DT-Web

DB01064 - Isoproterenol


Identification
Name Isoproterenol
Accession Number DB01064 (APRD00182)
Type small molecule
Description Isopropyl analog of epinephrine; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 211.2576
Groups approved
Monoisotopic Weight 211.120843415
Pharmacology
Indication For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
Mechanism of action The pharmacologic effects of isoproterenol are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Excretion following inhalation administration is primarily renal and the major metabolite is the sulfate conjugate of isoproterenol.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Antagonism
Amitriptyline The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of isoproterenol.
Amoxapine The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of isoproterenol.
Atenolol Antagonism
Bisoprolol Antagonism
Carvedilol Antagonism
Clomipramine The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of isoproterenol.
Desipramine The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of isoproterenol.
Doxepin The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of isoproterenol.
Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, isoproterenol.
Esmolol Antagonism
Imipramine The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of isoproterenol.
Isocarboxazid Increased arterial pressure
Labetalol Antagonism
Linezolid Possible increase of arterial pressure
Methyldopa Increased arterial pressure
Metoprolol Antagonism
Midodrine Increased arterial pressure
Moclobemide Moclobemide increases the sympathomimetic effect of isoproterenol.
Nadolol Antagonism
Nortriptyline The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of isoproterenol.
Oxprenolol Antagonism
Phenelzine Increased arterial pressure
Pindolol Antagonism
Propranolol Antagonism
Rasagiline Increased arterial pressure
Reserpine Increased arterial pressure
Timolol Antagonism
Food Interactions Not Available

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions agonist
References
  • Sato M, Gong H, Terracciano CM, Ranu H, Harding SE: Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. J Mol Cell Cardiol. 2004 Jan;36(1):43-8. - Pubmed
  • Jurgens CW, Rau KE, Knudson CA, King JD, Carr PA, Porter JE, Doze VA: Beta1 adrenergic receptor-mediated enhancement of hippocampal CA3 network activity. J Pharmacol Exp Ther. 2005 Aug;314(2):552-60. Epub 2005 May 20. - Pubmed
  • Kobayashi H, Narita Y, Nishida M, Kurose H: Beta-arrestin2 enhances beta2-adrenergic receptor-mediated nuclear translocation of ERK. Cell Signal. 2005 Oct;17(10):1248-53. Epub 2005 Feb 12. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. - Pubmed
DTHybrid score 1.053
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action yes
Actions agonist
References
  • Abraham G, Kottke C, Dhein S, Ungemach FR: Pharmacological and biochemical characterization of the beta-adrenergic signal transduction pathway in different segments of the respiratory tract. Biochem Pharmacol. 2003 Sep 15;66(6):1067-81. - Pubmed
  • Jones SM, Hiller FC, Jacobi SE, Foreman SK, Pittman LM, Cornett LE: Enhanced beta2-adrenergic receptor (beta2AR) signaling by adeno-associated viral (AAV)-mediated gene transfer. BMC Pharmacol. 2003 Dec 4;3:15. - Pubmed
  • Teixeira CE, Baracat JS, Zanesco A, Antunes E, De Nucci G: Atypical beta-adrenoceptor subtypes mediate relaxations of rabbit corpus cavernosum. J Pharmacol Exp Ther. 2004 May;309(2):587-93. Epub 2004 Jan 29. - Pubmed
  • Odley A, Hahn HS, Lynch RA, Marreez Y, Osinska H, Robbins J, Dorn GW 2nd: Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7082-7. Epub 2004 Apr 22. - Pubmed
  • Uezono Y, Kaibara M, Murasaki O, Taniyama K: Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system. Am J Physiol Cell Physiol. 2004 Oct;287(4):C885-94. Epub 2004 May 19. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. - Pubmed
DTHybrid score 1.0533
Beta-3 adrenergic receptor
Name Beta-3 adrenergic receptor
Gene Name ADRB3
Pharmacological action yes
Actions agonist
References
  • Ahlquist RP: Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. - Pubmed
  • Schiffelers SL, Blaak EE, Saris WH, van Baak MA: In vivo beta3-adrenergic stimulation of human thermogenesis and lipid use. Clin Pharmacol Ther. 2000 May;67(5):558-66. - Pubmed
DTHybrid score 0.7242
Mitogen-activated protein kinase 1
Name Mitogen-activated protein kinase 1
Gene Name MAPK1
Pharmacological action unknown
Actions inducer
References
