DT-Web

DB00571 - Propranolol


Identification
Name Propranolol
Accession Number DB00571 (APRD00194)
Type small molecule
Description A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 259.3434
Groups approved
Monoisotopic Weight 259.157228921
Pharmacology
Indication For the prophylaxis of migraine.
Mechanism of action Propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.
Absorption Propranolol is almost completely absorbed from the GI tract; however, plasma concentrations attained are quite variable among individuals.
Protein binding More than 90%
Biotransformation Hepatic
Route of elimination Propranolol is extensively metabolized with most metabolites appearing in the urine.
Toxicity Symptoms of overdose include bradycardia, cardiac failure, hypotension, and brochospasm. LD50=565 mg/kg (orally in mice).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetohexamide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Aminophylline Antagonism of action and increased effect of theophylline
Bromazepam Co-administration with propranolol will cause a reduction in bromazepam clearance and increases half-life.
Chlorpromazine Increased effect of both drugs
Chlorpropamide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Cimetidine Cimetidine may increase the serum concentration of propranolol by decreasing its metabolism.
Citalopram The SSRI, citalopram, may increase the bradycardic effect of the beta-blocker, propranolol.
Clonidine Increased hypertension when clonidine stopped
Dihydroergotamine Ischemia with risk of gangrene
Dihydroergotoxine Ischemia with risk of gangrene
Diltiazem Increased risk of bradycardia
Disopyramide The beta-blocker, propranolol, may increase the toxicity of disopyramide.
Dronedarone Propranolol is a CYP2D6 substrate and because dronedarone inhibits this enzyme, will increase propranolol exposure 1.3-fold. Lower dose of metoprolol.
Dyphylline Antagonism of action and increased effect of theophylline
Epinephrine Hypertension, then bradycardia
Ergonovine Ischemia with risk of gangrene
Ergotamine Ischemia with risk of gangrene
Escitalopram The SSRI, escitalopram, may increase the bradycardic effect of the beta-blocker, propranolol.
Fenoterol Antagonism
Fluoxetine The SSRI, fluoxetine, may increase the bradycardic effect of the beta-blocker, propranolol.
Formoterol Antagonism
Gliclazide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Glipizide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Glisoxepide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Glyburide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Glycodiazine The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Haloperidol Increased effect of both drugs
Hydralazine Increased effect of both drugs
Ibuprofen Risk of inhibition of renal prostaglandins
Indacaterol Beta-adrenergic antagonists, especially those that are not cardioselective, may interfere with the effect of indacaterol when administered concurrently. Beta-blockers may exacerbate bronchospasms in patients with COPD.
Indomethacin Risk of inhibition of renal prostaglandins
Insulin Glargine The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Isoproterenol Antagonism
Lidocaine The beta-blocker, propranolol, may increase the effect and toxicity of lidocaine.
Maprotiline Propranolol increases the serum levels of cisapride
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methyldopa Possible hypertensive crisis
Methysergide Ischemia with risk of gangrene
Orciprenaline Antagonism
Oxtriphylline Antagonism of action and increased effect of theophylline
Paroxetine The SSRI, paroxetine, may increase the bradycardic effect of the beta-blocker, propranolol.
Phenobarbital The barbiturate decreases the effect of the metabolized beta-blocker
Pipobroman Antagonism
Pirbuterol Antagonism
Piroxicam Risk of inhibition of renal prostaglandins
Prazosin Risk of hypotension at the beginning of therapy
Primidone The barbiturate decreases the effect of metabolized beta-blocker
Procaterol Antagonism
Propafenone Propafenone may increase the effect of the beta-blocker, propranolol.
Repaglinide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin Rifampin may decrease the serum concentration of propranolol by increasing its metabolism.
Rizatriptan Propranolol increases the effect and toxicity of rizatriptan
Salbutamol Antagonism
Salmeterol Antagonism
Sertraline The SSRI, sertraline, may increase the bradycardic effect of the beta-blocker, propranolol.
Terazosin Increased risk of hypotension. Initiate concomitant therapy cautiously.
Terbinafine Terbinafine may reduce the metabolism and clearance of Propranolol. Consider alternate therapy or monitor for therapeutic/adverse effects of Propranolol if Terbinafine is initiated, discontinued or dose changed.
