DT-Web: DB00814

Identification

Name

Meloxicam

Accession Number

DB00814 (APRD00529)

Type

small molecule

Description

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve the symptoms of arthritis, primary dysmenorrhea, fever; and as an analgesic, especially where there is an inflammatory component. It is closely related to piroxicam. In Europe it is marketed under the brand names Movalis, Melox, and Recoxa. In North America it is generally marketed under the brand name Mobic. In Latin America, the drug is marketed as Tenaron. [Wikipedia]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

351.401

Groups

approved

Monoisotopic Weight

351.034747299

Pharmacology

Indication

For symptomatic treatment of arthritis and osteoarthritis.

Mechanism of action

Anti-inflammatory effects of meloxicam are believed to be due to inhibition of prostaglandin synthetase (cylooxygenase), leading to the inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis may be associated with the analgesic and antipyretic effects of meloxicam.

Absorption

Absolute bioavailability = 89%

Protein binding

99.4% bound, primarily to albumin

Biotransformation

Meloxicam is almost completely metabolized into inactive metabolites by the cytochrome P450 (CYP450) isozymes. CYP2C9 is primarily responsible for metabolism of meloxicam while CYP3A4 plays a minor role. An intermediate metabolite, 5'-hydroxymethyl meloxicam, is further metabolized to 5'-carboxy meloxicam, the major metabolite. Peroxidase activity is thought to produce the two other inactive metabolites of meloxicam.

Route of elimination

Meloxicam is almost completely metabolized to four pharmacologically inactive metabolites. Meloxicam excretion is predominantly in the form of metabolites, and occurs to equal extents in the urine and feces. Only traces of the unchanged parent compound are excreted in the urine (0.2%) and feces (1.6%). The extent of the urinary excretion was confirmed for unlabeled multiple 7.5 mg doses: 0.5%, 6% and 13% of the dose were found in urine in the form of meloxicam, and the 5'-hydroxymethyl and 5'-carboxy metabolites, respectively.

Toxicity

LD₅₀, Acute: 84 mg/kg (Rat); Oral 470 mg/kg (Mouse); Oral 320 mg/kg (Rabbit)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Meloxicam may increase the anticoagulant effect of acenocoumarol.
Anisindione	Meloxicam may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil	Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam	Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Dicumarol	Meloxicam may increase the anticoagulant effect of dicumarol.
Eltrombopag	Increases levels of Meloxicam via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Ginkgo biloba	Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Lithium	Meloxicam increases serum levels of lithium
Pralatrexate	NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Telmisartan	Concomitant use of Telmisartan and Meloxicam may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol	The NSAID, Meloxicam, may antagonize the antihypertensive effect of Timolol.
Trandolapril	The NSAID, Meloxicam, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Meloxicam is initiated, discontinued or dose changed.
Treprostinil	The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Meloxicam. Monitor for increased bleeding during concomitant thearpy.
Voriconazole	Voriconazole may increase the serum concentration of meloxicam by decreasing its metabolism via CYP2C9 and CYP3A4. Monitor for changes in the therapeutic and adverse effects of meloxicam if voriconazole is initiated, discontinued or dose changed.
Warfarin	The antiplatelet effects of meloxicam may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.

Food Interactions

Take without regard to meals.

Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Poulsen Nautrup B, Horstermann D: [Pharmacodynamic and pharmacokinetic aspects of the non-inflammatory non-steroidal agent meloxicam in dogs] Dtsch Tierarztl Wochenschr. 1999 Mar;106(3):94-100. - Pubmed Tegeder I, Lotsch J, Krebs S, Muth-Selbach U, Brune K, Geisslinger G: Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state. Clin Pharmacol Ther. 1999 May;65(5):533-44. - Pubmed Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F: Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. - Pubmed Panara MR, Renda G, Sciulli MG, Santini G, Di Giamberardino M, Rotondo MT, Tacconelli S, Seta F, Patrono C, Patrignani P: Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. J Pharmacol Exp Ther. 1999 Jul;290(1):276-80. - Pubmed Gross JM, Dwyer JE, Knox FG: Natriuretic response to increased pressure is preserved with COX-2 inhibitors. Hypertension. 1999 Nov;34(5):1163-7. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5617
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	inhibitor
References	Blanco FJ, Guitian R, Moreno J, de Toro FJ, Galdo F: Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. - Pubmed Panara MR, Renda G, Sciulli MG, Santini G, Di Giamberardino M, Rotondo MT, Tacconelli S, Seta F, Patrono C, Patrignani P: Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects. J Pharmacol Exp Ther. 1999 Jul;290(1):276-80. - Pubmed
DTHybrid score	0.6345