  • Vaniotis G, Del Duca D, Trieu P, Rohlicek CV, Hebert TE, Allen BG: Nuclear beta-adrenergic receptors modulate gene expression in adult rat heart. Cell Signal. 2010 Aug 21. - Pubmed
  • Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM: Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003 Oct 28;108(17):2147-52. Epub 2003 Sep 8. - Pubmed
  • Azzi M, Charest PG, Angers S, Rousseau G, Kohout T, Bouvier M, Pineyro G: Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11406-11. Epub 2003 Sep 17. - Pubmed
  • Adissu HA, Schuller HM: Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention. Int J Oncol. 2004 Jun;24(6):1467-72. - Pubmed
  • Dubey RK, Jackson EK, Gillespie DG, Zacharia LC, Imthurn B: Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. J Clin Endocrinol Metab. 2004 Aug;89(8):3922-31. - Pubmed
  • Yeh CK, Ghosh PM, Dang H, Liu Q, Lin AL, Zhang BX, Katz MS: beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP. Am J Physiol Cell Physiol. 2005 Jun;288(6):C1357-66. Epub 2005 Feb 2. - Pubmed
DTHybrid score 1.2392
Phosphatidylinositol 3-kinase regulatory subunit alpha
Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Gene Name PIK3R1
Pharmacological action unknown
Actions agonist
References
  • Slomiany BL, Slomiany A: Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation. Biochem Biophys Res Commun. 2004 May 21;318(1):247-52. - Pubmed
  • Slomiany BL, Slomiany A: Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2004 Sep;55(3):627-38. - Pubmed
  • Slomiany BL, Slomiany A: Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation. Inflammopharmacology. 2004;12(3):233-45. - Pubmed
  • Machida K, Inoue H, Matsumoto K, Tsuda M, Fukuyama S, Koto H, Aizawa H, Kureishi Y, Hara N, Nakanishi Y: Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L860-7. Epub 2004 Dec 23. - Pubmed
  • Slomiany BL, Slomiany A: Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2005 Jun;56(2):247-58. - Pubmed
DTHybrid score 0.6881
Phosphatidylinositol 3-kinase regulatory subunit beta
Name Phosphatidylinositol 3-kinase regulatory subunit beta
Gene Name PIK3R2
Pharmacological action unknown
Actions agonist
References
  • Slomiany BL, Slomiany A: Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation. Biochem Biophys Res Commun. 2004 May 21;318(1):247-52. - Pubmed
  • Slomiany BL, Slomiany A: Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2004 Sep;55(3):627-38. - Pubmed
  • Slomiany BL, Slomiany A: Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation. Inflammopharmacology. 2004;12(3):233-45. - Pubmed
  • Machida K, Inoue H, Matsumoto K, Tsuda M, Fukuyama S, Koto H, Aizawa H, Kureishi Y, Hara N, Nakanishi Y: Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L860-7. Epub 2004 Dec 23. - Pubmed
  • Slomiany BL, Slomiany A: Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2005 Jun;56(2):247-58. - Pubmed
DTHybrid score 0.6378
Phosphatidylinositol 3-kinase regulatory subunit gamma
Name Phosphatidylinositol 3-kinase regulatory subunit gamma
Gene Name PIK3R3
Pharmacological action unknown
Actions agonist
References
  • Slomiany BL, Slomiany A: Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation. Biochem Biophys Res Commun. 2004 May 21;318(1):247-52. - Pubmed
  • Slomiany BL, Slomiany A: Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2004 Sep;55(3):627-38. - Pubmed
  • Slomiany BL, Slomiany A: Src-kinase-dependent epidermal growth factor receptor transactivation in salivary mucin secretion in response to beta-adrenergic G-protein-coupled receptor activation. Inflammopharmacology. 2004;12(3):233-45. - Pubmed
  • Machida K, Inoue H, Matsumoto K, Tsuda M, Fukuyama S, Koto H, Aizawa H, Kureishi Y, Hara N, Nakanishi Y: Activation of PI3K-Akt pathway mediates antiapoptotic effects of beta-adrenergic agonist in airway eosinophils. Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L860-7. Epub 2004 Dec 23. - Pubmed
  • Slomiany BL, Slomiany A: Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal growth factor receptor transactivation. J Physiol Pharmacol. 2005 Jun;56(2):247-58. - Pubmed
DTHybrid score 0.6406

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3547

Predictions


Id Partner name Gene Name Score
4141 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA 0.1972
4119 Cytochrome P450 2D6 CYP2D6 0.1564
6246 Serine/threonine-protein kinase PLK1 PLK1 0.1442
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.1234
4200 Cytochrome P450 1A2 CYP1A2 0.116
1588 Multidrug resistance protein 1 ABCB1 0.0958
