSTB 0.0421
6166 Organic solute transporter subunit alpha OSTA 0.0421
904 Glutathione S-transferase P GSTP1 0.0418
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0417
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0415
756 Sex hormone-binding globulin SHBG 0.0414
5626 Nucleoside diphosphate kinase B NME2 0.0414
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0412
885 5-hydroxytryptamine 1B receptor HTR1B 0.041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.041
436 5-hydroxytryptamine 2B receptor HTR2B 0.0406
6070 Nischarin NISCH 0.0402
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0398
614 Progesterone receptor PGR 0.0396
2539 Tubulin alpha-1 chain TUBA4A 0.0388
869 Estrogen receptor beta ESR2 0.0387
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0384
26 Vascular endothelial growth factor receptor 3 FLT4 0.0384
273 Apoptosis regulator Bcl-2 BCL2 0.0383
1757 Myeloperoxidase MPO 0.0375
146 Androgen receptor AR 0.0374
407 Vascular endothelial growth factor receptor 2 KDR 0.0367
32 Vascular endothelial growth factor receptor 1 FLT1 0.0367
6020 Aldehyde oxidase AOX1 0.0357
725 5-hydroxytryptamine 1D receptor HTR1D 0.0355
228 Beta platelet-derived growth factor receptor PDGFRB 0.0355
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0348
6085 Fatty acid-binding protein, intestinal FABP2 0.0347
474 Acetylcholinesterase ACHE 0.0343
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0338
124 Histamine H2 receptor HRH2 0.0335
5294 Nucleoside diphosphate kinase A NME1 0.0332
5923 Microtubule-associated protein tau MAPT 0.033
5924 Microtubule-associated protein 4 MAP4 0.033
1852 Microtubule-associated protein 2 MAP2 0.033
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0329
1262 Corticotropin-lipotropin POMC 0.0326
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0322
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0316
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0315
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0314
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0311
908 Glutathione S-transferase theta-1 GSTT1 0.0309
357 Carbonic anhydrase 2 CA2 0.0308
122 P2Y purinoceptor 12 P2RY12 0.0306
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0305
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0302
3426 Glutamine synthetase glnA 0.0298
3987 Glutamine synthetase GLUL 0.0298
4192 DNA topoisomerase 2-beta TOP2B 0.0298
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0292
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.029
1650 Heme carrier protein 1 SLC46A1 0.0287
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0282
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0282
373 Transthyretin TTR 0.028
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0279
3917 Methylenetetrahydrofolate reductase MTHFR 0.0278
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0276
1353 DNA topoisomerase 1 TOP1 0.0275
3552 DNA topoisomerase 1 topA 0.0275
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0271
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.027
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.027
275 Arachidonate 5-lipoxygenase ALOX5 0.0269
94 5-hydroxytryptamine 4 receptor HTR4 0.0268
3611 Cytidine deaminase cdd 0.0267
3707 Cytidine deaminase cdd 0.0267
4211 Cytidine deaminase CDA 0.0267
1656 CYP2B protein CYP2B 0.0267
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0265
432 D(4) dopamine receptor DRD4 0.0261
293 Gamma-glutamyl hydrolase GGH 0.026
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0259
36 Insulin receptor INSR 0.0258
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0255
6149 Solute carrier family 22 member 10 SLC22A10 0.0253
165 FL cytokine receptor FLT3 0.0252
702 UMP-CMP kinase CMPK1 0.0251
3868 Calcineurin subunit B isoform 2 PPP3R2 0.025
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.025
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0249
6432 Transporter snf 0.0248
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0247
117 Sterol O-acyltransferase 1 SOAT1 0.0245
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0245
2808 Chloramphenicol acetyltransferase 3 cat3 0.0243
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0242
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0242
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0241
952 Dipeptidyl peptidase 4 DPP4 0.0241
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0239
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0239
7 Nitric oxide synthase, inducible NOS2 0.0238
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0238
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0238
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0238
