DT-Web

DB01283 - Lumiracoxib


Identification
Name Lumiracoxib
Accession Number DB01283
Type small molecule
Description Lumiracoxib is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug. On August 11, 2007, Australia's Therapeutic Goods Administration (TGA, the Australian equivalent of the FDA) cancelled the registration of lumiracoxib in Australia due to concerns that it may cause liver failure. New Zealand and Canada have also followed suit in recalling the drug.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 293.721
Groups approved
Monoisotopic Weight 293.061884577
Pharmacology
Indication For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults.
Mechanism of action The mechanism of action of lumiracoxib is due to inhibition of prostaglandin synthesis via inhibition of cyclooygenase-2 (COX-2). Lumiracoxib does not inhibit COX-1 at therapeutic concentrations.
Absorption Rapidly absorbed following oral administration, with an absolute oral bioavailablity of 74%.
Protein binding Highly bound to plasma proteins (>= 98%).
Biotransformation Hepatic oxidation and hydroxylation via CYP2C9. Three major metabolites have been identified in plasma: 4'-hydroxy-lumiracoxib, 5-carboxy-lumiracoxib, and 4'-hydroxy-5-carboxy-lumiracoxib.
Route of elimination Not Available
Toxicity Single oral doses in mice and rats resulted in mortality and/or moribundity at doses of 600 mg/kg and 500 mg/kg, respectively. Single intraperitoneal doses in mice and rats results in mortality/moribundity at 750 mg/kg and 1000 mg/kg, respectively. The maximum non-lethal single oral and intraperitoneal dose in mouse was 300 mg/kg and 250 mg/kg, respectively. In the rat it was 150 mg/kg and 250 mg/kg, respectively.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Lumiracoxib may increase the anticoagulant effect of acenocoumarol.
Anisindione Lumiracoxib may increase the anticoagulant effect of anisindione.
Dicumarol Lumiracoxib may increase the anticoagulant effect of dicumarol.
Lithium The COX-2 inhibitor increases serum levels of lithium
Telmisartan Concomitant use of Telmisartan and Lumiracoxib may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Lumiracoxib, may antagonize the antihypertensive effect of Timolol.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Lumiracoxib. Consider alternate therapy or monitor for changes in Lumiracoxib therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Trandolapril The NSAID, Lumiracoxib, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Lumiracoxib is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Lumiracoxib. Monitor for increased bleeding during concomitant thearpy.
Warfarin Lumiracoxib may increase the anticoagulant effect of warfarin.
Food Interactions
  • Take with or without food. Food has no effect on the absorption of the product.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Capone ML, Tacconelli S, Sciulli MG, Patrignani P: Clinical pharmacology of selective COX-2 inhibitors. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):49-58. - Pubmed
  • Tacconelli S, Capone ML, Patrignani P: Clinical pharmacology of novel selective COX-2 inhibitors. Curr Pharm Des. 2004;10(6):589-601. - Pubmed
  • Atherton C, Jones J, McKaig B, Bebb J, Cunliffe R, Burdsall J, Brough J, Stevenson D, Bonner J, Rordorf C, Scott G, Branson J, Hawkey CJ: Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study. Clin Gastroenterol Hepatol. 2004 Feb;2(2):113-20. - Pubmed
  • Kalbag J, Yeh CM, Milosavljev S, Lasseter K, Oberstein S, Rordorf C: No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. Pharmacol Res. 2004 Aug;50(2):181-6. - Pubmed
  • Esser R, Berry C, Du Z, Dawson J, Fox A, Fujimoto RA, Haston W, Kimble EF, Koehler J, Peppard J, Quadros E, Quintavalla J, Toscano K, Urban L, van Duzer J, Zhang X, Zhou S, Marshall PJ: Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5582
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Capone ML, Tacconelli S, Sciulli MG, Patrignani P: Clinical pharmacology of selective COX-2 inhibitors. Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):49-58. - Pubmed
  • Esser R, Berry C, Du Z, Dawson J, Fox A, Fujimoto RA, Haston W, Kimble EF, Koehler J, Peppard J, Quadros E, Quintavalla J, Toscano K, Urban L, van Duzer J, Zhang X, Zhou S, Marshall PJ: Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50. - Pubmed
  • Jermany J, Branson J, Schmouder R, Guillaume M, Rordorf C: Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects. J Clin Pharmacol. 2005 Oct;45(10):1172-8. - Pubmed
  • Warner TD, Vojnovic I, Bishop-Bailey D, Mitchell JA: Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2. FASEB J. 2006 Mar;20(3):542-4. Epub 2006 Jan 10. - Pubmed
  • Blobaum AL, Marnett LJ: Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J Biol Chem. 2007 Jun 1;282(22):16379-90. Epub 2007 Apr 12. - Pubmed
DTHybrid score 0.6464

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4583
