DT-Web: DB00461

Identification

Name

Nabumetone

Accession Number

DB00461 (APRD01128)

Type

small molecule

Description

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid family (which includes diclofenac). Marketed under the brand name Relafen, it has been shown to have a slightly lower risk of gastrointestinal side effects than most other non-selective NSAIDs.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

228.2863

Groups

approved

Monoisotopic Weight

228.115029756

Pharmacology

Indication

For acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.

Mechanism of action

The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthylacetic acid (6MNA), that is a potent inhibitor of prostaglandin synthesis, most likely through binding to the COX-2 and COX-1 receptors.

Absorption

Well absorbed from the gastrointestinal tract. Coadministration of food increases the rate of absorption and subsequent appearance of 6MNA (the active metabolite) in the plasma but does not affect the extent of conversion of nabumetone into 6MNA.

Protein binding

The active metabolite, 6MNA, is more than 99% bound to plasma proteins.

Biotransformation

Undergoes rapid biotransformation to the principal active metabolite, 6-methoxy-2-naphthylacetic acid (6MNA). Approximately 35% of a 1000 mg oral dose of nabumetone is converted to 6MNA and 50% is converted into unidentified metabolites which are subsequently excreted in the urine.

Route of elimination

Approximately 35% of a 1000 mg oral dose of nabumetone is converted to 6MNA and 50% is converted into unidentified metabolites which are subsequently excreted in the urine.

Toxicity

The one overdose occurred in a 17-year-old female patient who had a history of abdominal pain and was hospitalized for increased abdominal pain following ingestion of 30 nabumetone tablets (15 grams total). Stools were negative for occult blood and there was no fall in serum hemoglobin concentration. The patient had no other symptoms.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	The NSAID, nabumetone, may increase the anticoagulant effect of acenocoumarol.
Alendronate	Increased risk of gastric toxicity
Anisindione	The NSAID, nabumetone, may increase the anticoagulant effect anisindione.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine	Monitor for nephrotoxicity
Dicumarol	The NSAID, nabumetone, may increase the anticoagulant effect of dicumarol.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Methotrexate	The NSAID, nabumetone, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Telmisartan	Concomitant use of Telmisartan and Nabumetone may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Nabumetone, may antagonize the antihypertensive effect of Timolol.
Trandolapril	The NSAID, Nabumetone, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Nabumetone is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Nabumetone. Monitor for increased bleeding during concomitant thearpy.
Warfarin	The antiplatelet effects of nabumetone may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Take with food for faster absorption.
Avoid alcohol.

Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Fackovcova D, Kristova V, Kriska M: Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance. Bratisl Lek Listy. 2000;101(8):417-22. - Pubmed Roy HK, Karolski WJ, Ratashak A: Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone. Int J Cancer. 2001 May 15;92(4):609-15. - Pubmed van Kraaij DJ, Hovestad-Witterland AH, de Metz M, Vollaard EJ: A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers. Br J Clin Pharmacol. 2002 Jun;53(6):644-7. - Pubmed Hedner T, Samulesson O, Wahrborg P, Wadenvik H, Ung KA, Ekbom A: Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. Drugs. 2004;64(20):2315-43; discussion 2344-5. - Pubmed Elliott SN, McKnight W, Cirino G, Wallace JL: A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology. 1995 Aug;109(2):524-30. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5465
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	inhibitor
References	Giuliano F, Ferraz JG, Pereira R, de Nucci G, Warner TD: Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation. Eur J Pharmacol. 2001 Aug 24;426(1-2):95-103. - Pubmed Takeuchi K, Smale S, Premchand P, Maiden L, Sherwood R, Thjodleifsson B, Bjornsson E, Bjarnason I: Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2006 Feb;4(2):196-202. - Pubmed Cipollone F, Ganci A, Panara MR, Greco A, Cuccurullo F, Patrono C, Patrignani P: Effects of nabumetone on prostanoid biosynthesis in humans. Clin Pharmacol Ther. 1995 Sep;58(3):335-41. - Pubmed Bensen W, Zizzo A: Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis. Can Fam Physician. 1998 Jan;44:101-2, 105-7. - Pubmed
DTHybrid score	0.5857

