DT-Web

DB00575 - Clonidine


Identification
Name Clonidine
Accession Number DB00575 (APRD00174, DB07566)
Type small molecule
Description Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 230.094
Groups approved
Monoisotopic Weight 229.017352717
Pharmacology
Indication May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD).
Mechanism of action See Pharmacology section above.
Absorption Well absorbed following oral administration. Bioavailability following chronic administration is approximately 65%.
Protein binding 20-40%, primarily to albumin
Biotransformation Hepatic. Metabolized via minor pathways. The major metabolite, p-hydroxyclonidine, is present in concentrations less than 10% of those of unchanged clonidine in urine. Four metabolites have been detected, but only p-hydroxyclonidine has been identified.
Route of elimination Not Available
Toxicity Oral LD50 is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Increased hypertension when clonidine stopped
Amitriptyline The tricyclic antidepressant, amitriptyline, decreases the effect of clonidine.
Amoxapine The tricyclic antidepressant, amoxapine, decreases the effect of clonidine.
Atenolol Increased hypertension when clonidine stopped
Betaxolol Increased hypertension when clonidine stopped
Bevantolol Increased hypertension when clonidine stopped
Bisoprolol Increased hypertension when clonidine stopped
Carteolol Increased hypertension when clonidine stopped
Carvedilol Increased hypertension when clonidine stopped
Clomipramine The tricyclic antidepressant, clomipramine, may decrease the effect of clonidine.
Desipramine The tricyclic antidepressant, desipramine, decreases the effect of clonidine.
Doxepin The tricyclic antidepressant, doxepin, decreases the effect of clonidine.
Esmolol Increased hypertension when clonidine stopped
Imipramine The tricyclic antidepressant, imipramine, decreases the effect of clonidine.
Labetalol Increased hypertension when clonidine stopped
Metoprolol Increased hypertension when clonidine stopped
Milnacipran Because Savella inhibits norepinephrine reuptake, co-administration with clonidine may inhibit clonidine's anti-hypertensive effect.
Mirtazapine Possible hypertensive crisis
Nadolol Increased hypertension when clonidine stopped
Nortriptyline The tricyclic antidepressant, nortriptyline, decreases the effect of clonidine.
Oxprenolol Increased hypertension when clonidine stopped
Penbutolol Increased hypertension when clonidine stopped
Pindolol Increased hypertension when clonidine stopped
Practolol Increased hypertension when clonidine stopped
Propranolol Increased hypertension when clonidine stopped
Protriptyline The tricyclic antidepressant, protriptyline, decreases the effect of clonidine.
Sotalol Increased hypertension when clonidine stopped
Timolol Increased hypertension when clonidine stopped
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Trimipramine Trimipramine may reduce the antihypertensive effect of the alpha2-agonist, Clonidine. Trimipramine may also increase the rebound hypertensive effect of Clonidine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Clonidine if Trimipramine is initiated, discontinued or dose changed. Clonidine should be withdrawn very gradually to reduce the risk of hypertensive crisis.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Fairbanks CA, Stone LS, Kitto KF, Nguyen HO, Posthumus IJ, Wilcox GL: alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J Pharmacol Exp Ther. 2002 Jan;300(1):282-90. - Pubmed
  • Hein, L. (2004). α-Adrenergic system. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 27-30). Berlin, Germany: Springer. -
  • Lavand'homme PM, Ma W, De Kock M, Eisenach JC: Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology. 2002 Oct;97(4):972-80. - Pubmed
  • Ozdogan UK, Lahdesmaki J, Hakala K, Scheinin M: The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol. 2004 Aug 23;497(2):161-71. - Pubmed
  • Ozdogan UK, Lahdesmaki J, Mansikka H, Scheinin M: Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice. Eur J Pharmacol. 2004 Feb 6;485(1-3):193-6. - Pubmed
  • Wang XM, Zhang ZJ, Bains R, Mokha SS: Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat. Pain. 2002 Jul;98(1-2):27-35. - Pubmed
DTHybrid score 0.4744
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action yes
Actions agonist
References
  • Hein, L. (2004). α-Adrenergic system. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 27-30). Berlin, Germany: Springer. -
DTHybrid score 0.3269
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action yes
Actions agonist
References
  • Hein, L. (2004). α-Adrenergic system. In S. Offermanns, & W. Rosenthal (Eds.). _Encyclopedic reference of molecular pharmacology_ (pp. 27-30). Berlin, Germany: Springer. -