4512 Cytochrome P450 3A4 CYP3A4 0.0944
1540 Mitogen-activated protein kinase 14 MAPK14 0.09
320 5-hydroxytryptamine 1A receptor HTR1A 0.0743
556 Alpha-1A adrenergic receptor ADRA1A 0.0698
1372 Insulin receptor substrate 1 IRS1 0.065
318 Alpha-2A adrenergic receptor ADRA2A 0.0567
1836 Mitogen-activated protein kinase 10 MAPK10 0.0554
885 5-hydroxytryptamine 1B receptor HTR1B 0.0541
6016 Cytochrome P450 2C19 CYP2C19 0.0538
1820 Beta-nerve growth factor NGF 0.0493
6144 Solute carrier family 22 member 2 SLC22A2 0.0484
629 Alpha-2B adrenergic receptor ADRA2B 0.0432
36 Insulin receptor INSR 0.0421
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0408
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0407
4757 Cytochrome P450 2C9 CYP2C9 0.0404
378 Alpha-2C adrenergic receptor ADRA2C 0.04
1714 Mitogen-activated protein kinase 3 MAPK3 0.0394
3923 Cholinesterase BCHE 0.0377
4118 Cytochrome P450 3A5 CYP3A5 0.0375
777 Tumor necrosis factor TNF 0.037
632 Alpha-1B adrenergic receptor ADRA1B 0.035
6013 Cytochrome P450 2E1 CYP2E1 0.0334
5718 Cytochrome P450 2A6 CYP2A6 0.0329
828 Phenylalanine-4-hydroxylase PAH 0.0319
3109 Phenylalanine-4-hydroxylase phhA 0.0319
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0302
1898 Cytochrome P450 1B1 CYP1B1 0.03
4924 Cytochrome P450 2C8 CYP2C8 0.0296
6145 Solute carrier family 22 member 1 SLC22A1 0.0287
3959 Cell division protein kinase 4 CDK4 0.0284
1742 D-HSCDK2 CDK2deltaT 0.0274
1771 Cell division control protein 2 homolog CDK1 0.0274
3321 Cell division control protein 2 homolog CRK2 0.0274
789 Alpha-1D adrenergic receptor ADRA1D 0.0272
2240 Cell division protein kinase 2 CDK2 0.0269
1058 Cell division protein kinase 5 CDK5 0.0266
6107 Cytochrome P450 3A7 CYP3A7 0.0264
2300 Lysozyme E 0.0243
3633 Lysozyme R 0.0243
5597 Lysozyme 17 0.0243
3941 Amine oxidase [flavin-containing] A MAOA 0.0239
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.023
4750 Protein S100-A11 S100A11 0.0216
3810 Catechol O-methyltransferase COMT 0.0211
6030 Cytochrome P450 2B6 CYP2B6 0.0208
824 Sodium-dependent serotonin transporter SLC6A4 0.0201
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0197
3482 Cell division protein kinase 7 CDK7 0.0189
4751 Mitogen-activated protein kinase 12 MAPK12 0.0189
3005 Threonine-phosphate decarboxylase cobD 0.0188
6147 Solute carrier family 22 member 3 SLC22A3 0.0183
713 Sodium-dependent dopamine transporter SLC6A3 0.0182
2530 Protein kinase C theta type PRKCQ 0.0174
118 Organic cation/carnitine transporter 2 SLC22A5 0.0165
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0164
587 Serum albumin ALB 0.0159
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0154
131 Synaptic vesicular amine transporter SLC18A2 0.0153
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0147
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0146
1422 Serine/threonine-protein kinase 6 AURKA 0.0135
1569 G1/S-specific cyclin-D1 CCND1 0.0129
3939 Amine oxidase [flavin-containing] B MAOB 0.0127
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0127
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
2207 Rhodopsin RHO 0.0122
3076 Antigen 85-C fbpC 0.0122
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0119
48 Pyridoxal kinase PDXK 0.0116
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0114
20 Prostaglandin G/H synthase 1 PTGS1 0.011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0109
6151 Monocarboxylate transporter 10 SLC16A10 0.0108
468 Cytochrome P450 4A11 CYP4A11 0.0106
1629 Transcription factor AP-1 JUN 0.0106
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.01
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0098
6847 Lactase-phlorizin hydrolase LCT 0.0093
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0086
6014 Cytochrome P450 2A13 CYP2A13 0.0084
6106 Cytochrome P450 2C18 CYP2C18 0.0084
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
776 Bile salt export pump ABCB11 0.008
2499 Tubulin beta-2C chain TUBB2C 0.0079
1374 Natriuretic peptides B NPPB 0.0078
1827 Gap junction alpha-1 protein GJA1 0.0078
1908 Vascular cell adhesion protein 1 VCAM1 0.0078
23 D(1A) dopamine receptor DRD1 0.0076
136 Estrogen receptor ESR1 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0072
2449 Tubulin alpha-3 chain TUBA1A 0.0072
1729 Solute carrier family 22 member 6 SLC22A6 0.0072
492 Histamine H1 receptor HRH1 0.0068
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0067
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0066
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0066
