DT-Web

DB01197 - Captopril


Identification
Name Captopril
Accession Number DB01197 (APRD00164)
Type small molecule
Description Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 217.285
Groups approved
Monoisotopic Weight 217.077264041
Pharmacology
Indication For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
Mechanism of action There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Captopril, one of the few ACE inhibitors that is not a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Captopril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors. Captopril's affinity for ACE is approximately 30,000 times greater than that of ATI.
Absorption 60-75% in fasting individuals; food decreases absorption by 25-40% (some evidence indicates that this is not clinically significant)
Protein binding 25-30% bound to plasma proteins, primarily albumin
Biotransformation Hepatic. Major metabolites are captopril-cysteine disulfide and the disulfide dimer of captopril. Metabolites may undergo reversible interconversion.
Route of elimination Not Available
Toxicity Symptoms of overdose include emesis and decreased blood pressure. Side effects include dose-dependent rash (usually maculopapular), taste alterations, hypotension, gastric irritation, cough, and angioedema.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiloride Increased risk of hyperkalemia
Aprotinin In study of nine patients with untreated hypertension, aprotinin infused intravenously in a dose of 2 million KIU over two hours blocked the acute hypotensive effect of 100mg of captopril.
Azilsartan medoxomil Pharmacodynamic synergism: dual blockade of renin-angiotensin system. Increases risks of hypotension, hyperkalemia, renal impairment.
Drospirenone Increased risk of hyperkalemia
Icatibant Icatibant may attenuate the antihypertensive effect of ACE inhibitors by pharmacodynamic antagonism. Monitor concomitant therapy closely.
Lithium The ACE inhibitor increases serum levels of lithium
Potassium Increased risk of hyperkalemia
Spironolactone Increased risk of hyperkalemia
Terbinafine Terbinafine may reduce the metabolism and clearance of Captopril. Consider alternate therapy or monitor for therapeutic/adverse effects of Captopril if Terbinafine is initiated, discontinued or dose changed.
Tizanidine Tizanidine increases the risk of hypotension with the ACE inhibitor
Tobramycin Increased risk of nephrotoxicity
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triamterene Increased risk of hyperkalemia
Food Interactions
  • Captopril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
  • Food decreases absorption by 25 - 40%. Clinical significance is debatable.
  • Herbs that may attenuate the antihypertensive effect of captopril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of captopril.