DTHybrid score 0.3285

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF: CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. Epub 2010 Jun 22. - Pubmed
DTHybrid score 0.6015
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF: CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. Epub 2010 Jun 22. - Pubmed
DTHybrid score 0.5435
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF: CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. Epub 2010 Jun 22. - Pubmed
DTHybrid score 0.7468
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF: CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. Epub 2010 Jun 22. - Pubmed
DTHybrid score 0.3002
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF: CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. Epub 2010 Jun 22. - Pubmed
DTHybrid score 0.3722

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
  • Martel F, Vetter T, Russ H, Grundemann D, Azevedo I, Koepsell H, Schomig E: Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):320-6. - Pubmed
DTHybrid score 0.3817
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions inhibitor
References
  • Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ, Leibach FH, Ganapathy V: Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. - Pubmed
  • Martel F, Grundemann D, Calhau C, Schomig E: Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jan;363(1):40-9. - Pubmed
DTHybrid score 0.2593
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score 0.3575
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.255
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score 0.4977

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.2816
6016 Cytochrome P450 2C19 CYP2C19 0.2679
6107 Cytochrome P450 3A7 CYP3A7 0.2409
556 Alpha-1A adrenergic receptor ADRA1A 0.2328
6144 Solute carrier family 22 member 2 SLC22A2 0.2306
4924 Cytochrome P450 2C8 CYP2C8 0.2056
6030 Cytochrome P450 2B6 CYP2B6 0.1723
6013 Cytochrome P450 2E1 CYP2E1 0.1682
502 5-hydroxytryptamine 2A receptor HTR2A 0.1641
831 D(2) dopamine receptor DRD2 0.1584
23 D(1A) dopamine receptor DRD1 0.154
492 Histamine H1 receptor HRH1 0.1435
320 5-hydroxytryptamine 1A receptor HTR1A 0.1407
632 Alpha-1B adrenergic receptor ADRA1B 0.1353
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1201
590 5-hydroxytryptamine 2C receptor HTR2C 0.1199
638 D(3) dopamine receptor DRD3 0.1173
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1119
5718 Cytochrome P450 2A6 CYP2A6 0.1102
163 D(1B) dopamine receptor DRD5 0.1051
725 5-hydroxytryptamine 1D receptor HTR1D 0.1045
766 Beta-2 adrenergic receptor ADRB2 0.1041
432 D(4) dopamine receptor DRD4 0.1031
587 Serum albumin ALB 0.1025
824 Sodium-dependent serotonin transporter SLC6A4 0.1025
885 5-hydroxytryptamine 1B receptor HTR1B 0.1011
789 Alpha-1D adrenergic receptor ADRA1D 0.1009
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0961
193 Beta-1 adrenergic receptor ADRB1 0.0949
1729 Solute carrier family 22 member 6 SLC22A6 0.0935
6142 Solute carrier family 22 member 8 SLC22A8 0.0924
862 Multidrug resistance-associated protein 1 ABCC1 0.0879
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0859
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0848
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0833
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0796
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0784
51 Muscarinic acetylcholine receptor M3 CHRM3 0.076
713 Sodium-dependent dopamine transporter SLC6A3 0.0742
1898 Cytochrome P450 1B1 CYP1B1 0.0722
436 5-hydroxytryptamine 2B receptor HTR2B 0.07
3941 Amine oxidase [flavin-containing] A MAOA 0.0643
716 5-hydroxytryptamine 7 receptor HTR7 0.0601
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0594
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0594
6106 Cytochrome P450 2C18 CYP2C18 0.0565
776 Bile salt export pump ABCB11 0.0564
20 Prostaglandin G/H synthase 1 PTGS1 0.0555
6070 Nischarin NISCH 0.0545
341 5-hydroxytryptamine 3 receptor HTR3A 0.0536
131 Synaptic vesicular amine transporter SLC18A2 0.0533
817 DNA topoisomerase 2-alpha TOP2A 0.0525
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0523
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.052
450 Muscarinic acetylcholine receptor M4 CHRM4 0.051
477 DNA topoisomerase 4 subunit A parC 0.0505
886 DNA topoisomerase 4 subunit A parC 0.0505
6226 DNA topoisomerase 4 subunit A parC 0.0505
3939 Amine oxidase [flavin-containing] B MAOB 0.0498
404 DNA gyrase subunit A gyrA 0.0497
6224 DNA gyrase subunit A gyrA 0.0497
3923 Cholinesterase BCHE 0.0494
3811 Cytochrome P450 19A1 CYP19A1 0.0479
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0473
1517 Beta-3 adrenergic receptor ADRB3 0.0466