Terbutaline Antagonism
Theophylline Antagonism of action and increased effect of theophylline
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Tolazamide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Tolbutamide The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Topotecan The p-glycoprotein inhibitor, Propranolol, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Verapamil Increased effect of both drugs
Food Interactions
  • Take with food.
  • Avoid alcohol.
  • Avoid natural licorice.

Targets


Beta-1 adrenergic receptor
Name Beta-1 adrenergic receptor
Gene Name ADRB1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Lewis CJ, Gong H, Brown MJ, Harding SE: Overexpression of beta 1-adrenoceptors in adult rat ventricular myocytes enhances CGP 12177A cardiostimulation: implications for 'putative' beta 4-adrenoceptor pharmacology. Br J Pharmacol. 2004 Mar;141(5):813-24. Epub 2004 Feb 2. - Pubmed
  • Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. - Pubmed
  • Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. - Pubmed
  • Rezmann-Vitti LA, Louis SN, Nero TL, Jackman GP, Machida CA, Louis WJ: Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding. Eur J Med Chem. 2004 Jul;39(7):625-31. - Pubmed
  • Yazawa K, Wang JW, Hao LY, Onoue Y, Kameyama M: Verrucotoxin, a stonefish venom, modulates calcium channel activity in guinea-pig ventricular myocytes. Br J Pharmacol. 2007 Aug;151(8):1198-203. Epub 2007 Jun 18. - Pubmed
DTHybrid score 0.964
Beta-2 adrenergic receptor
Name Beta-2 adrenergic receptor
Gene Name ADRB2
Pharmacological action unknown
Actions antagonist
References
  • Isaza C, Henao J, Ramirez E, Cuesta F, Cacabelos R: Polymorphic variants of the beta2-adrenergic receptor (ADRB2) gene and ADRB2-related propanolol-induced dyslipidemia in the Colombian population. Methods Find Exp Clin Pharmacol. 2005 May;27(4):237-44. - Pubmed
  • Rouget C, Barthez O, Goirand F, Leroy MJ, Breuiller-Fouche M, Rakotoniaina Z, Guerard P, Morcillo EJ, Advenier C, Sagot P, Cabrol D, Dumas M, Bardou M: Stimulation of the ADRB3 adrenergic receptor induces relaxation of human placental arteries: influence of preeclampsia. Biol Reprod. 2006 Jan;74(1):209-16. Epub 2005 Sep 21. - Pubmed
  • Illingworth CJ, Gooding SR, Winn PJ, Jones GA, Ferenczy GG, Reynolds CA: Classical polarization in hybrid QM/MM methods. J Phys Chem A. 2006 May 25;110(20):6487-97. - Pubmed
  • Horinouchi T, Morishima S, Tanaka T, Suzuki F, Tanaka Y, Koike K, Miwa S, Muramatsu I: Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. Epub 2007 Jun 16. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9691
Beta-3 adrenergic receptor
Name Beta-3 adrenergic receptor
Gene Name ADRB3
Pharmacological action unknown
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Berg T, Piercey BW, Jensen J: Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats. Hypertension. 2010 May;55(5):1224-30. Epub 2010 Mar 15. - Pubmed
DTHybrid score 0.4772
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions other/unknown
References
  • Smejkal-Jagar L, Boranic M: Serotonin and serotoninergic agents affect proliferation of normal and transformed lymphoid cells. Immunopharmacol Immunotoxicol. 1995 Feb;17(1):151-62. - Pubmed
DTHybrid score 0.3892
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions other/unknown
References
  • Bailey SR, Elliott J: Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins. Eur J Pharmacol. 1998 Aug 21;355(2-3):175-87. - Pubmed
  • Choppin A, O'Connor SE: Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. Br J Pharmacol. 1995 Jan;114(2):309-14. - Pubmed
DTHybrid score 0.2864

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5109
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. - Pubmed
DTHybrid score 0.7812
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3988
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. - Pubmed
  • Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Carrillo JA, Benitez J: Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. - Pubmed
  • Masubuchi Y, Hosokawa S, Horie T, Suzuki T, Ohmori S, Kitada M, Narimatsu S: Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. - Pubmed
DTHybrid score 0.6248
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.501
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9292
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3508

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Dudley AJ, Bleasby K, Brown CD: The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9. - Pubmed
DTHybrid score 0.2523
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • D'Emanuele A, Jevprasesphant R, Penny J, Attwood D: The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release. 2004 Mar 24;95(3):447-53. - Pubmed
DTHybrid score 0.6271

Carriers


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions
References Not Available
DTHybrid score 0.2523
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6271

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.4053
4924 Cytochrome P450 2C8 CYP2C8 0.2854
6030 Cytochrome P450 2B6 CYP2B6 0.2092
6013 Cytochrome P450 2E1 CYP2E1 0.2038
