DT-Web

DB01267 - Paliperidone


Identification
Name Paliperidone
Accession Number DB01267
Type small molecule
Description Paliperidone is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed that paliperidone and risperidone act via similar if not the same pathways. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 426.4839
Groups approved
Monoisotopic Weight 426.206718955
Pharmacology
Indication For the treatment of schizophrenia.
Mechanism of action Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.
Absorption The absolute oral bioavailability of paliperidone following paliperidone administration is 28%.
Protein binding The plasma protein binding of racemic paliperidone is 74%.
Biotransformation Although in vitro studies suggested a role for CYP2D6 and CYP3A4 in the metabolism of paliperidone, in vivo results indicate that these isozymes play a limited role in the overall elimination of paliperidone. Four primary metabolic pathways have been identified in vivo, none of which could be shown to account for more than 10% of the dose: dealkylation, hydroxylation, dehydrogenation, and benzisoxazole scission. Paliperidone does not undergo extensive metabolism and a significant portion of its metabolism occurs in the kidneys.
Route of elimination One week following administration of a single oral dose of 1 mg immediate-release 14C-paliperidone to 5 healthy volunteers, 59% (range 51% - 67%) of the dose was excreted unchanged into urine, 32% (26% - 41%) of the dose was recovered as metabolites, and 6% - 12% of the dose was not recovered.
Toxicity The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amantadine The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, amantadine. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Apomorphine The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, apomorphine. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Bromocriptine The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, bromocriptine. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Levodopa The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, levodopa. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Methotrimeprazine The CNS depressant agents, paliperidone and methotrimeprazine, may cause additive CNS depressant effects. Monitor for increased CNS depressant effects during concomitant therapy.
Metoclopramide Metoclopramide may increase the risk of extrapyramidal side effects of paliperidone. Concomitant therapy should be avoided.
Pramipexole The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, pramipexole. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Risperidone Paliperidone is the active metabolite of risperidone, 9-OH-risperidone. Concomitant therapy may increase the adverse effects of paliperidone due to additive paliperidone exposure. Consider alternate therapy.
Ropinirole The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, ropinirole. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Tacrine Tacrine, a central acetylcholinesterase inhibitor, may augment the central neurotoxic effect of antipsychotics such as Paliperidone. Monitor for extrapyramidal symptoms.
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Triprolidine The CNS depressants, Triprolidine and Paliperidone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions
  • Avoid alcohol.

Targets


5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Cohen LJ: Risperidone. Pharmacotherapy. 1994 May-Jun;14(3):253-65. - Pubmed
  • He H, Richardson JS: A pharmacological, pharmacokinetic and clinical overview of risperidone, a new antipsychotic that blocks serotonin 5-HT2 and dopamine D2 receptors. Int Clin Psychopharmacol. 1995 Mar;10(1):19-30. - Pubmed
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Yamada Y, Ohno Y, Nakashima Y, Fukuda M, Takayanagi R, Sato H, Tsuchiya F, Sawada Y, Iga T: Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. Synapse. 2002 Oct;46(1):32-7. - Pubmed
DTHybrid score 0.7675
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Cohen LJ: Risperidone. Pharmacotherapy. 1994 May-Jun;14(3):253-65. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
  • Regenthal R, Kunstler U, Hesse S, Sabri O, Preiss R: D2 dopamine receptor occupancy, risperidone plasma level and extrapyramidal motor symptoms in previously drug-free schizophrenic patients. Int J Clin Pharmacol Ther. 2005 Aug;43(8):370-8. - Pubmed
  • Remington G, Mamo D, Labelle A, Reiss J, Shammi C, Mannaert E, Mann S, Kapur S: A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone. Am J Psychiatry. 2006 Mar;163(3):396-401. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Yamada Y, Ohno Y, Nakashima Y, Fukuda M, Takayanagi R, Sato H, Tsuchiya F, Sawada Y, Iga T: Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy. Synapse. 2002 Oct;46(1):32-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8573
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action unknown
Actions agonist
References
  • Cohen LJ: Risperidone. Pharmacotherapy. 1994 May-Jun;14(3):253-65. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.7469
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Cohen LJ: Risperidone. Pharmacotherapy. 1994 May-Jun;14(3):253-65. - Pubmed
  • Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. - Pubmed
  • Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. - Pubmed
  • Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
