DT-Web

DB00264 - Metoprolol


Identification
Name Metoprolol
Accession Number DB00264 (APRD00208)
Type small molecule
Description Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β-1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 267.3639
Groups approved
Monoisotopic Weight 267.183443671
Pharmacology
Indication For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Mechanism of action Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Absorption Rapid and complete, 50%
Protein binding 12%
Biotransformation Primarily hepatic
Route of elimination Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.
Toxicity LD50=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD50=2090 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetohexamide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Chlorpropamide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Cimetidine Cimetidine may increase the serum concentration of metoprolol by decreasing its metabolism.
Citalopram The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, metoprolol.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Dihydroergotoxine Ischemia with risk of gangrene
Diltiazem Increased risk of bradycardia
Disopyramide The beta-blocker, metoprolol, may increase adverse effects of disopyramide.
Dronedarone Metoprolol is a CYP2D6 substrate and because dronedarone inhibits this enzyme, will increase metoprolol exposure 1.6-fold. Lower dose of metoprolol.
Epinephrine Hypertension, then bradycardia
Ergonovine Ischemia with risk of gangrene
Ergotamine Ischemia with risk of gangrene
Escitalopram The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, metoprolol.
Fenoterol Antagonism
Fluoxetine The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, metoprolol.
Formoterol Antagonism
Gliclazide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Glipizide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Glisoxepide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Glycodiazine The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Hydralazine Increased effect of both drugs
Ibuprofen Risk of inhibition of renal prostaglandins
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Isoproterenol Antagonism
Lidocaine The beta-blocker, metoprolol, may increase the effect and toxicity of lidocaine
Methysergide Ischemia with risk of gangrene
Mirabegron Mirabegron is a moderate CYP2D6 inhibitor and may cause an increase in exposure of CYP2D6 substrates. Monitor concomitant therapy closely.
Orciprenaline Antagonism
Paroxetine The SSRI increases the effect of the beta-blocker
Phenobarbital The barbiturate decreases the effect of the metabolized beta-blocker
Pipobroman Antagonism
Pirbuterol Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Prazosin Risk of hypotension at the beginning of therapy
Primidone The barbiturate decreases the effect of metabolized beta-blocker
Procaterol Antagonism
Propafenone Propafenone may increase the effect of beta-blocker, metoprolol.
Repaglinide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Rifampin Rifampin may decrease the serum concentration of metoprolol by increasing its metabolism.
Salbutamol Antagonism
Salmeterol Antagonism
Sertraline The SSRI increases the effect of the beta-blocker
Telithromycin Telithromycin may possibly increase metoprolol effect
Terazosin Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbinafine Terbinafine may reduce the metabolism and clearance of Metoprolol. Consider alternate therapy or monitor for therapeutic/adverse effects of Metoprolol if Terbinafine is initiated, discontinued or dose changed.
Terbutaline Antagonism
Tolazamide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Tolbutamide The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Verapamil Increased effect of both drugs
Food Interactions
  • Take with food.
  • Avoid alcohol.
  • Avoid natural licorice.

