DT-Web

Tryptophan 5-hydroxylase 1


Partner ID 134
Name Tryptophan 5-hydroxylase 1
Synonyms 406
Gene name TPH1
General function Amino acid transport and metabolism
Specific function Not Available
Gene sequence + ...

ATGATTGAAGACAATAAGGAGAACAAAGACCATTCCTTAGAAAGGGGAAGAGCAAGTCTCATTTTTTCCTTAAAGAATGAAGTTGGAGGACTTATAAAAGCCCTGAAAATCTTTCAGGAGAAGCATGTGAATCTGTTACATATCGAGTCCCGAAAATCAAAAAGAAGAAACTCAGAATTTGAGATTTTTGTTGACTGTGACATCAACAGAGAACAATTGAATGATATTTTTCATCTGCTGAAGTCTCATACCAATGTTCTCTCTGTGAATCTACCAGATAATTTTACTTTGAAGGAAGATGGTATGGAAACTGTTCCTTGGTTTCCAAAGAAGATTTCTGACCTGGACCATTGTGCCAACAGAGTTCTGATGTATGGATCTGAACTAGATGCAGACCATCCTGGCTTCAAAGACAATGTCTACCGTAAACGTCGAAAGTATTTTGCGGACTTGGCTATGAACTATAAACATGGAGACCCCATTCCAAAGGTTGAATTCACTGAAGAGGAGATTAAGACCTGGGGAACCGTATTCCAAGAGCTCAACAAACTCTACCCAACCCATGCTTGCAGAGAGTATCTCAAAAACTTACCTTTGCTTTCTAAATATTGTGGATATCGGGAGGATAATATCCCACAATTGGAAGATGTCTCCAACTTTTTAAAAGAGCGTACAGGTTTTTCCATCCGTCCTGTGGCTGGTTACTTATCACCAAGAGATTTCTTATCAGGTTTAGCCTTTCGAGTTTTTCACTGCACTCAATATGTGAGACACAGTTCAGATCCCTTCTATACCCCAGAGCCAGATACCTGCCATGAACTCTTAGGTCATGTCCCGCTTTTGGCTGAACCTAGTTTTGCCCAATTCTCCCAAGAAATTGGCTTGGCTTCTCTTGGCGCTTCAGAGGAGGCTGTTCAAAAACTGGCAACGTGCTACTTTTTCACTGTGGAGTTTGGTCTATGTAAACAAGATGGACAGCTAAGAGTCTTTGGTGCTGGCTTACTTTCTTCTATCAGTGAACTCAAACATGCACTTTCTGGACATGCCAAAGTAAAGCCCTTTGATCCCAAGATTACCTGCAAACAGGAATGTCTTATCACAACTTTTCAAGATGTCTACTTTGTATCTGAAAGTTTTGAAGATGCAAAGGAGAAGATGAGAGAATTTACCAAAACAATTAAGCGTCCATTTGGAGTGAAGTATAATCCATATACACGGAGTATTCAGATCCTGAAAGACACCAAGAGCATAACCAGTGCCATGAATGAGCTGCAGCATGATCTCGATGTTGTCAGTGATGCCCTTGCTAAGGTCAGCAGGAAGCCGAGTATCTAA
Protein sequence + ...

MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
GO Classification
function
monooxygenase activity
binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
tryptophan 5-monooxygenase activity
catalytic activity
amine binding
oxidoreductase activity
amino acid binding
ion binding
cation binding
transition metal ion binding
iron ion binding
process
aromatic amino acid family metabolism
metabolism
cellular metabolism
amino acid metabolism
amino acid and derivative metabolism
physiological process
neurotransmitter metabolism
neurotransmitter biosynthesis
serotonin biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00360 Tetrahydrobiopterin
DB03271 7,8-Dihydro-L-Biopterin