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0435
6143 Solute carrier family 22 member 7 SLC22A7 0.0421
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0418
871 Glucocorticoid receptor NR3C1 0.0414
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0407
124 Histamine H2 receptor HRH2 0.0401
465 Calmodulin CALM1 0.0388
136 Estrogen receptor ESR1 0.0378
1024 Solute carrier family 22 member 11 SLC22A11 0.037
847 Mu-type opioid receptor OPRM1 0.0355
1256 5-hydroxytryptamine 6 receptor HTR6 0.0354
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0349
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0345
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0341
6020 Aldehyde oxidase AOX1 0.034
1636 Trace amine-associated receptor 1 TAAR1 0.0336
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0332
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.033
828 Phenylalanine-4-hydroxylase PAH 0.0325
3109 Phenylalanine-4-hydroxylase phhA 0.0325
474 Acetylcholinesterase ACHE 0.0323
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0318
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0311
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.031
2164 Multidrug resistance-associated protein 4 ABCC4 0.0304
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0303
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0301
731 HIV-1 protease HIV-1 protease 0.0298
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0297
6148 Multidrug resistance-associated protein 7 ABCC10 0.029
290 Prostaglandin G/H synthase 2 PTGS2 0.0288
467 Delta-type opioid receptor OPRD1 0.0287
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0282
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0282
696 Kappa-type opioid receptor OPRK1 0.028
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0278
6014 Cytochrome P450 2A13 CYP2A13 0.0277
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0274
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0273
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0267
6031 Cytochrome P450 3A43 CYP3A43 0.0267
528 5-hydroxytryptamine 1E receptor HTR1E 0.0262
36 Insulin receptor INSR 0.0258
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0257
3947 Xanthine dehydrogenase/oxidase XDH 0.025
468 Cytochrome P450 4A11 CYP4A11 0.0246
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
2472 Voltage-gated potassium channel kcsA 0.0241
6366 Voltage-gated potassium channel kcsA 0.0241
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0233
449 Ornithine decarboxylase ODC1 0.0233
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0232
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0226
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.022
1757 Myeloperoxidase MPO 0.0217
6182 Cytochrome P450 2J2 CYP2J2 0.0211
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0211
738 Monocarboxylate transporter 1 SLC16A1 0.0211
756 Sex hormone-binding globulin SHBG 0.0211
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
777 Tumor necrosis factor TNF 0.0208
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0207
4604 Liver carboxylesterase 1 CES1 0.0206
2429 Putrescine-binding periplasmic protein potF 0.0206
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0204
844 Epidermal growth factor receptor EGFR 0.0203
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0201
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0199
624 Guanidinoacetate N-methyltransferase GAMT 0.0198
6137 Multidrug resistance-associated protein 6 ABCC6 0.0197
614 Progesterone receptor PGR 0.0195
737 Mineralocorticoid receptor NR3C2 0.0195
6141 Sodium/bile acid cotransporter SLC10A1 0.0194
380 Cytochrome P450 17A1 CYP17A1 0.0193
161 Tubulin beta chain TUBB 0.0192
312 Tubulin beta chain TUB2 0.0192
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.019
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.019
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0189
5126 Arginase rocF 0.0188
159 Penicillin-binding protein 2B penA 0.0187
6121 Penicillin-binding protein 2B penA 0.0187
260 Cytochrome P450 51 ERG11 0.0184
761 Cytochrome P450 51 ERG11 0.0184
3163 Cytochrome P450 51 cyp51 0.0184
6151 Monocarboxylate transporter 10 SLC16A10 0.0184
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0183
164 Histamine H4 receptor HRH4 0.0182
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0181
4203 Histamine N-methyltransferase HNMT 0.0179
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0177
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
734 D1 dopamine receptor-interacting protein calcyon CALY 0.017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0169
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0167
6136 Multidrug resistance-associated protein 5 ABCC5 0.0167