Myeloperoxidase
Name	Myeloperoxidase
Gene Name	MPO
Actions	inhibitor
References	Saleh TS, Calixto JB, Medeiros YS: Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan. Peptides. 1999;20(8):949-56. - Pubmed
DTHybrid score	0.3356
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Turpeinen M, Hofmann U, Klein K, Murdter T, Schwab M, Zanger UM: A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. Drug Metab Dispos. 2009 May;37(5):1017-24. Epub 2009 Feb 9. - Pubmed
DTHybrid score	0.2607

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.1606
4512	Cytochrome P450 3A4	CYP3A4	0.1181
6016	Cytochrome P450 2C19	CYP2C19	0.0869
4924	Cytochrome P450 2C8	CYP2C8	0.0787
1729	Solute carrier family 22 member 6	SLC22A6	0.0742
4119	Cytochrome P450 2D6	CYP2D6	0.0704
275	Arachidonate 5-lipoxygenase	ALOX5	0.0678
587	Serum albumin	ALB	0.0629
6024	Cytochrome P450 1A1	CYP1A1	0.0598
6013	Cytochrome P450 2E1	CYP2E1	0.0579
1588	Multidrug resistance protein 1	ABCB1	0.0515
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0468
6030	Cytochrome P450 2B6	CYP2B6	0.0431
4118	Cytochrome P450 3A5	CYP3A5	0.0389
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.033
6142	Solute carrier family 22 member 8	SLC22A8	0.0312
1736	Somatostatin	SST	0.0311
4186	Neuropeptide Y receptor type 2	NPY2R	0.0311
723	Cytosolic phospholipase A2	PLA2G4A	0.0293
5718	Cytochrome P450 2A6	CYP2A6	0.0285
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.028
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.028
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.028
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0278
6107	Cytochrome P450 3A7	CYP3A7	0.0264
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0264
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0262
36	Insulin receptor	INSR	0.0258
309	Antithrombin-III	SERPINC1	0.0254
563	Thyroid peroxidase	TPO	0.0249
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0247
153	Dopamine beta-hydroxylase	DBH	0.0243
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0242
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0239
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0237
2164	Multidrug resistance-associated protein 4	ABCC4	0.023
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0216
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0214
3923	Cholinesterase	BCHE	0.0214
503	Somatostatin receptor type 1	SSTR1	0.0214
6106	Cytochrome P450 2C18	CYP2C18	0.0211
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.021
54	Prothrombin	F2	0.021
3866	Serum amyloid A protein	SAA1	0.0209
1932	Apolipoprotein E	APOE	0.0208
1200	AMBP protein	AMBP	0.0208
3947	Xanthine dehydrogenase/oxidase	XDH	0.0208
6020	Aldehyde oxidase	AOX1	0.0208
3872	Somatostatin receptor type 5	SSTR5	0.02
6008	Somatostatin receptor type 2	SSTR2	0.02
3312	Fatty acid-binding protein, brain	FABP7	0.0199
1024	Solute carrier family 22 member 11	SLC22A11	0.0193
118	Organic cation/carnitine transporter 2	SLC22A5	0.019
856	Vitamin D3 receptor	VDR	0.0189
1159	Interleukin-6	IL6	0.0185
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0185
3941	Amine oxidase [flavin-containing] A	MAOA	0.0182
239	Coagulation factor X	F10	0.0177
1898	Cytochrome P450 1B1	CYP1B1	0.0177
373	Transthyretin	TTR	0.0175
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0168
908	Glutathione S-transferase theta-1	GSTT1	0.0164
6146	High affinity copper uptake protein 1	SLC31A1	0.0164
777	Tumor necrosis factor	TNF	0.016
115	Penicillin-binding protein 2	mrdA	0.016
6069	Penicillin-binding protein 2	mrdA	0.016
6118	Penicillin-binding protein 2	penA	0.016
6187	Penicillin-binding protein 2	pbpA	0.016
6686	Penicillin-binding protein 2	pbp2	0.016
6939	Penicillin-binding protein 2	mrdA	0.016
7163	Penicillin-binding protein 2	pbpA	0.016
867	Penicillin-binding protein 3	pbpC	0.016
6119	Penicillin-binding protein 3	pbp3	0.016
7154	Penicillin-binding protein 3	pbp3	0.016
7157	Penicillin-binding protein 3	LMHCC_2184	0.016
7162	Penicillin-binding protein 3	pbpB	0.016
7172	Penicillin-binding protein 3	pbp3	0.016
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0156
3811	Cytochrome P450 19A1	CYP19A1	0.0155
6143	Solute carrier family 22 member 7	SLC22A7	0.0153
6165	Copper-transporting ATPase 1	ATP7A	0.015
6163	Copper-transporting ATPase 2	ATP7B	0.015
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0149
3939	Amine oxidase [flavin-containing] B	MAOB	0.0147
6220	Aryl hydrocarbon receptor	AHR	0.0139
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0138
904	Glutathione S-transferase P	GSTP1	0.0136
6102	Arylamine N-acetyltransferase 2	NAT2	0.0135
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0132
703	NADPH azoreductase	azr	0.0132
713	Sodium-dependent dopamine transporter	SLC6A3	0.0132
633	Penicillin-binding proteins 1A/1B	pbpA	0.0132
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.013