6014 Cytochrome P450 2A13 CYP2A13 0.0237
6168 Solute carrier family 22 member 16 SLC22A16 0.0236
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
811 Translocator protein TSPO 0.0234
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0233
449 Ornithine decarboxylase ODC1 0.0233
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0231
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0231
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.023
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.023
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0229
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0229
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0229
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0229
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0226
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0226
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0226
921 Glutamate receptor 2 GRIA2 0.0225
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0225
466 Solute carrier family 12 member 3 SLC12A3 0.0222
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0222
6599 HTH-type transcriptional regulator ttgR ttgR 0.0221
777 Tumor necrosis factor TNF 0.0219
4148 Serine/threonine-protein kinase mTOR MTOR 0.0218
1010 Cytochrome P450 51A1 CYP51A1 0.0217
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0217
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0217
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0216
6171 Solute carrier family 28 member 3 SLC28A3 0.0213
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0213
891 Dihydropteroate synthase folP 0.0212
5359 Dihydropteroate synthase folP 0.0212
7175 Dihydropteroate synthase sulI 0.0212
1108 Calpastatin CAST 0.0211
1089 Cartilage oligomeric matrix protein COMP 0.0211
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
49 Endothelin B receptor EDNRB 0.0209
365 Dihydrofolate reductase DHFR 0.0209
2381 Dihydrofolate reductase DFR1 0.0209
2833 Dihydrofolate reductase Not Available 0.0209
2931 Dihydrofolate reductase folA 0.0209
3544 Dihydrofolate reductase folA 0.0209
3682 Dihydrofolate reductase folA 0.0209
6642 Dihydrofolate reductase folA 0.0209
6756 Dihydrofolate reductase dfrA 0.0209
2429 Putrescine-binding periplasmic protein potF 0.0206
232 Corticosteroid-binding globulin SERPINA6 0.0206
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0205
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0203
683 Potassium transporter GK0582 0.0203
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0202
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0202
3810 Catechol O-methyltransferase COMT 0.0199
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0198
818 50S ribosomal protein L10 rplJ 0.0198
578 Endothelin-1 receptor EDNRA 0.0197
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0196
469 Annexin A1 ANXA1 0.0195
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0192
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0191
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0191
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0191
1256 5-hydroxytryptamine 6 receptor HTR6 0.019
3809 Estrogen-related receptor gamma ESRRG 0.0189
592 Carbonic anhydrase 4 CA4 0.0189
758 Thyroid hormone receptor alpha THRA 0.0188
3086 Plasmepsin-2 Not Available 0.0188
976 Platelet glycoprotein IX GP9 0.0188
159 Penicillin-binding protein 2B penA 0.0187
6121 Penicillin-binding protein 2B penA 0.0187
1517 Beta-3 adrenergic receptor ADRB3 0.0185
6102 Arylamine N-acetyltransferase 2 NAT2 0.0185
244 Angiotensin-converting enzyme ACE 0.0184
1629 Transcription factor AP-1 JUN 0.0183
6146 High affinity copper uptake protein 1 SLC31A1 0.0183
6135 Sodium channel subunit beta-4 SCN4B 0.0182
6133 Sodium channel subunit beta-2 SCN2B 0.0182
6127 Carbonic anhydrase-related protein CA8 0.0182
6134 Sodium channel subunit beta-3 SCN3B 0.0182
6132 Sodium channel subunit beta-1 SCN1B 0.0182
6129 Carbonic anhydrase-related protein 11 CA11 0.0182
6128 Carbonic anhydrase-related protein 10 CA10 0.0182
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0181
3270 Elongation factor G fusA 0.0181
1830 5'-nucleotidase NT5E 0.0181
163 D(1B) dopamine receptor DRD5 0.018
716 5-hydroxytryptamine 7 receptor HTR7 0.0179
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0178
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0177
6126 Carbonic anhydrase 7 CA7 0.0175
84 Nuclear receptor 0B1 NR0B1 0.0174
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0173
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
6151 Monocarboxylate transporter 10 SLC16A10 0.0173
183 Vascular endothelial growth factor A VEGFA 0.0173
4237 50S ribosomal protein L22 rplV 0.0172