  • Nourian Z, Mow T, Muftic D, Burek S, Pedersen ML, Matz J, Mulvany MJ: Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function. Psychopharmacology (Berl). 2008 Jul;199(1):15-27. Epub 2008 Jun 10. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. - Pubmed
DTHybrid score 0.8074
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Cohen LJ: Risperidone. Pharmacotherapy. 1994 May-Jun;14(3):253-65. - Pubmed
  • Eltze M: In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1996 Jan 4;295(1):69-73. - Pubmed
  • Fenton C, Scott LJ: Risperidone: a review of its use in the treatment of bipolar mania. CNS Drugs. 2005;19(5):429-44. - Pubmed
  • Keks NA, Culhane C: Risperidone (Risperdal): clinical experience with a new antipsychosis drug. Expert Opin Investig Drugs. 1999 Apr;8(4):443-52. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
  • Nourian Z, Mow T, Muftic D, Burek S, Pedersen ML, Matz J, Mulvany MJ: Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function. Psychopharmacology (Berl). 2008 Jul;199(1):15-27. Epub 2008 Jun 10. - Pubmed
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
  • Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. - Pubmed
DTHybrid score 0.5574
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action yes
Actions antagonist
References
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
DTHybrid score 0.4746
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.4322
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action yes
Actions antagonist
References
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
DTHybrid score 0.5049
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action yes
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.5406
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.8262
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.5845
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions agonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.5706
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions antagonist
References
  • Richelson E, Souder T: Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39. - Pubmed
DTHybrid score 0.6329
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
  • Megens AA, Awouters FH, Schotte A, Meert TF, Dugovic C, Niemegeers CJ, Leysen JE: Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology (Berl). 1994 Feb;114(1):9-23. - Pubmed
DTHybrid score 0.7126
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Pharmacological action unknown
Actions Not Available
References
  • Gunes A, Spina E, Dahl ML, Scordo MG: ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety. Ther Drug Monit. 2008 Oct;30(5):628-33. - Pubmed
DTHybrid score 0.7942
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Pharmacological action unknown
Actions Not Available
References
  • Boerth JM, Caley CF, Goethe JW: Interpreting serum risperidone concentrations. Pharmacotherapy. 2005 Feb;25(2):299-302. - Pubmed
DTHybrid score 0.7853
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Pharmacological action unknown
Actions Not Available
References
  • Yasui-Furukori N, Hidestrand M, Spina E, Facciola G, Scordo MG, Tybring G: Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos. 2001 Oct;29(10):1263-8. - Pubmed
  • Yasui-Furukori N, Hidestrand M, Spina E, Facciola G, Scordo MG, Tybring G: Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos. 2001 Oct;29(10):1263-8. - Pubmed
DTHybrid score 0.3492

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.4142
885 5-hydroxytryptamine 1B receptor HTR1B 0.3863
163 D(1B) dopamine receptor DRD5 0.3532
1588 Multidrug resistance protein 1 ABCB1 0.3375
436 5-hydroxytryptamine 2B receptor HTR2B 0.2919
789 Alpha-1D adrenergic receptor ADRA1D 0.2833
6016 Cytochrome P450 2C19 CYP2C19 0.2449
716 5-hydroxytryptamine 7 receptor HTR7 0.2418
4757 Cytochrome P450 2C9 CYP2C9 0.2403
6107 Cytochrome P450 3A7 CYP3A7 0.2366
103 Muscarinic acetylcholine receptor M1 CHRM1 0.2265
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1953
824 Sodium-dependent serotonin transporter SLC6A4 0.1791
617 Muscarinic acetylcholine receptor M2 CHRM2 0.1693
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1661
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1659
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1614
1256 5-hydroxytryptamine 6 receptor HTR6 0.1498
6013 Cytochrome P450 2E1 CYP2E1 0.1459
4924 Cytochrome P450 2C8 CYP2C8 0.1441
6145 Solute carrier family 22 member 1 SLC22A1 0.1431
766 Beta-2 adrenergic receptor ADRB2 0.1338
713 Sodium-dependent dopamine transporter SLC6A3 0.1336
6030 Cytochrome P450 2B6 CYP2B6 0.1321
193 Beta-1 adrenergic receptor ADRB1 0.1288
3941 Amine oxidase [flavin-containing] A MAOA 0.1187
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1054
587 Serum albumin ALB 0.1039
341 5-hydroxytryptamine 3 receptor HTR3A 0.0991
528 5-hydroxytryptamine 1E receptor HTR1E 0.0986
6024 Cytochrome P450 1A1 CYP1A1 0.0859
6144 Solute carrier family 22 member 2 SLC22A2 0.0838
131 Synaptic vesicular amine transporter SLC18A2 0.0812
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0765
511 5-hydroxytryptamine 1F receptor HTR1F 0.0756
5718 Cytochrome P450 2A6 CYP2A6 0.0657
6147 Solute carrier family 22 member 3 SLC22A3 0.0625
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0601
118 Organic cation/carnitine transporter 2 SLC22A5 0.0565
465 Calmodulin CALM1 0.0523
3923 Cholinesterase BCHE 0.0517
3876 Aromatic-L-amino-acid decarboxylase DDC 0.048
1517 Beta-3 adrenergic receptor ADRB3 0.0473
94 5-hydroxytryptamine 4 receptor HTR4 0.0452