6144	Solute carrier family 22 member 2	SLC22A2	0.013
477	DNA topoisomerase 4 subunit A	parC	0.0127
886	DNA topoisomerase 4 subunit A	parC	0.0127
6226	DNA topoisomerase 4 subunit A	parC	0.0127
404	DNA gyrase subunit A	gyrA	0.0125
6224	DNA gyrase subunit A	gyrA	0.0125
492	Histamine H1 receptor	HRH1	0.0124
850	Vasopressin V1b receptor	AVPR1B	0.0122
6145	Solute carrier family 22 member 1	SLC22A1	0.0122
896	Glutathione S-transferase Mu 1	GSTM1	0.012
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0117
318	Alpha-2A adrenergic receptor	ADRA2A	0.0116
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0114
817	DNA topoisomerase 2-alpha	TOP2A	0.0114
831	D(2) dopamine receptor	DRD2	0.0114
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0112
1507	Cytochrome c	CYCS	0.0111
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0111
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0109
3601	Dihydropteroate synthase 1	folP1	0.0109
3807	Dihydropteroate synthase 1	folP1	0.0109
3808	Dihydropteroate synthase 2	folP2	0.0109
185	Vasopressin V1a receptor	AVPR1A	0.0107
322	Vasopressin V2 receptor	AVPR2	0.0105
862	Multidrug resistance-associated protein 1	ABCC1	0.0103
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0102
556	Alpha-1A adrenergic receptor	ADRA1A	0.0102
958	Insulin-like growth factor 1 receptor	IGF1R	0.0101
885	5-hydroxytryptamine 1B receptor	HTR1B	0.01
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0099
1648	Elastin	ELN	0.0099
1439	Lactotransferrin	LTF	0.0098
146	Androgen receptor	AR	0.0097
571	Melatonin receptor type 1A	MTNR1A	0.0096
362	Melatonin receptor type 1B	MTNR1B	0.0096
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0091
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0091
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.009
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
738	Monocarboxylate transporter 1	SLC16A1	0.009
23	D(1A) dopamine receptor	DRD1	0.0089
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0088
824	Sodium-dependent serotonin transporter	SLC6A4	0.0088
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0088
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
6043	Putative G-protein coupled receptor 44	GPR44	0.0086
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0083
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0082
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0081
6137	Multidrug resistance-associated protein 6	ABCC6	0.0081
122	P2Y purinoceptor 12	P2RY12	0.008
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0079
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0079
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0079
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0079
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0078
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0078
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0076
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0075
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0075
833	Organic cation/carnitine transporter 1	SLC22A4	0.0074
465	Calmodulin	CALM1	0.0074
136	Estrogen receptor	ESR1	0.0073
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
193	Beta-1 adrenergic receptor	ADRB1	0.0071
468	Cytochrome P450 4A11	CYP4A11	0.0068
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0067
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0067
6036	Eosinophil peroxidase	EPX	0.0066
16	Adenosine A1 receptor	ADORA1	0.0066
3830	Calreticulin	CALR	0.0066
130	Prostacyclin synthase	PTGIS	0.0065
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0064
661	ADP/ATP translocase 1	SLC25A4	0.0064
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0064
4604	Liver carboxylesterase 1	CES1	0.0063
70	Type-1 angiotensin II receptor	AGTR1	0.0063
6034	Hydroxyindole O-methyltransferase	ASMT	0.0063
6035	Nuclear receptor ROR-beta	RORB	0.0063
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0062
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
632	Alpha-1B adrenergic receptor	ADRA1B	0.0062
1656	CYP2B protein	CYP2B	0.0062
3823	Cytokine receptor common gamma chain	IL2RG	0.0061
1714	Mitogen-activated protein kinase 3	MAPK3	0.006
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.006
828	Phenylalanine-4-hydroxylase	PAH	0.006
3109	Phenylalanine-4-hydroxylase	phhA	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
341	5-hydroxytryptamine 3 receptor	HTR3A	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
6147	Solute carrier family 22 member 3	SLC22A3	0.0059
6168	Solute carrier family 22 member 16	SLC22A16	0.0058
33	Cystine/glutamate transporter	SLC7A11	0.0058
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0058
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0058
789	Alpha-1D adrenergic receptor	ADRA1D	0.0057
6500	Phospholipase A2	PLA2G1B	0.0057
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0057
