DT-Web

DB00966 - Telmisartan


Identification
Name Telmisartan
Accession Number DB00966 (APRD01247)
Type small molecule
Description Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 514.6169
Groups approved
Monoisotopic Weight 514.236876224
Pharmacology
Indication Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors).
Mechanism of action Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Telmisartan does not inhibit the angiotensin converting enzyme, other hormone receptors, or ion channels. Studies also suggest that telmisartan is a partial agonist of PPARγ, which is an established target for antidiabetic drugs. This suggests that telmisartan can improve carbohydrate and lipid metabolism, as well as control insulin resistance without causing the side effects that are associated with full PPARγ activators.
Absorption Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).
Protein binding Highly bound to plasma proteins (>99.5%), mainly albumin and a1-acid glycoprotein. Binding is not dose-dependent.
Biotransformation Minimally metabolized by conjugation to form a pharmacologically inactive acylglucuronide; the glucuronide of the parent compound is the only metabolite that has been identified in human plasma and urine. The cytochrome P450 isoenzymes are not involved in the metabolism of telmisartan.
Route of elimination Following either intravenous or oral administration of 14C-labeled telmisartan, most of the administered dose (>97%) was eliminated unchanged in feces via biliary excretion; only minute amounts were found in the urine (0.91% and 0.49% of total radioactivity, respectively).
Toxicity Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetylsalicylic acid Concomitant use of Telmisartan and Acetylsalicylic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Amifostine Telmisartan may increase the hypotensive effect of Amifostine. At chemotherapeutic doses of Amifostine, Telmisartan should be withheld for 24 hours prior to Amifostine administration. Use caution at lower doses of Amifostine.
Amiloride Telmisartan may increase the hyperkalemic effect of Amiloride. Monitor for increased serum potassium concentrations during concomitant therapy.
Celecoxib Concomitant use of Telmisartan and Celecoxib may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Diclofenac Concomitant use of Telmisartan and Diclofenac may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Diflunisal Concomitant use of Telmisartan and Diflunisal may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Digoxin Telmisartan may increase plasma Digoxin concentrations. Monitor Digoxin levels and adjust dose as required if Telmisartan is initiated, discontinued or dose changed.
Drospirenone Telmisartan may increase the hyperkalemic effect of Drospirenone. Monitor for increased serum potassium concentrations during concomitant therapy.
Fenoprofen Concomitant use of Telmisartan and Fenoprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Flurbiprofen Concomitant use of Telmisartan and Flurbiprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Indomethacin Concomitant use of Telmisartan and Indomethacin may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Ketoprofen Concomitant use of Telmisartan and Ketoprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Ketorolac Concomitant use of Telmisartan and Ketorolac may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Lithium Telmisartan may increase serum Lithium concentrations. Monitor serum Lithium levels during concomitant therapy to avoid Lithium toxicity.
Lumiracoxib Concomitant use of Telmisartan and Lumiracoxib may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Meclofenamic acid Concomitant use of Telmisartan and Meclofenamic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Meloxicam Concomitant use of Telmisartan and Meloxicam may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Nabumetone Concomitant use of Telmisartan and Nabumetone may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Naproxen Concomitant use of Telmisartan and Naproxen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Oxaprozin Concomitant use of Telmisartan and Oxaprozin may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Piroxicam Concomitant use of Telmisartan and Piroxicam may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Potassium Potassium may increase the hyperkalemic effect of Telmisartan. Monitor serum potassium levels during concomitant use.
Potassium Chloride Potassium Chloride may increase the hyperkalemic effect of Telmisartan. Monitor serum potassium levels during concomitant use.
Rituximab Telmisartan may increase the hypotensive effect of Rituximab. Telmisartan should be withheld prior to and throughout Rituximab administration.
Spironolactone Telmisartan may increase the hyperkalemic effect of Spironolactone. Monitor for increased serum potassium concentrations during concomitant therapy.
