DT-Web

DB01235 - Levodopa


Identification
Name Levodopa
Accession Number DB01235 (APRD00309, EXPT01107)
Type small molecule
Description The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 197.1879
Groups approved
Monoisotopic Weight 197.068807845
Pharmacology
Indication For the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication.
Mechanism of action Striatal dopamine levels in symptomatic Parkinson's disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine through administration of dopamine's precursor, levodopa. A small percentage of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thus compensating for the depleted supply of endogenous dopamine.
Absorption Levodopa is rapidly absorbed from the proximal small intestine by the large neutral amino acid (LNAA) transport carrier system.
Protein binding High
Biotransformation 95% of an administered oral dose of levodopa is pre-systemically decarboxylated to dopamine by the L-aromatic amino acid decarboxylase (AAAD) enzyme in the stomach, lumen of the intestine, kidney, and liver. Levodopa also may be methoxylated by the hepatic catechol-O-methyltransferase (COMT) enzyme system to 3-O-methyldopa (3-OMD), which cannot be converted to central dopamine.
Route of elimination Not Available
Toxicity Oral, mouse: LD50 = 2363 mg/kg; Oral, rabbit: LD50 = 609 mg/kg; Oral, rat: LD50 = 1780 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Fosphenytoin The hydantoin decreases the effect of levodopa
Iron Dextran Iron decreases the absorption of dopa derivatives
Isocarboxazid Possible hypertensive crisis
Methyldopa Methyldopa increases the effect and toxicity of levodopa
Metoclopramide Levodopa decreases the effect of metoclopramide
Paliperidone The atypical antipsychotic agent, paliperidone, may decrease the therapeutic effect of the anti-Parkinson's agent, levodopa. This interaction may be due to the dopamine antagonist properties of paliperidone. Consider an alternate antipsychotic in those with Parkinson's disease or consider using clozapine or quetiapine if an atypical antipsychotic is necessary.
Phenelzine Possible hypertensive crisis
Phenytoin The hydantoin decreases the effect of levodopa
Tetrabenazine Tetrabenazine may cause Parkinsonian symptoms and neutralize the effect of Levodopa.
Thiothixene Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Levodopa. Consider alternate therapy or monitor for decreased effects of both agents.
Tranylcypromine Levodopa may increase the adverse effects of Tranylcypromine. Risk of severe hypertension. Concomitant therapy should be avoided or monitored closely for adverse effects of Tranylcypromine.
Ziprasidone The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, levodopa. Consider alternate therapy or monitor for worsening of movement disorder.
Zuclopenthixol Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and levodopa, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed.
Food Interactions Not Available

Targets


D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions agonist
References
  • Onofrj M, Bonanni L, Thomas A: An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Koller WC, Rueda MG: Mechanism of action of dopaminergic agents in Parkinson's disease. Neurology. 1998 Jun;50(6 Suppl 6):S11-4; discussion S44-8. - Pubmed
DTHybrid score 0.5051
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action yes
Actions agonist
References
  • Onofrj M, Bonanni L, Thomas A: An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Koller WC, Rueda MG: Mechanism of action of dopaminergic agents in Parkinson's disease. Neurology. 1998 Jun;50(6 Suppl 6):S11-4; discussion S44-8. - Pubmed
DTHybrid score 0.3235
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions agonist
References
  • Dupre KB, Eskow KL, Negron G, Bishop C: The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat. Brain Res. 2007 Jul 16;1158:135-43. Epub 2007 May 8. - Pubmed
  • Mori A, Ohashi S, Nakai M, Moriizumi T, Mitsumoto Y: Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice. Neurosci Res. 2005 Mar;51(3):265-74. Epub 2005 Jan 8. - Pubmed
  • Zappia M, Annesi G, Nicoletti G, Arabia G, Annesi F, Messina D, Pugliese P, Spadafora P, Tarantino P, Carrideo S, Civitelli D, De Marco EV, Ciro-Candiano IC, Gambardella A, Quattrone A: Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. Arch Neurol. 2005 Apr;62(4):601-5. - Pubmed
  • Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J: D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci. 2005 Feb 23;25(8):2157-65. - Pubmed
  • Onofrj M, Bonanni L, Thomas A: An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Koller WC, Rueda MG: Mechanism of action of dopaminergic agents in Parkinson's disease. Neurology. 1998 Jun;50(6 Suppl 6):S11-4; discussion S44-8. - Pubmed
