DT-Web

DB00246 - Ziprasidone


Identification
Name Ziprasidone
Accession Number DB00246 (APRD00540)
Type small molecule
Description Ziprasidone (marketed as Geodon, Zeldox) was the fifth atypical antipsychotic to gain FDA approval (February 2001). Ziprasidone is Food and Drug Administration (FDA) approved for the treatment of schizophrenia, and the intramuscular injection form of ziprasidone is approved for acute agitation in schizophrenic patients. Ziprasidone has also received approval for acute treatment of mania associated with bipolar disorder. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 412.936
Groups approved
Monoisotopic Weight 412.112459711
Pharmacology
Indication For the treatment of schizophrenia and related psychotic disorders.
Mechanism of action Ziprasidone's antipsychotic activity is likely due to a combination of its antagonistic function at D2 receptors in the mesolimbic pathways and at 5HT2A receptors in the frontal cortex. Alleviation of positive symptoms is due to antagonism at D2 receptors while relief of negative symptoms are due to 5HT2A antagonism.
Absorption ~60%
Protein binding 99%
Biotransformation Hepatic
Route of elimination Ziprasidone is extensively metabolized after oral administration with only a small amount excreted in the urine (<1%) or feces (<4%) as unchanged drug. Approximately 20% of the dose is excreted in the urine, with approximately 66% being eliminated in the feces.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abarelix Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Amantadine The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, amantadine. Consider alternate therapy or monitor for worsening of movement disorder.
Amiodarone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Amitriptyline Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Amoxapine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Apomorphine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Arsenic trioxide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Asenapine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Azithromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Bromocriptine The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, bromocriptine. Consider alternate therapy or monitor for worsening of movement disorder.
Carbamazepine Increases the effect and toxicity of ziprasidone
Chlorpromazine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Cisapride Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Citalopram Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Clarithromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Clomipramine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Dasatinib Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Desipramine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Disopyramide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Dofetilide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Dolasetron Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Domperidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Donepezil Possible antagonism of action
Doxepin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Dronedarone Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Droperidol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Erythromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Escitalopram Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Flecainide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Fluconazole Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Fluoxetine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Flupenthixol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Foscarnet Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Galantamine Possible antagonism of action
Gatifloxacin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Halofantrine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Haloperidol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Ibutilide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Iloperidone Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Imipramine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Indapamide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Isradipine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Ketoconazole Ketoconazole increases the effect and toxicity of ziprasidone
Lapatinib Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Levodopa The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, levodopa. Consider alternate therapy or monitor for worsening of movement disorder.
Levofloxacin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Loxapine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Mefloquine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Mesoridazine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Methadone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Methotrimeprazine Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Moxifloxacin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Nilotinib Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Norfloxacin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Nortriptyline Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Octreotide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Pazopanib Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Pentamidine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Perflutren Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Pergolide The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, pergolide. Consider alternate therapy or monitor for worsening of movement disorder.
Pimozide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Pramipexole The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, pramipexole. Consider alternate therapy or monitor for worsening of movement disorder.
Probucol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Procainamide Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Propafenone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Protriptyline Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Quetiapine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Quinidine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Quinine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Ranolazine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Risperidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Romidepsin Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Ropinirole The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, ropinirole. Consider alternate therapy or monitor for worsening of movement disorder.
Rotigotine The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, rotigotine. Consider alternate therapy or monitor for worsening of movement disorder.
Sotalol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Sparfloxacin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Sunitinib Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Tacrine Tacrine, a central acetylcholinesterase inhibitor, may augment the central neurotoxic effect of antipsychotics such as Ziprasidone. Monitor for extrapyramidal symptoms.