Sulindac Concomitant use of Telmisartan and Sulindac may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Tiaprofenic acid Concomitant use of Telmisartan and Tiaprofenic acid may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Tobramycin Increased risk of nephrotoxicity
Tolmetin Concomitant use of Telmisartan and Tolmetin may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Trandolapril The angiotensin II receptor blocker, Telmisartan, may increase the adverse effects of Trandolapril.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triamterene Telmisartan may increase the hyperkalemic effect of Triamterene. Monitor for increased serum potassium concentrations during concomitant therapy.
Food Interactions Not Available

Targets


Type-1 angiotensin II receptor
Name Type-1 angiotensin II receptor
Gene Name AGTR1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Karlberg BE, Lins LE, Hermansson K: Efficacy and safety of telmisartan, a selective AT1 receptor antagonist, compared with enalapril in elderly patients with primary hypertension. TEES Study Group. J Hypertens. 1999 Feb;17(2):293-302. - Pubmed
  • Balt JC, Mathy MJ, Nap A, Pfaffendorf M, van Zwieten PA: Effect of the AT1-receptor antagonists losartan, irbesartan, and telmisartan on angiotensin II-induced facilitation of sympathetic neurotransmission in the rat mesenteric artery. J Cardiovasc Pharmacol. 2001 Jul;38(1):141-8. - Pubmed
  • Gohlke P, Weiss S, Jansen A, Wienen W, Stangier J, Rascher W, Culman J, Unger T: AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats. J Pharmacol Exp Ther. 2001 Jul;298(1):62-70. - Pubmed
  • Strohmenger HU, Lindner KH, Wienen W, Vogt J: Effects of the AT1-selective angiotensin II antagonist, telmisartan, on hemodynamics and ventricular function after cardiopulmonary resuscitation in pigs. Resuscitation. 1997 Aug;35(1):61-8. - Pubmed
  • Fujimoto M, Masuzaki H, Tanaka T, Yasue S, Tomita T, Okazawa K, Fujikura J, Chusho H, Ebihara K, Hayashi T, Hosoda K, Nakao K: An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in 3T3-L1 adipocytes. FEBS Lett. 2004 Oct 22;576(3):492-7. - Pubmed
  • Sharpe M, Jarvis B, Goa KL: Telmisartan: a review of its use in hypertension. Drugs. 2001;61(10):1501-29. - Pubmed
  • McClellan KJ, Markham A: Telmisartan. Drugs. 1998 Dec;56(6):1039-44; discussion 1045-6. - Pubmed
  • Galzerano D, Capogrosso C, Di Michele S, Galzerano A, Paparello P, Lama D, Gaudio C: New standards in hypertension and cardiovascular risk management: focus on telmisartan. Vasc Health Risk Manag. 2010 Mar 24;6:113-33. - Pubmed
  • Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, Naruse M: A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. Endocrinology. 2009 Feb;150(2):862-70. Epub 2009 Jan 15. - Pubmed
  • Imayama I, Ichiki T, Inanaga K, Ohtsubo H, Fukuyama K, Ono H, Hashiguchi Y, Sunagawa K: Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma. Cardiovasc Res. 2006 Oct 1;72(1):184-90. Epub 2006 Jul 21. - Pubmed
  • Kurtz TW: Beyond the classic angiotensin-receptor-blocker profile. Nat Clin Pract Cardiovasc Med. 2008 Jul;5 Suppl 1:S19-26. - Pubmed
  • Yamagishi S, Takeuchi M: Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property. Med Hypotheses. 2005;64(3):476-8. - Pubmed
  • Yamagishi S, Nakamura K, Matsui T: Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders. Curr Mol Med. 2007 Aug;7(5):463-9. - Pubmed
DTHybrid score 0.6969
Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action yes
Actions partial agonist
References
  • Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, Naruse M: A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones. Endocrinology. 2009 Feb;150(2):862-70. Epub 2009 Jan 15. - Pubmed
  • Imayama I, Ichiki T, Inanaga K, Ohtsubo H, Fukuyama K, Ono H, Hashiguchi Y, Sunagawa K: Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma. Cardiovasc Res. 2006 Oct 1;72(1):184-90. Epub 2006 Jul 21. - Pubmed
  • Kurtz TW: Beyond the classic angiotensin-receptor-blocker profile. Nat Clin Pract Cardiovasc Med. 2008 Jul;5 Suppl 1:S19-26. - Pubmed
  • Yamagishi S, Takeuchi M: Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property. Med Hypotheses. 2005;64(3):476-8. - Pubmed
  • Kurtz TW: Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator. Acta Diabetol. 2005 Apr;42 Suppl 1:S9-16. - Pubmed
  • Yamagishi S, Nakamura K, Matsui T: Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders. Curr Mol Med. 2007 Aug;7(5):463-9. - Pubmed
  • Yamagishi S, Takenaka K, Inoue H: Role of insulin-sensitizing property of telmisartan, a commercially available angiotensin II type 1 receptor blocker in preventing the development of atrial fibrillation. Med Hypotheses. 2006;66(1):118-20. Epub 2005 Sep 12. - Pubmed