DTHybrid score 0.599
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action yes
Actions agonist
References
  • Onofrj M, Bonanni L, Thomas A: An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Koller WC, Rueda MG: Mechanism of action of dopaminergic agents in Parkinson's disease. Neurology. 1998 Jun;50(6 Suppl 6):S11-4; discussion S44-8. - Pubmed
DTHybrid score 0.3471
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action yes
Actions agonist
References
  • Onofrj M, Bonanni L, Thomas A: An expert opinion on safinamide in Parkinson's disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25. - Pubmed
  • Deleu D, Northway MG, Hanssens Y: Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. - Pubmed
  • Koller WC, Rueda MG: Mechanism of action of dopaminergic agents in Parkinson's disease. Neurology. 1998 Jun;50(6 Suppl 6):S11-4; discussion S44-8. - Pubmed
DTHybrid score 0.3306

Enzymes


Aromatic-L-amino-acid decarboxylase
Name Aromatic-L-amino-acid decarboxylase
Gene Name DDC
Actions Not Available
References
  • BIRKMAYER W, HORNYKIEWICZ O: [The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia]. Wien Klin Wochenschr. 1961 Nov 10;73:787-8. - Pubmed
DTHybrid score 0.4376
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4119

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL: CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50. - Pubmed
  • Tamai I, Nakanishi T, Nakahara H, Sai Y, Ganapathy V, Leibach FH, Tsuji A: Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1. J Pharm Sci. 1998 Dec;87(12):1542-6. - Pubmed
DTHybrid score 0.3277
Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.516
Large neutral amino acids transporter small subunit 1
Name Large neutral amino acids transporter small subunit 1
Gene Name SLC7A5
Actions Not Available
References
  • Pinho MJ, Serrao MP, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P: Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int. 2004 Jul;66(1):216-26. - Pubmed
  • Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M, Tsuruo T, Minato N, Shimohama S: The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res. 2000 Oct 6;879(1-2):115-21. - Pubmed
DTHybrid score 0.5918
Large neutral amino acids transporter small subunit 2
Name Large neutral amino acids transporter small subunit 2
Gene Name SLC7A8
Actions Not Available
References
  • Pinho MJ, Serrao MP, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P: Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int. 2004 Jul;66(1):216-26. - Pubmed
DTHybrid score 0.3596

Predictions


Id Partner name Gene Name Score
502 5-hydroxytryptamine 2A receptor HTR2A 0.2951
4512 Cytochrome P450 3A4 CYP3A4 0.2033
318 Alpha-2A adrenergic receptor ADRA2A 0.2012
629 Alpha-2B adrenergic receptor ADRA2B 0.1946
320 5-hydroxytryptamine 1A receptor HTR1A 0.1872
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1862
378 Alpha-2C adrenergic receptor ADRA2C 0.1839
556 Alpha-1A adrenergic receptor ADRA1A 0.1822
590 5-hydroxytryptamine 2C receptor HTR2C 0.1822
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.158
4200 Cytochrome P450 1A2 CYP1A2 0.1396
1588 Multidrug resistance protein 1 ABCB1 0.1389
725 5-hydroxytryptamine 1D receptor HTR1D 0.1371
632 Alpha-1B adrenergic receptor ADRA1B 0.133
885 5-hydroxytryptamine 1B receptor HTR1B 0.1264
436 5-hydroxytryptamine 2B receptor HTR2B 0.1178
492 Histamine H1 receptor HRH1 0.1012
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0995
1566 Corticoliberin CRH 0.0993
716 5-hydroxytryptamine 7 receptor HTR7 0.0963
244 Angiotensin-converting enzyme ACE 0.0944
6016 Cytochrome P450 2C19 CYP2C19 0.0892
4757 Cytochrome P450 2C9 CYP2C9 0.0812
4118 Cytochrome P450 3A5 CYP3A5 0.0727
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0694
807 D-alanine--D-alanine ligase A ddlA 0.0692
894 Alanine racemase alr 0.0691
2453 Alanine racemase alr 0.0691
6147 Solute carrier family 22 member 3 SLC22A3 0.0676
789 Alpha-1D adrenergic receptor ADRA1D 0.0663
6107 Cytochrome P450 3A7 CYP3A7 0.0635
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0631
6145 Solute carrier family 22 member 1 SLC22A1 0.0624
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0618
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0613
587 Serum albumin ALB 0.0603
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0589
1256 5-hydroxytryptamine 6 receptor HTR6 0.0583
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.058
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.058
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.058
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.058
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.058
118 Organic cation/carnitine transporter 2 SLC22A5 0.0579