Tacrolimus Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Telavancin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Telithromycin Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Tetrabenazine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Thioridazine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Thiothixene Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Trimipramine Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Triprolidine The CNS depressants, Triprolidine and Ziprasidone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Vorinostat Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Food Interactions
  • Avoid alcohol.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Kopecek M, Bares M, Mohr P: Ziprasidone-induced galactorrhea: a case report. Neuro Endocrinol Lett. 2005 Feb;26(1):69-70. - Pubmed
  • Seeger TF, Seymour PA, Schmidt AW, Zorn SH, Schulz DW, Lebel LA, McLean S, Guanowsky V, Howard HR, Lowe JA 3rd, et al.: Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Stahl SM, Shayegan DK: The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry. 2003;64 Suppl 19:6-12. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1377
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Mansbach RS, Carver J, Zorn SH: Blockade of drug-induced deficits in prepulse inhibition of acoustic startle by ziprasidone. Pharmacol Biochem Behav. 2001 Jul-Aug;69(3-4):535-42. - Pubmed
  • Ichikawa J, Li Z, Dai J, Meltzer HY: Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism. Brain Res. 2002 Nov 29;956(2):349-57. - Pubmed
  • Lu BY, Lundgren R, Escalona PR, Roberts BB: A case of ziprasidone-induced mania and the role of 5-HT2A in mood changes induced by atypical antipsychotics. J Clin Psychiatry. 2002 Dec;63(12):1185-6. - Pubmed
  • Mamo D, Kapur S, Shammi CM, Papatheodorou G, Mann S, Therrien F, Remington G: A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone. Am J Psychiatry. 2004 May;161(5):818-25. - Pubmed
  • Kast RE, Focosi D, Petrini M, Altschuler EL: Treatment schedules for 5-HT2A blocking in progressive multifocal leukoencephalopathy using risperidone or ziprasidone. Bone Marrow Transplant. 2007 Jun;39(12):811-2. Epub 2007 Apr 23. - Pubmed
  • Stahl SM, Shayegan DK: The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry. 2003;64 Suppl 19:6-12. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1004
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.963
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.5905
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action unknown
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.731
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action unknown
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6886
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions antagonist
References
  • Sprouse JS, Reynolds LS, Braselton JP, Rollema H, Zorn SH: Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology. 1999 Nov;21(5):622-31. - Pubmed
  • Rollema H, Lu Y, Schmidt AW, Sprouse JS, Zorn SH: 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000 Aug 1;48(3):229-37. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Wilner KD, Anziano RJ, Johnson AC, Miceli JJ, Fricke JR, Titus CK: The anxiolytic effect of the novel antipsychotic ziprasidone compared with diazepam in subjects anxious before dental surgery. J Clin Psychopharmacol. 2002 Apr;22(2):206-10. - Pubmed
  • Newman-Tancredi A, Rivet JM, Cussac D, Touzard M, Chaput C, Marini L, Millan MJ: Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):188-99. Epub 2003 Aug 16. - Pubmed
  • Stahl SM, Shayegan DK: The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry. 2003;64 Suppl 19:6-12. - Pubmed
DTHybrid score 0.9006
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.6901
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions antagonist
References
  • Stahl SM, Shayegan DK: The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry. 2003;64 Suppl 19:6-12. - Pubmed
  • Wilner KD, Anziano RJ, Johnson AC, Miceli JJ, Fricke JR, Titus CK: The anxiolytic effect of the novel antipsychotic ziprasidone compared with diazepam in subjects anxious before dental surgery. J Clin Psychopharmacol. 2002 Apr;22(2):206-10. - Pubmed
  • Seeger TF, Seymour PA, Schmidt AW, Zorn SH, Schulz DW, Lebel LA, McLean S, Guanowsky V, Howard HR, Lowe JA 3rd, et al.: Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Sprouse JS, Reynolds LS, Braselton JP, Rollema H, Zorn SH: Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology. 1999 Nov;21(5):622-31. - Pubmed
DTHybrid score 0.675
5-hydroxytryptamine 1E receptor
Name 5-hydroxytryptamine 1E receptor
Gene Name HTR1E
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.2663
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions antagonist
References
  • Stahl SM, Shayegan DK: The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. J Clin Psychiatry. 2003;64 Suppl 19:6-12. - Pubmed
  • Sanchez C, Arnt J: In-vivo assessment of 5-HT2A and 5-HT2C antagonistic properties of newer antipsychotics. Behav Pharmacol. 2000 Jun;11(3-4):291-8. - Pubmed
  • Seeger TF, Seymour PA, Schmidt AW, Zorn SH, Schulz DW, Lebel LA, McLean S, Guanowsky V, Howard HR, Lowe JA 3rd, et al.: Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995 Oct;275(1):101-13. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Wood MD, Scott C, Clarke K, Cato KJ, Patel N, Heath J, Worby A, Gordon L, Campbell L, Riley G, Davies CH, Gribble A, Jones DN: Pharmacological profile of antipsychotics at monoamine receptors: atypicality beyond 5-HT2A receptor blockade. CNS Neurol Disord Drug Targets. 2006 Aug;5(4):445-52. - Pubmed