DTHybrid score 0.9526

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.253

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, Haefeli WE, Benndorf RA: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61. - Pubmed
DTHybrid score 0.3613
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, Haefeli WE, Benndorf RA: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61. - Pubmed
DTHybrid score 0.2546
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger RH, Haefeli WE, Benndorf RA: Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61. - Pubmed
DTHybrid score 0.2409

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2459
4757 Cytochrome P450 2C9 CYP2C9 0.2166
4924 Cytochrome P450 2C8 CYP2C8 0.1469
4119 Cytochrome P450 2D6 CYP2D6 0.1274
4200 Cytochrome P450 1A2 CYP1A2 0.1247
4118 Cytochrome P450 3A5 CYP3A5 0.121
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.12
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0831
587 Serum albumin ALB 0.0824
6107 Cytochrome P450 3A7 CYP3A7 0.0773
862 Multidrug resistance-associated protein 1 ABCC1 0.0773
6030 Cytochrome P450 2B6 CYP2B6 0.076
20 Prostaglandin G/H synthase 1 PTGS1 0.0728
5852 Type-2 angiotensin II receptor AGTR2 0.0627
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0606
6013 Cytochrome P450 2E1 CYP2E1 0.0575
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0572
6024 Cytochrome P450 1A1 CYP1A1 0.0558
776 Bile salt export pump ABCB11 0.0486
6228 Nuclear receptor coactivator 1 NCOA1 0.0486
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0479
1729 Solute carrier family 22 member 6 SLC22A6 0.0442
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0427
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0424
2164 Multidrug resistance-associated protein 4 ABCC4 0.0407
5718 Cytochrome P450 2A6 CYP2A6 0.0389
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0384
80 Peroxisome proliferator-activated receptor alpha PPARA 0.036
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0344
1898 Cytochrome P450 1B1 CYP1B1 0.0337
290 Prostaglandin G/H synthase 2 PTGS2 0.0335
6144 Solute carrier family 22 member 2 SLC22A2 0.0335
6145 Solute carrier family 22 member 1 SLC22A1 0.0332
6241 Nuclear receptor coactivator 2 NCOA2 0.0303
817 DNA topoisomerase 2-alpha TOP2A 0.029
459 Retinoic acid receptor RXR-alpha RXRA 0.029
6142 Solute carrier family 22 member 8 SLC22A8 0.0288
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0275
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0274
6137 Multidrug resistance-associated protein 6 ABCC6 0.027
6148 Multidrug resistance-associated protein 7 ABCC10 0.0269
6106 Cytochrome P450 2C18 CYP2C18 0.0267
275 Arachidonate 5-lipoxygenase ALOX5 0.0254
118 Organic cation/carnitine transporter 2 SLC22A5 0.0238
136 Estrogen receptor ESR1 0.0231
6141 Sodium/bile acid cotransporter SLC10A1 0.0226
6143 Solute carrier family 22 member 7 SLC22A7 0.0225
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0225
824 Sodium-dependent serotonin transporter SLC6A4 0.0223
3811 Cytochrome P450 19A1 CYP19A1 0.0207
844 Epidermal growth factor receptor EGFR 0.0207
1629 Transcription factor AP-1 JUN 0.0201
1353 DNA topoisomerase 1 TOP1 0.0199
3552 DNA topoisomerase 1 topA 0.0199
731 HIV-1 protease HIV-1 protease 0.0196
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0194
1024 Solute carrier family 22 member 11 SLC22A11 0.0193
220 Sodium channel protein type 5 subunit alpha SCN5A 0.019
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.019
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0185
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0185
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0185
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0178
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0177
492 Histamine H1 receptor HRH1 0.0174
504 Mast/stem cell growth factor receptor KIT 0.0171
6147 Solute carrier family 22 member 3 SLC22A3 0.0171
556 Alpha-1A adrenergic receptor ADRA1A 0.0169
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0165
33 Cystine/glutamate transporter SLC7A11 0.0164
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0156
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0151
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.015
4604 Liver carboxylesterase 1 CES1 0.015
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.015
477 DNA topoisomerase 4 subunit A parC 0.0149
886 DNA topoisomerase 4 subunit A parC 0.0149
6226 DNA topoisomerase 4 subunit A parC 0.0149
404 DNA gyrase subunit A gyrA 0.0146