758 Thyroid hormone receptor alpha THRA 0.0531
4924 Cytochrome P450 2C8 CYP2C8 0.0528
763 Tyrosine aminotransferase TAT 0.0527
5493 Tyrosine aminotransferase Not Available 0.0527
199 Monocarboxylate transporter 8 SLC16A2 0.0516
6013 Cytochrome P450 2E1 CYP2E1 0.0507
828 Phenylalanine-4-hydroxylase PAH 0.0475
3109 Phenylalanine-4-hydroxylase phhA 0.0475
676 Tyrosine 3-monooxygenase TH 0.0464
633 Penicillin-binding proteins 1A/1B pbpA 0.0461
346 Thyroid hormone receptor beta-1 THRB 0.0459
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0438
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0416
528 5-hydroxytryptamine 1E receptor HTR1E 0.0399
6144 Solute carrier family 22 member 2 SLC22A2 0.0399
1729 Solute carrier family 22 member 6 SLC22A6 0.0393
6030 Cytochrome P450 2B6 CYP2B6 0.0387
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0386
3923 Cholinesterase BCHE 0.0383
341 5-hydroxytryptamine 3 receptor HTR3A 0.0375
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0366
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0366
193 Beta-1 adrenergic receptor ADRB1 0.0365
824 Sodium-dependent serotonin transporter SLC6A4 0.0346
314 System N amino acid transporter 1 SLC38A3 0.034
532 Neutral amino acid transporter A SLC1A4 0.0335
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0334
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0334
766 Beta-2 adrenergic receptor ADRB2 0.0332
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0324
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0321
594 Thyroxine-binding globulin SERPINA7 0.0319
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0311
90 Tryptophan 5-hydroxylase 2 TPH2 0.0311
169 Cysteine desulfurase, mitochondrial NFS1 0.0308
349 Serine--pyruvate aminotransferase AGXT 0.0306
6142 Solute carrier family 22 member 8 SLC22A8 0.0305
3939 Amine oxidase [flavin-containing] B MAOB 0.0301
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.03
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0292
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0291
2532 Pantoate--beta-alanine ligase panC 0.0285
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0282
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0281
174 Sigma 1-type opioid receptor SIGMAR1 0.0276
6024 Cytochrome P450 1A1 CYP1A1 0.0271
465 Calmodulin CALM1 0.0268
694 Matrix protein 2 M 0.0265
713 Sodium-dependent dopamine transporter SLC6A3 0.0264
435 Kynureninase KYNU 0.0264
4654 Kynureninase kynU 0.0264
765 Indoleamine 2,3-dioxygenase IDO1 0.0257
735 Alanine aminotransferase 1 GPT 0.0253
3904 Alanine aminotransferase 2 GPT2 0.0253
3941 Amine oxidase [flavin-containing] A MAOA 0.0251
1181 Alpha-1-acid glycoprotein 1 ORM1 0.025
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0245
6645 D-amino-acid oxidase DAO 0.0245
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0244
263 Neutral amino acid transporter B(0) SLC1A5 0.0241
1 Peptidoglycan synthetase ftsI ftsI 0.0235
4155 Peptidoglycan synthetase ftsI ftsI 0.0235
3426 Glutamine synthetase glnA 0.0233
3987 Glutamine synthetase GLUL 0.0233
5925 Neuropeptide Y NPY 0.0231
134 Tryptophan 5-hydroxylase 1 TPH1 0.0229
2452 Tryptophanyl-tRNA synthetase trpS 0.0229
6012 Tryptophan 2,3-dioxygenase TDO2 0.0227
1385 Angiotensin-converting enzyme 2 ACE2 0.0222
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0222
645 Penicillin-binding protein 1A mrcA 0.0221
5805 Penicillin-binding protein 1A ponA 0.0221
6185 Penicillin-binding protein 1A mrcA 0.0221
6799 Penicillin-binding protein 1A pbpA 0.0221
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.022
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0218
563 Thyroid peroxidase TPO 0.0212
3810 Catechol O-methyltransferase COMT 0.0207
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0204
373 Transthyretin TTR 0.0202
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
5718 Cytochrome P450 2A6 CYP2A6 0.0195
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0182
534 Threonine synthase-like 1 THNSL1 0.0178
543 Penicillin-binding protein 1B mrcB 0.0174
6186 Penicillin-binding protein 1B ponB 0.0174
6822 Penicillin-binding protein 1b pbp1b 0.0174
6844 Penicillin-binding protein 1b pbp1b 0.0174
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0173
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0173
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0173
3989 Glutaminyl-tRNA synthetase QARS 0.0173
1008 CTP synthase 1 CTPS 0.0173
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0173
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0173
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0173
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0169
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0169
