DT-Web

DB01345 - Potassium


Identification
Name Potassium
Accession Number DB01345
Type small molecule
Description Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential--a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups experimental
Monoisotopic Weight Not Available
Pharmacology
Indication Not Available
Mechanism of action Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential--a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiloride Increased risk of hyperkalemia
Benazepril Increased risk of hyperkalemia
Candesartan Increased risk of hyperkalemia
Captopril Increased risk of hyperkalemia
Cilazapril Increased risk of hyperkalemia
Drospirenone Increased risk of hyperkalemia
Enalapril Increased risk of hyperkalemia
Eplerenone This association presents an increased risk of hyperkalemia
Eprosartan Increased risk of hyperkalemia
Forasartan Increased risk of hyperkalemia
Fosinopril Increased risk of hyperkalemia
Irbesartan Increased risk of hyperkalemia
Lisinopril Increased risk of hyperkalemia
Lithium The urine alkalizer decreases the effect of lithium
Losartan Increased risk of hyperkalemia
Moexipril Increased risk of hyperkalemia
Perindopril Increased risk of hyperkalemia
Polystyrene sulfonate Risk of alkalosis in renal impairment
Quinapril Increased risk of hyperkalemia
Ramipril Increased risk of hyperkalemia
Saprisartan Increased risk of hyperkalemia
Spirapril Increased risk of hyperkalemia
Spironolactone Increased risk of hyperkalemia
Tasosartan Increased risk of hyperkalemia
Telmisartan Potassium may increase the hyperkalemic effect of Telmisartan. Monitor serum potassium levels during concomitant use.
Trandolapril Increased risk of hyperkalemia
Triamterene Increased risk of hyperkalemia
Valsartan Increased risk of hyperkalemia
Food Interactions Not Available

Targets


Sodium/potassium-transporting ATPase alpha-1 chain
Name Sodium/potassium-transporting ATPase alpha-1 chain
Gene Name ATP1A1
Pharmacological action unknown
Actions Not Available
References
  • Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. - Pubmed
  • Li C, Geering K, Horisberger JD: The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol. 2006;213(1):1-9. Epub 2007 Mar 8. - Pubmed
  • Stanely Mainzen Prince P, Karthick M: Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21(1):1-6. - Pubmed
  • Simon WA, Herrmann M, Klein T, Shin JM, Huber R, Senn-Bilfinger J, Postius S: Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16. - Pubmed
  • Iannello S, Milazzo P, Belfiore F: Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects. Obes Rev. 2007 May;8(3):231-51. - Pubmed
DTHybrid score 0.7588

Predictions


Id Partner name Gene Name Score
566 Serotransferrin TF 0.0538
558 Solute carrier family 12 member 1 SLC12A1 0.0385
295 Carbonic anhydrase 1 CA1 0.0298
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.028
357 Carbonic anhydrase 2 CA2 0.0223
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0221
592 Carbonic anhydrase 4 CA4 0.0214
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0187
3932 Glutathione S-transferase A2 GSTA2 0.017
587 Serum albumin ALB 0.0164
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0156
1405 Thiopurine S-methyltransferase TPMT 0.0148
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0143
466 Solute carrier family 12 member 3 SLC12A3 0.0124
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0124
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0123
1588 Multidrug resistance protein 1 ABCB1 0.0123
3426 Glutamine synthetase glnA 0.0121
3987 Glutamine synthetase GLUL 0.0121
4205 Carbonic anhydrase 9 CA9 0.0118
3007 Carbonic anhydrase 12 CA12 0.0118
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0108
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0103
6142 Solute carrier family 22 member 8 SLC22A8 0.0102
1729 Solute carrier family 22 member 6 SLC22A6 0.0098
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0093
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0087
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0081
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.008
4512 Cytochrome P450 3A4 CYP3A4 0.0076
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0073
6167 Organic solute transporter subunit beta OSTB 0.0066
6166 Organic solute transporter subunit alpha OSTA 0.0066
6024 Cytochrome P450 1A1 CYP1A1 0.0065
465 Calmodulin CALM1 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0054
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
776 Bile salt export pump ABCB11 0.0041
4119 Cytochrome P450 2D6 CYP2D6 0.0037
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