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Chesne C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T: Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Ludwig E, Schmid J, Beschke K, Ebner T: Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. J Pharmacol Exp Ther. 1999 Jul;290(1):1-8. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4429
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Chesne C, Guyomard C, Guillouzo A, Schmid J, Ludwig E, Sauter T: Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica. 1998 Jan;28(1):1-13. - Pubmed Ludwig E, Schmid J, Beschke K, Ebner T: Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. J Pharmacol Exp Ther. 1999 Jul;290(1):1-8. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4481
6-phosphogluconate dehydrogenase, decarboxylating
Name	6-phosphogluconate dehydrogenase, decarboxylating
Gene Name	PGD
Actions	inhibitor
References	Akkemik E, Budak H, Ciftci M: Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem. 2010 Mar 17. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.5155
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3092

Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Uchida Y, Kamiie J, Ohtsuki S, Terasaki T: Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res. 2007 Dec;24(12):2281-96. Epub 2007 Oct 16. - Pubmed
DTHybrid score	0.1831

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.2074
4200	Cytochrome P450 1A2	CYP1A2	0.1784
4119	Cytochrome P450 2D6	CYP2D6	0.1743
1588	Multidrug resistance protein 1	ABCB1	0.1533
587	Serum albumin	ALB	0.1305
4118	Cytochrome P450 3A5	CYP3A5	0.1266
1729	Solute carrier family 22 member 6	SLC22A6	0.1213
6013	Cytochrome P450 2E1	CYP2E1	0.1146
6030	Cytochrome P450 2B6	CYP2B6	0.1033
6107	Cytochrome P450 3A7	CYP3A7	0.0883
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0774
6142	Solute carrier family 22 member 8	SLC22A8	0.0773
6024	Cytochrome P450 1A1	CYP1A1	0.0767
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0648
5718	Cytochrome P450 2A6	CYP2A6	0.064
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0628
2621	Thermoresistant gluconokinase	gntK	0.0571
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0548
1024	Solute carrier family 22 member 11	SLC22A11	0.054
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0537
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.053
275	Arachidonate 5-lipoxygenase	ALOX5	0.0517
766	Beta-2 adrenergic receptor	ADRB2	0.0512
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0507
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0485
862	Multidrug resistance-associated protein 1	ABCC1	0.0475
6106	Cytochrome P450 2C18	CYP2C18	0.0457
2206	Glucose-6-phosphate isomerase	GPI	0.0429
6136	Multidrug resistance-associated protein 5	ABCC5	0.0428
6143	Solute carrier family 22 member 7	SLC22A7	0.0405
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0402
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0376
1181	Alpha-1-acid glycoprotein 1	ORM1	0.036
492	Histamine H1 receptor	HRH1	0.0354
1757	Myeloperoxidase	MPO	0.0349
790	DNA polymerase subunit alpha B	POLA2	0.0348
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0345
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0309
3811	Cytochrome P450 19A1	CYP19A1	0.0306
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0303
776	Bile salt export pump	ABCB11	0.0249
871	Glucocorticoid receptor	NR3C1	0.0249
136	Estrogen receptor	ESR1	0.0242
1898	Cytochrome P450 1B1	CYP1B1	0.0233
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0232
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.022
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0219
373	Transthyretin	TTR	0.0215
738	Monocarboxylate transporter 1	SLC16A1	0.0215
118	Organic cation/carnitine transporter 2	SLC22A5	0.0214
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0213
824	Sodium-dependent serotonin transporter	SLC6A4	0.0213
6148	Multidrug resistance-associated protein 7	ABCC10	0.0212
6145	Solute carrier family 22 member 1	SLC22A1	0.0212
3923	Cholinesterase	BCHE	0.021
6141	Sodium/bile acid cotransporter	SLC10A1	0.0209
6144	Solute carrier family 22 member 2	SLC22A2	0.0201
24	Thymidylate synthase	TMP1	0.0201
359	Thymidylate synthase	TYMS	0.0201
2626	Thymidylate synthase	thyA	0.0201
2729	Thymidylate synthase	thyA	0.0201
5352	Thymidylate synthase	THYA	0.0201
1648	Elastin	ELN	0.02
3312	Fatty acid-binding protein, brain	FABP7	0.0199
558	Solute carrier family 12 member 1	SLC12A1	0.0193
146	Androgen receptor	AR	0.0192
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0188
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0188
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0186
1159	Interleukin-6	IL6	0.0185
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0185
502	5-hydroxytryptamine 2A receptor	HTR2A	0.018
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.018
847	Mu-type opioid receptor	OPRM1	0.0177
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0175
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0175
70	Type-1 angiotensin II receptor	AGTR1	0.0174
5294	Nucleoside diphosphate kinase A	NME1	0.0173
777	Tumor necrosis factor	TNF	0.0172
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0172
6137	Multidrug resistance-associated protein 6	ABCC6	0.0168
467	Delta-type opioid receptor	OPRD1	0.0166
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0166
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0165