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3364
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2598
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3529

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2829
4924 Cytochrome P450 2C8 CYP2C8 0.1915
4119 Cytochrome P450 2D6 CYP2D6 0.1841
1588 Multidrug resistance protein 1 ABCB1 0.1308
587 Serum albumin ALB 0.1203
6013 Cytochrome P450 2E1 CYP2E1 0.1086
4118 Cytochrome P450 3A5 CYP3A5 0.1085
6030 Cytochrome P450 2B6 CYP2B6 0.1083
1729 Solute carrier family 22 member 6 SLC22A6 0.0975
6024 Cytochrome P450 1A1 CYP1A1 0.0877
6107 Cytochrome P450 3A7 CYP3A7 0.0765
5718 Cytochrome P450 2A6 CYP2A6 0.0759
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0738
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0732
275 Arachidonate 5-lipoxygenase ALOX5 0.0568
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0565
6106 Cytochrome P450 2C18 CYP2C18 0.0508
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0463
1757 Myeloperoxidase MPO 0.0449
2164 Multidrug resistance-associated protein 4 ABCC4 0.0429
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0419
6142 Solute carrier family 22 member 8 SLC22A8 0.0405
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0394
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0371
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0341
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0318
492 Histamine H1 receptor HRH1 0.0311
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0309
824 Sodium-dependent serotonin transporter SLC6A4 0.03
1024 Solute carrier family 22 member 11 SLC22A11 0.0285
862 Multidrug resistance-associated protein 1 ABCC1 0.0282
3810 Catechol O-methyltransferase COMT 0.0281
3811 Cytochrome P450 19A1 CYP19A1 0.027
6102 Arylamine N-acetyltransferase 2 NAT2 0.027
6143 Solute carrier family 22 member 7 SLC22A7 0.0269
36 Insulin receptor INSR 0.0258
1898 Cytochrome P450 1B1 CYP1B1 0.0252
502 5-hydroxytryptamine 2A receptor HTR2A 0.024
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0238
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0238
3923 Cholinesterase BCHE 0.0237
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0236
540 Sodium-dependent noradrenaline transporter SLC6A2 0.023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.023
831 D(2) dopamine receptor DRD2 0.0221
6145 Solute carrier family 22 member 1 SLC22A1 0.0216
6144 Solute carrier family 22 member 2 SLC22A2 0.0208
738 Monocarboxylate transporter 1 SLC16A1 0.0206
777 Tumor necrosis factor TNF 0.0205
3941 Amine oxidase [flavin-containing] A MAOA 0.0205
373 Transthyretin TTR 0.0203
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0203
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0202
3312 Fatty acid-binding protein, brain FABP7 0.0199
4604 Liver carboxylesterase 1 CES1 0.0195
4132 Chloride channel protein ClC-Ka CLCNKA 0.0194
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
696 Kappa-type opioid receptor OPRK1 0.0189
891 Dihydropteroate synthase folP 0.0187
5359 Dihydropteroate synthase folP 0.0187
7175 Dihydropteroate synthase sulI 0.0187
341 5-hydroxytryptamine 3 receptor HTR3A 0.0186
1159 Interleukin-6 IL6 0.0185
556 Alpha-1A adrenergic receptor ADRA1A 0.0185
467 Delta-type opioid receptor OPRD1 0.0184
847 Mu-type opioid receptor OPRM1 0.018
23 D(1A) dopamine receptor DRD1 0.0179
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0178
6220 Aryl hydrocarbon receptor AHR 0.0178
146 Androgen receptor AR 0.0177
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0174
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0174
318 Alpha-2A adrenergic receptor ADRA2A 0.0174
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0171
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0171
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0169
260 Cytochrome P450 51 ERG11 0.0169
761 Cytochrome P450 51 ERG11 0.0169
3163 Cytochrome P450 51 cyp51 0.0169
817 DNA topoisomerase 2-alpha TOP2A 0.0168
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0165
118 Organic cation/carnitine transporter 2 SLC22A5 0.0162
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0158
713 Sodium-dependent dopamine transporter SLC6A3 0.0158
590 5-hydroxytryptamine 2C receptor HTR2C 0.0157
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0156
3939 Amine oxidase [flavin-containing] B MAOB 0.0156
70 Type-1 angiotensin II receptor AGTR1 0.0151
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0149
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0149
136 Estrogen receptor ESR1 0.0147
766 Beta-2 adrenergic receptor ADRB2 0.0145
723 Cytosolic phospholipase A2 PLA2G4A 0.0144
731 HIV-1 protease HIV-1 protease 0.0144
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0142
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0139
885 5-hydroxytryptamine 1B receptor HTR1B 0.0139
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0139