124 Histamine H2 receptor HRH2 0.0451
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0451
174 Sigma 1-type opioid receptor SIGMAR1 0.0435
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0419
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.04
6070 Nischarin NISCH 0.0397
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0394
3939 Amine oxidase [flavin-containing] B MAOB 0.0382
6106 Cytochrome P450 2C18 CYP2C18 0.0363
20 Prostaglandin G/H synthase 1 PTGS1 0.0349
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0345
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0342
828 Phenylalanine-4-hydroxylase PAH 0.0334
3109 Phenylalanine-4-hydroxylase phhA 0.0334
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0332
696 Kappa-type opioid receptor OPRK1 0.0321
847 Mu-type opioid receptor OPRM1 0.0321
6020 Aldehyde oxidase AOX1 0.0309
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0299
1898 Cytochrome P450 1B1 CYP1B1 0.0289
1656 CYP2B protein CYP2B 0.0283
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0274
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.027
467 Delta-type opioid receptor OPRD1 0.0264
776 Bile salt export pump ABCB11 0.0261
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0259
833 Organic cation/carnitine transporter 1 SLC22A4 0.0258
862 Multidrug resistance-associated protein 1 ABCC1 0.0258
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.025
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0248
3811 Cytochrome P450 19A1 CYP19A1 0.0244
1636 Trace amine-associated receptor 1 TAAR1 0.0243
871 Glucocorticoid receptor NR3C1 0.0243
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0242
474 Acetylcholinesterase ACHE 0.0242
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0238
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0231
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.022
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0219
164 Histamine H4 receptor HRH4 0.0216
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0216
6151 Monocarboxylate transporter 10 SLC16A10 0.0214
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0206
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0203
1729 Solute carrier family 22 member 6 SLC22A6 0.0202
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0193
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0193
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0192
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0192
1341 Histamine H3 receptor HRH3 0.0189
3426 Glutamine synthetase glnA 0.0189
3987 Glutamine synthetase GLUL 0.0189
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0188
6182 Cytochrome P450 2J2 CYP2J2 0.0184
731 HIV-1 protease HIV-1 protease 0.018
6031 Cytochrome P450 3A43 CYP3A43 0.0178
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0177
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0172
3810 Catechol O-methyltransferase COMT 0.017
516 Neurotensin receptor type 2 NTSR2 0.0168
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0166
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0164
923 Glutamate receptor 3 GRIA3 0.0149
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0147
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0145
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0141
232 Corticosteroid-binding globulin SERPINA6 0.0139
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0139
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0136
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0136
153 Dopamine beta-hydroxylase DBH 0.0133
6432 Transporter snf 0.0132
233 Potassium channel subfamily K member 2 KCNK2 0.0132
6138 Multidrug resistance protein 3 ABCB4 0.0128
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0124
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0123
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0123
136 Estrogen receptor ESR1 0.0122
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.012
817 DNA topoisomerase 2-alpha TOP2A 0.0116
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0116
362 Melatonin receptor type 1B MTNR1B 0.0115
614 Progesterone receptor PGR 0.0115
571 Melatonin receptor type 1A MTNR1A 0.0115
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0111
260 Cytochrome P450 51 ERG11 0.0111
761 Cytochrome P450 51 ERG11 0.0111
3163 Cytochrome P450 51 cyp51 0.0111
4148 Serine/threonine-protein kinase mTOR MTOR 0.011
921 Glutamate receptor 2 GRIA2 0.0106
4120 NADPH--cytochrome P450 reductase POR 0.0106
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0105
290 Prostaglandin G/H synthase 2 PTGS2 0.0104
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0102
6142 Solute carrier family 22 member 8 SLC22A8 0.0101
6143 Solute carrier family 22 member 7 SLC22A7 0.0101
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0098
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0098
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0097
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0097
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
380 Cytochrome P450 17A1 CYP17A1 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
1275 Estrogen sulfotransferase SULT1E1 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0091
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
6148 Multidrug resistance-associated protein 7 ABCC10 0.0087
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0087
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0087