891	Dihydropteroate synthase	folP	0.0164
5359	Dihydropteroate synthase	folP	0.0164
7175	Dihydropteroate synthase	sulI	0.0164
731	HIV-1 protease	HIV-1 protease	0.0163
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0163
6220	Aryl hydrocarbon receptor	AHR	0.016
6102	Arylamine N-acetyltransferase 2	NAT2	0.016
831	D(2) dopamine receptor	DRD2	0.0159
6085	Fatty acid-binding protein, intestinal	FABP2	0.0158
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0157
696	Kappa-type opioid receptor	OPRK1	0.0156
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0154
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0152
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0152
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0149
556	Alpha-1A adrenergic receptor	ADRA1A	0.0148
260	Cytochrome P450 51	ERG11	0.0148
761	Cytochrome P450 51	ERG11	0.0148
3163	Cytochrome P450 51	cyp51	0.0148
4604	Liver carboxylesterase 1	CES1	0.0147
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0146
1650	Heme carrier protein 1	SLC46A1	0.0145
185	Vasopressin V1a receptor	AVPR1A	0.0142
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0142
3947	Xanthine dehydrogenase/oxidase	XDH	0.0141
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0141
811	Translocator protein	TSPO	0.014
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.014
322	Vasopressin V2 receptor	AVPR2	0.014
5626	Nucleoside diphosphate kinase B	NME2	0.0139
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0137
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0137
614	Progesterone receptor	PGR	0.0136
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0135
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
122	P2Y purinoceptor 12	P2RY12	0.0134
6147	Solute carrier family 22 member 3	SLC22A3	0.0133
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0133
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0133
6020	Aldehyde oxidase	AOX1	0.0132
703	NADPH azoreductase	azr	0.0132
6033	High affinity interleukin-8 receptor A	CXCR1	0.013
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.013
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0129
357	Carbonic anhydrase 2	CA2	0.0128
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0128
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0126
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0126
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0126
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0126
6043	Putative G-protein coupled receptor 44	GPR44	0.0125
504	Mast/stem cell growth factor receptor	KIT	0.0124
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0124
850	Vasopressin V1b receptor	AVPR1B	0.0122
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0122
318	Alpha-2A adrenergic receptor	ADRA2A	0.0121
365	Dihydrofolate reductase	DHFR	0.012
2381	Dihydrofolate reductase	DFR1	0.012
2833	Dihydrofolate reductase	Not Available	0.012
2931	Dihydrofolate reductase	folA	0.012
3544	Dihydrofolate reductase	folA	0.012
3682	Dihydrofolate reductase	folA	0.012
6642	Dihydrofolate reductase	folA	0.012
6756	Dihydrofolate reductase	dfrA	0.012
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.012
232	Corticosteroid-binding globulin	SERPINA6	0.012
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.012
6031	Cytochrome P450 3A43	CYP3A43	0.0118
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0118
1507	Cytochrome c	CYCS	0.0117
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0116
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0116
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0113
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
293	Gamma-glutamyl hydrolase	GGH	0.0112
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0112
468	Cytochrome P450 4A11	CYP4A11	0.0111
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0111
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0111
723	Cytosolic phospholipase A2	PLA2G4A	0.0111
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0109
130	Prostacyclin synthase	PTGIS	0.0109
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0109
2757	Inorganic pyrophosphatase	ppa	0.0107
6238	Inorganic pyrophosphatase	ppa	0.0107
6968	Inorganic pyrophosphatase	PPA1	0.0107
2383	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
2937	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
4620	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6594	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6609	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
6646	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	ispF	0.0107
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0107
6182	Cytochrome P450 2J2	CYP2J2	0.0106
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0106
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0106
407	Vascular endothelial growth factor receptor 2	KDR	0.0105
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0105
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0104
713	Sodium-dependent dopamine transporter	SLC6A3	0.0103
632	Alpha-1B adrenergic receptor	ADRA1B	0.0101
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.01
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.01
23	D(1A) dopamine receptor	DRD1	0.0099
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0099
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0099
737	Mineralocorticoid receptor	NR3C2	0.0099
6149	Solute carrier family 22 member 10	SLC22A10	0.0098
