DT-Web

DB00413 - Pramipexole


Identification
Name Pramipexole
Accession Number DB00413 (APRD00156)
Type small molecule
Description Pramipexole is a medication indicated for treating Parkinson's disease and restless legs syndrome (RLS). It is also sometimes used off-label as a treatment for cluster headache or to counteract the problems with low libido experienced by some users of SSRI antidepressant drugs. Pramipexole has shown robust effects on pilot studies in bipolar disorder. Pramipexole is classified as a non-ergoline dopamine agonist.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 211.327
Groups approved
Monoisotopic Weight 211.114318249
Pharmacology
Indication For the treatment of signs and symptoms of idiopathic Parkinson's disease
Mechanism of action The precise mechanism of action of Pramipexole as a treatment for Parkinson's disease is unknown, although it is believed to be related to its ability to stimulate dopamine receptors in the striatum.
Absorption Rapid. Absolute bioavailability is greater than 90%, indicating that pramipexole is well absorbed and undergoes little presystemic metabolism. Food does not affect the extent of absorption.
Protein binding About 15% bound to plasma proteins.
Biotransformation No metabolites have been identified in plasma or urine.
Route of elimination Urinary excretion is the major route of pramipexole elimination, with 90% of a pramipexole dose recovered in urine, almost all as unchanged drug. Nonrenal routes may contribute to a small extent to pramipexole elimination, although no metabolites have been identified in plasma or urine.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cimetidine Cimetidine may increase the effect and toxicity of pramipexole.
Dihydrocodeine Dihydrocodeine may enhance the sedative effect of pramipexole. It is recommended to monitor therapy
Paliperidone The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, pramipexole. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Thiothixene Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Pramipexole. Consider alternate therapy or monitor for decreased effects of both agents.
Triprolidine The CNS depressants, Triprolidine and Pramipexole, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Ziprasidone The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, pramipexole. Consider alternate therapy or monitor for worsening of movement disorder.
Zuclopenthixol Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and pramipexole, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed.
Food Interactions
  • Take without regard to meals, however if nausea is a problem, taking the product with food may reduce its incidence.

Targets


D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.5705
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.8924
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.5329
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.6373
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.705
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.5661
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions partial agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.7991
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.5753
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.7825
5-hydroxytryptamine 2B receptor
Name 5-hydroxytryptamine 2B receptor
Gene Name HTR2B
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.4743
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.6098
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions unknown
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.6263
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions unknown
References
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.7757
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action unknown
Actions unknown
References
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.5032

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.2611
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Ishiguro N, Saito A, Yokoyama K, Morikawa M, Igarashi T, Tamai I: Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney. Drug Metab Dispos. 2005 Apr;33(4):495-9. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.3513