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0064
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
465 Calmodulin CALM1 0.0059
3947 Xanthine dehydrogenase/oxidase XDH 0.0058
183 Vascular endothelial growth factor A VEGFA 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
833 Organic cation/carnitine transporter 1 SLC22A4 0.0056
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0054
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
871 Glucocorticoid receptor NR3C1 0.0052
290 Prostaglandin G/H synthase 2 PTGS2 0.0051
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0051
862 Multidrug resistance-associated protein 1 ABCC1 0.005
820 Glycine receptor subunit alpha-2 GLRA2 0.005
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0049
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0048
502 5-hydroxytryptamine 2A receptor HTR2A 0.0047
3932 Glutathione S-transferase A2 GSTA2 0.0047
3811 Cytochrome P450 19A1 CYP19A1 0.0047
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0044
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
590 5-hydroxytryptamine 2C receptor HTR2C 0.0043
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0042
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
6142 Solute carrier family 22 member 8 SLC22A8 0.0041
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0041
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0041
831 D(2) dopamine receptor DRD2 0.004
33 Cystine/glutamate transporter SLC7A11 0.004
6766 O-GlcNAcase BT_4395 BT_4395 0.004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0038
638 D(3) dopamine receptor DRD3 0.0038
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
461 Glycine receptor subunit alpha-3 GLRA3 0.0035
1256 5-hydroxytryptamine 6 receptor HTR6 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
844 Epidermal growth factor receptor EGFR 0.0034
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0034
4203 Histamine N-methyltransferase HNMT 0.0034
1757 Myeloperoxidase MPO 0.0034
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0033
1010 Cytochrome P450 51A1 CYP51A1 0.0033
716 5-hydroxytryptamine 7 receptor HTR7 0.0032
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0032
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0031
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0031
2112 Toll-like receptor 9 TLR9 0.0029
432 D(4) dopamine receptor DRD4 0.0029
6220 Aryl hydrocarbon receptor AHR 0.0029
6148 Multidrug resistance-associated protein 7 ABCC10 0.0028
124 Histamine H2 receptor HRH2 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
6432 Transporter snf 0.0027
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0027
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
2236 Casein kinase II subunit alpha CSNK2A1 0.0027
106 Cannabinoid receptor 2 CNR2 0.0026
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0026
436 5-hydroxytryptamine 2B receptor HTR2B 0.0026
68 Cannabinoid receptor 1 CNR1 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0024
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0024
817 DNA topoisomerase 2-alpha TOP2A 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
16 Adenosine A1 receptor ADORA1 0.0024
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0024
1178 Adenosine A2a receptor ADORA2A 0.0023
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0023
146 Androgen receptor AR 0.0023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
233 Potassium channel subfamily K member 2 KCNK2 0.0023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0023
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0023
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
5934 Cytochrome P450 26A1 CYP26A1 0.0022
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0021
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0021
373 Transthyretin TTR 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.0021
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0021
51 Muscarinic acetylcholine receptor M3 CHRM3 0.002
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0019
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0019
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0019
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0019
3830 Calreticulin CALR 0.0018
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0018
1992 Vitamin D-binding protein GC 0.0018
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0018
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0017
