DT-Web

DB00344 - Protriptyline


Identification
Name Protriptyline
Accession Number DB00344 (APRD00441)
Type small molecule
Description Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 263.3767
Groups approved
Monoisotopic Weight 263.167399677
Pharmacology
Indication For the treatment of depression.
Mechanism of action Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Cumulative urinary excretion during 16 days accounted for approximately 50% of the drug. The fecal route of excretion did not seem to be important.
Toxicity Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal discomfort, sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if atazanavir if initiated, discontinued or dose changed.
Butabarbital Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like protriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as protriptyline. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Cimetidine Cimetidine may increase the effect of tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trimipramine if cimetidine is initiated, discontinued or dose changed.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clonidine The tricyclic antidepressant, protriptyline, decreases the effect of clonidine.
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Donepezil Possible antagonism of action
Epinephrine The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of epinephrine.
Fenoterol The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of fenoterol.
Fluoxetine The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of protriptyline if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of protriptyline if fluvoxamine is initiated, discontinued or dose changed.
Galantamine Possible antagonism of action
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine The tricyclic antidepressant, protriptyline, decreases the effect of guanethidine.
Isocarboxazid Possibility of severe adverse effects
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Moclobemide Possible severe adverse reaction with this combination
Orciprenaline The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of orciprenaline.
Phenelzine Possibility of severe adverse effects
Phenylephrine The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of phenylpropanolamine.
Pseudoephedrine The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of pseudoephedrine.
Quinidine Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Rasagiline Possibility of severe adverse effects
Rifabutin The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, protriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if rifabutin is initiated, discontinued or dose changed.
Rifampin The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, protriptyline, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if rifampin is initiated, discontinued or dose changed.
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Protriptyline, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Terbinafine Terbinafine may reduce the metabolism and clearance of Protriptyline. Consider alternate therapy or monitor for therapeutic/adverse effects of Protriptyline if Terbinafine is initiated, discontinued or dose changed.
Terbutaline The tricyclic antidepressant, protriptyline, increases the sympathomimetic effect of terbutaline.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Tramadol increases the risk of serotonin syndrome and seizures.
Tranylcypromine Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide Trimethobenzamide and Protriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine Triprolidine and Protriptyline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Protriptyline, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and protriptyline, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
  • Cheetham SC, Viggers JA, Butler SA, Prow MR, Heal DJ: [3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan;35(1):63-70. - Pubmed
DTHybrid score 0.4709
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • McDougle CJ, Epperson CN, Price LH, Gelernter J: Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder. Mol Psychiatry. 1998 May;3(3):270-3. - Pubmed
  • Rouillon F, Blachier C, Dreyfus JP, Bouhassira M, Allicar MP: [Pharmaco-epidemiologic study of the use of antidepressant drugs in the general population] Encephale. 1996 May;22 Spec No 1:39-48. - Pubmed
  • Frazer A, Daws LC: Serotonin transporter function in vivo: assessment by chronoamperometry. Ann N Y Acad Sci. 1998 Dec 15;861:217-29. - Pubmed
  • Daws LC, Toney GM, Gerhardt GA, Frazer A: In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. J Pharmacol Exp Ther. 1998 Aug;286(2):967-76. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
  • Kovachich GB, Aronson CE, Brunswick DJ: Effect of repeated administration of antidepressants on serotonin uptake sites in limbic and neocortical structures of rat brain determined by quantitative autoradiography. Neuropsychopharmacology. 1992 Dec;7(4):317-24. - Pubmed
DTHybrid score 0.3577