291 Nitric-oxide synthase, endothelial NOS3 0.0172
890 Niemann-Pick C1-like protein 1 NPC1L1 0.017
284 DNA-directed RNA polymerase beta chain rpoB 0.017
5773 DNA-directed RNA polymerase beta chain rpoB 0.017
5787 Angiopoietin-1 receptor TEK 0.017
427 Substance-P receptor TACR1 0.017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.017
174 Sigma 1-type opioid receptor SIGMAR1 0.0169
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0169
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0169
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0168
511 5-hydroxytryptamine 1F receptor HTR1F 0.0168
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0167
346 Thyroid hormone receptor beta-1 THRB 0.0167
4238 50S ribosomal protein L4 rplD 0.0166
5578 50S ribosomal protein L4 rplD 0.0166
6173 50S ribosomal protein L4 rplD 0.0166
6219 50S ribosomal protein L4 rplD 0.0166
2472 Voltage-gated potassium channel kcsA 0.0166
6366 Voltage-gated potassium channel kcsA 0.0166
1192 Sulfotransferase 1A1 SULT1A1 0.0166
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0165
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0165
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0164
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0164
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0163
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0162
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0162
6010 Thiamine transporter 1 SLC19A2 0.0162
594 Thyroxine-binding globulin SERPINA7 0.0161
6130 Carbonic anhydrase 13 CA13 0.0159
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0159
896 Glutathione S-transferase Mu 1 GSTM1 0.0159
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0159
6131 Carbonic anhydrase 14 CA14 0.0157
125 DNA polymerase beta POLB 0.0157
5818 Folate receptor alpha FOLR1 0.0157
887 DNA gyrase subunit B gyrB 0.0156
4150 DNA gyrase subunit B gyrB 0.0156
6225 DNA gyrase subunit B gyrB 0.0156
85 Growth hormone receptor GHR 0.0156
992 Protein tyrosine kinase 2 beta PTK2B 0.0155
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0154
3856 Fibroblast growth factor receptor 3 FGFR3 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0153
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0153
4122 Histone deacetylase 2 HDAC2 0.0152
1760 Aminopeptidase N ANPEP 0.0152
6843 Aminopeptidase N pepN 0.0152
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
624 Guanidinoacetate N-methyltransferase GAMT 0.0151
6218 Pannexin-1 PANX1 0.015
6165 Copper-transporting ATPase 1 ATP7A 0.0149
6163 Copper-transporting ATPase 2 ATP7B 0.0149
2449 Tubulin alpha-3 chain TUBA1A 0.0149
1630 Integrin beta-2 ITGB2 0.0148
6122 Carbonic anhydrase 3 CA3 0.0147
723 Cytosolic phospholipase A2 PLA2G4A 0.0147
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0146
175 Thiamin pyrophosphokinase 1 TPK1 0.0146
1618 High affinity nerve growth factor receptor NTRK1 0.0146
4203 Histamine N-methyltransferase HNMT 0.0143
489 Monocarboxylate transporter 2 SLC16A7 0.0143
2981 Phospholipase A2, membrane associated PLA2G2A 0.0143
299 Folate receptor beta FOLR2 0.0142
718 Folate receptor gamma FOLR3 0.0142
804 Mitochondrial folate transporter/carrier SLC25A32 0.0142
303 Diamine acetyltransferase 2 SAT2 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
823 Fibroblast growth factor receptor 2 FGFR2 0.0141
633 Penicillin-binding proteins 1A/1B pbpA 0.0139
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0139
5880 Thrombopoietin receptor MPL 0.0139
1178 Adenosine A2a receptor ADORA2A 0.0138
1636 Trace amine-associated receptor 1 TAAR1 0.0137
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0137
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0137
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0137
6044 Serum paraoxonase/lactonase 3 PON3 0.0137
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0137
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0135
1648 Elastin ELN 0.0135
6174 50S ribosomal protein L32 rpmF 0.0134
1050 Bile salt sulfotransferase SULT2A1 0.0133
461 Glycine receptor subunit alpha-3 GLRA3 0.0132
319 Opioid receptor, sigma 1 OPRS1 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
6043 Putative G-protein coupled receptor 44 GPR44 0.013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.013
1360 Sphingomyelin phosphodiesterase SMPD1 0.013
3307 Acriflavine resistance protein B acrB 0.013
768 FK506-binding protein 1A FKBP1A 0.0128
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
5126 Arginase rocF 0.0127
3007 Carbonic anhydrase 12 CA12 0.0127
4205 Carbonic anhydrase 9 CA9 0.0127
123 Diamine acetyltransferase 1 SAT1 0.0127
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
2132 Protein S100-B S100B 0.0126