1439	Lactotransferrin	LTF	0.0098
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
26	Vascular endothelial growth factor receptor 3	FLT4	0.0096
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0096
2755	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	LACZ	0.0095
4553	Bifunctional adenosylcobalamin biosynthesis protein cobU	cobU	0.0094
2647	RNA-directed RNA polymerase	P2	0.0094
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0094
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0093
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0093
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0092
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0092
3941	Amine oxidase [flavin-containing] A	MAOA	0.0092
32	Vascular endothelial growth factor receptor 1	FLT1	0.0092
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0092
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.009
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.009
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.009
4132	Chloride channel protein ClC-Ka	CLCNKA	0.009
33	Cystine/glutamate transporter	SLC7A11	0.009
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
3010	Regulatory protein blaR1	blaR1	0.0087
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0087
2149	Angiogenin	ANG	0.0087
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
817	DNA topoisomerase 2-alpha	TOP2A	0.0086
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0086
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0086
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0085
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0085
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0085
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0085
2727	S-adenosylmethionine synthetase	metK	0.0084
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0084
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0082
2885	Carboxyethyl-arginine beta-lactam-synthase	bls	0.0082
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0082
4600	Malonamidase E2	Not Available	0.0082
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0082
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0082
952	Dipeptidyl peptidase 4	DPP4	0.0082
427	Substance-P receptor	TACR1	0.0082
489	Monocarboxylate transporter 2	SLC16A7	0.0082
29	Tubulin beta-1 chain	TUBB1	0.0081
1656	CYP2B protein	CYP2B	0.0081
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0081
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0081
465	Calmodulin	CALM1	0.008
1141	Sialidase-1	NEU1	0.008
64	Neuraminidase	NA	0.008
641	Neuraminidase	NA	0.008
2676	Neuraminidase	NA	0.008
3026	Neuraminidase	NA	0.008
3519	Neuraminidase	NA	0.008
6007	Neuraminidase	NA	0.008
2981	Phospholipase A2, membrane associated	PLA2G2A	0.008
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
5818	Folate receptor alpha	FOLR1	0.0079
2717	Folylpolyglutamate synthase	fgs	0.0079
789	Alpha-1D adrenergic receptor	ADRA1D	0.0079
1405	Thiopurine S-methyltransferase	TPMT	0.0078
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0077
823	Fibroblast growth factor receptor 2	FGFR2	0.0077
4221	Vascular endothelial growth factor	VEGF	0.0075
165	FL cytokine receptor	FLT3	0.0075
5816	Cadherin-5	CDH5	0.0075
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0074
1541	Metalloproteinase	mmp20	0.0074
6395	Myosin-14	MYH14	0.0074
2428	Thiamine-phosphate pyrophosphorylase	thiE	0.0074
459	Retinoic acid receptor RXR-alpha	RXRA	0.0074
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0073
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0073
3823	Cytokine receptor common gamma chain	IL2RG	0.0073
3939	Amine oxidase [flavin-containing] B	MAOB	0.0072
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0072
833	Organic cation/carnitine transporter 1	SLC22A4	0.0072
3810	Catechol O-methyltransferase	COMT	0.0072
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0072
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0072
1275	Estrogen sulfotransferase	SULT1E1	0.0071
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0071
725	5-hydroxytryptamine 1D receptor	HTR1D	0.007
49	Endothelin B receptor	EDNRB	0.0069
3808	Dihydropteroate synthase 2	folP2	0.0069
3601	Dihydropteroate synthase 1	folP1	0.0069
3807	Dihydropteroate synthase 1	folP1	0.0069
68	Cannabinoid receptor 1	CNR1	0.0069
1050	Bile salt sulfotransferase	SULT2A1	0.0069
2021	Thrombomodulin	THBD	0.0068
844	Epidermal growth factor receptor	EGFR	0.0068
6500	Phospholipase A2	PLA2G1B	0.0068
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0068
869	Estrogen receptor beta	ESR2	0.0068
295	Carbonic anhydrase 1	CA1	0.0068
592	Carbonic anhydrase 4	CA4	0.0067
6103	Arylamine N-acetyltransferase 1	NAT1	0.0065
6014	Cytochrome P450 2A13	CYP2A13	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
380	Cytochrome P450 17A1	CYP17A1	0.0065
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0065
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0065
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0064
1629	Transcription factor AP-1	JUN	0.0064
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0064
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0064
273	Apoptosis regulator Bcl-2	BCL2	0.0063
724	Interleukin-2 receptor alpha chain	IL2RA	0.0063
717	Interleukin-2 receptor subunit beta	IL2RB	0.0063
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0063
133	Dihydropterate synthase	sulI	0.0063