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0167
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0167
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0164
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0163
146 Androgen receptor AR 0.0163
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0162
6010 Thiamine transporter 1 SLC19A2 0.0162
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0158
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0157
6432 Transporter snf 0.0157
3810 Catechol O-methyltransferase COMT 0.0156
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
504 Mast/stem cell growth factor receptor KIT 0.0151
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0151
6220 Aryl hydrocarbon receptor AHR 0.0151
869 Estrogen receptor beta ESR2 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0149
2449 Tubulin alpha-3 chain TUBA1A 0.0148
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0148
175 Thiamin pyrophosphokinase 1 TPK1 0.0146
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0144
976 Platelet glycoprotein IX GP9 0.0143
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0142
303 Diamine acetyltransferase 2 SAT2 0.0141
1317 Spermine synthase SMS 0.0141
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0141
5626 Nucleoside diphosphate kinase B NME2 0.0141
623 Spermine oxidase SMOX 0.0141
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0141
29 Tubulin beta-1 chain TUBB1 0.0139
4120 NADPH--cytochrome P450 reductase POR 0.0136
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0134
1341 Histamine H3 receptor HRH3 0.0132
818 50S ribosomal protein L10 rplJ 0.0131
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.013
122 P2Y purinoceptor 12 P2RY12 0.0129
2300 Lysozyme E 0.0129
3633 Lysozyme R 0.0129
5597 Lysozyme 17 0.0129
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0128
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0128
1178 Adenosine A2a receptor ADORA2A 0.0128
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0128
123 Diamine acetyltransferase 1 SAT1 0.0127
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0126
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0126
4773 Deoxycytidine kinase DCK 0.0126
228 Beta platelet-derived growth factor receptor PDGFRB 0.0124
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0124
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0124
16 Adenosine A1 receptor ADORA1 0.0124
633 Penicillin-binding proteins 1A/1B pbpA 0.0123
613 Atrial natriuretic peptide receptor A NPR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0121
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0121
1656 CYP2B protein CYP2B 0.0118
48 Pyridoxal kinase PDXK 0.0116
952 Dipeptidyl peptidase 4 DPP4 0.0116
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0114
5294 Nucleoside diphosphate kinase A NME1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.011
158 Sodium channel protein type 1 subunit alpha SCN1A 0.011
2112 Toll-like receptor 9 TLR9 0.0109
26 Vascular endothelial growth factor receptor 3 FLT4 0.0109
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0108
1010 Cytochrome P450 51A1 CYP51A1 0.0108
407 Vascular endothelial growth factor receptor 2 KDR 0.0107
1192 Sulfotransferase 1A1 SULT1A1 0.0106
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0106
769 High-affinity choline transporter 1 SLC5A7 0.0106
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0106
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0106
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0106
3927 Choline transporter-like protein 3 SLC44A3 0.0106
1686 Choline transporter-like protein 1 SLC44A1 0.0106
861 Choline kinase alpha CHKA 0.0106
3926 Choline transporter-like protein 2 SLC44A2 0.0106
700 Choline dehydrogenase, mitochondrial CHDH 0.0106
576 Choline O-acetyltransferase CHAT 0.0106
3925 Choline transporter-like protein 4 SLC44A4 0.0106
3922 Phospholipase D2 PLD2 0.0106
3924 Phospholipase D1 PLD1 0.0106
5682 Ribonuclease pancreatic RNASE1 0.0105
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0105
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0105
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0105
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0105
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0105
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0105
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0105
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0105
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0104
2539 Tubulin alpha-1 chain TUBA4A 0.0104
32 Vascular endothelial growth factor receptor 1 FLT1 0.0104
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0104