5469 Head decoration protein shp 0.0168
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0163
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.016
2457 Bacillolysin nprS 0.016
1517 Beta-3 adrenergic receptor ADRB3 0.0159
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0157
917 Glutaminase kidney isoform, mitochondrial GLS 0.0157
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0157
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0157
5 Glutaminase liver isoform, mitochondrial GLS2 0.0157
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0157
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0156
5261 Phosphoribosylformylglycinamidine synthase purL 0.0156
833 Organic cation/carnitine transporter 1 SLC22A4 0.0154
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
153 Dopamine beta-hydroxylase DBH 0.0144
3 Histidine decarboxylase HDC 0.0144
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0143
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.014
738 Monocarboxylate transporter 1 SLC16A1 0.0138
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
6 Coagulation factor XIII A chain F13A1 0.0134
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0134
413 Amidophosphoribosyltransferase PPAT 0.0133
2515 Amidophosphoribosyltransferase purF 0.0133
3714 Amidophosphoribosyltransferase purF 0.0133
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0132
6106 Cytochrome P450 2C18 CYP2C18 0.0131
6141 Sodium/bile acid cotransporter SLC10A1 0.0131
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0131
358 Cystathionine beta-synthase CBS 0.013
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0128
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
20 Prostaglandin G/H synthase 1 PTGS1 0.0125
3977 ASRGL1 protein ASRGL1 0.0121
1757 Myeloperoxidase MPO 0.0117
4604 Liver carboxylesterase 1 CES1 0.0115
847 Mu-type opioid receptor OPRM1 0.0113
131 Synaptic vesicular amine transporter SLC18A2 0.0113
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0111
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0111
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0109
221 Lysyl-tRNA synthetase KARS 0.0109
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
6067 Penicillin binding protein 2a mecA 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
124 Histamine H2 receptor HRH2 0.0103
184 L-serine dehydratase SDS 0.0102
431 Serine racemase SRR 0.0102
491 Serine palmitoyltransferase 1 SPTLC1 0.0102
727 Serine palmitoyltransferase 2 SPTLC2 0.0102
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0102
3917 Methylenetetrahydrofolate reductase MTHFR 0.0101
482 Glycine receptor subunit alpha-1 GLRA1 0.0101
5650 NimA-related protein DR_0842 0.0101
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
33 Cystine/glutamate transporter SLC7A11 0.0098
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0098
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
1024 Solute carrier family 22 member 11 SLC22A11 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
500 Monocarboxylate transporter 4 SLC16A3 0.0094
474 Acetylcholinesterase ACHE 0.0094
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
6143 Solute carrier family 22 member 7 SLC22A7 0.0091
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0089
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
467 Delta-type opioid receptor OPRD1 0.0087
489 Monocarboxylate transporter 2 SLC16A7 0.0086
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0086
1898 Cytochrome P450 1B1 CYP1B1 0.0085
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0084
696 Kappa-type opioid receptor OPRK1 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
923 Glutamate receptor 3 GRIA3 0.0082
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
499 Arginine decarboxylase ADC 0.0074
94 5-hydroxytryptamine 4 receptor HTR4 0.0073
776 Bile salt export pump ABCB11 0.0069
862 Multidrug resistance-associated protein 1 ABCC1 0.0069
380 Cytochrome P450 17A1 CYP17A1 0.0069
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
164 Histamine H4 receptor HRH4 0.0067
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
89 Cysteine sulfinic acid decarboxylase CSAD 0.0067
2164 Multidrug resistance-associated protein 4 ABCC4 0.0065
707 72 kDa type IV collagenase MMP2 0.0059
868 Cystathionine gamma-lyase CTH 0.0057
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0056
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
3877 Growth-inhibiting protein 18 GIG18 0.0055
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0054
4252 Penicillin-binding protein 5 dacA 0.0054
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0053
426 Aspartate aminotransferase, mitochondrial GOT2 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