638	D(3) dopamine receptor	DRD3	0.0063
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0062
5482	Sialidase-2	NEU2	0.0062
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0062
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0062
629	Alpha-2B adrenergic receptor	ADRA2B	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0062
3685	Catabolite gene activator	crp	0.0061
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0061
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0061
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0061
4655	Adenylate cyclase	cyaC	0.0061
4759	Adenylate cyclase	cyaB2	0.0061
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0061
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0061
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0061
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0061
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0061
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
756	Sex hormone-binding globulin	SHBG	0.0059
193	Beta-1 adrenergic receptor	ADRB1	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
6167	Organic solute transporter subunit beta	OSTB	0.0058
6166	Organic solute transporter subunit alpha	OSTA	0.0058
3957	Adenosine deaminase	ADA	0.0058
828	Phenylalanine-4-hydroxylase	PAH	0.0058
3109	Phenylalanine-4-hydroxylase	phhA	0.0058
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0058
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0057
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0057
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0056
908	Glutathione S-transferase theta-1	GSTT1	0.0056
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0055
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0055
904	Glutathione S-transferase P	GSTP1	0.0055
4120	NADPH--cytochrome P450 reductase	POR	0.0055
1714	Mitogen-activated protein kinase 3	MAPK3	0.0055
1192	Sulfotransferase 1A1	SULT1A1	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
7	Nitric oxide synthase, inducible	NOS2	0.0054
716	5-hydroxytryptamine 7 receptor	HTR7	0.0053
94	5-hydroxytryptamine 4 receptor	HTR4	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0053
4217	Telomerase reverse transcriptase	TERT	0.0052
4760	Mll3241 protein	mll3241	0.0052
161	Tubulin beta chain	TUBB	0.0052
312	Tubulin beta chain	TUB2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0051
4203	Histamine N-methyltransferase	HNMT	0.0051
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0051
378	Alpha-2C adrenergic receptor	ADRA2C	0.005
634	Squalene monooxygenase	SQLE	0.005
7196	Squalene monooxygenase	ERG1	0.005
718	Folate receptor gamma	FOLR3	0.005
299	Folate receptor beta	FOLR2	0.005
804	Mitochondrial folate transporter/carrier	SLC25A32	0.005
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0049
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0049
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
1010	Cytochrome P450 51A1	CYP51A1	0.0049
856	Vitamin D3 receptor	VDR	0.0049
6146	High affinity copper uptake protein 1	SLC31A1	0.0049
814	Ryanodine receptor 1	RYR1	0.0048
921	Glutamate receptor 2	GRIA2	0.0048
4226	Uridine phosphorylase 2	UPP2	0.0048
3639	Thymidine phosphorylase	deoA	0.0048
3936	Thymidine phosphorylase	TYMP	0.0048
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0047
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0047
1792	Tissue-type plasminogen activator	PLAT	0.0047
1198	Serum paraoxonase/arylesterase 1	PON1	0.0047
6223	Penicillin-binding protein 1C	pbpC	0.0047
291	Nitric-oxide synthase, endothelial	NOS3	0.0047
2236	Casein kinase II subunit alpha	CSNK2A1	0.0046
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0046
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0046
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0046
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0045
183	Vascular endothelial growth factor A	VEGFA	0.0045
474	Acetylcholinesterase	ACHE	0.0045
6042	Prostaglandin reductase 2	PTGR2	0.0045
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0045
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
432	D(4) dopamine receptor	DRD4	0.0044
6171	Solute carrier family 28 member 3	SLC28A3	0.0044
4225	Uridine phosphorylase 1	UPP1	0.0044
3809	Estrogen-related receptor gamma	ESRRG	0.0043
1313	Lactoylglutathione lyase	GLO1	0.0043
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0043
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0042
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0042
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0041
413	Amidophosphoribosyltransferase	PPAT	0.0041
2515	Amidophosphoribosyltransferase	purF	0.0041
3714	Amidophosphoribosyltransferase	purF	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
106	Cannabinoid receptor 2	CNR2	0.0041
3932	Glutathione S-transferase A2	GSTA2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2320	Thymidine kinase, cytosolic	TK1	0.004
518	Peroxidase/catalase T	katG	0.004
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.004
4773	Deoxycytidine kinase	DCK	0.004
780	Retinoic acid receptor RXR-gamma	RXRG	0.0039
6138	Multidrug resistance protein 3	ABCB4	0.0039
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
6126	Carbonic anhydrase 7	CA7	0.0038
1618	High affinity nerve growth factor receptor	NTRK1	0.0037
284	DNA-directed RNA polymerase beta chain	rpoB	0.0037
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0037