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • Schafer M, Frischkopf K, Taimor G, Piper HM, Schluter KD: Hypertrophic effect of selective beta(1)-adrenoceptor stimulation on ventricular cardiomyocytes from adult rat. Am J Physiol Cell Physiol. 2000 Aug;279(2):C495-503. - Pubmed
  • Staudt A, Mobini R, Fu M, Grosse Y, Stangl V, Stangl K, Thiele A, Baumann G, Felix SB: beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes. Eur J Pharmacol. 2001 Jul 6;423(2-3):115-9. - Pubmed
  • Staudt Y, Mobini R, Fu M, Felix SB, Kuhn JP, Staudt A: Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. Eur J Pharmacol. 2003 Apr 11;466(1-2):1-6. - Pubmed
  • Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. - Pubmed
  • Liu J, Liu ZQ, Tan ZR, Chen XP, Wang LS, Zhou G, Zhou HH: Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther. 2003 Oct;74(4):372-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7289
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action unknown
Actions antagonist
References
  • Zebrack JS, Munger M, Macgregor J, Lombardi WL, Stoddard GP, Gilbert EM: Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy. 2009 Aug;29(8):883-90. - Pubmed
DTHybrid score 0.7381

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Belpaire FM, Wijnant P, Temmerman A, Rasmussen BB, Brosen K: The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors. Eur J Clin Pharmacol. 1998 May;54(3):261-4. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4356
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.277

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. - Pubmed
DTHybrid score 0.1956
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed
  • Doppenschmitt S, Langguth P, Regardh CG, Andersson TB, Hilgendorf C, Spahn-Langguth H: Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay. J Pharmacol Exp Ther. 1999 Jan;288(1):348-57. - Pubmed
  • Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. - Pubmed
DTHybrid score 0.3435

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2815
4757 Cytochrome P450 2C9 CYP2C9 0.1805
4200 Cytochrome P450 1A2 CYP1A2 0.1639
1517 Beta-3 adrenergic receptor ADRB3 0.1421
4118 Cytochrome P450 3A5 CYP3A5 0.118
6145 Solute carrier family 22 member 1 SLC22A1 0.1153
4924 Cytochrome P450 2C8 CYP2C8 0.1135
556 Alpha-1A adrenergic receptor ADRA1A 0.0974
6107 Cytochrome P450 3A7 CYP3A7 0.0868
6030 Cytochrome P450 2B6 CYP2B6 0.0855
6024 Cytochrome P450 1A1 CYP1A1 0.0754
320 5-hydroxytryptamine 1A receptor HTR1A 0.0739
6013 Cytochrome P450 2E1 CYP2E1 0.0735
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0609
1181 Alpha-1-acid glycoprotein 1 ORM1 0.06
824 Sodium-dependent serotonin transporter SLC6A4 0.0596
5718 Cytochrome P450 2A6 CYP2A6 0.0592
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.059
318 Alpha-2A adrenergic receptor ADRA2A 0.0583
492 Histamine H1 receptor HRH1 0.0534
118 Organic cation/carnitine transporter 2 SLC22A5 0.052
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0502
6147 Solute carrier family 22 member 3 SLC22A3 0.0499
3923 Cholinesterase BCHE 0.0493
632 Alpha-1B adrenergic receptor ADRA1B 0.0457
587 Serum albumin ALB 0.0456
885 5-hydroxytryptamine 1B receptor HTR1B 0.0434
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.043
831 D(2) dopamine receptor DRD2 0.0388
629 Alpha-2B adrenergic receptor ADRA2B 0.0385
713 Sodium-dependent dopamine transporter SLC6A3 0.038
862 Multidrug resistance-associated protein 1 ABCC1 0.0356
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0351
502 5-hydroxytryptamine 2A receptor HTR2A 0.0351
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0351
378 Alpha-2C adrenergic receptor ADRA2C 0.0344
20 Prostaglandin G/H synthase 1 PTGS1 0.0334
3941 Amine oxidase [flavin-containing] A MAOA 0.0331
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0331
6106 Cytochrome P450 2C18 CYP2C18 0.0329
833 Organic cation/carnitine transporter 1 SLC22A4 0.0324
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0323
789 Alpha-1D adrenergic receptor ADRA1D 0.0311
1729 Solute carrier family 22 member 6 SLC22A6 0.0309
2300 Lysozyme E 0.0297
3633 Lysozyme R 0.0297
5597 Lysozyme 17 0.0297
6142 Solute carrier family 22 member 8 SLC22A8 0.0286
23 D(1A) dopamine receptor DRD1 0.0279
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0268
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0263
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0263
776 Bile salt export pump ABCB11 0.0246
3810 Catechol O-methyltransferase COMT 0.024
124 Histamine H2 receptor HRH2 0.024
3939 Amine oxidase [flavin-containing] B MAOB 0.022
1898 Cytochrome P450 1B1 CYP1B1 0.0214
590 5-hydroxytryptamine 2C receptor HTR2C 0.0212
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0194
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0189
341 5-hydroxytryptamine 3 receptor HTR3A 0.0188
6143 Solute carrier family 22 member 7 SLC22A7 0.0186
828 Phenylalanine-4-hydroxylase PAH 0.0185
3109 Phenylalanine-4-hydroxylase phhA 0.0185
465 Calmodulin CALM1 0.0185
638 D(3) dopamine receptor DRD3 0.0182
847 Mu-type opioid receptor OPRM1 0.0177
777 Tumor necrosis factor TNF 0.0175
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0172
731 HIV-1 protease HIV-1 protease 0.0171
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0168
1820 Beta-nerve growth factor NGF 0.0166
817 DNA topoisomerase 2-alpha TOP2A 0.0166
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0164