5482 Sialidase-2 NEU2 0.0052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0052
834 Arginase-2, mitochondrial ARG2 0.0051
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0051
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.005
921 Glutamate receptor 2 GRIA2 0.005
577 Argininosuccinate lyase ASL 0.0049
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0049
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
65 Matrix metalloproteinase-9 Not Available 0.0048
332 Beta-lactamase blaZ 0.0047
2478 Beta-lactamase ampC 0.0047
2613 Beta-lactamase ampC 0.0047
2635 Beta-lactamase ampC 0.0047
2700 Beta-lactamase penP 0.0047
5445 Beta-lactamase blaB 0.0047
6019 Beta-lactamase SHV-7 0.0047
6701 Beta-lactamase cphA 0.0047
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0046
509 Thymidine kinase TK 0.0046
570 Thymidine kinase TK 0.0046
2559 Thymidine kinase TK 0.0046
3430 Thymidine kinase tdk 0.0046
3518 Thymidine kinase TK 0.0046
5301 Thymidine kinase tdk 0.0046
5771 Thymidine kinase ORF36 0.0046
7009 Thymidine kinase ORF36 0.0046
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0046
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0045
2112 Toll-like receptor 9 TLR9 0.0044
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0043
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0043
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0043
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0042
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0042
3760 Penicillin-binding protein 5 precursor dacA 0.0042
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
6859 Protein S100-A4 S100A4 0.0041
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0041
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.004
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.004
338 DNA polymerase UL30 0.004
379 DNA polymerase UL54 0.004
697 DNA polymerase ORF28 0.004
2482 DNA polymerase 43 0.004
4104 DNA polymerase BALF5 0.004
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.004
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
3884 SHMT2 protein SHMT2 0.0039
3901 SHMT2 protein SHMT2 0.0039
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0039
3879 Serine hydroxymethyltransferase 2 Not Available 0.0039
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0039
3893 DDC protein DDC 0.0038
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0038
867 Penicillin-binding protein 3 pbpC 0.0038
6119 Penicillin-binding protein 3 pbp3 0.0038
7154 Penicillin-binding protein 3 pbp3 0.0038
7157 Penicillin-binding protein 3 LMHCC_2184 0.0038
7162 Penicillin-binding protein 3 pbpB 0.0038
7172 Penicillin-binding protein 3 pbp3 0.0038
3891 Putative L-Dopa decarboxylase DDC 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0037
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
3947 Xanthine dehydrogenase/oxidase XDH 0.0036
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0036
7 Nitric oxide synthase, inducible NOS2 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
420 Glutamate decarboxylase 1 GAD1 0.0034
3900 Glutamate decarboxylase 1 GAD1 0.0034
665 Phosphoserine aminotransferase PSAT1 0.0034
4652 Phosphoserine aminotransferase serC 0.0034
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0034
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0034
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0034
427 Substance-P receptor TACR1 0.0034
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0034
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
6506 Stathmin-4 STMN4 0.0033
6182 Cytochrome P450 2J2 CYP2J2 0.0033
173 Toll-like receptor 7 TLR7 0.0033
291 Nitric-oxide synthase, endothelial NOS3 0.0033
1671 Excitatory amino acid transporter 3 SLC1A1 0.0033
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0033
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0031
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0031
3911 Uncharacterized protein C20orf38 SPTLC3 0.0031
3906 Serine dehydratase-like SDSL 0.0031
3881 Selenocysteine lyase variant Not Available 0.0031
3887 Phosphorylase PYGB 0.0031
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0031
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0031
3878 GAD1 protein GAD1 0.0031
3883 Ornithine aminotransferase variant Not Available 0.0031
306 Pyridoxal phosphate phosphatase PDXP 0.0031
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0031
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
3880 Serine hydroxymethyltransferase 1 Not Available 0.0031
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0031
3894 KIAA0251 protein PDXDC1 0.0031
3875 Glycogen phosphorylase, brain form PYGB 0.0031