6138 Multidrug resistance protein 3 ABCB4 0.0104
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0103
153 Dopamine beta-hydroxylase DBH 0.0103
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0102
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0102
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0101
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0101
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0101
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0101
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0101
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0101
233 Potassium channel subfamily K member 2 KCNK2 0.0101
1353 DNA topoisomerase 1 TOP1 0.0101
3552 DNA topoisomerase 1 topA 0.0101
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
1360 Sphingomyelin phosphodiesterase SMPD1 0.0098
6146 High affinity copper uptake protein 1 SLC31A1 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0097
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0097
3932 Glutathione S-transferase A2 GSTA2 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0096
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0095
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0094
373 Transthyretin TTR 0.0093
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0093
33 Cystine/glutamate transporter SLC7A11 0.0093
904 Glutathione S-transferase P GSTP1 0.0093
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0092
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0092
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0091
672 Prostaglandin F2-alpha receptor PTGFR 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0089
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0089
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0089
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0089
499 Arginine decarboxylase ADC 0.0089
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
94 5-hydroxytryptamine 4 receptor HTR4 0.0088
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0088
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0087
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
4237 50S ribosomal protein L22 rplV 0.0087
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0087
3426 Glutamine synthetase glnA 0.0086
3987 Glutamine synthetase GLUL 0.0086
751 Potassium channel subfamily K member 6 KCNK6 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0085
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
577 Argininosuccinate lyase ASL 0.0085
6168 Solute carrier family 22 member 16 SLC22A16 0.0084
834 Arginase-2, mitochondrial ARG2 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
811 Translocator protein TSPO 0.0083
7 Nitric oxide synthase, inducible NOS2 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
908 Glutathione S-transferase theta-1 GSTT1 0.0082
70 Type-1 angiotensin II receptor AGTR1 0.0081
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.008
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.008
645 Penicillin-binding protein 1A mrcA 0.0079
5805 Penicillin-binding protein 1A ponA 0.0079
6185 Penicillin-binding protein 1A mrcA 0.0079
6799 Penicillin-binding protein 1A pbpA 0.0079
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0079
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0079
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0079
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0079
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0079
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0079
705 Glutamate receptor 1 GRIA1 0.0079
740 Argininosuccinate synthase ASS1 0.0079
865 Argininosuccinate synthase ASS1 0.0079
2680 Argininosuccinate synthase argG 0.0079
3194 Argininosuccinate synthase argG 0.0079
172 Potassium channel subfamily K member 1 KCNK1 0.0079
4122 Histone deacetylase 2 HDAC2 0.0079
173 Toll-like receptor 7 TLR7 0.0079
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0078
571 Melatonin receptor type 1A MTNR1A 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
814 Ryanodine receptor 1 RYR1 0.0078
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
4311 tRNA TRDMT1 0.0076
4325 tRNA trmD 0.0076
4328 tRNA trmD 0.0076
239 Coagulation factor X F10 0.0076
1629 Transcription factor AP-1 JUN 0.0076
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0075
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0074
6766 O-GlcNAcase BT_4395 BT_4395 0.0074
4238 50S ribosomal protein L4 rplD 0.0074
5578 50S ribosomal protein L4 rplD 0.0074
6173 50S ribosomal protein L4 rplD 0.0074
6219 50S ribosomal protein L4 rplD 0.0074
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0073
551 Carnitine O-acetyltransferase CRAT 0.0073
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0072
