DT-Web

DB00268 - Ropinirole


Identification
Name Ropinirole
Accession Number DB00268 (APRD00302)
Type small molecule
Description Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson's disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 260.3746
Groups approved
Monoisotopic Weight 260.1888634
Pharmacology
Indication For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.
Mechanism of action Ropinirole binds the dopamine receptors D3 and D2. Although the precise mechanism of action of ropinirole as a treatment for Parkinson's disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.
Absorption Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.
Protein binding 40% bound to plasma proteins with a blood-to-plasma ratio of 1:1.
Biotransformation Hepatic. Ropinirole is extensively metabolized to inactive metabolites via N -despropylation and hydroxylation pathways, largely by the P450 isoenzyme CYP1A2. N-despropyl ropinirole is the predominant metabolite found in urine (40%), followed by the carboxylic acid metabolite (10%), and the glucuronide of the hydroxy metabolite (10%).
Route of elimination Ropinirole is extensively metabolized by the liver to inactive metabolites, and less than 10% of the administered dose is excreted as unchanged drug in urine.
Toxicity Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ciprofloxacin Ciprofloxacin may increase the effect and toxicity of ropinirole.
Dihydrocodeine Dihydrocodeine may enhance the sedative effect of ropinirole. It is recommended to monitor therapy
Fluvoxamine Increases the effect and toxicity of ropinirole
Paliperidone The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, ropinirole. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Thiothixene Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Ropinirole. Consider alternate therapy or monitor for decreased effects of both agents.
Ziprasidone The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, ropinirole. Consider alternate therapy or monitor for worsening of movement disorder.
Zuclopenthixol Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and ropinirole, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed.
Food Interactions Not Available

Targets


D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score 0.5828
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • de Mey C, Enterling D, Meineke I, Yeulet S: Interactions between domperidone and ropinirole, a novel dopamine D2-receptor agonist. Br J Clin Pharmacol. 1991 Oct;32(4):483-8. - Pubmed
  • Iida M, Miyazaki I, Tanaka K, Kabuto H, Iwata-Ichikawa E, Ogawa N: Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res. 1999 Aug 14;838(1-2):51-9. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
  • Matsukawa N, Maki M, Yasuhara T, Hara K, Yu G, Xu L, Kim KM, Morgan JC, Sethi KD, Borlongan CV: Overexpression of D2/D3 receptors increases efficacy of ropinirole in chronically 6-OHDA-lesioned Parkinsonian rats. Brain Res. 2007 Jul 30;1160:113-23. Epub 2007 May 26. - Pubmed
DTHybrid score 0.9115
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action unknown
Actions agonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.5412
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.7198
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.5793
5-hydroxytryptamine 2B receptor
Name 5-hydroxytryptamine 2B receptor
Gene Name HTR2B
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.4824
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.7865
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.5075
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.5901
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.8051
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.6314
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.817
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.6405
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions agonist
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score 0.625

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5918
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7284
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7445