823	Fibroblast growth factor receptor 2	FGFR2	0.0057
551	Carnitine O-acetyltransferase	CRAT	0.0057
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0056
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
6033	High affinity interleukin-8 receptor A	CXCR1	0.0056
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0054
765	Indoleamine 2,3-dioxygenase	IDO1	0.0054
871	Glucocorticoid receptor	NR3C1	0.0054
766	Beta-2 adrenergic receptor	ADRB2	0.0054
273	Apoptosis regulator Bcl-2	BCL2	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
6014	Cytochrome P450 2A13	CYP2A13	0.0053
489	Monocarboxylate transporter 2	SLC16A7	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
724	Interleukin-2 receptor alpha chain	IL2RA	0.0053
717	Interleukin-2 receptor subunit beta	IL2RB	0.0053
558	Solute carrier family 12 member 1	SLC12A1	0.0053
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0053
638	D(3) dopamine receptor	DRD3	0.0052
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0051
6085	Fatty acid-binding protein, intestinal	FABP2	0.0051
274	Muscarinic acetylcholine receptor M5	CHRM5	0.005
2236	Casein kinase II subunit alpha	CSNK2A1	0.005
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
459	Retinoic acid receptor RXR-alpha	RXRA	0.005
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0049
811	Translocator protein	TSPO	0.0048
737	Mineralocorticoid receptor	NR3C2	0.0048
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0046
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0046
6149	Solute carrier family 22 member 10	SLC22A10	0.0046
1650	Heme carrier protein 1	SLC46A1	0.0045
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0044
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0043
614	Progesterone receptor	PGR	0.0043
6136	Multidrug resistance-associated protein 5	ABCC5	0.0043
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0043
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0043
822	Aldose reductase	AKR1B1	0.0043
291	Nitric-oxide synthase, endothelial	NOS3	0.0043
7	Nitric oxide synthase, inducible	NOS2	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
6148	Multidrug resistance-associated protein 7	ABCC10	0.0042
427	Substance-P receptor	TACR1	0.0041
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0041
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.004
432	D(4) dopamine receptor	DRD4	0.004
260	Cytochrome P450 51	ERG11	0.004
761	Cytochrome P450 51	ERG11	0.004
3163	Cytochrome P450 51	cyp51	0.004
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.004
232	Corticosteroid-binding globulin	SERPINA6	0.0039
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0039
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0039
6141	Sodium/bile acid cotransporter	SLC10A1	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2853	14 kDa fatty acid-binding protein	Not Available	0.0037
1192	Sulfotransferase 1A1	SULT1A1	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
4192	DNA topoisomerase 2-beta	TOP2B	0.0036
1629	Transcription factor AP-1	JUN	0.0035
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
565	Extracellular calcium-sensing receptor	CASR	0.0034
712	Tubulin alpha chain	TUB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0034
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0033
4122	Histone deacetylase 2	HDAC2	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
634	Squalene monooxygenase	SQLE	0.0032
7196	Squalene monooxygenase	ERG1	0.0032
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0031
1275	Estrogen sulfotransferase	SULT1E1	0.0031
716	5-hydroxytryptamine 7 receptor	HTR7	0.0031
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0031
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0031
818	50S ribosomal protein L10	rplJ	0.003
847	Mu-type opioid receptor	OPRM1	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
696	Kappa-type opioid receptor	OPRK1	0.003
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.003
1050	Bile salt sulfotransferase	SULT2A1	0.003
173	Toll-like receptor 7	TLR7	0.003
117	Sterol O-acyltransferase 1	SOAT1	0.003
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0029
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0029
2021	Thrombomodulin	THBD	0.0029
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0029
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0028
776	Bile salt export pump	ABCB11	0.0028
163	D(1B) dopamine receptor	DRD5	0.0028
467	Delta-type opioid receptor	OPRD1	0.0028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
6103	Arylamine N-acetyltransferase 1	NAT1	0.0028
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0028
6044	Serum paraoxonase/lactonase 3	PON3	0.0028
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0027
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0027
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0026