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0139
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0138
320 5-hydroxytryptamine 1A receptor HTR1A 0.0136
632 Alpha-1B adrenergic receptor ADRA1B 0.0136
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0134
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0132
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0132
703 NADPH azoreductase azr 0.0132
776 Bile salt export pump ABCB11 0.0131
122 P2Y purinoceptor 12 P2RY12 0.0131
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0129
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0129
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0124
850 Vasopressin V1b receptor AVPR1B 0.0122
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0122
489 Monocarboxylate transporter 2 SLC16A7 0.0121
459 Retinoic acid receptor RXR-alpha RXRA 0.0121
51 Muscarinic acetylcholine receptor M3 CHRM3 0.012
6500 Phospholipase A2 PLA2G1B 0.012
468 Cytochrome P450 4A11 CYP4A11 0.012
193 Beta-1 adrenergic receptor ADRB1 0.012
6137 Multidrug resistance-associated protein 6 ABCC6 0.0118
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0117
6043 Putative G-protein coupled receptor 44 GPR44 0.0117
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0117
725 5-hydroxytryptamine 1D receptor HTR1D 0.0117
6103 Arylamine N-acetyltransferase 1 NAT1 0.0116
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0116
1507 Cytochrome c CYCS 0.0116
3947 Xanthine dehydrogenase/oxidase XDH 0.0115
1648 Elastin ELN 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0112
571 Melatonin receptor type 1A MTNR1A 0.011
362 Melatonin receptor type 1B MTNR1B 0.011
1502 Peroxisome proliferator-activated receptor delta PPARD 0.011
638 D(3) dopamine receptor DRD3 0.011
823 Fibroblast growth factor receptor 2 FGFR2 0.0109
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0107
6085 Fatty acid-binding protein, intestinal FABP2 0.0107
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0106
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
789 Alpha-1D adrenergic receptor ADRA1D 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
6031 Cytochrome P450 3A43 CYP3A43 0.0105
6147 Solute carrier family 22 member 3 SLC22A3 0.0105
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0105
130 Prostacyclin synthase PTGIS 0.0102
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0102
26 Vascular endothelial growth factor receptor 3 FLT4 0.0101
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0099
504 Mast/stem cell growth factor receptor KIT 0.0098
1439 Lactotransferrin LTF 0.0098
465 Calmodulin CALM1 0.0098
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0097
1275 Estrogen sulfotransferase SULT1E1 0.0097
32 Vascular endothelial growth factor receptor 1 FLT1 0.0097
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0097
228 Beta platelet-derived growth factor receptor PDGFRB 0.0097
1656 CYP2B protein CYP2B 0.0096
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0095
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0095
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0094
407 Vascular endothelial growth factor receptor 2 KDR 0.0093
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0092
811 Translocator protein TSPO 0.0092
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0092
6141 Sodium/bile acid cotransporter SLC10A1 0.0091
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0091
629 Alpha-2B adrenergic receptor ADRA2B 0.009
273 Apoptosis regulator Bcl-2 BCL2 0.0089
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0089
6014 Cytochrome P450 2A13 CYP2A13 0.0088
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0088
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0087
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0086
558 Solute carrier family 12 member 1 SLC12A1 0.0086
54 Prothrombin F2 0.0085
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0084
427 Substance-P receptor TACR1 0.0084
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0083
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0083
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0083
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0083
1192 Sulfotransferase 1A1 SULT1A1 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0077
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0076
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0076
16 Adenosine A1 receptor ADORA1 0.0075
4221 Vascular endothelial growth factor VEGF 0.0075
2981 Phospholipase A2, membrane associated PLA2G2A 0.0075
5816 Cadherin-5 CDH5 0.0075
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0075
833 Organic cation/carnitine transporter 1 SLC22A4 0.0074
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0074
2021 Thrombomodulin THBD 0.0074
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0073
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0073