468 Cytochrome P450 4A11 CYP4A11 0.0087
2164 Multidrug resistance-associated protein 4 ABCC4 0.0086
844 Epidermal growth factor receptor EGFR 0.0086
737 Mineralocorticoid receptor NR3C2 0.0086
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0083
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0081
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0079
952 Dipeptidyl peptidase 4 DPP4 0.0079
6859 Protein S100-A4 S100A4 0.0076
504 Mast/stem cell growth factor receptor KIT 0.0075
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0075
818 50S ribosomal protein L10 rplJ 0.0074
1618 High affinity nerve growth factor receptor NTRK1 0.0074
6220 Aryl hydrocarbon receptor AHR 0.0073
705 Glutamate receptor 1 GRIA1 0.0072
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0071
146 Androgen receptor AR 0.0071
427 Substance-P receptor TACR1 0.007
2112 Toll-like receptor 9 TLR9 0.0069
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0068
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0068
29 Tubulin beta-1 chain TUBB1 0.0068
161 Tubulin beta chain TUBB 0.0068
312 Tubulin beta chain TUB2 0.0068
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0067
811 Translocator protein TSPO 0.0065
4604 Liver carboxylesterase 1 CES1 0.0065
4203 Histamine N-methyltransferase HNMT 0.0064
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0064
407 Vascular endothelial growth factor receptor 2 KDR 0.0064
904 Glutathione S-transferase P GSTP1 0.0064
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0063
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0062
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0061
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.006
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
777 Tumor necrosis factor TNF 0.006
756 Sex hormone-binding globulin SHBG 0.006
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0059
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0058
26 Vascular endothelial growth factor receptor 3 FLT4 0.0058
6137 Multidrug resistance-associated protein 6 ABCC6 0.0058
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0058
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0058
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0058
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0056
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0056
122 P2Y purinoceptor 12 P2RY12 0.0056
32 Vascular endothelial growth factor receptor 1 FLT1 0.0055
228 Beta platelet-derived growth factor receptor PDGFRB 0.0055
6506 Stathmin-4 STMN4 0.0055
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0055
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0054
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0054
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0054
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0054
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0054
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0053
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
768 FK506-binding protein 1A FKBP1A 0.005
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.005
4237 50S ribosomal protein L22 rplV 0.0049
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0049
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
814 Ryanodine receptor 1 RYR1 0.0048
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0047
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0047
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0047
565 Extracellular calcium-sensing receptor CASR 0.0046
1010 Cytochrome P450 51A1 CYP51A1 0.0046
3086 Plasmepsin-2 Not Available 0.0046
2539 Tubulin alpha-1 chain TUBA4A 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
1360 Sphingomyelin phosphodiesterase SMPD1 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0043
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
477 DNA topoisomerase 4 subunit A parC 0.0042
886 DNA topoisomerase 4 subunit A parC 0.0042
6226 DNA topoisomerase 4 subunit A parC 0.0042
404 DNA gyrase subunit A gyrA 0.0042
6224 DNA gyrase subunit A gyrA 0.0042
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0042
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
1024 Solute carrier family 22 member 11 SLC22A11 0.0041
295 Carbonic anhydrase 1 CA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
856 Vitamin D3 receptor VDR 0.004
165 FL cytokine receptor FLT3 0.004
239 Coagulation factor X F10 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0039
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6102 Arylamine N-acetyltransferase 2 NAT2 0.0038
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
70 Type-1 angiotensin II receptor AGTR1 0.0038
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
1178 Adenosine A2a receptor ADORA2A 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
6014 Cytochrome P450 2A13 CYP2A13 0.0037
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0037
6136 Multidrug resistance-associated protein 5 ABCC5 0.0036
54 Prothrombin F2 0.0036
738 Monocarboxylate transporter 1 SLC16A1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1483 Membrane copper amine oxidase AOC3 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0034
284 DNA-directed RNA polymerase beta chain rpoB 0.0034
5773 DNA-directed RNA polymerase beta chain rpoB 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0034
4238 50S ribosomal protein L4 rplD 0.0033
5578 50S ribosomal protein L4 rplD 0.0033
6173 50S ribosomal protein L4 rplD 0.0033