DTHybrid score 0.7782
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.3844
5-hydroxytryptamine 6 receptor
Name 5-hydroxytryptamine 6 receptor
Gene Name HTR6
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.3802
5-hydroxytryptamine 7 receptor
Name 5-hydroxytryptamine 7 receptor
Gene Name HTR7
Pharmacological action unknown
Actions antagonist
References
  • Stark AD, Jordan S, Allers KA, Bertekap RL, Chen R, Mistry Kannan T, Molski TF, Yocca FD, Sharp T, Kikuchi T, Burris KD: Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies. Psychopharmacology (Berl). 2007 Feb;190(3):373-82. Epub 2006 Nov 25. - Pubmed
  • Meltzer HY: The role of serotonin in antipsychotic drug action. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):106S-115S. - Pubmed
  • Meltzer HY: Role of serotonin in the action of atypical antipsychotic drugs. Clin Neurosci. 1995;3(2):64-75. - Pubmed
DTHybrid score 0.5025
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action no
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Arnt J: Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine. Eur J Pharmacol. 1995 Sep 5;283(1-3):55-62. - Pubmed
DTHybrid score 0.994
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action no
Actions antagonist
References
  • Andersohn F, Schmedt N, Weinmann S, Willich SN, Garbe E: Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity. J Clin Psychopharmacol. 2010 Feb;30(1):68-71. - Pubmed
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0135
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7079
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0365
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7752
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7746
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1541
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0006
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.9929
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.776
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.6824

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D: Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions. Br J Clin Pharmacol. 2000;49 Suppl 1:35S-42S. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Nakamura H, Nakasa H, Ishii I, Ariyoshi N, Igarashi T, Ohmori S, Kitada M: Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes. Drug Metab Dispos. 2002 May;30(5):534-40. - Pubmed
DTHybrid score 1.1949
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.5611
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.45
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8097
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.1626

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.5431
4757 Cytochrome P450 2C9 CYP2C9 0.4314
6016 Cytochrome P450 2C19 CYP2C19 0.4277
436 5-hydroxytryptamine 2B receptor HTR2B 0.4248
789 Alpha-1D adrenergic receptor ADRA1D 0.3879
6013 Cytochrome P450 2E1 CYP2E1 0.2653
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2636
4924 Cytochrome P450 2C8 CYP2C8 0.2484
824 Sodium-dependent serotonin transporter SLC6A4 0.2409
6030 Cytochrome P450 2B6 CYP2B6 0.2302
6145 Solute carrier family 22 member 1 SLC22A1 0.2078
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1789
713 Sodium-dependent dopamine transporter SLC6A3 0.1724
766 Beta-2 adrenergic receptor ADRB2 0.1717
6024 Cytochrome P450 1A1 CYP1A1 0.1679
193 Beta-1 adrenergic receptor ADRB1 0.1677
3941 Amine oxidase [flavin-containing] A MAOA 0.1661
3923 Cholinesterase BCHE 0.1519
511 5-hydroxytryptamine 1F receptor HTR1F 0.1491
587 Serum albumin ALB 0.1439
6144 Solute carrier family 22 member 2 SLC22A2 0.1426
5718 Cytochrome P450 2A6 CYP2A6 0.1391
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.1147
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.1044
734 D1 dopamine receptor-interacting protein calcyon CALY 0.094
174 Sigma 1-type opioid receptor SIGMAR1 0.0933
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.093
118 Organic cation/carnitine transporter 2 SLC22A5 0.0888
124 Histamine H2 receptor HRH2 0.0828
6147 Solute carrier family 22 member 3 SLC22A3 0.0818
131 Synaptic vesicular amine transporter SLC18A2 0.0812
465 Calmodulin CALM1 0.075
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0723
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.072
94 5-hydroxytryptamine 4 receptor HTR4 0.0714
20 Prostaglandin G/H synthase 1 PTGS1 0.0713
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0683
1517 Beta-3 adrenergic receptor ADRB3 0.065
6106 Cytochrome P450 2C18 CYP2C18 0.0633
847 Mu-type opioid receptor OPRM1 0.0613
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0612
833 Organic cation/carnitine transporter 1 SLC22A4 0.0594
3876 Aromatic-L-amino-acid decarboxylase DDC 0.058
1898 Cytochrome P450 1B1 CYP1B1 0.0564
696 Kappa-type opioid receptor OPRK1 0.0562
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0555
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0491
3939 Amine oxidase [flavin-containing] B MAOB 0.0486
467 Delta-type opioid receptor OPRD1 0.0462
164 Histamine H4 receptor HRH4 0.0452
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0446
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0442