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0162
3811 Cytochrome P450 19A1 CYP19A1 0.0162
131 Synaptic vesicular amine transporter SLC18A2 0.0161
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0156
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0152
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0151
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0151
436 5-hydroxytryptamine 2B receptor HTR2B 0.0151
467 Delta-type opioid receptor OPRD1 0.0149
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0145
260 Cytochrome P450 51 ERG11 0.0144
761 Cytochrome P450 51 ERG11 0.0144
3163 Cytochrome P450 51 cyp51 0.0144
696 Kappa-type opioid receptor OPRK1 0.0143
474 Acetylcholinesterase ACHE 0.0142
432 D(4) dopamine receptor DRD4 0.014
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0138
1024 Solute carrier family 22 member 11 SLC22A11 0.0138
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0137
2164 Multidrug resistance-associated protein 4 ABCC4 0.0137
290 Prostaglandin G/H synthase 2 PTGS2 0.0132
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.013
871 Glucocorticoid receptor NR3C1 0.013
6137 Multidrug resistance-associated protein 6 ABCC6 0.0129
7 Nitric oxide synthase, inducible NOS2 0.0128
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0128
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0126
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0125
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0123
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0122
3076 Antigen 85-C fbpC 0.0122
6148 Multidrug resistance-associated protein 7 ABCC10 0.012
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0118
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0118
136 Estrogen receptor ESR1 0.0117
6182 Cytochrome P450 2J2 CYP2J2 0.0117
725 5-hydroxytryptamine 1D receptor HTR1D 0.0114
161 Tubulin beta chain TUBB 0.0105
312 Tubulin beta chain TUB2 0.0105
6136 Multidrug resistance-associated protein 5 ABCC5 0.0102
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0101
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0099
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0097
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0097
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0097
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0097
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0096
468 Cytochrome P450 4A11 CYP4A11 0.0095
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0094
380 Cytochrome P450 17A1 CYP17A1 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0093
716 5-hydroxytryptamine 7 receptor HTR7 0.0092
163 D(1B) dopamine receptor DRD5 0.0092
4120 NADPH--cytochrome P450 reductase POR 0.0092
477 DNA topoisomerase 4 subunit A parC 0.0092
886 DNA topoisomerase 4 subunit A parC 0.0092
6226 DNA topoisomerase 4 subunit A parC 0.0092
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0091
4203 Histamine N-methyltransferase HNMT 0.0091
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0091
844 Epidermal growth factor receptor EGFR 0.0091
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0091
6432 Transporter snf 0.0091
404 DNA gyrase subunit A gyrA 0.009
6224 DNA gyrase subunit A gyrA 0.009
3947 Xanthine dehydrogenase/oxidase XDH 0.009
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0089
146 Androgen receptor AR 0.0089
1176 Mitogen-activated protein kinase 1 MAPK1 0.0089
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0089
6141 Sodium/bile acid cotransporter SLC10A1 0.0087
4773 Deoxycytidine kinase DCK 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0086
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0084
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0083
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0083
504 Mast/stem cell growth factor receptor KIT 0.0083
4604 Liver carboxylesterase 1 CES1 0.0082
6031 Cytochrome P450 3A43 CYP3A43 0.0082
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0082
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0082
122 P2Y purinoceptor 12 P2RY12 0.0082
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0081
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0081
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0079
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0079
183 Vascular endothelial growth factor A VEGFA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
614 Progesterone receptor PGR 0.0076
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0075
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0075
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0075
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0075
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0074
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
1374 Natriuretic peptides B NPPB 0.0074
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0074
1827 Gap junction alpha-1 protein GJA1 0.0074
1908 Vascular cell adhesion protein 1 VCAM1 0.0074
1256 5-hydroxytryptamine 6 receptor HTR6 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.007
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.007
1770 Phospholipase C PLCL1 0.007
2841 Phospholipase C plc 0.007
1192 Sulfotransferase 1A1 SULT1A1 0.0068
738 Monocarboxylate transporter 1 SLC16A1 0.0066
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0065
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0065