Targets


Angiotensin-converting enzyme
Name Angiotensin-converting enzyme
Gene Name ACE
Pharmacological action yes
Actions inhibitor
References
  • Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. - Pubmed
  • Dalkas GA, Marchand D, Galleyrand JC, Martinez J, Spyroulias GA, Cordopatis P, Cavelier F: Study of a lipophilic captopril analogue binding to angiotensin I converting enzyme. J Pept Sci. 2010 Feb;16(2):91-7. - Pubmed
  • Natesh R, Schwager SL, Evans HR, Sturrock ED, Acharya KR: Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme. Biochemistry. 2004 Jul 13;43(27):8718-24. - Pubmed
  • Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. - Pubmed
  • Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. - Pubmed
  • Tzakos AG, Naqvi N, Comporozos K, Pierattelli R, Theodorou V, Husain A, Gerothanassis IP: The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5084-7. Epub 2006 Aug 2. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6277
72 kDa type IV collagenase
Name 72 kDa type IV collagenase
Gene Name MMP2
Pharmacological action unknown
Actions inhibitor
References
  • Brower GL, Levick SP, Janicki JS: Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64. Epub 2007 Feb 16. - Pubmed
  • Okada M, Kikuzuki R, Harada T, Hori Y, Yamawaki H, Hara Y: Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats. J Pharmacol Sci. 2008 Dec;108(4):487-94. Epub 2008 Dec 5. - Pubmed
  • Prontera C, Mariani B, Rossi C, Poggi A, Rotilio D: Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma. Int J Cancer. 1999 May 31;81(5):761-6. - Pubmed
  • Reinhardt D, Sigusch HH, Hensse J, Tyagi SC, Korfer R, Figulla HR: Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP. Heart. 2002 Nov;88(5):525-30. - Pubmed
  • Williams RN, Parsons SL, Morris TM, Rowlands BJ, Watson SA: Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models. Eur J Surg Oncol. 2005 Nov;31(9):1042-50. Epub 2005 Jul 1. - Pubmed
  • Yamamoto D, Takai S, Hirahara I, Kusano E: Captopril directly inhibits matrix metalloproteinase-2 activity in continuous ambulatory peritoneal dialysis therapy. Clin Chim Acta. 2010 May 2;411(9-10):762-4. Epub 2010 Feb 22. - Pubmed
DTHybrid score 0.674
Matrix metalloproteinase-9
Name Matrix metalloproteinase-9
Gene Name Not Available
Pharmacological action unknown
Actions inhibitor
References
  • Okada M, Kikuzuki R, Harada T, Hori Y, Yamawaki H, Hara Y: Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats. J Pharmacol Sci. 2008 Dec;108(4):487-94. Epub 2008 Dec 5. - Pubmed
  • Reinhardt D, Sigusch HH, Hensse J, Tyagi SC, Korfer R, Figulla HR: Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP. Heart. 2002 Nov;88(5):525-30. - Pubmed
  • Williams RN, Parsons SL, Morris TM, Rowlands BJ, Watson SA: Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models. Eur J Surg Oncol. 2005 Nov;31(9):1042-50. Epub 2005 Jul 1. - Pubmed
  • Yamamoto D, Takai S, Miyazaki M: Inhibitory profiles of captopril on matrix metalloproteinase-9 activity. Eur J Pharmacol. 2008 Jul 7;588(2-3):277-9. Epub 2008 May 22. - Pubmed
DTHybrid score 1.0248

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3128

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. - Pubmed
DTHybrid score 0.3542
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Watanabe K, Sawano T, Terada K, Endo T, Sakata M, Sato J: Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2. Biol Pharm Bull. 2002 Jul;25(7):885-90. - Pubmed
  • Temple CS, Boyd CA: Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter. Biochim Biophys Acta. 1998 Aug 14;1373(1):277-81. - Pubmed
DTHybrid score 0.5325
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Kuze K, Graves P, Leahy A, Wilson P, Stuhlmann H, You G: Heterologous expression and functional characterization of a mouse renal organic anion transporter in mammalian cells. J Biol Chem. 1999 Jan 15;274(3):1519-24. - Pubmed
DTHybrid score 0.3479

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.3542
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions
References Not Available
DTHybrid score 0.5325
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.3479