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
614 Progesterone receptor PGR 0.0071
124 Histamine H2 receptor HRH2 0.0071
33 Cystine/glutamate transporter SLC7A11 0.007
49 Endothelin B receptor EDNRB 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
436 5-hydroxytryptamine 2B receptor HTR2B 0.0069
871 Glucocorticoid receptor NR3C1 0.0069
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0067
1618 High affinity nerve growth factor receptor NTRK1 0.0067
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0067
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0067
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0067
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0067
6033 High affinity interleukin-8 receptor A CXCR1 0.0067
432 D(4) dopamine receptor DRD4 0.0067
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0066
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0066
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
828 Phenylalanine-4-hydroxylase PAH 0.0066
3109 Phenylalanine-4-hydroxylase phhA 0.0066
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0066
511 5-hydroxytryptamine 1F receptor HTR1F 0.0066
183 Vascular endothelial growth factor A VEGFA 0.0065
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0065
378 Alpha-2C adrenergic receptor ADRA2C 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0064
1050 Bile salt sulfotransferase SULT2A1 0.0064
6182 Cytochrome P450 2J2 CYP2J2 0.0064
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0063
133 Dihydropterate synthase sulI 0.0063
3808 Dihydropteroate synthase 2 folP2 0.0063
3601 Dihydropteroate synthase 1 folP1 0.0063
3807 Dihydropteroate synthase 1 folP1 0.0063
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0063
1178 Adenosine A2a receptor ADORA2A 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
6149 Solute carrier family 22 member 10 SLC22A10 0.0062
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0062
921 Glutamate receptor 2 GRIA2 0.0062
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
950 Alpha platelet-derived growth factor receptor PDGFRA 0.006
1714 Mitogen-activated protein kinase 3 MAPK3 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
737 Mineralocorticoid receptor NR3C2 0.0059
592 Carbonic anhydrase 4 CA4 0.0058
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0057
94 5-hydroxytryptamine 4 receptor HTR4 0.0056
759 Free fatty acid receptor 1 FFAR1 0.0056
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
6042 Prostaglandin reductase 2 PTGR2 0.0056
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0055
716 5-hydroxytryptamine 7 receptor HTR7 0.0055
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
7 Nitric oxide synthase, inducible NOS2 0.0053
634 Squalene monooxygenase SQLE 0.0053
7196 Squalene monooxygenase ERG1 0.0053
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0053
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
1039 Histone deacetylase 9 HDAC9 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
1792 Tissue-type plasminogen activator PLAT 0.0052
904 Glutathione S-transferase P GSTP1 0.0051
365 Dihydrofolate reductase DHFR 0.0051
2381 Dihydrofolate reductase DFR1 0.0051
2833 Dihydrofolate reductase Not Available 0.0051
2931 Dihydrofolate reductase folA 0.0051
3544 Dihydrofolate reductase folA 0.0051
3682 Dihydrofolate reductase folA 0.0051
6642 Dihydrofolate reductase folA 0.0051
6756 Dihydrofolate reductase dfrA 0.0051
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0051
295 Carbonic anhydrase 1 CA1 0.005
2236 Casein kinase II subunit alpha CSNK2A1 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.005
528 5-hydroxytryptamine 1E receptor HTR1E 0.005
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0049
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
844 Epidermal growth factor receptor EGFR 0.0049
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0049
4122 Histone deacetylase 2 HDAC2 0.0049
1010 Cytochrome P450 51A1 CYP51A1 0.0048
291 Nitric-oxide synthase, endothelial NOS3 0.0048
106 Cannabinoid receptor 2 CNR2 0.0048
908 Glutathione S-transferase theta-1 GSTT1 0.0048
1629 Transcription factor AP-1 JUN 0.0046
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
380 Cytochrome P450 17A1 CYP17A1 0.0046
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0046
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0046
68 Cannabinoid receptor 1 CNR1 0.0046
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
1650 Heme carrier protein 1 SLC46A1 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
5798 Mitogen-activated protein kinase 11 MAPK11 0.0045
756 Sex hormone-binding globulin SHBG 0.0045
869 Estrogen receptor beta ESR2 0.0044
163 D(1B) dopamine receptor DRD5 0.0044
818 50S ribosomal protein L10 rplJ 0.0043
357 Carbonic anhydrase 2 CA2 0.0043
1313 Lactoylglutathione lyase GLO1 0.0043
822 Aldose reductase AKR1B1 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0042