705 Glutamate receptor 1 GRIA1 0.0125
6138 Multidrug resistance protein 3 ABCB4 0.0123
558 Solute carrier family 12 member 1 SLC12A1 0.0123
6210 Tubulin delta chain TUBD1 0.0122
6212 Tubulin gamma-1 chain TUBG1 0.0122
6211 Tubulin epsilon chain TUBE1 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0118
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
2391 Ferrochelatase hemH 0.0117
6502 Ferrochelatase DKFZp686P18130 0.0117
1591 Ferrochelatase, mitochondrial FECH 0.0117
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0117
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0117
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0116
88 Retinoic acid receptor RXR-beta RXRB 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
4226 Uridine phosphorylase 2 UPP2 0.0115
3932 Glutathione S-transferase A2 GSTA2 0.0113
3808 Dihydropteroate synthase 2 folP2 0.0113
3601 Dihydropteroate synthase 1 folP1 0.0113
3807 Dihydropteroate synthase 1 folP1 0.0113
482 Glycine receptor subunit alpha-1 GLRA1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
1 Peptidoglycan synthetase ftsI ftsI 0.0111
4155 Peptidoglycan synthetase ftsI ftsI 0.0111
528 5-hydroxytryptamine 1E receptor HTR1E 0.011
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0109
239 Coagulation factor X F10 0.0108
2300 Lysozyme E 0.0108
3633 Lysozyme R 0.0108
5597 Lysozyme 17 0.0108
6033 High affinity interleukin-8 receptor A CXCR1 0.0108
2443 Azurin azu 0.0108
1313 Lactoylglutathione lyase GLO1 0.0108
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0107
645 Penicillin-binding protein 1A mrcA 0.0107
5805 Penicillin-binding protein 1A ponA 0.0107
6185 Penicillin-binding protein 1A mrcA 0.0107
6799 Penicillin-binding protein 1A pbpA 0.0107
563 Thyroid peroxidase TPO 0.0106
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0105
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0105
4225 Uridine phosphorylase 1 UPP1 0.0105
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0105
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0105
780 Retinoic acid receptor RXR-gamma RXRG 0.0104
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0102
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0101
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0101
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0101
6493 Cytochrome c oxidase subunit 6C COX6C 0.0101
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0101
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0101
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0101
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0101
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0101
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0101
6559 Cytochrome c oxidase subunit 2 ctaC 0.0101
6669 Cytochrome c oxidase subunit 2 ctaC 0.0101
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0101
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0101
6558 Cytochrome c oxidase subunit 1 ctaD 0.0101
572 Integrin alpha-L ITGAL 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
164 Histamine H4 receptor HRH4 0.01
740 Argininosuccinate synthase ASS1 0.0099
865 Argininosuccinate synthase ASS1 0.0099
2680 Argininosuccinate synthase argG 0.0099
3194 Argininosuccinate synthase argG 0.0099
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
413 Amidophosphoribosyltransferase PPAT 0.0099
2515 Amidophosphoribosyltransferase purF 0.0099
3714 Amidophosphoribosyltransferase purF 0.0099
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0099
153 Dopamine beta-hydroxylase DBH 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0099
551 Carnitine O-acetyltransferase CRAT 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
199 Monocarboxylate transporter 8 SLC16A2 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
6042 Prostaglandin reductase 2 PTGR2 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
5934 Cytochrome P450 26A1 CYP26A1 0.0096
5300 Antigen peptide transporter 1 TAP1 0.0096
76 Nitric-oxide synthase, brain NOS1 0.0096
3639 Thymidine phosphorylase deoA 0.0095
3936 Thymidine phosphorylase TYMP 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
603 DNA polymerase alpha catalytic subunit POLA1 0.0094
3957 Adenosine deaminase ADA 0.0094
68 Cannabinoid receptor 1 CNR1 0.0094
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0094
2540 Choloylglycine hydrolase cbh 0.0093
267 Plasminogen activator inhibitor 1 SERPINE1 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
517 Alcohol dehydrogenase 1C ADH1C 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0091
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0091
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0091
828 Phenylalanine-4-hydroxylase PAH 0.0091