1024 Solute carrier family 22 member 11 SLC22A11 0.0017
6034 Hydroxyindole O-methyltransferase ASMT 0.0017
6035 Nuclear receptor ROR-beta RORB 0.0017
6036 Eosinophil peroxidase EPX 0.0017
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0017
976 Platelet glycoprotein IX GP9 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
477 DNA topoisomerase 4 subunit A parC 0.0016
886 DNA topoisomerase 4 subunit A parC 0.0016
6226 DNA topoisomerase 4 subunit A parC 0.0016
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0016
1063 Signal transducer and activator of transcription 5B STAT5B 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0016
404 DNA gyrase subunit A gyrA 0.0016
6224 DNA gyrase subunit A gyrA 0.0016
295 Carbonic anhydrase 1 CA1 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
6182 Cytochrome P450 2J2 CYP2J2 0.0016
822 Aldose reductase AKR1B1 0.0016
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
2164 Multidrug resistance-associated protein 4 ABCC4 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
765 Indoleamine 2,3-dioxygenase IDO1 0.0015
251 Alcohol dehydrogenase 1A ADH1A 0.0015
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
571 Melatonin receptor type 1A MTNR1A 0.0014
362 Melatonin receptor type 1B MTNR1B 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0013
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0013
856 Vitamin D3 receptor VDR 0.0013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0013
484 Tyrosine-protein kinase ABL2 ABL2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0013
4192 DNA topoisomerase 2-beta TOP2B 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
6136 Multidrug resistance-associated protein 5 ABCC5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
4122 Histone deacetylase 2 HDAC2 0.0012
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
869 Estrogen receptor beta ESR2 0.0012
634 Squalene monooxygenase SQLE 0.0011
7196 Squalene monooxygenase ERG1 0.0011
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0011
908 Glutathione S-transferase theta-1 GSTT1 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
6102 Arylamine N-acetyltransferase 2 NAT2 0.0011
504 Mast/stem cell growth factor receptor KIT 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0011
1050 Bile salt sulfotransferase SULT2A1 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
3007 Carbonic anhydrase 12 CA12 0.0011
4205 Carbonic anhydrase 9 CA9 0.0011
6137 Multidrug resistance-associated protein 6 ABCC6 0.0011
4120 NADPH--cytochrome P450 reductase POR 0.0011
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0011
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0011
6126 Carbonic anhydrase 7 CA7 0.001
780 Retinoic acid receptor RXR-gamma RXRG 0.001
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
369 Coagulation factor VII F7 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.001
345 Plasma retinol-binding protein RBP4 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
88 Retinoic acid receptor RXR-beta RXRB 0.0009
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
260 Cytochrome P450 51 ERG11 0.0009
761 Cytochrome P450 51 ERG11 0.0009
3163 Cytochrome P450 51 cyp51 0.0009
3957 Adenosine deaminase ADA 0.0009
162 Retinoic acid receptor gamma-1 RARG 0.0009
904 Glutathione S-transferase P GSTP1 0.0009
469 Annexin A1 ANXA1 0.0009
6020 Aldehyde oxidase AOX1 0.0009
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
592 Carbonic anhydrase 4 CA4 0.0008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0008
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0008
737 Mineralocorticoid receptor NR3C2 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0008
239 Coagulation factor X F10 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
614 Progesterone receptor PGR 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
164 Histamine H4 receptor HRH4 0.0007
275 Arachidonate 5-lipoxygenase ALOX5 0.0007
4604 Liver carboxylesterase 1 CES1 0.0006
54 Prothrombin F2 0.0006
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
357 Carbonic anhydrase 2 CA2 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0006
528 5-hydroxytryptamine 1E receptor HTR1E 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0005
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0005
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0005
725 5-hydroxytryptamine 1D receptor HTR1D 0.0004
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