4192	DNA topoisomerase 2-beta	TOP2B	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
54	Prothrombin	F2	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
4122	Histone deacetylase 2	HDAC2	0.0037
482	Glycine receptor subunit alpha-1	GLRA1	0.0036
822	Aldose reductase	AKR1B1	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
6218	Pannexin-1	PANX1	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
1178	Adenosine A2a receptor	ADORA2A	0.0035
939	50S ribosomal protein L3	rplC	0.0035
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0035
645	Penicillin-binding protein 1A	mrcA	0.0035
5805	Penicillin-binding protein 1A	ponA	0.0035
6185	Penicillin-binding protein 1A	mrcA	0.0035
6799	Penicillin-binding protein 1A	pbpA	0.0035
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0035
124	Histamine H2 receptor	HRH2	0.0034
1483	Membrane copper amine oxidase	AOC3	0.0034
5300	Antigen peptide transporter 1	TAP1	0.0034
581	Cytochrome P450 2R1	CYP2R1	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
3587	Gastrotropin	FABP6	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1196	Complement decay-accelerating factor	CD55	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.003
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.003
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.003
705	Glutamate receptor 1	GRIA1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
115	Penicillin-binding protein 2	mrdA	0.003
6069	Penicillin-binding protein 2	mrdA	0.003
6118	Penicillin-binding protein 2	penA	0.003
6187	Penicillin-binding protein 2	pbpA	0.003
6686	Penicillin-binding protein 2	pbp2	0.003
6939	Penicillin-binding protein 2	mrdA	0.003
7163	Penicillin-binding protein 2	pbpA	0.003
2207	Rhodopsin	RHO	0.0029
153	Dopamine beta-hydroxylase	DBH	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
896	Glutathione S-transferase Mu 1	GSTM1	0.0029
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0028
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0028
543	Penicillin-binding protein 1B	mrcB	0.0028
6186	Penicillin-binding protein 1B	ponB	0.0028
6822	Penicillin-binding protein 1b	pbp1b	0.0028
6844	Penicillin-binding protein 1b	pbp1b	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
1	Peptidoglycan synthetase ftsI	ftsI	0.0028
4155	Peptidoglycan synthetase ftsI	ftsI	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1852	Microtubule-associated protein 2	MAP2	0.0028
6131	Carbonic anhydrase 14	CA14	0.0027
2808	Chloramphenicol acetyltransferase 3	cat3	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
84	Nuclear receptor 0B1	NR0B1	0.0027
5787	Angiopoietin-1 receptor	TEK	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0027
702	UMP-CMP kinase	CMPK1	0.0027
469	Annexin A1	ANXA1	0.0027
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0027
239	Coagulation factor X	F10	0.0027
163	D(1B) dopamine receptor	DRD5	0.0027
1374	Natriuretic peptides B	NPPB	0.0026
1827	Gap junction alpha-1 protein	GJA1	0.0026
1908	Vascular cell adhesion protein 1	VCAM1	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0026
3856	Fibroblast growth factor receptor 3	FGFR3	0.0026
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0026
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
2417	Chloramphenicol acetyltransferase	cat	0.0025
3278	Chloramphenicol acetyltransferase	cat	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0025
2810	Dr hemagglutinin structural subunit	draA	0.0025
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
310	Solute carrier family 12 member 2	SLC12A2	0.0024
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0024
3814	Complement C1r subcomponent	C1R	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
2112	Toll-like receptor 9	TLR9	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1039	Histone deacetylase 9	HDAC9	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
4311	tRNA	TRDMT1	0.0022
4325	tRNA	trmD	0.0022
4328	tRNA	trmD	0.0022
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
1992	Vitamin D-binding protein	GC	0.0022
164	Histamine H4 receptor	HRH4	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
319	Opioid receptor, sigma 1	OPRS1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0022
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0022
2232	Interleukin-5	IL5	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0021
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
976	Platelet glycoprotein IX	GP9	0.0021
1630	Integrin beta-2	ITGB2	0.0021
4041	Microsomal glutathione S-transferase 2	MGST2	0.0021
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0021
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.002
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
1864	RET proto-oncogene	RET	0.0019
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0019
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0019
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
5923	Microtubule-associated protein tau	MAPT	0.0019
5924	Microtubule-associated protein 4	MAP4	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0018
174	Sigma 1-type opioid receptor	SIGMAR1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
1262	Corticotropin-lipotropin	POMC	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6048	Troponin C, skeletal muscle	TNNC2	0.0018
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0018
683	Potassium transporter	GK0582	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
199	Monocarboxylate transporter 8	SLC16A2	0.0018