6224 DNA gyrase subunit A gyrA 0.0146
260 Cytochrome P450 51 ERG11 0.0146
761 Cytochrome P450 51 ERG11 0.0146
3163 Cytochrome P450 51 cyp51 0.0146
1757 Myeloperoxidase MPO 0.0143
468 Cytochrome P450 4A11 CYP4A11 0.0142
4120 NADPH--cytochrome P450 reductase POR 0.014
228 Beta platelet-derived growth factor receptor PDGFRB 0.0137
871 Glucocorticoid receptor NR3C1 0.0135
26 Vascular endothelial growth factor receptor 3 FLT4 0.0135
831 D(2) dopamine receptor DRD2 0.0134
738 Monocarboxylate transporter 1 SLC16A1 0.0133
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0133
3923 Cholinesterase BCHE 0.0131
766 Beta-2 adrenergic receptor ADRB2 0.013
193 Beta-1 adrenergic receptor ADRB1 0.013
1650 Heme carrier protein 1 SLC46A1 0.013
6136 Multidrug resistance-associated protein 5 ABCC5 0.0129
32 Vascular endothelial growth factor receptor 1 FLT1 0.0129
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0125
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0124
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0124
117 Sterol O-acyltransferase 1 SOAT1 0.0123
703 NADPH azoreductase azr 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.012
614 Progesterone receptor PGR 0.0118
407 Vascular endothelial growth factor receptor 2 KDR 0.0117
502 5-hydroxytryptamine 2A receptor HTR2A 0.0117
908 Glutathione S-transferase theta-1 GSTT1 0.0117
3941 Amine oxidase [flavin-containing] A MAOA 0.0116
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0114
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0113
6599 HTH-type transcriptional regulator ttgR ttgR 0.0113
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0113
632 Alpha-1B adrenergic receptor ADRA1B 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
161 Tubulin beta chain TUBB 0.011
312 Tubulin beta chain TUB2 0.011
904 Glutathione S-transferase P GSTP1 0.0108
2443 Azurin azu 0.0108
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
6182 Cytochrome P450 2J2 CYP2J2 0.0106
833 Organic cation/carnitine transporter 1 SLC22A4 0.0105
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0104
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0103
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0103
2539 Tubulin alpha-1 chain TUBA4A 0.0103
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0103
146 Androgen receptor AR 0.0103
320 5-hydroxytryptamine 1A receptor HTR1A 0.0102
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0101
713 Sodium-dependent dopamine transporter SLC6A3 0.0101
29 Tubulin beta-1 chain TUBB1 0.01
4773 Deoxycytidine kinase DCK 0.01
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0097
869 Estrogen receptor beta ESR2 0.0097
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0096
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
6146 High affinity copper uptake protein 1 SLC31A1 0.0095
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
789 Alpha-1D adrenergic receptor ADRA1D 0.0093
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0092
273 Apoptosis regulator Bcl-2 BCL2 0.0091
24 Thymidylate synthase TMP1 0.0091
359 Thymidylate synthase TYMS 0.0091
2626 Thymidylate synthase thyA 0.0091
2729 Thymidylate synthase thyA 0.0091
5352 Thymidylate synthase THYA 0.0091
6163 Copper-transporting ATPase 2 ATP7B 0.0091
6165 Copper-transporting ATPase 1 ATP7A 0.0091
23 D(1A) dopamine receptor DRD1 0.009
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0089
165 FL cytokine receptor FLT3 0.0089
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0088
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0087
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0087
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0087
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0086
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0086
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0085
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0085
6031 Cytochrome P450 3A43 CYP3A43 0.0085
124 Histamine H2 receptor HRH2 0.0084
1852 Microtubule-associated protein 2 MAP2 0.0084
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0082
777 Tumor necrosis factor TNF 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
885 5-hydroxytryptamine 1B receptor HTR1B 0.0081
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.008
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.008
1192 Sulfotransferase 1A1 SULT1A1 0.008
3939 Amine oxidase [flavin-containing] B MAOB 0.008
896 Glutathione S-transferase Mu 1 GSTM1 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
461 Glycine receptor subunit alpha-3 GLRA3 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