Predictions


Id Partner name Gene Name Score
556 Alpha-1A adrenergic receptor ADRA1A 0.4542
632 Alpha-1B adrenergic receptor ADRA1B 0.3205
1588 Multidrug resistance protein 1 ABCB1 0.2981
716 5-hydroxytryptamine 7 receptor HTR7 0.2812
492 Histamine H1 receptor HRH1 0.2598
6016 Cytochrome P450 2C19 CYP2C19 0.2317
4757 Cytochrome P450 2C9 CYP2C9 0.2309
4118 Cytochrome P450 3A5 CYP3A5 0.2106
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1964
789 Alpha-1D adrenergic receptor ADRA1D 0.1883
824 Sodium-dependent serotonin transporter SLC6A4 0.1863
6107 Cytochrome P450 3A7 CYP3A7 0.1663
3941 Amine oxidase [flavin-containing] A MAOA 0.1514
6013 Cytochrome P450 2E1 CYP2E1 0.1514
617 Muscarinic acetylcholine receptor M2 CHRM2 0.1504
1256 5-hydroxytryptamine 6 receptor HTR6 0.1495
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1492
51 Muscarinic acetylcholine receptor M3 CHRM3 0.146
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1451
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1442
511 5-hydroxytryptamine 1F receptor HTR1F 0.1331
4924 Cytochrome P450 2C8 CYP2C8 0.1318
6145 Solute carrier family 22 member 1 SLC22A1 0.1257
766 Beta-2 adrenergic receptor ADRB2 0.1239
193 Beta-1 adrenergic receptor ADRB1 0.1226
6030 Cytochrome P450 2B6 CYP2B6 0.1139
528 5-hydroxytryptamine 1E receptor HTR1E 0.1134
341 5-hydroxytryptamine 3 receptor HTR3A 0.1067
6024 Cytochrome P450 1A1 CYP1A1 0.1011
587 Serum albumin ALB 0.0941
713 Sodium-dependent dopamine transporter SLC6A3 0.0881
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0813
6144 Solute carrier family 22 member 2 SLC22A2 0.0812
5718 Cytochrome P450 2A6 CYP2A6 0.0745
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0741
131 Synaptic vesicular amine transporter SLC18A2 0.0598
94 5-hydroxytryptamine 4 receptor HTR4 0.0582
1517 Beta-3 adrenergic receptor ADRB3 0.0549
6147 Solute carrier family 22 member 3 SLC22A3 0.0536
3923 Cholinesterase BCHE 0.0521
118 Organic cation/carnitine transporter 2 SLC22A5 0.0503
3876 Aromatic-L-amino-acid decarboxylase DDC 0.047
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0465
3939 Amine oxidase [flavin-containing] B MAOB 0.0449
465 Calmodulin CALM1 0.0445
20 Prostaglandin G/H synthase 1 PTGS1 0.0438
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0437
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.043
174 Sigma 1-type opioid receptor SIGMAR1 0.0426
124 Histamine H2 receptor HRH2 0.0421
6070 Nischarin NISCH 0.0421
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0406
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.035
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0342
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0328
6106 Cytochrome P450 2C18 CYP2C18 0.0324
6020 Aldehyde oxidase AOX1 0.0311
1898 Cytochrome P450 1B1 CYP1B1 0.0295
3811 Cytochrome P450 19A1 CYP19A1 0.0294
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0293
847 Mu-type opioid receptor OPRM1 0.0288
474 Acetylcholinesterase ACHE 0.0274
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0271
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.027
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0264
696 Kappa-type opioid receptor OPRK1 0.0263
36 Insulin receptor INSR 0.0258
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0243
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0237
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0231
6151 Monocarboxylate transporter 10 SLC16A10 0.0228
828 Phenylalanine-4-hydroxylase PAH 0.0225
3109 Phenylalanine-4-hydroxylase phhA 0.0225
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.022
467 Delta-type opioid receptor OPRD1 0.0214
3810 Catechol O-methyltransferase COMT 0.0211
833 Organic cation/carnitine transporter 1 SLC22A4 0.0208
862 Multidrug resistance-associated protein 1 ABCC1 0.0203
871 Glucocorticoid receptor NR3C1 0.0203
1729 Solute carrier family 22 member 6 SLC22A6 0.0196
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0194
5251 Carbonyl reductase [NADPH] 1 CBR1 0.019
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0189
164 Histamine H4 receptor HRH4 0.0185
776 Bile salt export pump ABCB11 0.0173
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0172
290 Prostaglandin G/H synthase 2 PTGS2 0.017
6432 Transporter snf 0.017
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0168
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0168
571 Melatonin receptor type 1A MTNR1A 0.0167
362 Melatonin receptor type 1B MTNR1B 0.0167
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0166
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0166
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0166
817 DNA topoisomerase 2-alpha TOP2A 0.0166
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0161
731 HIV-1 protease HIV-1 protease 0.016
153 Dopamine beta-hydroxylase DBH 0.0158
136 Estrogen receptor ESR1 0.0156
1656 CYP2B protein CYP2B 0.0152
3426 Glutamine synthetase glnA 0.0152
3987 Glutamine synthetase GLUL 0.0152
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0151
923 Glutamate receptor 3 GRIA3 0.0149
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
1636 Trace amine-associated receptor 1 TAAR1 0.0141
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0141
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0138
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0135
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0132