Predictions


Id Partner name Gene Name Score
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.3546
4512 Cytochrome P450 3A4 CYP3A4 0.2226
4757 Cytochrome P450 2C9 CYP2C9 0.1277
6016 Cytochrome P450 2C19 CYP2C19 0.1235
6142 Solute carrier family 22 member 8 SLC22A8 0.1096
4200 Cytochrome P450 1A2 CYP1A2 0.1028
4924 Cytochrome P450 2C8 CYP2C8 0.095
4118 Cytochrome P450 3A5 CYP3A5 0.0855
1385 Angiotensin-converting enzyme 2 ACE2 0.0853
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0818
1024 Solute carrier family 22 member 11 SLC22A11 0.074
118 Organic cation/carnitine transporter 2 SLC22A5 0.0726
6143 Solute carrier family 22 member 7 SLC22A7 0.0659
633 Penicillin-binding proteins 1A/1B pbpA 0.0633
20 Prostaglandin G/H synthase 1 PTGS1 0.062
6107 Cytochrome P450 3A7 CYP3A7 0.0603
6030 Cytochrome P450 2B6 CYP2B6 0.0584
6013 Cytochrome P450 2E1 CYP2E1 0.0573
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0561
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0551
290 Prostaglandin G/H synthase 2 PTGS2 0.0492
3923 Cholinesterase BCHE 0.0473
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0466
6024 Cytochrome P450 1A1 CYP1A1 0.0461
294 Neprilysin MME 0.0432
862 Multidrug resistance-associated protein 1 ABCC1 0.0402
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.04
492 Histamine H1 receptor HRH1 0.0393
645 Penicillin-binding protein 1A mrcA 0.0393
5805 Penicillin-binding protein 1A ponA 0.0393
6185 Penicillin-binding protein 1A mrcA 0.0393
6799 Penicillin-binding protein 1A pbpA 0.0393
6145 Solute carrier family 22 member 1 SLC22A1 0.0377
4604 Liver carboxylesterase 1 CES1 0.0371
556 Alpha-1A adrenergic receptor ADRA1A 0.037
831 D(2) dopamine receptor DRD2 0.0351
824 Sodium-dependent serotonin transporter SLC6A4 0.0346
1 Peptidoglycan synthetase ftsI ftsI 0.0345
4155 Peptidoglycan synthetase ftsI ftsI 0.0345
2164 Multidrug resistance-associated protein 4 ABCC4 0.0335
5718 Cytochrome P450 2A6 CYP2A6 0.0327
6201 Matrix metalloproteinase-27 MMP27 0.0326
6198 Matrix metalloproteinase-24 MMP24 0.0326
6191 Matrix metalloproteinase-14 MMP14 0.0326
6197 Matrix metalloproteinase-23 MMP23A 0.0326
6200 Matrix metalloproteinase-26 MMP26 0.0326
6192 Matrix metalloproteinase-15 MMP15 0.0326
6199 Matrix metalloproteinase-25 MMP25 0.0326
6193 Matrix metalloproteinase-17 MMP17 0.0326
6194 Matrix metalloproteinase-19 MMP19 0.0326
6196 Matrix metalloproteinase-21 MMP21 0.0326
6202 Matrix metalloproteinase-28 MMP28 0.0325
543 Penicillin-binding protein 1B mrcB 0.0323
6186 Penicillin-binding protein 1B ponB 0.0323
6822 Penicillin-binding protein 1b pbp1b 0.0323
6844 Penicillin-binding protein 1b pbp1b 0.0323
3917 Methylenetetrahydrofolate reductase MTHFR 0.0318
502 5-hydroxytryptamine 2A receptor HTR2A 0.0309
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0305
2970 Matrix metalloproteinase-16 MMP16 0.0281
6195 Matrix metalloproteinase-20 MMP20 0.0278
6188 Stromelysin-2 MMP10 0.0277
6190 Stromelysin-3 MMP11 0.0272
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.027
3090 Chitosanase csn 0.0267
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0267
193 Beta-1 adrenergic receptor ADRB1 0.0265
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.026
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0254
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0253
6144 Solute carrier family 22 member 2 SLC22A2 0.0252
766 Beta-2 adrenergic receptor ADRB2 0.025
632 Alpha-1B adrenergic receptor ADRA1B 0.0248
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0241
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0241
777 Tumor necrosis factor TNF 0.024
6189 Matrilysin MMP7 0.0239
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0236
891 Dihydropteroate synthase folP 0.0232
5359 Dihydropteroate synthase folP 0.0232
7175 Dihydropteroate synthase sulI 0.0232
1253 Interferon gamma IFNG 0.023
23 D(1A) dopamine receptor DRD1 0.0229
318 Alpha-2A adrenergic receptor ADRA2A 0.0229
6702 Organic hydroperoxide resistance protein, putative VC_A1006 0.0228
4587 Carbapenem-hydrolyzing beta-lactamase blaB-1 blaB1 0.0228
4586 FEZ-1 protein blaFEZ-1 0.0228
1167 Interstitial collagenase MMP1 0.0225