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0065
1360 Sphingomyelin phosphodiesterase SMPD1 0.0065
228 Beta platelet-derived growth factor receptor PDGFRB 0.0065
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0063
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0063
2449 Tubulin alpha-3 chain TUBA1A 0.0063
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0062
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0061
26 Vascular endothelial growth factor receptor 3 FLT4 0.0061
952 Dipeptidyl peptidase 4 DPP4 0.0061
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.006
950 Alpha platelet-derived growth factor receptor PDGFRA 0.006
694 Matrix protein 2 M 0.0059
1656 CYP2B protein CYP2B 0.0058
70 Type-1 angiotensin II receptor AGTR1 0.0058
373 Transthyretin TTR 0.0058
32 Vascular endothelial growth factor receptor 1 FLT1 0.0058
869 Estrogen receptor beta ESR2 0.0058
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0057
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0057
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0057
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0057
756 Sex hormone-binding globulin SHBG 0.0057
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0056
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0056
2112 Toll-like receptor 9 TLR9 0.0055
1629 Transcription factor AP-1 JUN 0.0054
407 Vascular endothelial growth factor receptor 2 KDR 0.0053
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0053
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0052
6151 Monocarboxylate transporter 10 SLC16A10 0.0052
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0051
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
1757 Myeloperoxidase MPO 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.005
737 Mineralocorticoid receptor NR3C2 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
6146 High affinity copper uptake protein 1 SLC31A1 0.0049
904 Glutathione S-transferase P GSTP1 0.0049
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0048
6070 Nischarin NISCH 0.0048
164 Histamine H4 receptor HRH4 0.0048
528 5-hydroxytryptamine 1E receptor HTR1E 0.0047
6211 Tubulin epsilon chain TUBE1 0.0047
6212 Tubulin gamma-1 chain TUBG1 0.0047
6210 Tubulin delta chain TUBD1 0.0047
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
976 Platelet glycoprotein IX GP9 0.0046
1618 High affinity nerve growth factor receptor NTRK1 0.0046
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0046
723 Cytosolic phospholipase A2 PLA2G4A 0.0046
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0045
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0045
3611 Cytidine deaminase cdd 0.0044
3707 Cytidine deaminase cdd 0.0044
4211 Cytidine deaminase CDA 0.0044
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0044
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0044
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0044
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0043
1010 Cytochrome P450 51A1 CYP51A1 0.0043
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0043
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0042
365 Dihydrofolate reductase DHFR 0.0042
2381 Dihydrofolate reductase DFR1 0.0042
2833 Dihydrofolate reductase Not Available 0.0042
2931 Dihydrofolate reductase folA 0.0042
3544 Dihydrofolate reductase folA 0.0042
3682 Dihydrofolate reductase folA 0.0042
6642 Dihydrofolate reductase folA 0.0042
6756 Dihydrofolate reductase dfrA 0.0042
1830 5'-nucleotidase NT5E 0.0042
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0042
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0041
891 Dihydropteroate synthase folP 0.0041
5359 Dihydropteroate synthase folP 0.0041
7175 Dihydropteroate synthase sulI 0.0041
94 5-hydroxytryptamine 4 receptor HTR4 0.0041
1341 Histamine H3 receptor HRH3 0.0041
125 DNA polymerase beta POLB 0.004
319 Opioid receptor, sigma 1 OPRS1 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
6220 Aryl hydrocarbon receptor AHR 0.004
818 50S ribosomal protein L10 rplJ 0.0039
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0039
4217 Telomerase reverse transcriptase TERT 0.0039
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0038
4103 Proteasome subunit beta type 2 PSMB2 0.0038
4102 Proteasome subunit beta type 5 PSMB5 0.0038
4101 Proteasome subunit beta type 1 PSMB1 0.0038
908 Glutathione S-transferase theta-1 GSTT1 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0038
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0037
6163 Copper-transporting ATPase 2 ATP7B 0.0037
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0037
6165 Copper-transporting ATPase 1 ATP7A 0.0037
5300 Antigen peptide transporter 1 TAP1 0.0037
6085 Fatty acid-binding protein, intestinal FABP2 0.0037
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0037
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
527 Prostacyclin receptor PTGIR 0.0036
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0036
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0035
702 UMP-CMP kinase CMPK1 0.0035
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
5126 Arginase rocF 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0034
1864 RET proto-oncogene RET 0.0034
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0034
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0034
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0034