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.472
556 Alpha-1A adrenergic receptor ADRA1A 0.4369
4512 Cytochrome P450 3A4 CYP3A4 0.3868
4200 Cytochrome P450 1A2 CYP1A2 0.3369
632 Alpha-1B adrenergic receptor ADRA1B 0.3127
716 5-hydroxytryptamine 7 receptor HTR7 0.2734
1588 Multidrug resistance protein 1 ABCB1 0.2311
492 Histamine H1 receptor HRH1 0.2232
789 Alpha-1D adrenergic receptor ADRA1D 0.1845
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1767
824 Sodium-dependent serotonin transporter SLC6A4 0.1548
617 Muscarinic acetylcholine receptor M2 CHRM2 0.1494
1256 5-hydroxytryptamine 6 receptor HTR6 0.1434
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1377
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1372
3941 Amine oxidase [flavin-containing] A MAOA 0.1367
4118 Cytochrome P450 3A5 CYP3A5 0.1347
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1335
6016 Cytochrome P450 2C19 CYP2C19 0.1331
511 5-hydroxytryptamine 1F receptor HTR1F 0.1284
766 Beta-2 adrenergic receptor ADRB2 0.1202
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1175
193 Beta-1 adrenergic receptor ADRB1 0.1163
4757 Cytochrome P450 2C9 CYP2C9 0.1158
6107 Cytochrome P450 3A7 CYP3A7 0.1122
528 5-hydroxytryptamine 1E receptor HTR1E 0.1097
6147 Solute carrier family 22 member 3 SLC22A3 0.1042
341 5-hydroxytryptamine 3 receptor HTR3A 0.1039
6013 Cytochrome P450 2E1 CYP2E1 0.0844
118 Organic cation/carnitine transporter 2 SLC22A5 0.0821
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0723
713 Sodium-dependent dopamine transporter SLC6A3 0.072
587 Serum albumin ALB 0.0718
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0647
131 Synaptic vesicular amine transporter SLC18A2 0.0612
1517 Beta-3 adrenergic receptor ADRB3 0.0552
3876 Aromatic-L-amino-acid decarboxylase DDC 0.053
3923 Cholinesterase BCHE 0.0518
4924 Cytochrome P450 2C8 CYP2C8 0.0517
94 5-hydroxytryptamine 4 receptor HTR4 0.0515
833 Organic cation/carnitine transporter 1 SLC22A4 0.0513
124 Histamine H2 receptor HRH2 0.0508
6070 Nischarin NISCH 0.0486
6030 Cytochrome P450 2B6 CYP2B6 0.0448
6024 Cytochrome P450 1A1 CYP1A1 0.0445
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0417
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0405
3939 Amine oxidase [flavin-containing] B MAOB 0.0403
174 Sigma 1-type opioid receptor SIGMAR1 0.0402
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0364
465 Calmodulin CALM1 0.0359
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0355
5718 Cytochrome P450 2A6 CYP2A6 0.0346
6142 Solute carrier family 22 member 8 SLC22A8 0.031
474 Acetylcholinesterase ACHE 0.0308
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0301
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0285
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0281
828 Phenylalanine-4-hydroxylase PAH 0.0279
3109 Phenylalanine-4-hydroxylase phhA 0.0279
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0275
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0267
6020 Aldehyde oxidase AOX1 0.0258
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0243
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0236
6151 Monocarboxylate transporter 10 SLC16A10 0.0223
164 Histamine H4 receptor HRH4 0.0223
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0221
3810 Catechol O-methyltransferase COMT 0.0219
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0218
1729 Solute carrier family 22 member 6 SLC22A6 0.0213
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.021
776 Bile salt export pump ABCB11 0.021
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0209
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0194
6106 Cytochrome P450 2C18 CYP2C18 0.0183
6432 Transporter snf 0.0176
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0175
153 Dopamine beta-hydroxylase DBH 0.0171
20 Prostaglandin G/H synthase 1 PTGS1 0.0171
1898 Cytochrome P450 1B1 CYP1B1 0.017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
6010 Thiamine transporter 1 SLC19A2 0.0159
862 Multidrug resistance-associated protein 1 ABCC1 0.0154
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0152
923 Glutamate receptor 3 GRIA3 0.0149
3426 Glutamine synthetase glnA 0.0146
3987 Glutamine synthetase GLUL 0.0146
6143 Solute carrier family 22 member 7 SLC22A7 0.0143
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.014
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
696 Kappa-type opioid receptor OPRK1 0.0131
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0127
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0127
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0127
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
694 Matrix protein 2 M 0.0125
4773 Deoxycytidine kinase DCK 0.0124
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0124
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0122
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
904 Glutathione S-transferase P GSTP1 0.012
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0114
1636 Trace amine-associated receptor 1 TAAR1 0.011
7 Nitric oxide synthase, inducible NOS2 0.0109
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0109
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0104
362 Melatonin receptor type 1B MTNR1B 0.0103
571 Melatonin receptor type 1A MTNR1A 0.0103
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
847 Mu-type opioid receptor OPRM1 0.0095
6148 Multidrug resistance-associated protein 7 ABCC10 0.0095
1656 CYP2B protein CYP2B 0.0095
921 Glutamate receptor 2 GRIA2 0.0092
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
4203 Histamine N-methyltransferase HNMT 0.0083
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0078
1830 5'-nucleotidase NT5E 0.0077