3882 Brain glycogen phosphorylase variant Not Available 0.0031
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0031
3886 Migration-inducing protein 4 ALAS1 0.0031
3905 Molybdenum cofactor sulfurase MOCOS 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
914 Formimidoyltransferase-cyclodeaminase FTCD 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0029
565 Extracellular calcium-sensing receptor CASR 0.0028
6031 Cytochrome P450 3A43 CYP3A43 0.0028
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0028
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0028
3913 Glutamic acid decarboxylase GAD65 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0027
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0027
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0027
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0027
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
3811 Cytochrome P450 19A1 CYP19A1 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0023
472 Ornithine aminotransferase, mitochondrial OAT 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
449 Ornithine decarboxylase ODC1 0.002
1656 CYP2B protein CYP2B 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
4203 Histamine N-methyltransferase HNMT 0.0019
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
10 Glycogen phosphorylase, liver form PYGL 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
146 Androgen receptor AR 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0016
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
4120 NADPH--cytochrome P450 reductase POR 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
1152 Glycogen phosphorylase, muscle form PYGM 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
6432 Transporter snf 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
705 Glutamate receptor 1 GRIA1 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
6148 Multidrug resistance-associated protein 7 ABCC10 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0011
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0011
6014 Cytochrome P450 2A13 CYP2A13 0.0011
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0011
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0011
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0011
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0011
664 Glutamate decarboxylase 2 GAD2 0.0011
3890 Glutamate decarboxylase 2 GAD2 0.0011
4026 Aspartyl aminopeptidase DNPEP 0.0011
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0011
1912 Excitatory amino acid transporter 1 SLC1A3 0.0011
4016 Excitatory amino acid transporter 5 SLC1A7 0.0011
4019 Excitatory amino acid transporter 4 SLC1A6 0.0011
4017 5-oxoprolinase OPLAH 0.0011
1047 Excitatory amino acid transporter 2 SLC1A2 0.0011
926 Metabotropic glutamate receptor 7 GRM7 0.0011
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0011
4018 Glutamate receptor delta-2 subunit GRID2 0.0011
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0011
922 Glutamate receptor 4 GRIA4 0.0011
927 Metabotropic glutamate receptor 8 GRM8 0.0011
925 Metabotropic glutamate receptor 4 GRM4 0.0011
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0011
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0011
4020 Glutamyl aminopeptidase ENPEP 0.0011
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0011
4027 Glutamate receptor delta-1 subunit GRID1 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.001
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.001
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
518 Peroxidase/catalase T katG 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
777 Tumor necrosis factor TNF 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
625 Glutamate carboxypeptidase 2 FOLH1 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
916 Metabotropic glutamate receptor 1 GRM1 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
4773 Deoxycytidine kinase DCK 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
1618 High affinity nerve growth factor receptor NTRK1 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
976 Platelet glycoprotein IX GP9 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
572 Integrin alpha-L ITGAL 0.0005
904 Glutathione S-transferase P GSTP1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
357 Carbonic anhydrase 2 CA2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0004
136 Estrogen receptor ESR1 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0003
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
469 Annexin A1 ANXA1 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
869 Estrogen receptor beta ESR2 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
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