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.013
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0122
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0121
921 Glutamate receptor 2 GRIA2 0.0119
904 Glutathione S-transferase P GSTP1 0.0115
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0109
260 Cytochrome P450 51 ERG11 0.01
761 Cytochrome P450 51 ERG11 0.01
3163 Cytochrome P450 51 cyp51 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
380 Cytochrome P450 17A1 CYP17A1 0.0097
233 Potassium channel subfamily K member 2 KCNK2 0.0096
6142 Solute carrier family 22 member 8 SLC22A8 0.0096
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
232 Corticosteroid-binding globulin SERPINA6 0.0093
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0091
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0091
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0091
6143 Solute carrier family 22 member 7 SLC22A7 0.009
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0089
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
818 50S ribosomal protein L10 rplJ 0.0089
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0088
16 Adenosine A1 receptor ADORA1 0.0087
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0086
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0086
6031 Cytochrome P450 3A43 CYP3A43 0.0086
2164 Multidrug resistance-associated protein 4 ABCC4 0.0085
6220 Aryl hydrocarbon receptor AHR 0.0083
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0082
1178 Adenosine A2a receptor ADORA2A 0.0082
468 Cytochrome P450 4A11 CYP4A11 0.0081
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0079
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0079
173 Toll-like receptor 7 TLR7 0.0079
6182 Cytochrome P450 2J2 CYP2J2 0.0078
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0076
777 Tumor necrosis factor TNF 0.0076
614 Progesterone receptor PGR 0.0076
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0075
4120 NADPH--cytochrome P450 reductase POR 0.0075
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0073
6014 Cytochrome P450 2A13 CYP2A13 0.0065
427 Substance-P receptor TACR1 0.0065
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0064
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
504 Mast/stem cell growth factor receptor KIT 0.0062
122 P2Y purinoceptor 12 P2RY12 0.0061
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0061
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0061
952 Dipeptidyl peptidase 4 DPP4 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0061
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.006
6148 Multidrug resistance-associated protein 7 ABCC10 0.006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0059
161 Tubulin beta chain TUBB 0.0058
312 Tubulin beta chain TUB2 0.0058
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0056
146 Androgen receptor AR 0.0056
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0055
6859 Protein S100-A4 S100A4 0.0055
4122 Histone deacetylase 2 HDAC2 0.0055
6506 Stathmin-4 STMN4 0.0055
1618 High affinity nerve growth factor receptor NTRK1 0.0054
844 Epidermal growth factor receptor EGFR 0.0054
5998 Toll-like receptor 8 TLR8 0.0053
407 Vascular endothelial growth factor receptor 2 KDR 0.0052
712 Tubulin alpha chain TUB1 0.0052
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0052
2112 Toll-like receptor 9 TLR9 0.0051
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0051
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
4604 Liver carboxylesterase 1 CES1 0.005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
373 Transthyretin TTR 0.0049
26 Vascular endothelial growth factor receptor 3 FLT4 0.0049
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0049
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
228 Beta platelet-derived growth factor receptor PDGFRB 0.0047
32 Vascular endothelial growth factor receptor 1 FLT1 0.0047
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0047
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0047
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0046
1757 Myeloperoxidase MPO 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
814 Ryanodine receptor 1 RYR1 0.0046
869 Estrogen receptor beta ESR2 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
70 Type-1 angiotensin II receptor AGTR1 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0045
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0044
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0044
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0044
6102 Arylamine N-acetyltransferase 2 NAT2 0.0044
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0043
1629 Transcription factor AP-1 JUN 0.0042
811 Translocator protein TSPO 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1010 Cytochrome P450 51A1 CYP51A1 0.0042
1024 Solute carrier family 22 member 11 SLC22A11 0.0042
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0042
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0042
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0042
756 Sex hormone-binding globulin SHBG 0.0041
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0041
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.004
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.004
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.004
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.004