2164 Multidrug resistance-associated protein 4 ABCC4 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0076
3811 Cytochrome P450 19A1 CYP19A1 0.0075
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0075
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0074
125 DNA polymerase beta POLB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
233 Potassium channel subfamily K member 2 KCNK2 0.0072
6171 Solute carrier family 28 member 3 SLC28A3 0.007
3947 Xanthine dehydrogenase/oxidase XDH 0.0069
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0068
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0068
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0068
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0068
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0067
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
6137 Multidrug resistance-associated protein 6 ABCC6 0.0065
467 Delta-type opioid receptor OPRD1 0.0065
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
5126 Arginase rocF 0.0064
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0063
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0062
6136 Multidrug resistance-associated protein 5 ABCC5 0.0061
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.006
1618 High affinity nerve growth factor receptor NTRK1 0.006
1341 Histamine H3 receptor HRH3 0.006
380 Cytochrome P450 17A1 CYP17A1 0.006
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
477 DNA topoisomerase 4 subunit A parC 0.0056
886 DNA topoisomerase 4 subunit A parC 0.0056
6226 DNA topoisomerase 4 subunit A parC 0.0056
404 DNA gyrase subunit A gyrA 0.0055
6224 DNA gyrase subunit A gyrA 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0054
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0053
4120 NADPH--cytochrome P450 reductase POR 0.0053
756 Sex hormone-binding globulin SHBG 0.0053
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
624 Guanidinoacetate N-methyltransferase GAMT 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
136 Estrogen receptor ESR1 0.005
6165 Copper-transporting ATPase 1 ATP7A 0.0049
6163 Copper-transporting ATPase 2 ATP7B 0.0049
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
731 HIV-1 protease HIV-1 protease 0.0047
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
976 Platelet glycoprotein IX GP9 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0045
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0045
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0044
612 P protein [Includes: DNA-directed DNA polymerase P 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0042
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0042
6859 Protein S100-A4 S100A4 0.0041
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
817 DNA topoisomerase 2-alpha TOP2A 0.004
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0039
896 Glutathione S-transferase Mu 1 GSTM1 0.0039
869 Estrogen receptor beta ESR2 0.0039
5626 Nucleoside diphosphate kinase B NME2 0.0038
702 UMP-CMP kinase CMPK1 0.0037
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
527 Prostacyclin receptor PTGIR 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
6167 Organic solute transporter subunit beta OSTB 0.0036
6166 Organic solute transporter subunit alpha OSTA 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
723 Cytosolic phospholipase A2 PLA2G4A 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
1757 Myeloperoxidase MPO 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
427 Substance-P receptor TACR1 0.0034
1864 RET proto-oncogene RET 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0033
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0033
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
6014 Cytochrome P450 2A13 CYP2A13 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.003
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.003
6218 Pannexin-1 PANX1 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0026
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0025
228 Beta platelet-derived growth factor receptor PDGFRB 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
4217 Telomerase reverse transcriptase TERT 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
1629 Transcription factor AP-1 JUN 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0023
504 Mast/stem cell growth factor receptor KIT 0.0023
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
737 Mineralocorticoid receptor NR3C2 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
161 Tubulin beta chain TUBB 0.0021
312 Tubulin beta chain TUB2 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
614 Progesterone receptor PGR 0.002
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0017
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0017
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0017
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0017
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0017
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0017
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0017
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0017
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0017
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0016
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0015
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0015
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0013
3587 Gastrotropin FABP6 0.0012
468 Cytochrome P450 4A11 CYP4A11 0.0012
33 Cystine/glutamate transporter SLC7A11 0.001
6031 Cytochrome P450 3A43 CYP3A43 0.0009
290 Prostaglandin G/H synthase 2 PTGS2 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
146 Androgen receptor AR 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
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