556 Alpha-1A adrenergic receptor ADRA1A 0.1966
318 Alpha-2A adrenergic receptor ADRA2A 0.1798
6145 Solute carrier family 22 member 1 SLC22A1 0.178
587 Serum albumin ALB 0.176
725 5-hydroxytryptamine 1D receptor HTR1D 0.1624
502 5-hydroxytryptamine 2A receptor HTR2A 0.1579
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1494
831 D(2) dopamine receptor DRD2 0.1465
5718 Cytochrome P450 2A6 CYP2A6 0.141
629 Alpha-2B adrenergic receptor ADRA2B 0.1351
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1308
378 Alpha-2C adrenergic receptor ADRA2C 0.1298
492 Histamine H1 receptor HRH1 0.123
632 Alpha-1B adrenergic receptor ADRA1B 0.1217
824 Sodium-dependent serotonin transporter SLC6A4 0.1212
23 D(1A) dopamine receptor DRD1 0.1091
590 5-hydroxytryptamine 2C receptor HTR2C 0.1058
3941 Amine oxidase [flavin-containing] A MAOA 0.1048
638 D(3) dopamine receptor DRD3 0.0958
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0955
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0929
789 Alpha-1D adrenergic receptor ADRA1D 0.0876
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0874
862 Multidrug resistance-associated protein 1 ABCC1 0.0856
20 Prostaglandin G/H synthase 1 PTGS1 0.0852
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0842
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0833
6106 Cytochrome P450 2C18 CYP2C18 0.0818
118 Organic cation/carnitine transporter 2 SLC22A5 0.0804
432 D(4) dopamine receptor DRD4 0.0791
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0786
6147 Solute carrier family 22 member 3 SLC22A3 0.0782
1898 Cytochrome P450 1B1 CYP1B1 0.0773
511 5-hydroxytryptamine 1F receptor HTR1F 0.0767
436 5-hydroxytryptamine 2B receptor HTR2B 0.0762
3923 Cholinesterase BCHE 0.0741
713 Sodium-dependent dopamine transporter SLC6A3 0.072
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0673
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0658
1729 Solute carrier family 22 member 6 SLC22A6 0.0639
716 5-hydroxytryptamine 7 receptor HTR7 0.0628
163 D(1B) dopamine receptor DRD5 0.0616
341 5-hydroxytryptamine 3 receptor HTR3A 0.0604
776 Bile salt export pump ABCB11 0.0584
847 Mu-type opioid receptor OPRM1 0.0581
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0572
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0538
777 Tumor necrosis factor TNF 0.0527
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0524
3811 Cytochrome P450 19A1 CYP19A1 0.0517
833 Organic cation/carnitine transporter 1 SLC22A4 0.0512
1820 Beta-nerve growth factor NGF 0.0512
6142 Solute carrier family 22 member 8 SLC22A8 0.047
871 Glucocorticoid receptor NR3C1 0.0468
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0447
3939 Amine oxidase [flavin-containing] B MAOB 0.0447
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0447
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0422
465 Calmodulin CALM1 0.0404
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0399
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0399
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0398
817 DNA topoisomerase 2-alpha TOP2A 0.0397
290 Prostaglandin G/H synthase 2 PTGS2 0.0393
6143 Solute carrier family 22 member 7 SLC22A7 0.0385
6031 Cytochrome P450 3A43 CYP3A43 0.0385
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.038
731 HIV-1 protease HIV-1 protease 0.0379
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0378
467 Delta-type opioid receptor OPRD1 0.0375
136 Estrogen receptor ESR1 0.037
828 Phenylalanine-4-hydroxylase PAH 0.037
3109 Phenylalanine-4-hydroxylase phhA 0.037
696 Kappa-type opioid receptor OPRK1 0.0366
1256 5-hydroxytryptamine 6 receptor HTR6 0.036
124 Histamine H2 receptor HRH2 0.0358
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0351
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0332
2164 Multidrug resistance-associated protein 4 ABCC4 0.0332
94 5-hydroxytryptamine 4 receptor HTR4 0.033
468 Cytochrome P450 4A11 CYP4A11 0.0328
528 5-hydroxytryptamine 1E receptor HTR1E 0.0328
260 Cytochrome P450 51 ERG11 0.0326
761 Cytochrome P450 51 ERG11 0.0326
3163 Cytochrome P450 51 cyp51 0.0326
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0325
844 Epidermal growth factor receptor EGFR 0.0322
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.032
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0315
477 DNA topoisomerase 4 subunit A parC 0.0309
886 DNA topoisomerase 4 subunit A parC 0.0309
6226 DNA topoisomerase 4 subunit A parC 0.0309
404 DNA gyrase subunit A gyrA 0.0304
6224 DNA gyrase subunit A gyrA 0.0304
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0299
2300 Lysozyme E 0.0297
3633 Lysozyme R 0.0297
5597 Lysozyme 17 0.0297
6148 Multidrug resistance-associated protein 7 ABCC10 0.0296
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0293
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0288
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0287
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0287
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.028
131 Synaptic vesicular amine transporter SLC18A2 0.028
6182 Cytochrome P450 2J2 CYP2J2 0.0278
1176 Mitogen-activated protein kinase 1 MAPK1 0.0277