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0034
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0034
6506 Stathmin-4 STMN4 0.0033
174 Sigma 1-type opioid receptor SIGMAR1 0.0033
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0033
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6102 Arylamine N-acetyltransferase 2 NAT2 0.0033
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0032
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0031
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.003
612 P protein [Includes: DNA-directed DNA polymerase P 0.003
592 Carbonic anhydrase 4 CA4 0.003
6171 Solute carrier family 28 member 3 SLC28A3 0.003
2320 Thymidine kinase, cytosolic TK1 0.003
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
511 5-hydroxytryptamine 1F receptor HTR1F 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0029
683 Potassium transporter GK0582 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
427 Substance-P receptor TACR1 0.0028
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0028
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0028
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0028
4192 DNA topoisomerase 2-beta TOP2B 0.0028
4311 tRNA TRDMT1 0.0028
4325 tRNA trmD 0.0028
4328 tRNA trmD 0.0028
823 Fibroblast growth factor receptor 2 FGFR2 0.0028
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0028
165 FL cytokine receptor FLT3 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0027
153 Dopamine beta-hydroxylase DBH 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
49 Endothelin B receptor EDNRB 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0026
6166 Organic solute transporter subunit alpha OSTA 0.0026
239 Coagulation factor X F10 0.0026
6218 Pannexin-1 PANX1 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0026
5626 Nucleoside diphosphate kinase B NME2 0.0026
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
921 Glutamate receptor 2 GRIA2 0.0026
85 Growth hormone receptor GHR 0.0025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
106 Cannabinoid receptor 2 CNR2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6174 50S ribosomal protein L32 rpmF 0.0023
518 Peroxidase/catalase T katG 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
295 Carbonic anhydrase 1 CA1 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0022
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0022
811 Translocator protein TSPO 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
68 Cannabinoid receptor 1 CNR1 0.0022
357 Carbonic anhydrase 2 CA2 0.0022
6126 Carbonic anhydrase 7 CA7 0.0022
563 Thyroid peroxidase TPO 0.0022
1630 Integrin beta-2 ITGB2 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
5294 Nucleoside diphosphate kinase A NME1 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
489 Monocarboxylate transporter 2 SLC16A7 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
144 Hemoglobin subunit alpha HBA1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
4122 Histone deacetylase 2 HDAC2 0.0019
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0019
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0019
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0019
469 Annexin A1 ANXA1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
5787 Angiopoietin-1 receptor TEK 0.0018
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
581 Cytochrome P450 2R1 CYP2R1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0017
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0016
572 Integrin alpha-L ITGAL 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
1992 Vitamin D-binding protein GC 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0015
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6755 Poliovirus receptor PVR 0.0015
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0015
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0015
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0015
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0015
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0015
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0015
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
3086 Plasmepsin-2 Not Available 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
482 Glycine receptor subunit alpha-1 GLRA1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
3809 Estrogen-related receptor gamma ESRRG 0.0013
3404 Exotoxin A eta 0.0013
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0013
3957 Adenosine deaminase ADA 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
84 Nuclear receptor 0B1 NR0B1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
2021 Thrombomodulin THBD 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
856 Vitamin D3 receptor VDR 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
6459 Glycodelin PAEP 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
3830 Calreticulin CALR 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
3937 Fatty-acid amide hydrolase FAAH 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
54 Prothrombin F2 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6043 Putative G-protein coupled receptor 44 GPR44 0.0008
2207 Rhodopsin RHO 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
6020 Aldehyde oxidase AOX1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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