776 Bile salt export pump ABCB11 0.0224
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0224
320 5-hydroxytryptamine 1A receptor HTR1A 0.0222
6106 Cytochrome P450 2C18 CYP2C18 0.0217
738 Monocarboxylate transporter 1 SLC16A1 0.0215
183 Vascular endothelial growth factor A VEGFA 0.0197
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.019
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.019
847 Mu-type opioid receptor OPRM1 0.0186
2154 Neutrophil collagenase MMP8 0.0179
1330 Collagenase 3 MMP13 0.0178
2203 Macrophage metalloelastase MMP12 0.0178
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0178
22 30S ribosomal protein S4 rpsD 0.0175
6714 30S ribosomal protein S4 rpsD 0.0175
404 DNA gyrase subunit A gyrA 0.0174
6224 DNA gyrase subunit A gyrA 0.0174
833 Organic cation/carnitine transporter 1 SLC22A4 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
1654 Interleukin-1 beta IL1B 0.0168
1926 Stromelysin-1 MMP3 0.0166
140 30S ribosomal protein S9 rpsI 0.0165
6719 30S ribosomal protein S9 rpsI 0.0165
6725 30S ribosomal protein S9 rpsI 0.0165
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0165
713 Sodium-dependent dopamine transporter SLC6A3 0.0163
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0161
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0158
338 DNA polymerase UL30 0.0156
379 DNA polymerase UL54 0.0156
697 DNA polymerase ORF28 0.0156
2482 DNA polymerase 43 0.0156
4104 DNA polymerase BALF5 0.0156
474 Acetylcholinesterase ACHE 0.0152
494 Caspase-1 CASP1 0.015
590 5-hydroxytryptamine 2C receptor HTR2C 0.015
1757 Myeloperoxidase MPO 0.0149
1898 Cytochrome P450 1B1 CYP1B1 0.0148
592 Carbonic anhydrase 4 CA4 0.0148
696 Kappa-type opioid receptor OPRK1 0.0146
295 Carbonic anhydrase 1 CA1 0.0146
6067 Penicillin binding protein 2a mecA 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
467 Delta-type opioid receptor OPRD1 0.0144
5754 Metallo-beta-lactamase L1 Not Available 0.0143
1507 Cytochrome c CYCS 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0142
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0142
817 DNA topoisomerase 2-alpha TOP2A 0.014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.014
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0139
3626 Probable polysaccharide deacetylase pdaA pdaA 0.0138
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0138
275 Arachidonate 5-lipoxygenase ALOX5 0.0137
638 D(3) dopamine receptor DRD3 0.0135
871 Glucocorticoid receptor NR3C1 0.0132
357 Carbonic anhydrase 2 CA2 0.013
6141 Sodium/bile acid cotransporter SLC10A1 0.0129
2077 Caspase-3 CASP3 0.0129
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0128
373 Transthyretin TTR 0.0127
3941 Amine oxidase [flavin-containing] A MAOA 0.0126
4787 Envelope glycoprotein gp160 env 0.0125
4820 Envelope glycoprotein gp160 env 0.0125
5727 Envelope glycoprotein gp160 env 0.0125
465 Calmodulin CALM1 0.0125
6147 Solute carrier family 22 member 3 SLC22A3 0.0125
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0122
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0117
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0114
1373 Glucosylceramidase GBA 0.0114
4666 Fucose-binding lectin PA-IIL lecB 0.0114
136 Estrogen receptor ESR1 0.0113
3639 Thymidine phosphorylase deoA 0.0111
3936 Thymidine phosphorylase TYMP 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
844 Epidermal growth factor receptor EGFR 0.0109
3810 Catechol O-methyltransferase COMT 0.0109
731 HIV-1 protease HIV-1 protease 0.0109
159 Penicillin-binding protein 2B penA 0.0108
6121 Penicillin-binding protein 2B penA 0.0108
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0108
789 Alpha-1D adrenergic receptor ADRA1D 0.0108
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
4252 Penicillin-binding protein 5 dacA 0.0108
6136 Multidrug resistance-associated protein 5 ABCC5 0.0107
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0106
3811 Cytochrome P450 19A1 CYP19A1 0.0106
2211 Fatty acid-binding protein, heart FABP3 0.0105
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0104
3140 Hemagglutinin-neuraminidase HN 0.0104
3609 Hemagglutinin-neuraminidase HN 0.0104
436 5-hydroxytryptamine 2B receptor HTR2B 0.0104