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.027
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0264
36 Insulin receptor INSR 0.0258
3810 Catechol O-methyltransferase COMT 0.0252
614 Progesterone receptor PGR 0.0248
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0246
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0242
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0241
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0241
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0235
380 Cytochrome P450 17A1 CYP17A1 0.0224
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0223
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0222
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0219
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0219
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0217
1024 Solute carrier family 22 member 11 SLC22A11 0.0212
3876 Aromatic-L-amino-acid decarboxylase DDC 0.021
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0207
504 Mast/stem cell growth factor receptor KIT 0.0205
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0205
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0204
737 Mineralocorticoid receptor NR3C2 0.0203
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0203
6137 Multidrug resistance-associated protein 6 ABCC6 0.02
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0198
6014 Cytochrome P450 2A13 CYP2A13 0.0196
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0195
1757 Myeloperoxidase MPO 0.0192
474 Acetylcholinesterase ACHE 0.0191
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0189
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0188
1656 CYP2B protein CYP2B 0.0187
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
228 Beta platelet-derived growth factor receptor PDGFRB 0.0183
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0183
756 Sex hormone-binding globulin SHBG 0.0182
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
3947 Xanthine dehydrogenase/oxidase XDH 0.0181
146 Androgen receptor AR 0.018
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0179
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0179
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0178
6220 Aryl hydrocarbon receptor AHR 0.0178
6141 Sodium/bile acid cotransporter SLC10A1 0.0176
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0175
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0175
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0174
6136 Multidrug resistance-associated protein 5 ABCC5 0.0174
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0173
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0173
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0173
2449 Tubulin alpha-3 chain TUBA1A 0.017
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.017
122 P2Y purinoceptor 12 P2RY12 0.0167
232 Corticosteroid-binding globulin SERPINA6 0.0166
818 50S ribosomal protein L10 rplJ 0.0165
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0164
4604 Liver carboxylesterase 1 CES1 0.0162
161 Tubulin beta chain TUBB 0.016
312 Tubulin beta chain TUB2 0.016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0158
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0158
4120 NADPH--cytochrome P450 reductase POR 0.0157
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0156
26 Vascular endothelial growth factor receptor 3 FLT4 0.0152
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0152
1010 Cytochrome P450 51A1 CYP51A1 0.0152
4203 Histamine N-methyltransferase HNMT 0.0151
7 Nitric oxide synthase, inducible NOS2 0.0149
183 Vascular endothelial growth factor A VEGFA 0.0149
6432 Transporter snf 0.0149
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0145
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0145
32 Vascular endothelial growth factor receptor 1 FLT1 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
768 FK506-binding protein 1A FKBP1A 0.0143
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0143
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0142
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0142
407 Vascular endothelial growth factor receptor 2 KDR 0.0139
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0139
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0138
1178 Adenosine A2a receptor ADORA2A 0.0138
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0138
811 Translocator protein TSPO 0.0136
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0136
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0135
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0135
16 Adenosine A1 receptor ADORA1 0.0134
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0134
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0134
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0133
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0132
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0132
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0132
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0132
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0131