3109 Phenylalanine-4-hydroxylase phhA 0.0091
814 Ryanodine receptor 1 RYR1 0.009
672 Prostaglandin F2-alpha receptor PTGFR 0.009
2021 Thrombomodulin THBD 0.009
162 Retinoic acid receptor gamma-1 RARG 0.009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.009
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.009
499 Arginine decarboxylase ADC 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0088
2216 Fibroblast growth factor receptor 4 FGFR4 0.0087
6501 Fatty acid-binding protein, liver FABP1 0.0087
1374 Natriuretic peptides B NPPB 0.0087
1827 Gap junction alpha-1 protein GJA1 0.0087
1908 Vascular cell adhesion protein 1 VCAM1 0.0087
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
577 Argininosuccinate lyase ASL 0.0085
1341 Histamine H3 receptor HRH3 0.0085
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
6824 Tyrosine-protein kinase Lyn LYN 0.0084
6221 Steroid hormone receptor ERR1 ESRRA 0.0084
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
4217 Telomerase reverse transcriptase TERT 0.0084
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0084
719 Retinoic acid receptor responder protein 1 RARRES1 0.0083
770 Retinoic acid-induced protein 3 GPRC5A 0.0083
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0083
1039 Histone deacetylase 9 HDAC9 0.0083
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0083
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0081
2298 Cytochrome P450-cam camC 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.008
6837 Serine/threonine-protein kinase 17B STK17B 0.008
1196 Complement decay-accelerating factor CD55 0.008
1525 Heparin-binding growth factor 2 FGF2 0.008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0079
4311 tRNA TRDMT1 0.0079
4325 tRNA trmD 0.0079
4328 tRNA trmD 0.0079
173 Toll-like receptor 7 TLR7 0.0079
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0078
2599 Tyrosine-protein kinase HCK HCK 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
936 Ephrin type-A receptor 2 EPHA2 0.0077
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
518 Peroxidase/catalase T katG 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
537 ATP synthase delta chain, mitochondrial ATP5D 0.0077
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0075
1864 RET proto-oncogene RET 0.0075
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0075
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0075
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0075
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0074
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0074
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0074
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0074
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0074
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0074
1541 Metalloproteinase mmp20 0.0074
54 Prothrombin F2 0.0074
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0074
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
6500 Phospholipase A2 PLA2G1B 0.0073
569 Retinal dehydrogenase 2 ALDH1A2 0.0073
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0073
714 Glutathione reductase, mitochondrial GSR 0.0072
5682 Ribonuclease pancreatic RNASE1 0.0072
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0072
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0072
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0072
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0072
769 High-affinity choline transporter 1 SLC5A7 0.0072
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0072
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0072
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0072
1686 Choline transporter-like protein 1 SLC44A1 0.0072
861 Choline kinase alpha CHKA 0.0072
700 Choline dehydrogenase, mitochondrial CHDH 0.0072
576 Choline O-acetyltransferase CHAT 0.0072
3927 Choline transporter-like protein 3 SLC44A3 0.0072
3926 Choline transporter-like protein 2 SLC44A2 0.0072
3925 Choline transporter-like protein 4 SLC44A4 0.0072
3922 Phospholipase D2 PLD2 0.0072
3924 Phospholipase D1 PLD1 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0071
856 Vitamin D3 receptor VDR 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0069
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0068
611 Retinal dehydrogenase 1 ALDH1A1 0.0068
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0068
106 Cannabinoid receptor 2 CNR2 0.0068
1483 Membrane copper amine oxidase AOC3 0.0067
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
581 Cytochrome P450 2R1 CYP2R1 0.0065
2320 Thymidine kinase, cytosolic TK1 0.0065
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0065