273 Apoptosis regulator Bcl-2 BCL2 0.004
856 Vitamin D3 receptor VDR 0.004
29 Tubulin beta-1 chain TUBB1 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.004
365 Dihydrofolate reductase DHFR 0.004
2381 Dihydrofolate reductase DFR1 0.004
2833 Dihydrofolate reductase Not Available 0.004
2931 Dihydrofolate reductase folA 0.004
3544 Dihydrofolate reductase folA 0.004
3682 Dihydrofolate reductase folA 0.004
6642 Dihydrofolate reductase folA 0.004
6756 Dihydrofolate reductase dfrA 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
295 Carbonic anhydrase 1 CA1 0.0039
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6137 Multidrug resistance-associated protein 6 ABCC6 0.0038
592 Carbonic anhydrase 4 CA4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0038
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
1050 Bile salt sulfotransferase SULT2A1 0.0036
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0033
737 Mineralocorticoid receptor NR3C2 0.0033
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0032
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0032
275 Arachidonate 5-lipoxygenase ALOX5 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0031
482 Glycine receptor subunit alpha-1 GLRA1 0.0031
6136 Multidrug resistance-associated protein 5 ABCC5 0.0031
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4203 Histamine N-methyltransferase HNMT 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0029
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0029
4311 tRNA TRDMT1 0.0029
4325 tRNA trmD 0.0029
4328 tRNA trmD 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
3957 Adenosine deaminase ADA 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
518 Peroxidase/catalase T katG 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6141 Sodium/bile acid cotransporter SLC10A1 0.0026
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
563 Thyroid peroxidase TPO 0.0026
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1648 Elastin ELN 0.0026
49 Endothelin B receptor EDNRB 0.0026
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
1360 Sphingomyelin phosphodiesterase SMPD1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
634 Squalene monooxygenase SQLE 0.0025
7196 Squalene monooxygenase ERG1 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
738 Monocarboxylate transporter 1 SLC16A1 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
1192 Sulfotransferase 1A1 SULT1A1 0.0023
3086 Plasmepsin-2 Not Available 0.0023
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0023
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0023
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6146 High affinity copper uptake protein 1 SLC31A1 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
239 Coagulation factor X F10 0.0022
3404 Exotoxin A eta 0.0022
780 Retinoic acid receptor RXR-gamma RXRG 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
165 FL cytokine receptor FLT3 0.0021
298 Renin REN 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
33 Cystine/glutamate transporter SLC7A11 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.002
6126 Carbonic anhydrase 7 CA7 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1820 Beta-nerve growth factor NGF 0.002
88 Retinoic acid receptor RXR-beta RXRB 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
183 Vascular endothelial growth factor A VEGFA 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0019
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0019
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0019
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0019
823 Fibroblast growth factor receptor 2 FGFR2 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
976 Platelet glycoprotein IX GP9 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4103 Proteasome subunit beta type 2 PSMB2 0.0018
4102 Proteasome subunit beta type 5 PSMB5 0.0018
4101 Proteasome subunit beta type 1 PSMB1 0.0018
1374 Natriuretic peptides B NPPB 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
1243 Cathepsin D CTSD 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
268 Adenosine A2b receptor ADORA2B 0.0015
3937 Fatty-acid amide hydrolase FAAH 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
54 Prothrombin F2 0.0013
1864 RET proto-oncogene RET 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
908 Glutathione S-transferase theta-1 GSTT1 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
896 Glutathione S-transferase Mu 1 GSTM1 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
1295 Fatty acid synthase FASN 0.0012
936 Ephrin type-A receptor 2 EPHA2 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
162 Retinoic acid receptor gamma-1 RARG 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1630 Integrin beta-2 ITGB2 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
469 Annexin A1 ANXA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6085 Fatty acid-binding protein, intestinal FABP2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3830 Calreticulin CALR 0.0008
1867 Major prion protein PRNP 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
1025 Aquaporin-1 AQP1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
3809 Estrogen-related receptor gamma ESRRG 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
2207 Rhodopsin RHO 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
↑