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0072
68 Cannabinoid receptor 1 CNR1 0.007
273 Apoptosis regulator Bcl-2 BCL2 0.0069
6165 Copper-transporting ATPase 1 ATP7A 0.0069
6163 Copper-transporting ATPase 2 ATP7B 0.0069
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
6043 Putative G-protein coupled receptor 44 GPR44 0.0069
823 Fibroblast growth factor receptor 2 FGFR2 0.0068
6102 Arylamine N-acetyltransferase 2 NAT2 0.0068
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
702 UMP-CMP kinase CMPK1 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0067
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0067
291 Nitric-oxide synthase, endothelial NOS3 0.0066
1618 High affinity nerve growth factor receptor NTRK1 0.0066
6085 Fatty acid-binding protein, intestinal FABP2 0.0066
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0065
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0065
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0064
1714 Mitogen-activated protein kinase 3 MAPK3 0.0064
1820 Beta-nerve growth factor NGF 0.0064
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0063
896 Glutathione S-transferase Mu 1 GSTM1 0.0063
295 Carbonic anhydrase 1 CA1 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
427 Substance-P receptor TACR1 0.0062
511 5-hydroxytryptamine 1F receptor HTR1F 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0061
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
165 FL cytokine receptor FLT3 0.0059
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0059
1830 5'-nucleotidase NT5E 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
1852 Microtubule-associated protein 2 MAP2 0.0058
6171 Solute carrier family 28 member 3 SLC28A3 0.0058
4103 Proteasome subunit beta type 2 PSMB2 0.0058
4102 Proteasome subunit beta type 5 PSMB5 0.0058
4101 Proteasome subunit beta type 1 PSMB1 0.0058
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0058
788 Creatine kinase M-type CKM 0.0057
284 DNA-directed RNA polymerase beta chain rpoB 0.0056
5773 DNA-directed RNA polymerase beta chain rpoB 0.0056
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0055
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0055
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0055
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
357 Carbonic anhydrase 2 CA2 0.0054
54 Prothrombin F2 0.0054
856 Vitamin D3 receptor VDR 0.0054
4192 DNA topoisomerase 2-beta TOP2B 0.0053
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
365 Dihydrofolate reductase DHFR 0.0052
2381 Dihydrofolate reductase DFR1 0.0052
2833 Dihydrofolate reductase Not Available 0.0052
2931 Dihydrofolate reductase folA 0.0052
3544 Dihydrofolate reductase folA 0.0052
3682 Dihydrofolate reductase folA 0.0052
6642 Dihydrofolate reductase folA 0.0052
6756 Dihydrofolate reductase dfrA 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0052
1050 Bile salt sulfotransferase SULT2A1 0.0052
712 Tubulin alpha chain TUB1 0.0052
1074 Urokinase-type plasminogen activator PLAU 0.0052
694 Matrix protein 2 M 0.0051
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0051
5300 Antigen peptide transporter 1 TAP1 0.0051
275 Arachidonate 5-lipoxygenase ALOX5 0.0051
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0051
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6044 Serum paraoxonase/lactonase 3 PON3 0.005
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.005
6167 Organic solute transporter subunit beta OSTB 0.0049
6166 Organic solute transporter subunit alpha OSTA 0.0049
84 Nuclear receptor 0B1 NR0B1 0.0049
6149 Solute carrier family 22 member 10 SLC22A10 0.0048
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0048
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0048
469 Annexin A1 ANXA1 0.0048
3856 Fibroblast growth factor receptor 3 FGFR3 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
3957 Adenosine deaminase ADA 0.0047
592 Carbonic anhydrase 4 CA4 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
780 Retinoic acid receptor RXR-gamma RXRG 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0046
319 Opioid receptor, sigma 1 OPRS1 0.0046
3086 Plasmepsin-2 Not Available 0.0046
3611 Cytidine deaminase cdd 0.0045
3707 Cytidine deaminase cdd 0.0045
4211 Cytidine deaminase CDA 0.0045
5934 Cytochrome P450 26A1 CYP26A1 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0044
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0044
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0044
1063 Signal transducer and activator of transcription 5B STAT5B 0.0044
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0044
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
482 Glycine receptor subunit alpha-1 GLRA1 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