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.013
869 Estrogen receptor beta ESR2 0.0129
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0129
1050 Bile salt sulfotransferase SULT2A1 0.0128
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
1618 High affinity nerve growth factor receptor NTRK1 0.0126
952 Dipeptidyl peptidase 4 DPP4 0.0124
4292 Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase lpxA 0.0124
723 Cytosolic phospholipase A2 PLA2G4A 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
4773 Deoxycytidine kinase DCK 0.0122
3076 Antigen 85-C fbpC 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0121
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.012
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.012
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.012
6151 Monocarboxylate transporter 10 SLC16A10 0.0119
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0119
738 Monocarboxylate transporter 1 SLC16A1 0.0118
1192 Sulfotransferase 1A1 SULT1A1 0.0118
48 Pyridoxal kinase PDXK 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0114
373 Transthyretin TTR 0.0114
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0112
29 Tubulin beta-1 chain TUBB1 0.0111
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.011
571 Melatonin receptor type 1A MTNR1A 0.011
362 Melatonin receptor type 1B MTNR1B 0.011
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.011
2112 Toll-like receptor 9 TLR9 0.0109
6020 Aldehyde oxidase AOX1 0.0109
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0108
427 Substance-P receptor TACR1 0.0107
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0107
4237 50S ribosomal protein L22 rplV 0.0106
70 Type-1 angiotensin II receptor AGTR1 0.0103
1374 Natriuretic peptides B NPPB 0.0102
1827 Gap junction alpha-1 protein GJA1 0.0102
1908 Vascular cell adhesion protein 1 VCAM1 0.0102
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0102
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0101
1770 Phospholipase C PLCL1 0.0101
2841 Phospholipase C plc 0.0101
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.01
1629 Transcription factor AP-1 JUN 0.01
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.01
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.01
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0099
976 Platelet glycoprotein IX GP9 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
3932 Glutathione S-transferase A2 GSTA2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0097
6102 Arylamine N-acetyltransferase 2 NAT2 0.0096
273 Apoptosis regulator Bcl-2 BCL2 0.0095
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0094
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0094
4238 50S ribosomal protein L4 rplD 0.0094
5578 50S ribosomal protein L4 rplD 0.0094
6173 50S ribosomal protein L4 rplD 0.0094
6219 50S ribosomal protein L4 rplD 0.0094
4122 Histone deacetylase 2 HDAC2 0.0094
6847 Lactase-phlorizin hydrolase LCT 0.0093
164 Histamine H4 receptor HRH4 0.0093
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0093
6146 High affinity copper uptake protein 1 SLC31A1 0.0092
1360 Sphingomyelin phosphodiesterase SMPD1 0.0092
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0091
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0091
33 Cystine/glutamate transporter SLC7A11 0.009
814 Ryanodine receptor 1 RYR1 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
4311 tRNA TRDMT1 0.009
4325 tRNA trmD 0.009
4328 tRNA trmD 0.009
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0089
904 Glutathione S-transferase P GSTP1 0.0088
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0085
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0084
165 FL cytokine receptor FLT3 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
239 Coagulation factor X F10 0.0084
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0084
823 Fibroblast growth factor receptor 2 FGFR2 0.0084
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0083
1864 RET proto-oncogene RET 0.0083
5787 Angiopoietin-1 receptor TEK 0.0083
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0083
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0082
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0082
68 Cannabinoid receptor 1 CNR1 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
295 Carbonic anhydrase 1 CA1 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
1852 Microtubule-associated protein 2 MAP2 0.0079
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0079
705 Glutamate receptor 1 GRIA1 0.0079
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0079
173 Toll-like receptor 7 TLR7 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0076
469 Annexin A1 ANXA1 0.0076
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
6043 Putative G-protein coupled receptor 44 GPR44 0.0073
751 Potassium channel subfamily K member 6 KCNK6 0.0072
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0072
5300 Antigen peptide transporter 1 TAP1 0.0072
4192 DNA topoisomerase 2-beta TOP2B 0.0072
6070 Nischarin NISCH 0.0071
84 Nuclear receptor 0B1 NR0B1 0.0071