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0064
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
2417 Chloramphenicol acetyltransferase cat 0.0063
3278 Chloramphenicol acetyltransferase cat 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0063
133 Dihydropterate synthase sulI 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
484 Tyrosine-protein kinase ABL2 ABL2 0.0063
3937 Fatty-acid amide hydrolase FAAH 0.0062
5482 Sialidase-2 NEU2 0.0062
2810 Dr hemagglutinin structural subunit draA 0.0062
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1792 Tissue-type plasminogen activator PLAT 0.0062
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
1291 cAMP response element-binding protein CREB1 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
1275 Estrogen sulfotransferase SULT1E1 0.006
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
2232 Interleukin-5 IL5 0.0059
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0059
1593 Mucin-2 MUC2 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0057
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0057
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0057
788 Creatine kinase M-type CKM 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0056
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0056
543 Penicillin-binding protein 1B mrcB 0.0056
6186 Penicillin-binding protein 1B ponB 0.0056
6822 Penicillin-binding protein 1b pbp1b 0.0056
6844 Penicillin-binding protein 1b pbp1b 0.0056
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
6228 Nuclear receptor coactivator 1 NCOA1 0.0054
6241 Nuclear receptor coactivator 2 NCOA2 0.0054
760 Fibroblast growth factor 1 FGF1 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
4760 Mll3241 protein mll3241 0.0052
1992 Vitamin D-binding protein GC 0.0052
712 Tubulin alpha chain TUB1 0.0052
3913 Glutamic acid decarboxylase GAD65 0.0052
1074 Urokinase-type plasminogen activator PLAU 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
694 Matrix protein 2 M 0.0051
5798 Mitogen-activated protein kinase 11 MAPK11 0.0051
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
4041 Microsomal glutathione S-transferase 2 MGST2 0.005
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
6111 DNA polymerase epsilon subunit 4 POLE4 0.0049
6112 DNA polymerase epsilon subunit 3 POLE3 0.0048
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0048
6110 DNA polymerase epsilon subunit 2 POLE2 0.0048
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0048
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
4034 Glutaredoxin-1 GLRX 0.0046
1928 Leukotriene C4 synthase LTC4S 0.0046
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0046
4037 Hypothetical protein GPX1 0.0046
4297 Hypothetical protein SP_1951 0.0046
4521 Hypothetical protein BC_2969 0.0046
4540 Hypothetical protein TM_1070 0.0046
4555 Hypothetical protein MT1739 0.0046
4569 Hypothetical protein mshD 0.0046
4578 Hypothetical protein PA3270 0.0046
4747 Hypothetical protein PA3967 0.0046
5177 Hypothetical protein TM_0096 0.0046
5194 Hypothetical protein PA1204 0.0046
5240 Hypothetical protein Rv2991 0.0046
5370 Hypothetical protein TM_1158 0.0046
5710 Hypothetical protein Tb927.5.1360 0.0046
4029 Microsomal glutathione S-transferase 3 MGST3 0.0046
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0046
907 Glutathione peroxidase 2 GPX2 0.0046
4032 Microsomal glutathione S-transferase 1 MGST1 0.0046
910 Epididymal secretory glutathione peroxidase GPX5 0.0046
4036 Glutathione peroxidase 6 GPX6 0.0046
903 Glutathione S-transferase A5 GSTA5 0.0046
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0046
4040 Glutathione peroxidase 7 GPX7 0.0046
911 Glutathione peroxidase 3 GPX3 0.0046
906 Glutathione peroxidase 1 GPX1 0.0046
900 Glutathione S-transferase A4 GSTA4 0.0046
4035 Glutathione S-transferase Mu 5 GSTM5 0.0046
4033 S-formylglutathione hydrolase ESD 0.0046
4042 Glutathione transferase omega-2 GSTO2 0.0046
4038 Glutathione peroxidase 4 GPX4 0.0046
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0046
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
527 Prostacyclin receptor PTGIR 0.0045
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0045
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0045
1063 Signal transducer and activator of transcription 5B STAT5B 0.0045
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0045
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3904 Alanine aminotransferase 2 GPT2 0.0043
735 Alanine aminotransferase 1 GPT 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
3319 Hydroxyacylglutathione hydrolase HAGH 0.0042
898 Glutathione S-transferase A3 GSTA3 0.0042
897 Glutathione S-transferase kappa 1 GSTK1 0.0042