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3773

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
DTHybrid score 0.2876

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.229
713 Sodium-dependent dopamine transporter SLC6A3 0.1957
6016 Cytochrome P450 2C19 CYP2C19 0.115
4200 Cytochrome P450 1A2 CYP1A2 0.1097
4757 Cytochrome P450 2C9 CYP2C9 0.1069
556 Alpha-1A adrenergic receptor ADRA1A 0.0922
4118 Cytochrome P450 3A5 CYP3A5 0.0821
6030 Cytochrome P450 2B6 CYP2B6 0.0755
4924 Cytochrome P450 2C8 CYP2C8 0.0746
502 5-hydroxytryptamine 2A receptor HTR2A 0.0685
492 Histamine H1 receptor HRH1 0.0664
6107 Cytochrome P450 3A7 CYP3A7 0.0626
3941 Amine oxidase [flavin-containing] A MAOA 0.0564
590 5-hydroxytryptamine 2C receptor HTR2C 0.0553
6013 Cytochrome P450 2E1 CYP2E1 0.0538
103 Muscarinic acetylcholine receptor M1 CHRM1 0.053
318 Alpha-2A adrenergic receptor ADRA2A 0.0514
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0509
131 Synaptic vesicular amine transporter SLC18A2 0.0501
3939 Amine oxidase [flavin-containing] B MAOB 0.0462
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0405
193 Beta-1 adrenergic receptor ADRB1 0.0404
6024 Cytochrome P450 1A1 CYP1A1 0.0399
831 D(2) dopamine receptor DRD2 0.0399
766 Beta-2 adrenergic receptor ADRB2 0.039
632 Alpha-1B adrenergic receptor ADRA1B 0.0387
436 5-hydroxytryptamine 2B receptor HTR2B 0.0366
320 5-hydroxytryptamine 1A receptor HTR1A 0.0347
587 Serum albumin ALB 0.0327
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0319
5718 Cytochrome P450 2A6 CYP2A6 0.0307
6145 Solute carrier family 22 member 1 SLC22A1 0.0302
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0291
6144 Solute carrier family 22 member 2 SLC22A2 0.0281
274 Muscarinic acetylcholine receptor M5 CHRM5 0.027
629 Alpha-2B adrenergic receptor ADRA2B 0.0269
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0266
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0263
23 D(1A) dopamine receptor DRD1 0.0248
847 Mu-type opioid receptor OPRM1 0.0245
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0237
467 Delta-type opioid receptor OPRD1 0.0234
696 Kappa-type opioid receptor OPRK1 0.0227
789 Alpha-1D adrenergic receptor ADRA1D 0.0226
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0224
862 Multidrug resistance-associated protein 1 ABCC1 0.0223
118 Organic cation/carnitine transporter 2 SLC22A5 0.0219
6106 Cytochrome P450 2C18 CYP2C18 0.0213
378 Alpha-2C adrenergic receptor ADRA2C 0.0207
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0201
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0199
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0179
6182 Cytochrome P450 2J2 CYP2J2 0.0172
3923 Cholinesterase BCHE 0.017
6147 Solute carrier family 22 member 3 SLC22A3 0.0169
474 Acetylcholinesterase ACHE 0.0162
1656 CYP2B protein CYP2B 0.0153
1636 Trace amine-associated receptor 1 TAAR1 0.0152
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.015
20 Prostaglandin G/H synthase 1 PTGS1 0.0143
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0139
6432 Transporter snf 0.0136
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0132
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0131
341 5-hydroxytryptamine 3 receptor HTR3A 0.0131
1517 Beta-3 adrenergic receptor ADRB3 0.0131
833 Organic cation/carnitine transporter 1 SLC22A4 0.0131
776 Bile salt export pump ABCB11 0.013
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0125
1729 Solute carrier family 22 member 6 SLC22A6 0.0121
1898 Cytochrome P450 1B1 CYP1B1 0.012
871 Glucocorticoid receptor NR3C1 0.0117
885 5-hydroxytryptamine 1B receptor HTR1B 0.0114
465 Calmodulin CALM1 0.0111
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0109
638 D(3) dopamine receptor DRD3 0.0109
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0102
731 HIV-1 protease HIV-1 protease 0.0102
725 5-hydroxytryptamine 1D receptor HTR1D 0.0098
817 DNA topoisomerase 2-alpha TOP2A 0.0098
124 Histamine H2 receptor HRH2 0.0095
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0093
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0084
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0084
3811 Cytochrome P450 19A1 CYP19A1 0.0084
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0083
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0083
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0079
136 Estrogen receptor ESR1 0.0076
6142 Solute carrier family 22 member 8 SLC22A8 0.0075
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0073
6143 Solute carrier family 22 member 7 SLC22A7 0.0072
432 D(4) dopamine receptor DRD4 0.0072
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
94 5-hydroxytryptamine 4 receptor HTR4 0.0071
2164 Multidrug resistance-associated protein 4 ABCC4 0.007
844 Epidermal growth factor receptor EGFR 0.0068
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0068
4604 Liver carboxylesterase 1 CES1 0.0068
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0067
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0064
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0064
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0064
161 Tubulin beta chain TUBB 0.0063
312 Tubulin beta chain TUB2 0.0063
1192 Sulfotransferase 1A1 SULT1A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0063
380 Cytochrome P450 17A1 CYP17A1 0.0063
290 Prostaglandin G/H synthase 2 PTGS2 0.0062
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0062
319 Opioid receptor, sigma 1 OPRS1 0.0062
904 Glutathione S-transferase P GSTP1 0.0061
6148 Multidrug resistance-associated protein 7 ABCC10 0.0061
504 Mast/stem cell growth factor receptor KIT 0.0058
4120 NADPH--cytochrome P450 reductase POR 0.0058
952 Dipeptidyl peptidase 4 DPP4 0.0057
2112 Toll-like receptor 9 TLR9 0.0055
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0055
163 D(1B) dopamine receptor DRD5 0.0054
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0054
260 Cytochrome P450 51 ERG11 0.0053
761 Cytochrome P450 51 ERG11 0.0053
3163 Cytochrome P450 51 cyp51 0.0053
6137 Multidrug resistance-associated protein 6 ABCC6 0.0052
1757 Myeloperoxidase MPO 0.0052
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0052
174 Sigma 1-type opioid receptor SIGMAR1 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0052
614 Progesterone receptor PGR 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
2981 Phospholipase A2, membrane associated PLA2G2A 0.0049
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