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
517	Alcohol dehydrogenase 1C	ADH1C	0.0017
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0017
6044	Serum paraoxonase/lactonase 3	PON3	0.0017
6824	Tyrosine-protein kinase Lyn	LYN	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
605	Fumarate reductase flavoprotein subunit	frdA	0.0017
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0017
3673	Fumarate reductase flavoprotein subunit	fccA	0.0017
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0017
6549	Fumarate reductase flavoprotein subunit	frdA	0.0017
3937	Fatty-acid amide hydrolase	FAAH	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0016
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0016
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0016
4031	Glutathione S-transferase A1	GSTA1	0.0016
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6163	Copper-transporting ATPase 2	ATP7B	0.0016
6165	Copper-transporting ATPase 1	ATP7A	0.0016
4948	Cytochrome c-553	Not Available	0.0016
4923	Cytochrome c3	DvMF_2499	0.0016
4945	Cytochrome c3	Not Available	0.0016
4949	Cytochrome c3	DVU_3171	0.0016
4968	Cytochrome c3	cytc3	0.0016
4997	Cytochrome c3	SO_2727	0.0016
5219	Cytochrome c3	cyd	0.0016
3189	High-molecular-weight cytochrome c	hmcA	0.0016
4902	Nine-heme cytochrome c	Ddes_2038	0.0016
563	Thyroid peroxidase	TPO	0.0016
572	Integrin alpha-L	ITGAL	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0016
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0016
5798	Mitogen-activated protein kinase 11	MAPK11	0.0016
3913	Glutamic acid decarboxylase	GAD65	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0015
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0015
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
936	Ephrin type-A receptor 2	EPHA2	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
267	Plasminogen activator inhibitor 1	SERPINE1	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0014
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0014
6221	Steroid hormone receptor ERR1	ESRRA	0.0014
5934	Cytochrome P450 26A1	CYP26A1	0.0014
4386	Hemoglobin-like protein HbN	glbN	0.0014
4943	Cytochrome c6	petJ	0.0013
4954	Soluble cytochrome b558	Not Available	0.0013
4934	Cytochrome c-551	nirM	0.0013
5218	Cytochrome c-551	nirM	0.0013
4905	Cytochrome c2	Not Available	0.0013
4939	Cytochrome c2	cycA	0.0013
4964	Cytochrome c2	cycA	0.0013
4979	Cytochrome c2	cycA	0.0013
6673	Cytochrome c2	cycA	0.0013
4925	Cytochrome c-type protein SHP	shp	0.0013
4947	Bacterial hemoglobin	vhb	0.0013
4916	Cyanoglobin	glbN	0.0013
4984	Neuroglobin	NGB	0.0013
4994	Hemoglobin-like protein HbO	glbO	0.0013
4915	Cytochrome c-550	psbV	0.0013
4959	Cytochrome c-550	psbV	0.0013
5216	Cytochrome c-550	psbV	0.0013
4998	Hemoglobin-like protein yjbI	yjbI	0.0013
4936	Cytochrome c2 iso-2	Not Available	0.0013
4942	Diheme cytochrome c napB	napB	0.0013
4975	Cytochrome c-556	RPA3973	0.0013
4961	Hemophore HasA	hasA	0.0013
4910	Cytoglobin	CYGB	0.0013
4904	Cytochrome c family protein	GSU1996	0.0013
5000	HemO	hemO	0.0013
644	Heme oxygenase 2	HMOX2	0.0013
4982	Heme oxygenase 2	pbsA2	0.0013
751	Potassium channel subfamily K member 6	KCNK6	0.0013
4981	Iron-starvation protein PigA	pigA	0.0013
4909	CooA protein	cooA	0.0013
3116	Bacterioferritin	bfr	0.0013
4906	Bacterioferritin	bfr	0.0013
4965	Bacterioferritin	bfr	0.0013
4907	Cytochrome c-L	moxG	0.0013
6865	Cytochrome c-L	moxG	0.0013
4976	Apocytochrome f	petA	0.0013
6407	Apocytochrome f	petA	0.0013
4971	Nonaheme cytochrome c	hmcA	0.0013
4764	Cytochrome P450 165C4	CYP165C4	0.0013
4989	Cytochrome c551 peroxidase	ccp	0.0013
5222	Cytochrome c551 peroxidase	ccpA	0.0013
4935	Cytochrome c-554	cycA1	0.0013
4937	Cytochrome oxidase subunit II	rcoxA	0.0013
4999	Cytochrome P450 165B3	CYP165B3	0.0013
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0013
4960	Putative cytochrome P450-family protein	SCO7417	0.0013
4931	Cytochrome P450 167A1	CYP167A1	0.0013
4972	P450cin	cinA	0.0013
4993	Hydroxylamine oxidoreductase	hao1	0.0013
4922	Cytochrome c, putative	SO_4144	0.0013
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0013
4952	Catalase/peroxidase	katA	0.0013
4903	Methyl-accepting chemotaxis protein	Tar4	0.0013
3093	Catalase HPII	katE	0.0013
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0013
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0013
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0013
6501	Fatty acid-binding protein, liver	FABP1	0.0013
2216	Fibroblast growth factor receptor 4	FGFR4	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0013
735	Alanine aminotransferase 1	GPT	0.0013
3904	Alanine aminotransferase 2	GPT2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
4034	Glutaredoxin-1	GLRX	0.0013
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0013
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0013
910	Epididymal secretory glutathione peroxidase	GPX5	0.0013
4036	Glutathione peroxidase 6	GPX6	0.0013
903	Glutathione S-transferase A5	GSTA5	0.0013
911	Glutathione peroxidase 3	GPX3	0.0013
4037	Hypothetical protein	GPX1	0.0013
4297	Hypothetical protein	SP_1951	0.0013
4521	Hypothetical protein	BC_2969	0.0013
4540	Hypothetical protein	TM_1070	0.0013
4555	Hypothetical protein	MT1739	0.0013
4569	Hypothetical protein	mshD	0.0013
4578	Hypothetical protein	PA3270	0.0013
4747	Hypothetical protein	PA3967	0.0013
5177	Hypothetical protein	TM_0096	0.0013
5194	Hypothetical protein	PA1204	0.0013