756 Sex hormone-binding globulin SHBG 0.0078
465 Calmodulin CALM1 0.0077
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0077
725 5-hydroxytryptamine 1D receptor HTR1D 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0074
122 P2Y purinoceptor 12 P2RY12 0.0074
5923 Microtubule-associated protein tau MAPT 0.0074
5924 Microtubule-associated protein 4 MAP4 0.0074
6220 Aryl hydrocarbon receptor AHR 0.0074
6085 Fatty acid-binding protein, intestinal FABP2 0.0074
318 Alpha-2A adrenergic receptor ADRA2A 0.0073
847 Mu-type opioid receptor OPRM1 0.0073
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0073
467 Delta-type opioid receptor OPRD1 0.0072
2808 Chloramphenicol acetyltransferase 3 cat3 0.0072
373 Transthyretin TTR 0.0071
696 Kappa-type opioid receptor OPRK1 0.007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0069
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0069
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0069
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0069
5626 Nucleoside diphosphate kinase B NME2 0.0068
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0068
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0067
590 5-hydroxytryptamine 2C receptor HTR2C 0.0067
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0066
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0065
380 Cytochrome P450 17A1 CYP17A1 0.0064
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0064
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4192 DNA topoisomerase 2-beta TOP2B 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
5787 Angiopoietin-1 receptor TEK 0.0063
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0062
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0062
3270 Elongation factor G fusA 0.0062
737 Mineralocorticoid receptor NR3C2 0.0061
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0059
3809 Estrogen-related receptor gamma ESRRG 0.0059
1760 Aminopeptidase N ANPEP 0.0058
6843 Aminopeptidase N pepN 0.0058
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
5294 Nucleoside diphosphate kinase A NME1 0.0056
436 5-hydroxytryptamine 2B receptor HTR2B 0.0056
469 Annexin A1 ANXA1 0.0055
3917 Methylenetetrahydrofolate reductase MTHFR 0.0055
759 Free fatty acid receptor 1 FFAR1 0.0054
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0054
638 D(3) dopamine receptor DRD3 0.0053
183 Vascular endothelial growth factor A VEGFA 0.0053
2449 Tubulin alpha-3 chain TUBA1A 0.0052
6167 Organic solute transporter subunit beta OSTB 0.0052
6166 Organic solute transporter subunit alpha OSTA 0.0052
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
106 Cannabinoid receptor 2 CNR2 0.0051
6149 Solute carrier family 22 member 10 SLC22A10 0.005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0049
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0049
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0049
511 5-hydroxytryptamine 1F receptor HTR1F 0.0048
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
952 Dipeptidyl peptidase 4 DPP4 0.0047
1053 BC269730_2 FADS1 0.0047
1395 Sodium/calcium exchanger 1 SLC8A1 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0047
702 UMP-CMP kinase CMPK1 0.0046
823 Fibroblast growth factor receptor 2 FGFR2 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0046
1618 High affinity nerve growth factor receptor NTRK1 0.0046
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0045
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0045
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0045
293 Gamma-glutamyl hydrolase GGH 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
6837 Serine/threonine-protein kinase 17B STK17B 0.0044
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0044
3312 Fatty acid-binding protein, brain FABP7 0.0044
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0044
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0044
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0043
239 Coagulation factor X F10 0.0043
629 Alpha-2B adrenergic receptor ADRA2B 0.0043
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0043
6042 Prostaglandin reductase 2 PTGR2 0.0043
3810 Catechol O-methyltransferase COMT 0.0042
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0042
131 Synaptic vesicular amine transporter SLC18A2 0.0041
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0041
342 P protein [Includes: DNA-directed DNA polymerase P 0.0041
612 P protein [Includes: DNA-directed DNA polymerase P 0.0041
489 Monocarboxylate transporter 2 SLC16A7 0.0041
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.004
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.004