482 Glycine receptor subunit alpha-1 GLRA1 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
2616 Ganglioside GM2 activator GM2A 0.0047
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0045
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0045
869 Estrogen receptor beta ESR2 0.0044
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0044
1360 Sphingomyelin phosphodiesterase SMPD1 0.0044
122 P2Y purinoceptor 12 P2RY12 0.0043
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0043
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0043
1618 High affinity nerve growth factor receptor NTRK1 0.0042
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0042
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0041
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0041
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0041
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0041
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0041
146 Androgen receptor AR 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.004
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0039
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0038
228 Beta platelet-derived growth factor receptor PDGFRB 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
468 Cytochrome P450 4A11 CYP4A11 0.0037
373 Transthyretin TTR 0.0037
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
407 Vascular endothelial growth factor receptor 2 KDR 0.0037
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0037
777 Tumor necrosis factor TNF 0.0037
6136 Multidrug resistance-associated protein 5 ABCC5 0.0037
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0036
70 Type-1 angiotensin II receptor AGTR1 0.0036
738 Monocarboxylate transporter 1 SLC16A1 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
1024 Solute carrier family 22 member 11 SLC22A11 0.0036
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
3947 Xanthine dehydrogenase/oxidase XDH 0.0034
737 Mineralocorticoid receptor NR3C2 0.0034
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0034
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0033
1256 5-hydroxytryptamine 6 receptor HTR6 0.0033
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0032
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0031
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0031
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0031
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
756 Sex hormone-binding globulin SHBG 0.003
1629 Transcription factor AP-1 JUN 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.003
4102 Proteasome subunit beta type 5 PSMB5 0.003
4101 Proteasome subunit beta type 1 PSMB1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
6151 Monocarboxylate transporter 10 SLC16A10 0.0029
4203 Histamine N-methyltransferase HNMT 0.0029
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0029
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0029
683 Potassium transporter GK0582 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0028
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
1010 Cytochrome P450 51A1 CYP51A1 0.0025
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
165 FL cytokine receptor FLT3 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0022
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0022
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0022
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0022
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0022
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
24 Thymidylate synthase TMP1 0.0021
359 Thymidylate synthase TYMS 0.0021
2626 Thymidylate synthase thyA 0.0021
2729 Thymidylate synthase thyA 0.0021
5352 Thymidylate synthase THYA 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
144 Hemoglobin subunit alpha HBA1 0.002
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
4773 Deoxycytidine kinase DCK 0.0019
1050 Bile salt sulfotransferase SULT2A1 0.0019
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
3932 Glutathione S-transferase A2 GSTA2 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
6102 Arylamine N-acetyltransferase 2 NAT2 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0015
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0015
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0015
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
4311 tRNA TRDMT1 0.0014
4325 tRNA trmD 0.0014
4328 tRNA trmD 0.0014
6014 Cytochrome P450 2A13 CYP2A13 0.0014
469 Annexin A1 ANXA1 0.0014
3086 Plasmepsin-2 Not Available 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
3404 Exotoxin A eta 0.0013
164 Histamine H4 receptor HRH4 0.0013
3957 Adenosine deaminase ADA 0.0013
1630 Integrin beta-2 ITGB2 0.0013
976 Platelet glycoprotein IX GP9 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
694 Matrix protein 2 M 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
295 Carbonic anhydrase 1 CA1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6859 Protein S100-A4 S100A4 0.0012
3810 Catechol O-methyltransferase COMT 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
6459 Glycodelin PAEP 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
427 Substance-P receptor TACR1 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
811 Translocator protein TSPO 0.001
183 Vascular endothelial growth factor A VEGFA 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
518 Peroxidase/catalase T katG 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
1864 RET proto-oncogene RET 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1341 Histamine H3 receptor HRH3 0.0008
751 Potassium channel subfamily K member 6 KCNK6 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
2207 Rhodopsin RHO 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
229 Retinoic acid receptor beta RARB 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
1714 Mitogen-activated protein kinase 3 MAPK3 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1992 Vitamin D-binding protein GC 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
592 Carbonic anhydrase 4 CA4 0.0006
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
153 Dopamine beta-hydroxylase DBH 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
6218 Pannexin-1 PANX1 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6020 Aldehyde oxidase AOX1 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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