106 Cannabinoid receptor 2 CNR2 0.0043
936 Ephrin type-A receptor 2 EPHA2 0.0043
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0042
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0042
88 Retinoic acid receptor RXR-beta RXRB 0.0042
581 Cytochrome P450 2R1 CYP2R1 0.0041
1374 Natriuretic peptides B NPPB 0.0041
1827 Gap junction alpha-1 protein GJA1 0.0041
1908 Vascular cell adhesion protein 1 VCAM1 0.0041
125 DNA polymerase beta POLB 0.0041
1864 RET proto-oncogene RET 0.0041
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
564 Cellular retinoic acid-binding protein 1 CRABP1 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
2236 Casein kinase II subunit alpha CSNK2A1 0.004
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
484 Tyrosine-protein kinase ABL2 ABL2 0.0039
174 Sigma 1-type opioid receptor SIGMAR1 0.0038
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
6218 Pannexin-1 PANX1 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
921 Glutamate receptor 2 GRIA2 0.0036
634 Squalene monooxygenase SQLE 0.0036
7196 Squalene monooxygenase ERG1 0.0036
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0036
5923 Microtubule-associated protein tau MAPT 0.0036
5924 Microtubule-associated protein 4 MAP4 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0035
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
569 Retinal dehydrogenase 2 ALDH1A2 0.0035
1483 Membrane copper amine oxidase AOC3 0.0035
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
611 Retinal dehydrogenase 1 ALDH1A1 0.0032
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0032
162 Retinoic acid receptor gamma-1 RARG 0.0032
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
1039 Histone deacetylase 9 HDAC9 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
6126 Carbonic anhydrase 7 CA7 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
3809 Estrogen-related receptor gamma ESRRG 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
1992 Vitamin D-binding protein GC 0.0029
1275 Estrogen sulfotransferase SULT1E1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
518 Peroxidase/catalase T katG 0.0028
489 Monocarboxylate transporter 2 SLC16A7 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
1630 Integrin beta-2 ITGB2 0.0027
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3830 Calreticulin CALR 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
770 Retinoic acid-induced protein 3 GPRC5A 0.0027
719 Retinoic acid receptor responder protein 1 RARRES1 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
563 Thyroid peroxidase TPO 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
1648 Elastin ELN 0.0026
444 Alcohol dehydrogenase 1B ADH1B 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
6859 Protein S100-A4 S100A4 0.0025
251 Alcohol dehydrogenase 1A ADH1A 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
6034 Hydroxyindole O-methyltransferase ASMT 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0025
6036 Eosinophil peroxidase EPX 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
400 Coagulation factor IX F9 0.0024
5461 Coagulation factor IX F9 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
822 Aldose reductase AKR1B1 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0022
604 Vitamin K-dependent protein Z PROZ 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
765 Indoleamine 2,3-dioxygenase IDO1 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1196 Complement decay-accelerating factor CD55 0.0022
298 Renin REN 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
572 Integrin alpha-L ITGAL 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6221 Steroid hormone receptor ERR1 ESRRA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
422 Vitamin K-dependent protein C PROC 0.002
1245 Vitamin K-dependent protein S PROS1 0.002
6122 Carbonic anhydrase 3 CA3 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
3587 Gastrotropin FABP6 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
229 Retinoic acid receptor beta RARB 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
760 Fibroblast growth factor 1 FGF1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
798 Osteocalcin BGLAP 0.0016
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
1243 Cathepsin D CTSD 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
369 Coagulation factor VII F7 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3904 Alanine aminotransferase 2 GPT2 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2207 Rhodopsin RHO 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6677 Myelin P2 protein PMP2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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