936 Ephrin type-A receptor 2 EPHA2 0.004
474 Acetylcholinesterase ACHE 0.004
818 50S ribosomal protein L10 rplJ 0.0039
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0039
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0039
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0039
2021 Thrombomodulin THBD 0.0039
558 Solute carrier family 12 member 1 SLC12A1 0.0039
1313 Lactoylglutathione lyase GLO1 0.0039
1656 CYP2B protein CYP2B 0.0039
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0039
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0038
7 Nitric oxide synthase, inducible NOS2 0.0038
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0038
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0038
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0038
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0038
6043 Putative G-protein coupled receptor 44 GPR44 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0038
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0038
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0038
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0038
2232 Interleukin-5 IL5 0.0037
2981 Phospholipase A2, membrane associated PLA2G2A 0.0037
1593 Mucin-2 MUC2 0.0037
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0037
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0037
3587 Gastrotropin FABP6 0.0037
5300 Antigen peptide transporter 1 TAP1 0.0037
341 5-hydroxytryptamine 3 receptor HTR3A 0.0036
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0036
716 5-hydroxytryptamine 7 receptor HTR7 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
1630 Integrin beta-2 ITGB2 0.0035
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0035
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0034
365 Dihydrofolate reductase DHFR 0.0034
2381 Dihydrofolate reductase DFR1 0.0034
2833 Dihydrofolate reductase Not Available 0.0034
2931 Dihydrofolate reductase folA 0.0034
3544 Dihydrofolate reductase folA 0.0034
3682 Dihydrofolate reductase folA 0.0034
6642 Dihydrofolate reductase folA 0.0034
6756 Dihydrofolate reductase dfrA 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0034
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0033
319 Opioid receptor, sigma 1 OPRS1 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0033
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0033
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0033
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0033
6211 Tubulin epsilon chain TUBE1 0.0032
6210 Tubulin delta chain TUBD1 0.0032
6212 Tubulin gamma-1 chain TUBG1 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
6014 Cytochrome P450 2A13 CYP2A13 0.0032
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0032
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0032
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0032
4103 Proteasome subunit beta type 2 PSMB2 0.0032
4102 Proteasome subunit beta type 5 PSMB5 0.0032
4101 Proteasome subunit beta type 1 PSMB1 0.0032
357 Carbonic anhydrase 2 CA2 0.0032
4217 Telomerase reverse transcriptase TERT 0.0031
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
267 Plasminogen activator inhibitor 1 SERPINE1 0.0031
6221 Steroid hormone receptor ERR1 ESRRA 0.0031
921 Glutamate receptor 2 GRIA2 0.0031
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0031
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0031
1010 Cytochrome P450 51A1 CYP51A1 0.0031
378 Alpha-2C adrenergic receptor ADRA2C 0.003
484 Tyrosine-protein kinase ABL2 ABL2 0.003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.003
84 Nuclear receptor 0B1 NR0B1 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0029
6432 Transporter snf 0.0029
683 Potassium transporter GK0582 0.0029
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0028
1792 Tissue-type plasminogen activator PLAT 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0028
427 Substance-P receptor TACR1 0.0028
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0027
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0027
432 D(4) dopamine receptor DRD4 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0027
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0027
49 Endothelin B receptor EDNRB 0.0027
572 Integrin alpha-L ITGAL 0.0026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
85 Growth hormone receptor GHR 0.0025
5818 Folate receptor alpha FOLR1 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
5798 Mitogen-activated protein kinase 11 MAPK11 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
2320 Thymidine kinase, cytosolic TK1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0024