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.007
592 Carbonic anhydrase 4 CA4 0.007
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.007
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.007
319 Opioid receptor, sigma 1 OPRS1 0.0069
908 Glutathione S-transferase theta-1 GSTT1 0.0069
6044 Serum paraoxonase/lactonase 3 PON3 0.0068
284 DNA-directed RNA polymerase beta chain rpoB 0.0067
5773 DNA-directed RNA polymerase beta chain rpoB 0.0067
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0067
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0067
820 Glycine receptor subunit alpha-2 GLRA2 0.0066
172 Potassium channel subfamily K member 1 KCNK1 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0066
4102 Proteasome subunit beta type 5 PSMB5 0.0066
4101 Proteasome subunit beta type 1 PSMB1 0.0066
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0066
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0066
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0065
1830 5'-nucleotidase NT5E 0.0065
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
153 Dopamine beta-hydroxylase DBH 0.0064
921 Glutamate receptor 2 GRIA2 0.0064
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6085 Fatty acid-binding protein, intestinal FABP2 0.0063
365 Dihydrofolate reductase DHFR 0.0062
2381 Dihydrofolate reductase DFR1 0.0062
2833 Dihydrofolate reductase Not Available 0.0062
2931 Dihydrofolate reductase folA 0.0062
3544 Dihydrofolate reductase folA 0.0062
3682 Dihydrofolate reductase folA 0.0062
6642 Dihydrofolate reductase folA 0.0062
6756 Dihydrofolate reductase dfrA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0061
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0061
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.006
856 Vitamin D3 receptor VDR 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0059
5934 Cytochrome P450 26A1 CYP26A1 0.0059
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0059
694 Matrix protein 2 M 0.0059
5923 Microtubule-associated protein tau MAPT 0.0059
5924 Microtubule-associated protein 4 MAP4 0.0059
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0058
174 Sigma 1-type opioid receptor SIGMAR1 0.0058
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0058
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0058
1483 Membrane copper amine oxidase AOC3 0.0057
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0056
106 Cannabinoid receptor 2 CNR2 0.0056
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0055
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
6163 Copper-transporting ATPase 2 ATP7B 0.0055
6165 Copper-transporting ATPase 1 ATP7A 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
1196 Complement decay-accelerating factor CD55 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
780 Retinoic acid receptor RXR-gamma RXRG 0.0055
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0054
275 Arachidonate 5-lipoxygenase ALOX5 0.0054
54 Prothrombin F2 0.0054
891 Dihydropteroate synthase folP 0.0054
5359 Dihydropteroate synthase folP 0.0054
7175 Dihydropteroate synthase sulI 0.0054
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0054
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
357 Carbonic anhydrase 2 CA2 0.0052
49 Endothelin B receptor EDNRB 0.0052
712 Tubulin alpha chain TUB1 0.0052
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
6211 Tubulin epsilon chain TUBE1 0.0052
6212 Tubulin gamma-1 chain TUBG1 0.0052
6210 Tubulin delta chain TUBD1 0.0052
233 Potassium channel subfamily K member 2 KCNK2 0.0052
896 Glutathione S-transferase Mu 1 GSTM1 0.0052
581 Cytochrome P450 2R1 CYP2R1 0.0051
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
3611 Cytidine deaminase cdd 0.005
3707 Cytidine deaminase cdd 0.005
4211 Cytidine deaminase CDA 0.005
1630 Integrin beta-2 ITGB2 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.0049
88 Retinoic acid receptor RXR-beta RXRB 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0049
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0048
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0048
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0048
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0048
3856 Fibroblast growth factor receptor 3 FGFR3 0.0048
936 Ephrin type-A receptor 2 EPHA2 0.0048
634 Squalene monooxygenase SQLE 0.0048
7196 Squalene monooxygenase ERG1 0.0048
2808 Chloramphenicol acetyltransferase 3 cat3 0.0047
3957 Adenosine deaminase ADA 0.0047
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0047
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
125 DNA polymerase beta POLB 0.0047
683 Potassium transporter GK0582 0.0047
1525 Heparin-binding growth factor 2 FGF2 0.0046
1341 Histamine H3 receptor HRH3 0.0046
3086 Plasmepsin-2 Not Available 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0046
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0046
6174 50S ribosomal protein L32 rpmF 0.0045
569 Retinal dehydrogenase 2 ALDH1A2 0.0045
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0044
1063 Signal transducer and activator of transcription 5B STAT5B 0.0044
6126 Carbonic anhydrase 7 CA7 0.0044