504	Mast/stem cell growth factor receptor	KIT	0.0026
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0025
310	Solute carrier family 12 member 2	SLC12A2	0.0024
1517	Beta-3 adrenergic receptor	ADRB3	0.0024
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
106	Cannabinoid receptor 2	CNR2	0.0024
921	Glutamate receptor 2	GRIA2	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
6070	Nischarin	NISCH	0.0024
4103	Proteasome subunit beta type 2	PSMB2	0.0024
4102	Proteasome subunit beta type 5	PSMB5	0.0024
4101	Proteasome subunit beta type 1	PSMB1	0.0024
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
68	Cannabinoid receptor 1	CNR1	0.0023
1374	Natriuretic peptides B	NPPB	0.0023
1827	Gap junction alpha-1 protein	GJA1	0.0023
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
3957	Adenosine deaminase	ADA	0.0023
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0022
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
26	Vascular endothelial growth factor receptor 3	FLT4	0.0022
6042	Prostaglandin reductase 2	PTGR2	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
731	HIV-1 protease	HIV-1 protease	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
32	Vascular endothelial growth factor receptor 1	FLT1	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
869	Estrogen receptor beta	ESR2	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.002
1792	Tissue-type plasminogen activator	PLAT	0.002
1820	Beta-nerve growth factor	NGF	0.002
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
1243	Cathepsin D	CTSD	0.0019
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0019
124	Histamine H2 receptor	HRH2	0.0019
284	DNA-directed RNA polymerase beta chain	rpoB	0.0019
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0019
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
891	Dihydropteroate synthase	folP	0.0018
5359	Dihydropteroate synthase	folP	0.0018
7175	Dihydropteroate synthase	sulI	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
183	Vascular endothelial growth factor A	VEGFA	0.0018
1618	High affinity nerve growth factor receptor	NTRK1	0.0018
1864	RET proto-oncogene	RET	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0017
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0017
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0017
518	Peroxidase/catalase T	katG	0.0017
2207	Rhodopsin	RHO	0.0017
1313	Lactoylglutathione lyase	GLO1	0.0017
407	Vascular endothelial growth factor receptor 2	KDR	0.0017
1830	5'-nucleotidase	NT5E	0.0016
390	Adenosine A3 receptor	ADORA3	0.0016
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0016
1010	Cytochrome P450 51A1	CYP51A1	0.0016
474	Acetylcholinesterase	ACHE	0.0016
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
1039	Histone deacetylase 9	HDAC9	0.0015
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0015
6031	Cytochrome P450 3A43	CYP3A43	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6432	Transporter	snf	0.0015
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
2449	Tubulin alpha-3 chain	TUBA1A	0.0014
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0014
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0013
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0013
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0013
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0013
543	Penicillin-binding protein 1B	mrcB	0.0013
6186	Penicillin-binding protein 1B	ponB	0.0013
6822	Penicillin-binding protein 1b	pbp1b	0.0013
6844	Penicillin-binding protein 1b	pbp1b	0.0013
380	Cytochrome P450 17A1	CYP17A1	0.0013
844	Epidermal growth factor receptor	EGFR	0.0013
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0013
756	Sex hormone-binding globulin	SHBG	0.0013
645	Penicillin-binding protein 1A	mrcA	0.0013
5805	Penicillin-binding protein 1A	ponA	0.0013
6185	Penicillin-binding protein 1A	mrcA	0.0013
6799	Penicillin-binding protein 1A	pbpA	0.0013
159	Penicillin-binding protein 2B	penA	0.0013
6121	Penicillin-binding protein 2B	penA	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0011
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0011
4238	50S ribosomal protein L4	rplD	0.0011
5578	50S ribosomal protein L4	rplD	0.0011
6173	50S ribosomal protein L4	rplD	0.0011
6219	50S ribosomal protein L4	rplD	0.0011
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0011
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.001
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.001
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.001
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.001
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.001
4237	50S ribosomal protein L22	rplV	0.001
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.001
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.001
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.001
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.001