6219 50S ribosomal protein L4 rplD 0.0033
6141 Sodium/bile acid cotransporter SLC10A1 0.0033
373 Transthyretin TTR 0.0033
4311 tRNA TRDMT1 0.0033
4325 tRNA trmD 0.0033
4328 tRNA trmD 0.0033
1852 Microtubule-associated protein 2 MAP2 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
869 Estrogen receptor beta ESR2 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1050 Bile salt sulfotransferase SULT2A1 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
1629 Transcription factor AP-1 JUN 0.0031
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0031
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
4122 Histone deacetylase 2 HDAC2 0.0029
1374 Natriuretic peptides B NPPB 0.0029
1827 Gap junction alpha-1 protein GJA1 0.0029
1908 Vascular cell adhesion protein 1 VCAM1 0.0029
823 Fibroblast growth factor receptor 2 FGFR2 0.0029
16 Adenosine A1 receptor ADORA1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0028
183 Vascular endothelial growth factor A VEGFA 0.0028
469 Annexin A1 ANXA1 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
4773 Deoxycytidine kinase DCK 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
2449 Tubulin alpha-3 chain TUBA1A 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0026
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0026
49 Endothelin B receptor EDNRB 0.0026
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0026
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0025
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0025
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
5924 Microtubule-associated protein 4 MAP4 0.0024
5923 Microtubule-associated protein tau MAPT 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
84 Nuclear receptor 0B1 NR0B1 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
33 Cystine/glutamate transporter SLC7A11 0.0023
6174 50S ribosomal protein L32 rpmF 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
5787 Angiopoietin-1 receptor TEK 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
319 Opioid receptor, sigma 1 OPRS1 0.0022
273 Apoptosis regulator Bcl-2 BCL2 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
1196 Complement decay-accelerating factor CD55 0.0022
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
298 Renin REN 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
1630 Integrin beta-2 ITGB2 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
976 Platelet glycoprotein IX GP9 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1353 DNA topoisomerase 1 TOP1 0.0021
3552 DNA topoisomerase 1 topA 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
4192 DNA topoisomerase 2-beta TOP2B 0.0021
6126 Carbonic anhydrase 7 CA7 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
482 Glycine receptor subunit alpha-1 GLRA1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1525 Heparin-binding growth factor 2 FGF2 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
1192 Sulfotransferase 1A1 SULT1A1 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
1757 Myeloperoxidase MPO 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
780 Retinoic acid receptor RXR-gamma RXRG 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
3601 Dihydropteroate synthase 1 folP1 0.0017
3807 Dihydropteroate synthase 1 folP1 0.0017
3808 Dihydropteroate synthase 2 folP2 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
88 Retinoic acid receptor RXR-beta RXRB 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
518 Peroxidase/catalase T katG 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
572 Integrin alpha-L ITGAL 0.0016
3233 Bile acid receptor NR1H4 0.0015
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
1864 RET proto-oncogene RET 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
563 Thyroid peroxidase TPO 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
7 Nitric oxide synthase, inducible NOS2 0.0015
1541 Metalloproteinase mmp20 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
3904 Alanine aminotransferase 2 GPT2 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
719 Retinoic acid receptor responder protein 1 RARRES1 0.0012
770 Retinoic acid-induced protein 3 GPRC5A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
3809 Estrogen-related receptor gamma ESRRG 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
569 Retinal dehydrogenase 2 ALDH1A2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
267 Plasminogen activator inhibitor 1 SERPINE1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
4116 Dihydropteroate synthetase Not Available 0.001
6085 Fatty acid-binding protein, intestinal FABP2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
6146 High affinity copper uptake protein 1 SLC31A1 0.001
6221 Steroid hormone receptor ERR1 ESRRA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
908 Glutathione S-transferase theta-1 GSTT1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1648 Elastin ELN 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2298 Cytochrome P450-cam camC 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
751 Potassium channel subfamily K member 6 KCNK6 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
3957 Adenosine deaminase ADA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
2207 Rhodopsin RHO 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
2981 Phospholipase A2, membrane associated PLA2G2A 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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