474 Acetylcholinesterase ACHE 0.0436
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0426
6070 Nischarin NISCH 0.0421
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.041
862 Multidrug resistance-associated protein 1 ABCC1 0.0409
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.04
1656 CYP2B protein CYP2B 0.0398
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0387
3811 Cytochrome P450 19A1 CYP19A1 0.0385
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0357
776 Bile salt export pump ABCB11 0.0355
6020 Aldehyde oxidase AOX1 0.0353
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0349
828 Phenylalanine-4-hydroxylase PAH 0.0346
3109 Phenylalanine-4-hydroxylase phhA 0.0346
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0342
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0342
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.034
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.034
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0336
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0335
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0334
1729 Solute carrier family 22 member 6 SLC22A6 0.0328
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.032
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0319
2129 Sucrase-isomaltase, intestinal SI 0.0317
6031 Cytochrome P450 3A43 CYP3A43 0.0317
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0314
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0307
871 Glucocorticoid receptor NR3C1 0.0306
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0305
6432 Transporter snf 0.0286
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.028
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0276
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.027
6151 Monocarboxylate transporter 10 SLC16A10 0.0261
36 Insulin receptor INSR 0.0258
6182 Cytochrome P450 2J2 CYP2J2 0.0257
1636 Trace amine-associated receptor 1 TAAR1 0.0243
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0243
731 HIV-1 protease HIV-1 protease 0.0241
817 DNA topoisomerase 2-alpha TOP2A 0.024
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0237
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0231
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0223
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0223
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0223
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0212
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0212
3810 Catechol O-methyltransferase COMT 0.0211
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0208
723 Cytosolic phospholipase A2 PLA2G4A 0.0202
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
290 Prostaglandin G/H synthase 2 PTGS2 0.0201
6143 Solute carrier family 22 member 7 SLC22A7 0.0199
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0194
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0193
1341 Histamine H3 receptor HRH3 0.0189
3426 Glutamine synthetase glnA 0.0189
3987 Glutamine synthetase GLUL 0.0189
136 Estrogen receptor ESR1 0.0183
260 Cytochrome P450 51 ERG11 0.0182
761 Cytochrome P450 51 ERG11 0.0182
3163 Cytochrome P450 51 cyp51 0.0182
153 Dopamine beta-hydroxylase DBH 0.0181
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0179
614 Progesterone receptor PGR 0.0175
380 Cytochrome P450 17A1 CYP17A1 0.0168
516 Neurotensin receptor type 2 NTSR2 0.0168
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0167
571 Melatonin receptor type 1A MTNR1A 0.0167
362 Melatonin receptor type 1B MTNR1B 0.0167
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0161
6148 Multidrug resistance-associated protein 7 ABCC10 0.016
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.016
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0159
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0157
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0157
232 Corticosteroid-binding globulin SERPINA6 0.0156
1618 High affinity nerve growth factor receptor NTRK1 0.0153
2164 Multidrug resistance-associated protein 4 ABCC4 0.0153
737 Mineralocorticoid receptor NR3C2 0.0151
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0151
923 Glutamate receptor 3 GRIA3 0.0149
6142 Solute carrier family 22 member 8 SLC22A8 0.0148
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0148
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0147
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0147
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0144
468 Cytochrome P450 4A11 CYP4A11 0.0143
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0143
1360 Sphingomyelin phosphodiesterase SMPD1 0.0143
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0137
4120 NADPH--cytochrome P450 reductase POR 0.0135
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0135
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0133
233 Potassium channel subfamily K member 2 KCNK2 0.0132
3947 Xanthine dehydrogenase/oxidase XDH 0.0129
6138 Multidrug resistance protein 3 ABCB4 0.0128
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0126
6220 Aryl hydrocarbon receptor AHR 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
818 50S ribosomal protein L10 rplJ 0.0126
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0126
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0126
921 Glutamate receptor 2 GRIA2 0.0125
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0123