5240	Hypothetical protein	Rv2991	0.0013
5370	Hypothetical protein	TM_1158	0.0013
5710	Hypothetical protein	Tb927.5.1360	0.0013
1928	Leukotriene C4 synthase	LTC4S	0.0013
4029	Microsomal glutathione S-transferase 3	MGST3	0.0013
4032	Microsomal glutathione S-transferase 1	MGST1	0.0013
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0013
4040	Glutathione peroxidase 7	GPX7	0.0013
907	Glutathione peroxidase 2	GPX2	0.0013
906	Glutathione peroxidase 1	GPX1	0.0013
4035	Glutathione S-transferase Mu 5	GSTM5	0.0013
900	Glutathione S-transferase A4	GSTA4	0.0013
4042	Glutathione transferase omega-2	GSTO2	0.0013
4033	S-formylglutathione hydrolase	ESD	0.0013
4038	Glutathione peroxidase 4	GPX4	0.0013
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0013
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3221	Cytochrome c4	cc4	0.0012
172	Potassium channel subfamily K member 1	KCNK1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0012
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0012
2298	Cytochrome P450-cam	camC	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0011
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
897	Glutathione S-transferase kappa 1	GSTK1	0.0011
898	Glutathione S-transferase A3	GSTA3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
909	Maleylacetoacetate isomerase	GSTZ1	0.0011
899	Glutathione S-transferase Mu 3	GSTM3	0.0011
905	Glutathione transferase omega-1	GSTO1	0.0011
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.001
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.001
5251	Carbonyl reductase [NADPH] 1	CBR1	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4920	Peroxidase/catalase	katG	0.001
283	SEC14-like protein 2	SEC14L2	0.001
2165	Glutathione S-transferase Mu 2	GSTM2	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
2119	Cytochrome b5	CYB5A	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.001
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.001
4990	PpcA	ppcA	0.001
4988	Sulfite oxidase, mitochondrial	SUOX	0.001
3570	Cytochrome P450 152A1	cypC	0.001
4289	Cytochrome P450	TT_P0059	0.001
6262	Cytochrome P450	staP	0.001
4992	Cytochrome c peroxidase	Not Available	0.001
2915	Sensor protein fixL	fixL	0.001
4944	Sensor protein fixL	fixL	0.001
3375	Acidic cytochrome c3	Not Available	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
4385	Cytochrome c'	Not Available	0.001
4967	Cytochrome c'	cycA	0.001
5038	Cytochrome c'	Not Available	0.001
5223	Cytochrome c'	cycP	0.001
4813	Heme oxygenase	hmuO	0.001
5769	Heme oxygenase	Not Available	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
2230	Catalase	CAT	0.001
3249	Catalase	katA	0.001
3625	Catalase	katA	0.001
4539	Catalase	katA	0.001
4941	Catalase	katB	0.001
760	Fibroblast growth factor 1	FGF1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
901	Glutathione S-transferase Mu 4	GSTM4	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
76	Nitric-oxide synthase, brain	NOS1	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
6677	Myelin P2 protein	PMP2	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
3670	Soluble cytochrome b562 precursor	cybC	0.0009
3411	Cytochrome P450 121	cyp121	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2617	Nitric oxide synthase oxygenase	nos	0.0009
2701	Nitric oxide synthase oxygenase	nos	0.0009
3291	Cytochrome c-552	cycA	0.0009
4927	Cytochrome c-552	nrfA	0.0009
4938	Cytochrome c-552	cycA	0.0009
4953	Cytochrome c-552	nrfA	0.0009
5217	Cytochrome c-552	cycM	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
3102	Flavohemoprotein	hmp	0.0009
4969	Flavohemoprotein	hmp	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
3404	Exotoxin A	eta	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
714	Glutathione reductase, mitochondrial	GSR	0.0008
1867	Major prion protein	PRNP	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0008
6432	Transporter	snf	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0008
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0008
1025	Aquaporin-1	AQP1	0.0008
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0008
1268	Neuropeptide S receptor	NPSR1	0.0008
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0008
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
3830	Calreticulin	CALR	0.0008
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0008
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0008
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0008
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0008
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
4608	Putative cytochrome P450	SCO1207	0.0007
4963	Putative cytochrome P450	SCO2884	0.0007
6254	Putative cytochrome P450	SCO6998	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
358	Cystathionine beta-synthase	CBS	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0007
6072	Potassium channel subfamily K member 3	KCNK3	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
693	Hemoglobin subunit beta	HBB	0.0007
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
442	Envelope glycoprotein	gp41	0.0006
4859	Envelope glycoprotein	env	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
6268	Hydroxyacid oxidase 1	HAO1	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2430	Chondroitinase B	cslB	0.0005
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0005
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00814 - Meloxicam

Targets

Enzymes

Transporters

Predictions