909 Maleylacetoacetate isomerase GSTZ1 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
905 Glutathione transferase omega-1 GSTO1 0.004
899 Glutathione S-transferase Mu 3 GSTM3 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
4031 Glutathione S-transferase A1 GSTA1 0.0039
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
2165 Glutathione S-transferase Mu 2 GSTM2 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
207 Glutathione synthetase GSS 0.0036
5269 Glutathione synthetase gshB 0.0036
251 Alcohol dehydrogenase 1A ADH1A 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
444 Alcohol dehydrogenase 1B ADH1B 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
901 Glutathione S-transferase Mu 4 GSTM4 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
65 Matrix metalloproteinase-9 Not Available 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
277 Purine nucleoside phosphorylase PNP 0.0029
2870 Purine nucleoside phosphorylase punA 0.0029
2945 Purine nucleoside phosphorylase punA 0.0029
4659 Purine nucleoside phosphorylase TM_1596 0.0029
4825 Purine nucleoside phosphorylase TTHA1435 0.0029
292 Activin receptor type-1 ACVR1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
849 Activated CDC42 kinase 1 TNK2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
2207 Rhodopsin RHO 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3830 Calreticulin CALR 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
6021 Adenosine kinase ADK 0.0023
707 72 kDa type IV collagenase MMP2 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
2091 Endoplasmin HSP90B1 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
1058 Cell division protein kinase 5 CDK5 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
3221 Cytochrome c4 cc4 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4954 Soluble cytochrome b558 Not Available 0.0018
4925 Cytochrome c-type protein SHP shp 0.0018
4934 Cytochrome c-551 nirM 0.0018
5218 Cytochrome c-551 nirM 0.0018
4915 Cytochrome c-550 psbV 0.0018
4959 Cytochrome c-550 psbV 0.0018
5216 Cytochrome c-550 psbV 0.0018
4905 Cytochrome c2 Not Available 0.0018
4939 Cytochrome c2 cycA 0.0018
4964 Cytochrome c2 cycA 0.0018
4979 Cytochrome c2 cycA 0.0018
6673 Cytochrome c2 cycA 0.0018
4947 Bacterial hemoglobin vhb 0.0018
4975 Cytochrome c-556 RPA3973 0.0018
4916 Cyanoglobin glbN 0.0018
4943 Cytochrome c6 petJ 0.0018
4998 Hemoglobin-like protein yjbI yjbI 0.0018
4984 Neuroglobin NGB 0.0018
4936 Cytochrome c2 iso-2 Not Available 0.0018
4994 Hemoglobin-like protein HbO glbO 0.0018
4907 Cytochrome c-L moxG 0.0018
6865 Cytochrome c-L moxG 0.0018
4909 CooA protein cooA 0.0018
644 Heme oxygenase 2 HMOX2 0.0018
4982 Heme oxygenase 2 pbsA2 0.0018
4942 Diheme cytochrome c napB napB 0.0018
4910 Cytoglobin CYGB 0.0018
4981 Iron-starvation protein PigA pigA 0.0018
4935 Cytochrome c-554 cycA1 0.0018
5000 HemO hemO 0.0018
4961 Hemophore HasA hasA 0.0018
4971 Nonaheme cytochrome c hmcA 0.0018
4904 Cytochrome c family protein GSU1996 0.0018
4976 Apocytochrome f petA 0.0018
6407 Apocytochrome f petA 0.0018
4989 Cytochrome c551 peroxidase ccp 0.0018
5222 Cytochrome c551 peroxidase ccpA 0.0018
4999 Cytochrome P450 165B3 CYP165B3 0.0018
4764 Cytochrome P450 165C4 CYP165C4 0.0018
4960 Putative cytochrome P450-family protein SCO7417 0.0018
4931 Cytochrome P450 167A1 CYP167A1 0.0018
4926 Heme-based aerotactic transducer hemAT hemAT 0.0018
4937 Cytochrome oxidase subunit II rcoxA 0.0018
4903 Methyl-accepting chemotaxis protein Tar4 0.0018
4993 Hydroxylamine oxidoreductase hao1 0.0018
4972 P450cin cinA 0.0018
4922 Cytochrome c, putative SO_4144 0.0018
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0018
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0018
3093 Catalase HPII katE 0.0018
4952 Catalase/peroxidase katA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
4386 Hemoglobin-like protein HbN glbN 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
4920 Peroxidase/catalase katG 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
2119 Cytochrome b5 CYB5A 0.0013
4990 PpcA ppcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
2230 Catalase CAT 0.0013
3249 Catalase katA 0.0013
3625 Catalase katA 0.0013
4539 Catalase katA 0.0013
4941 Catalase katB 0.0013
1507 Cytochrome c CYCS 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
1295 Fatty acid synthase FASN 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
358 Cystathionine beta-synthase CBS 0.0009
693 Hemoglobin subunit beta HBB 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1867 Major prion protein PRNP 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
798 Osteocalcin BGLAP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
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