518 Peroxidase/catalase T katG 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
267 Plasminogen activator inhibitor 1 SERPINE1 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6044 Serum paraoxonase/lactonase 3 PON3 0.004
936 Ephrin type-A receptor 2 EPHA2 0.004
3937 Fatty-acid amide hydrolase FAAH 0.004
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.004
6126 Carbonic anhydrase 7 CA7 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0039
6221 Steroid hormone receptor ERR1 ESRRA 0.0039
4103 Proteasome subunit beta type 2 PSMB2 0.0039
4102 Proteasome subunit beta type 5 PSMB5 0.0039
4101 Proteasome subunit beta type 1 PSMB1 0.0039
4120 NADPH--cytochrome P450 reductase POR 0.0039
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
165 FL cytokine receptor FLT3 0.0038
3809 Estrogen-related receptor gamma ESRRG 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0036
4192 DNA topoisomerase 2-beta TOP2B 0.0036
5998 Toll-like receptor 8 TLR8 0.0035
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0035
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0034
5787 Angiopoietin-1 receptor TEK 0.0034
563 Thyroid peroxidase TPO 0.0033
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0032
1353 DNA topoisomerase 1 TOP1 0.0032
3552 DNA topoisomerase 1 topA 0.0032
1517 Beta-3 adrenergic receptor ADRB3 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0031
24 Thymidylate synthase TMP1 0.0031
359 Thymidylate synthase TYMS 0.0031
2626 Thymidylate synthase thyA 0.0031
2729 Thymidylate synthase thyA 0.0031
5352 Thymidylate synthase THYA 0.0031
153 Dopamine beta-hydroxylase DBH 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6432 Transporter snf 0.0031
780 Retinoic acid receptor RXR-gamma RXRG 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
1256 5-hydroxytryptamine 6 receptor HTR6 0.003
173 Toll-like receptor 7 TLR7 0.003
1374 Natriuretic peptides B NPPB 0.003
158 Sodium channel protein type 1 subunit alpha SCN1A 0.003
1827 Gap junction alpha-1 protein GJA1 0.003
1908 Vascular cell adhesion protein 1 VCAM1 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0029
1864 RET proto-oncogene RET 0.0028
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0028
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0028
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
161 Tubulin beta chain TUBB 0.0028
312 Tubulin beta chain TUB2 0.0028
88 Retinoic acid receptor RXR-beta RXRB 0.0027
474 Acetylcholinesterase ACHE 0.0027
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0027
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
284 DNA-directed RNA polymerase beta chain rpoB 0.0027
5773 DNA-directed RNA polymerase beta chain rpoB 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3957 Adenosine deaminase ADA 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0026
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
85 Growth hormone receptor GHR 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3830 Calreticulin CALR 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
1541 Metalloproteinase mmp20 0.0025
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
239 Coagulation factor X F10 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0024
3814 Complement C1r subcomponent C1R 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6070 Nischarin NISCH 0.0024
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0024
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0024
6174 50S ribosomal protein L32 rpmF 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
1196 Complement decay-accelerating factor CD55 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
976 Platelet glycoprotein IX GP9 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
6020 Aldehyde oxidase AOX1 0.0023
6131 Carbonic anhydrase 14 CA14 0.0022
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0022
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0022
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0022
2782 Complement C1s subcomponent C1S 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
6163 Copper-transporting ATPase 2 ATP7B 0.0022
6165 Copper-transporting ATPase 1 ATP7A 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
251 Alcohol dehydrogenase 1A ADH1A 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
2808 Chloramphenicol acetyltransferase 3 cat3 0.002
2207 Rhodopsin RHO 0.002
1820 Beta-nerve growth factor NGF 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.002
1243 Cathepsin D CTSD 0.0019
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
820 Glycine receptor subunit alpha-2 GLRA2 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
2417 Chloramphenicol acetyltransferase cat 0.0018
3278 Chloramphenicol acetyltransferase cat 0.0018
1253 Interferon gamma IFNG 0.0018
2810 Dr hemagglutinin structural subunit draA 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