Associated as Enzyme

Id Name
DB00150 L-Tryptophan

Associated as Prediction

Id Name
DB00005 Etanercept
DB00035 Desmopressin
DB00041 Aldesleukin
DB00114 Pyridoxal Phosphate
DB00117 L-Histidine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00154 gamma-Homolinolenic acid
DB00155 L-Citrulline
DB00156 L-Threonine
DB00159 Icosapent
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00172 L-Proline
DB00174 L-Asparagine
DB00190 Carbidopa
DB00233 Aminosalicylic Acid
DB00244 Mesalazine
DB00250 Dapsone
DB00260 Cycloserine
DB00279 Liothyronine
DB00316 Acetaminophen
DB00328 Indomethacin
DB00360 Tetrahydrobiopterin
DB00368 Norepinephrine
DB00451 Levothyroxine
DB00461 Nabumetone
DB00465 Ketorolac
DB00469 Tenoxicam
DB00480 Lenalidomide
DB00482 Celecoxib
DB00500 Tolmetin
DB00515 Cisplatin
DB00533 Rofecoxib
DB00554 Piroxicam
DB00573 Fenoprofen
DB00580 Valdecoxib
DB00586 Diclofenac
DB00605 Sulindac
DB00620 Triamcinolone
DB00668 Epinephrine
DB00712 Flurbiprofen
DB00720 Clodronate
DB00749 Etodolac
DB00765 Metyrosine
DB00773 Etoposide
DB00779 Nalidixic Acid
DB00784 Mefenamic acid
DB00788 Naproxen
DB00795 Sulfasalazine
DB00812 Phenylbutazone
DB00814 Meloxicam
DB00821 Carprofen
DB00856 Chlorphenesin
DB00861 Diflunisal
DB00870 Suprofen
DB00875 Flupenthixol
DB00884 Risedronate
DB00887 Bumetanide
DB00915 Amantadine
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00945 Acetylsalicylic acid
DB00963 Bromfenac
DB00991 Oxaprozin
DB00997 Doxorubicin
DB01009 Ketoprofen
DB01014 Balsalazide
DB01041 Thalidomide
DB01050 Ibuprofen
DB01065 Melatonin
DB01110 Miconazole
DB01234 Dexamethasone
DB01235 Levodopa
DB01283 Lumiracoxib
DB01395 Drospirenone
DB01397 Magnesium salicylate
DB01398 Salicylate-sodium
DB01399 Salsalate
DB01401 Trisalicylate-choline
DB01404 Ginseng
DB01419 Antrafenine
DB01435 Antipyrine
DB01583 Liotrix
DB01600 Tiaprofenic acid
DB01628 Etoricoxib
DB01686 N,N-dimethylarginine
DB01746 D-Leucine
DB01786 D-Alanine
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01831 Tryptophanyl-5'amp
DB01833 L-2-Amino-4-(Guanidinooxy)Butyric Acid
DB01835 4r-Fluoro-N6-Ethanimidoyl-L-Lysine
DB01997 3-Bromo-7-Nitroindazole
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02048 1,2,4-Triazole-Carboxamidine
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02141 S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB02207 7-Nitroindazole
DB02234 Ethylisothiourea
DB02266 Flufenamic Acid
DB02335 2-Aminothiazoline
DB02462 Thiocoumarin
DB02533 Aminoguanidine
DB02539 S-Ethylisothiourea
DB02556 D-Phenylalanine
DB02562 Quinonoid 7,8-Tetrahydrobiopterin
DB02589 Se-Ethyl-Isoselenourea
DB02644 N-Omega-Propyl-L-Arginine
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02709 Resveratrol
DB02911 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
DB02952 Alpha-Aminoisobutyric Acid
DB02979 N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
DB02994 Hydroxydimethylarsine Oxide
DB03014 Heme
DB03065 7-Nitroindazole-2-Carboxamidine
DB03100 6-Nitroindazole
DB03107 Beta-Alanine
DB03144 N-Omega-Hydroxy-L-Arginine
DB03225 D-Tryptophan
DB03271 7,8-Dihydro-L-Biopterin
DB03305 N5-Iminoethyl-L-Ornithine
DB03332 5,6-Cyclic-Tetrahydropteridine
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB03552 Meta-Tyrosine
DB03673 Beta(2-Thienyl)Alanine
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03839 D-Tyrosine
DB03866 Prostaglandin G2
DB03910 S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
DB03918 6s-5,6,7,8-Tetrahydrobiopterin
DB03929 D-Serine
DB03953 L-Thiocitrulline
DB03963 S-(Dimethylarsenic)Cysteine
DB03974 L-Homoarginine
DB04018 S-Isopropyl-Isothiourea
DB04223 Nitroarginine
DB04272 Citric Acid
DB04398 Lactic Acid
DB04400 7,8-Dihydrobiopterin
DB04419 Norleucine
DB04534 5-Nitroindazole
DB04537 L-Tryptophanamide
DB04552 Niflumic Acid
DB04559 N-(Chlorophenyl)-N'-Hydroxyguanidine
DB04743 Nimesulide
DB06262 Droxidopa
DB06725 Lornoxicam
DB06802 Nepafenac
DB06804 Nonoxynol-9
DB06879 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE
DB06916 N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE
DB07001 (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
DB07002 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
DB07003 (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
DB07007 (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
DB07008 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
DB07011 (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
DB07029 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
DB07306 ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07318 N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
DB07388 ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
DB07389 N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
DB07405 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08214 4-(1H-IMIDAZOL-1-YL)PHENOL
DB08750 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE
DB08814 Triflusal
DB08819 Tafluprost
DB08910 Pomalidomide
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