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0024
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0024
4122 Histone deacetylase 2 HDAC2 0.0024
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0024
6168 Solute carrier family 22 member 16 SLC22A16 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
1864 RET proto-oncogene RET 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0023
592 Carbonic anhydrase 4 CA4 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6174 50S ribosomal protein L32 rpmF 0.0023
6218 Pannexin-1 PANX1 0.0023
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0022
811 Translocator protein TSPO 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
1517 Beta-3 adrenergic receptor ADRB3 0.0022
6102 Arylamine N-acetyltransferase 2 NAT2 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
2240 Cell division protein kinase 2 CDK2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0018
1253 Interferon gamma IFNG 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
6020 Aldehyde oxidase AOX1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
4311 tRNA TRDMT1 0.0018
4325 tRNA trmD 0.0018
4328 tRNA trmD 0.0018
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0018
760 Fibroblast growth factor 1 FGF1 0.0017
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
163 D(1B) dopamine receptor DRD5 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
891 Dihydropteroate synthase folP 0.0017
5359 Dihydropteroate synthase folP 0.0017
7175 Dihydropteroate synthase sulI 0.0017
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
76 Nitric-oxide synthase, brain NOS1 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
172 Potassium channel subfamily K member 1 KCNK1 0.0015
1256 5-hydroxytryptamine 6 receptor HTR6 0.0015
976 Platelet glycoprotein IX GP9 0.0015
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0014
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0014
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0014
6126 Carbonic anhydrase 7 CA7 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
295 Carbonic anhydrase 1 CA1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
3932 Glutathione S-transferase A2 GSTA2 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0013
174 Sigma 1-type opioid receptor SIGMAR1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
518 Peroxidase/catalase T katG 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
563 Thyroid peroxidase TPO 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
292 Activin receptor type-1 ACVR1 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
634 Squalene monooxygenase SQLE 0.0012
7196 Squalene monooxygenase ERG1 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
2540 Choloylglycine hydrolase cbh 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
6459 Glycodelin PAEP 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
6501 Fatty acid-binding protein, liver FABP1 0.0011
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.001
4203 Histamine N-methyltransferase HNMT 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
5934 Cytochrome P450 26A1 CYP26A1 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
581 Cytochrome P450 2R1 CYP2R1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
3957 Adenosine deaminase ADA 0.0009
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
1360 Sphingomyelin phosphodiesterase SMPD1 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
3830 Calreticulin CALR 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
1992 Vitamin D-binding protein GC 0.0009
6500 Phospholipase A2 PLA2G1B 0.0009
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0009
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
229 Retinoic acid receptor beta RARB 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
856 Vitamin D3 receptor VDR 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4041 Microsomal glutathione S-transferase 2 MGST2 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
482 Glycine receptor subunit alpha-1 GLRA1 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
164 Histamine H4 receptor HRH4 0.0006
153 Dopamine beta-hydroxylase DBH 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2207 Rhodopsin RHO 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
4031 Glutathione S-transferase A1 GSTA1 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
2802 Endoglucanase G celCCG 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
3007 Carbonic anhydrase 12 CA12 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
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