444 Alcohol dehydrogenase 1B ADH1B 0.0018
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
896 Glutathione S-transferase Mu 1 GSTM1 0.0018
164 Histamine H4 receptor HRH4 0.0018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0018
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0018
581 Cytochrome P450 2R1 CYP2R1 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0017
1830 5'-nucleotidase NT5E 0.0016
1992 Vitamin D-binding protein GC 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
319 Opioid receptor, sigma 1 OPRS1 0.0016
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0016
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0016
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0016
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0016
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0016
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
1630 Integrin beta-2 ITGB2 0.0015
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
5934 Cytochrome P450 26A1 CYP26A1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
4217 Telomerase reverse transcriptase TERT 0.0015
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
814 Ryanodine receptor 1 RYR1 0.0014
174 Sigma 1-type opioid receptor SIGMAR1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0013
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0013
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
705 Glutamate receptor 1 GRIA1 0.0013
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
856 Vitamin D3 receptor VDR 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
162 Retinoic acid receptor gamma-1 RARG 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0012
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
572 Integrin alpha-L ITGAL 0.0012
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
2320 Thymidine kinase, cytosolic TK1 0.0011
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0011
3221 Cytochrome c4 cc4 0.0011
4237 50S ribosomal protein L22 rplV 0.001
6218 Pannexin-1 PANX1 0.001
4943 Cytochrome c6 petJ 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
4984 Neuroglobin NGB 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4947 Bacterial hemoglobin vhb 0.001
4994 Hemoglobin-like protein HbO glbO 0.001
4916 Cyanoglobin glbN 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4942 Diheme cytochrome c napB napB 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4975 Cytochrome c-556 RPA3973 0.001
4961 Hemophore HasA hasA 0.001
4936 Cytochrome c2 iso-2 Not Available 0.001
4910 Cytoglobin CYGB 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
5000 HemO hemO 0.001
4981 Iron-starvation protein PigA pigA 0.001
4904 Cytochrome c family protein GSU1996 0.001
4907 Cytochrome c-L moxG 0.001
6865 Cytochrome c-L moxG 0.001
4909 CooA protein cooA 0.001
4976 Apocytochrome f petA 0.001
6407 Apocytochrome f petA 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
4971 Nonaheme cytochrome c hmcA 0.001
4764 Cytochrome P450 165C4 CYP165C4 0.001
4989 Cytochrome c551 peroxidase ccp 0.001
5222 Cytochrome c551 peroxidase ccpA 0.001
4937 Cytochrome oxidase subunit II rcoxA 0.001
4926 Heme-based aerotactic transducer hemAT hemAT 0.001
4935 Cytochrome c-554 cycA1 0.001
4999 Cytochrome P450 165B3 CYP165B3 0.001
4960 Putative cytochrome P450-family protein SCO7417 0.001
4931 Cytochrome P450 167A1 CYP167A1 0.001
4972 P450cin cinA 0.001
4993 Hydroxylamine oxidoreductase hao1 0.001
4922 Cytochrome c, putative SO_4144 0.001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.001
4952 Catalase/peroxidase katA 0.001
4903 Methyl-accepting chemotaxis protein Tar4 0.001
3093 Catalase HPII katE 0.001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
1360 Sphingomyelin phosphodiesterase SMPD1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
751 Potassium channel subfamily K member 6 KCNK6 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1341 Histamine H3 receptor HRH3 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0009
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
172 Potassium channel subfamily K member 1 KCNK1 0.0009
1184 Interferon beta IFNB1 0.0008
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
469 Annexin A1 ANXA1 0.0008
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
952 Dipeptidyl peptidase 4 DPP4 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
4920 Peroxidase/catalase katG 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4773 Deoxycytidine kinase DCK 0.0008
4990 PpcA ppcA 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
358 Cystathionine beta-synthase CBS 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
798 Osteocalcin BGLAP 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
693 Hemoglobin subunit beta HBB 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
2298 Cytochrome P450-cam camC 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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