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.001
564	Cellular retinoic acid-binding protein 1	CRABP1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.001
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
6182	Cytochrome P450 2J2	CYP2J2	0.0009
780	Retinoic acid receptor RXR-gamma	RXRG	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0009
365	Dihydrofolate reductase	DHFR	0.0009
2381	Dihydrofolate reductase	DFR1	0.0009
2833	Dihydrofolate reductase	Not Available	0.0009
2931	Dihydrofolate reductase	folA	0.0009
3544	Dihydrofolate reductase	folA	0.0009
3682	Dihydrofolate reductase	folA	0.0009
6642	Dihydrofolate reductase	folA	0.0009
6756	Dihydrofolate reductase	dfrA	0.0009
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0009
4943	Cytochrome c6	petJ	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4984	Neuroglobin	NGB	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4916	Cyanoglobin	glbN	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4961	Hemophore HasA	hasA	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4910	Cytoglobin	CYGB	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
3116	Bacterioferritin	bfr	0.0008
4906	Bacterioferritin	bfr	0.0008
4965	Bacterioferritin	bfr	0.0008
5000	HemO	hemO	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4909	CooA protein	cooA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4972	P450cin	cinA	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
1184	Interferon beta	IFNB1	0.0008
88	Retinoic acid receptor RXR-beta	RXRB	0.0008
162	Retinoic acid receptor gamma-1	RARG	0.0008
6167	Organic solute transporter subunit beta	OSTB	0.0008
6166	Organic solute transporter subunit alpha	OSTA	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0008
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
976	Platelet glycoprotein IX	GP9	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
3810	Catechol O-methyltransferase	COMT	0.0007
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0007
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0007
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0007
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
4920	Peroxidase/catalase	katG	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4923	Cytochrome c3	DvMF_2499	0.0006
4945	Cytochrome c3	Not Available	0.0006
4949	Cytochrome c3	DVU_3171	0.0006
4968	Cytochrome c3	cytc3	0.0006
4997	Cytochrome c3	SO_2727	0.0006
5219	Cytochrome c3	cyd	0.0006
4948	Cytochrome c-553	Not Available	0.0006
2119	Cytochrome b5	CYB5A	0.0006
3189	High-molecular-weight cytochrome c	hmcA	0.0006
4902	Nine-heme cytochrome c	Ddes_2038	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4990	PpcA	ppcA	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
4386	Hemoglobin-like protein HbN	glbN	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
2430	Chondroitinase B	cslB	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0005
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0005
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0005
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0005
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0005
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
798	Osteocalcin	BGLAP	0.0005
5934	Cytochrome P450 26A1	CYP26A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
751	Potassium channel subfamily K member 6	KCNK6	0.0005
3221	Cytochrome c4	cc4	0.0005
4120	NADPH--cytochrome P450 reductase	POR	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0005
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0005
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0005
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0005
172	Potassium channel subfamily K member 1	KCNK1	0.0005
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
165	FL cytokine receptor	FLT3	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
24	Thymidylate synthase	TMP1	0.0004
359	Thymidylate synthase	TYMS	0.0004
2626	Thymidylate synthase	thyA	0.0004
2729	Thymidylate synthase	thyA	0.0004
5352	Thymidylate synthase	THYA	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0004
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0004
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0004
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0004
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0004
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0004
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0004
295	Carbonic anhydrase 1	CA1	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
2298	Cytochrome P450-cam	camC	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
164	Histamine H4 receptor	HRH4	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
952	Dipeptidyl peptidase 4	DPP4	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00461 - Nabumetone

Targets

Enzymes

Predictions