504 Mast/stem cell growth factor receptor KIT 0.0117
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0117
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
811 Translocator protein TSPO 0.0114
427 Substance-P receptor TACR1 0.0113
756 Sex hormone-binding globulin SHBG 0.0113
844 Epidermal growth factor receptor EGFR 0.0109
16 Adenosine A1 receptor ADORA1 0.0105
777 Tumor necrosis factor TNF 0.0104
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0102
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0102
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0101
228 Beta platelet-derived growth factor receptor PDGFRB 0.0101
26 Vascular endothelial growth factor receptor 3 FLT4 0.01
1178 Adenosine A2a receptor ADORA2A 0.01
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
1275 Estrogen sulfotransferase SULT1E1 0.0098
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
407 Vascular endothelial growth factor receptor 2 KDR 0.0096
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0096
32 Vascular endothelial growth factor receptor 1 FLT1 0.0096
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0095
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.009
6859 Protein S100-A4 S100A4 0.009
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0089
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
1010 Cytochrome P450 51A1 CYP51A1 0.0088
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0088
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0088
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0088
4604 Liver carboxylesterase 1 CES1 0.0088
29 Tubulin beta-1 chain TUBB1 0.0086
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0085
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0085
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0084
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0084
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0084
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0084
952 Dipeptidyl peptidase 4 DPP4 0.0084
146 Androgen receptor AR 0.0084
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0083
768 FK506-binding protein 1A FKBP1A 0.0083
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0082
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0082
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0082
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0081
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
161 Tubulin beta chain TUBB 0.008
312 Tubulin beta chain TUB2 0.008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.008
950 Alpha platelet-derived growth factor receptor PDGFRA 0.008
705 Glutamate receptor 1 GRIA1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0079
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0078
6014 Cytochrome P450 2A13 CYP2A13 0.0078
904 Glutathione S-transferase P GSTP1 0.0077
273 Apoptosis regulator Bcl-2 BCL2 0.0077
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0076
122 P2Y purinoceptor 12 P2RY12 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
4122 Histone deacetylase 2 HDAC2 0.0072
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0071
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0069
2112 Toll-like receptor 9 TLR9 0.0069
814 Ryanodine receptor 1 RYR1 0.0068
6136 Multidrug resistance-associated protein 5 ABCC5 0.0067
6137 Multidrug resistance-associated protein 6 ABCC6 0.0067
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0065
4238 50S ribosomal protein L4 rplD 0.0065
5578 50S ribosomal protein L4 rplD 0.0065
6173 50S ribosomal protein L4 rplD 0.0065
6219 50S ribosomal protein L4 rplD 0.0065
165 FL cytokine receptor FLT3 0.0065
4203 Histamine N-methyltransferase HNMT 0.0064
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0064
6102 Arylamine N-acetyltransferase 2 NAT2 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1757 Myeloperoxidase MPO 0.0062
869 Estrogen receptor beta ESR2 0.0062
1024 Solute carrier family 22 member 11 SLC22A11 0.0062
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0062
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0061
6097 Protein S100-A2 S100A2 0.006
1050 Bile salt sulfotransferase SULT2A1 0.006
1810 Protein S100-A1 S100A1 0.006
284 DNA-directed RNA polymerase beta chain rpoB 0.006
5773 DNA-directed RNA polymerase beta chain rpoB 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
2539 Tubulin alpha-1 chain TUBA4A 0.0059
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0059
6141 Sodium/bile acid cotransporter SLC10A1 0.0058
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0057
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0056
6044 Serum paraoxonase/lactonase 3 PON3 0.0056
6506 Stathmin-4 STMN4 0.0055
1852 Microtubule-associated protein 2 MAP2 0.0054
5998 Toll-like receptor 8 TLR8 0.0053
70 Type-1 angiotensin II receptor AGTR1 0.0053
712 Tubulin alpha chain TUB1 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
469 Annexin A1 ANXA1 0.0051
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0051
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0051
295 Carbonic anhydrase 1 CA1 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
239 Coagulation factor X F10 0.005
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0049
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0049
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0049