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0044
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
3601 Dihydropteroate synthase 1 folP1 0.0043
3807 Dihydropteroate synthase 1 folP1 0.0043
3808 Dihydropteroate synthase 2 folP2 0.0043
2472 Voltage-gated potassium channel kcsA 0.0043
6366 Voltage-gated potassium channel kcsA 0.0043
2417 Chloramphenicol acetyltransferase cat 0.0043
3278 Chloramphenicol acetyltransferase cat 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
4217 Telomerase reverse transcriptase TERT 0.0043
2810 Dr hemagglutinin structural subunit draA 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
611 Retinal dehydrogenase 1 ALDH1A1 0.0042
6149 Solute carrier family 22 member 10 SLC22A10 0.0041
518 Peroxidase/catalase T katG 0.0041
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3809 Estrogen-related receptor gamma ESRRG 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6167 Organic solute transporter subunit beta OSTB 0.004
6166 Organic solute transporter subunit alpha OSTA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
162 Retinoic acid receptor gamma-1 RARG 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
267 Plasminogen activator inhibitor 1 SERPINE1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
484 Tyrosine-protein kinase ABL2 ABL2 0.0039
5626 Nucleoside diphosphate kinase B NME2 0.0039
563 Thyroid peroxidase TPO 0.0038
719 Retinoic acid receptor responder protein 1 RARRES1 0.0038
770 Retinoic acid-induced protein 3 GPRC5A 0.0038
1992 Vitamin D-binding protein GC 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
85 Growth hormone receptor GHR 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0037
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0037
572 Integrin alpha-L ITGAL 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
527 Prostacyclin receptor PTGIR 0.0036
3830 Calreticulin CALR 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
702 UMP-CMP kinase CMPK1 0.0035
672 Prostaglandin F2-alpha receptor PTGFR 0.0035
5126 Arginase rocF 0.0035
6048 Troponin C, skeletal muscle TNNC2 0.0035
6221 Steroid hormone receptor ERR1 ESRRA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
6034 Hydroxyindole O-methyltransferase ASMT 0.0034
6035 Nuclear receptor ROR-beta RORB 0.0034
6036 Eosinophil peroxidase EPX 0.0034
251 Alcohol dehydrogenase 1A ADH1A 0.0033
2320 Thymidine kinase, cytosolic TK1 0.0033
65 Matrix metalloproteinase-9 Not Available 0.0033
444 Alcohol dehydrogenase 1B ADH1B 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6111 DNA polymerase epsilon subunit 4 POLE4 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6112 DNA polymerase epsilon subunit 3 POLE3 0.0031
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0031
6110 DNA polymerase epsilon subunit 2 POLE2 0.0031
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
342 P protein [Includes: DNA-directed DNA polymerase P 0.003
612 P protein [Includes: DNA-directed DNA polymerase P 0.003
3937 Fatty-acid amide hydrolase FAAH 0.003
6171 Solute carrier family 28 member 3 SLC28A3 0.003
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
765 Indoleamine 2,3-dioxygenase IDO1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
1275 Estrogen sulfotransferase SULT1E1 0.0029
6218 Pannexin-1 PANX1 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
624 Guanidinoacetate N-methyltransferase GAMT 0.0027
517 Alcohol dehydrogenase 1C ADH1C 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
1648 Elastin ELN 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
6859 Protein S100-A4 S100A4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
2981 Phospholipase A2, membrane associated PLA2G2A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
603 DNA polymerase alpha catalytic subunit POLA1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0023
822 Aldose reductase AKR1B1 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
489 Monocarboxylate transporter 2 SLC16A7 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.002
1039 Histone deacetylase 9 HDAC9 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
5682 Ribonuclease pancreatic RNASE1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0019
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
277 Purine nucleoside phosphorylase PNP 0.0018
2870 Purine nucleoside phosphorylase punA 0.0018
2945 Purine nucleoside phosphorylase punA 0.0018
4659 Purine nucleoside phosphorylase TM_1596 0.0018
4825 Purine nucleoside phosphorylase TTHA1435 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
229 Retinoic acid receptor beta RARB 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
798 Osteocalcin BGLAP 0.0016
1243 Cathepsin D CTSD 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
369 Coagulation factor VII F7 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
2021 Thrombomodulin THBD 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2207 Rhodopsin RHO 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6677 Myelin P2 protein PMP2 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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