373 Transthyretin TTR 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0049
2132 Protein S100-B S100B 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0047
738 Monocarboxylate transporter 1 SLC16A1 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
3086 Plasmepsin-2 Not Available 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
4311 tRNA TRDMT1 0.0045
4325 tRNA trmD 0.0045
4328 tRNA trmD 0.0045
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0045
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0044
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0043
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
1629 Transcription factor AP-1 JUN 0.0042
4773 Deoxycytidine kinase DCK 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
976 Platelet glycoprotein IX GP9 0.0042
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0042
275 Arachidonate 5-lipoxygenase ALOX5 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
3932 Glutathione S-transferase A2 GSTA2 0.0041
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
84 Nuclear receptor 0B1 NR0B1 0.0041
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
33 Cystine/glutamate transporter SLC7A11 0.0041
856 Vitamin D3 receptor VDR 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
365 Dihydrofolate reductase DHFR 0.004
2381 Dihydrofolate reductase DFR1 0.004
2833 Dihydrofolate reductase Not Available 0.004
2931 Dihydrofolate reductase folA 0.004
3544 Dihydrofolate reductase folA 0.004
3682 Dihydrofolate reductase folA 0.004
6642 Dihydrofolate reductase folA 0.004
6756 Dihydrofolate reductase dfrA 0.004
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
694 Matrix protein 2 M 0.0039
54 Prothrombin F2 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
823 Fibroblast growth factor receptor 2 FGFR2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1374 Natriuretic peptides B NPPB 0.0037
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0037
1192 Sulfotransferase 1A1 SULT1A1 0.0036
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0036
2808 Chloramphenicol acetyltransferase 3 cat3 0.0036
319 Opioid receptor, sigma 1 OPRS1 0.0036
780 Retinoic acid receptor RXR-gamma RXRG 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
3856 Fibroblast growth factor receptor 3 FGFR3 0.0035
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1630 Integrin beta-2 ITGB2 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0034
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
88 Retinoic acid receptor RXR-beta RXRB 0.0033
2810 Dr hemagglutinin structural subunit draA 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
482 Glycine receptor subunit alpha-1 GLRA1 0.0031
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
1864 RET proto-oncogene RET 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.003
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6048 Troponin C, skeletal muscle TNNC2 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0029
3957 Adenosine deaminase ADA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
518 Peroxidase/catalase T katG 0.0028
5934 Cytochrome P450 26A1 CYP26A1 0.0028
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0028
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
563 Thyroid peroxidase TPO 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0026
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0026
1648 Elastin ELN 0.0026
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0026
572 Integrin alpha-L ITGAL 0.0026
49 Endothelin B receptor EDNRB 0.0026
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
634 Squalene monooxygenase SQLE 0.0025
7196 Squalene monooxygenase ERG1 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
162 Retinoic acid receptor gamma-1 RARG 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0023
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
6174 50S ribosomal protein L32 rpmF 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
5787 Angiopoietin-1 receptor TEK 0.0022
6146 High affinity copper uptake protein 1 SLC31A1 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
7 Nitric oxide synthase, inducible NOS2 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.002
6126 Carbonic anhydrase 7 CA7 0.002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.002
1820 Beta-nerve growth factor NGF 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
908 Glutathione S-transferase theta-1 GSTT1 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0018
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4103 Proteasome subunit beta type 2 PSMB2 0.0018
4102 Proteasome subunit beta type 5 PSMB5 0.0018
4101 Proteasome subunit beta type 1 PSMB1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
1243 Cathepsin D CTSD 0.0016
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
268 Adenosine A2b receptor ADORA2B 0.0015
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1541 Metalloproteinase mmp20 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
1039 Histone deacetylase 9 HDAC9 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
896 Glutathione S-transferase Mu 1 GSTM1 0.0012
1295 Fatty acid synthase FASN 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
3830 Calreticulin CALR 0.0008
1867 Major prion protein PRNP 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
2207 Rhodopsin RHO 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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