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0101
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.01
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.01
477 DNA topoisomerase 4 subunit A parC 0.0099
886 DNA topoisomerase 4 subunit A parC 0.0099
6226 DNA topoisomerase 4 subunit A parC 0.0099
558 Solute carrier family 12 member 1 SLC12A1 0.0099
885 5-hydroxytryptamine 1B receptor HTR1B 0.0099
432 D(4) dopamine receptor DRD4 0.0099
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0098
380 Cytochrome P450 17A1 CYP17A1 0.0098
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0097
6148 Multidrug resistance-associated protein 7 ABCC10 0.0097
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0095
629 Alpha-2B adrenergic receptor ADRA2B 0.0095
566 Serotransferrin TF 0.0094
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0094
723 Cytosolic phospholipase A2 PLA2G4A 0.0093
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0093
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0093
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
756 Sex hormone-binding globulin SHBG 0.009
146 Androgen receptor AR 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.009
6126 Carbonic anhydrase 7 CA7 0.009
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0087
3760 Penicillin-binding protein 5 precursor dacA 0.0087
6182 Cytochrome P450 2J2 CYP2J2 0.0085
341 5-hydroxytryptamine 3 receptor HTR3A 0.0085
70 Type-1 angiotensin II receptor AGTR1 0.0083
725 5-hydroxytryptamine 1D receptor HTR1D 0.0083
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
378 Alpha-2C adrenergic receptor ADRA2C 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
163 D(1B) dopamine receptor DRD5 0.0082
3939 Amine oxidase [flavin-containing] B MAOB 0.0081
3426 Glutamine synthetase glnA 0.0081
3987 Glutamine synthetase GLUL 0.0081
3932 Glutathione S-transferase A2 GSTA2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
124 Histamine H2 receptor HRH2 0.0079
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0076
6085 Fatty acid-binding protein, intestinal FABP2 0.0075
4785 Ig gamma-1 chain C region IGHG1 0.0074
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0074
2320 Thymidine kinase, cytosolic TK1 0.0074
1192 Sulfotransferase 1A1 SULT1A1 0.0074
6137 Multidrug resistance-associated protein 6 ABCC6 0.0074
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0073
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0073
24 Thymidylate synthase TMP1 0.0072
359 Thymidylate synthase TYMS 0.0072
2626 Thymidylate synthase thyA 0.0072
2729 Thymidylate synthase thyA 0.0072
5352 Thymidylate synthase THYA 0.0072
537 ATP synthase delta chain, mitochondrial ATP5D 0.0072
509 Thymidine kinase TK 0.0072
570 Thymidine kinase TK 0.0072
2559 Thymidine kinase TK 0.0072
3430 Thymidine kinase tdk 0.0072
3518 Thymidine kinase TK 0.0072
5301 Thymidine kinase tdk 0.0072
5771 Thymidine kinase ORF36 0.0072
7009 Thymidine kinase ORF36 0.0072
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.007
122 P2Y purinoceptor 12 P2RY12 0.007
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0069
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
482 Glycine receptor subunit alpha-1 GLRA1 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
6149 Solute carrier family 22 member 10 SLC22A10 0.0067
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0067
705 Glutamate receptor 1 GRIA1 0.0066
614 Progesterone receptor PGR 0.0066
36 Insulin receptor INSR 0.0066
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0066
5626 Nucleoside diphosphate kinase B NME2 0.0065
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0065
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0065
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0065
504 Mast/stem cell growth factor receptor KIT 0.0065
6031 Cytochrome P450 3A43 CYP3A43 0.0064
869 Estrogen receptor beta ESR2 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
161 Tubulin beta chain TUBB 0.0063
312 Tubulin beta chain TUB2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
131 Synaptic vesicular amine transporter SLC18A2 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0062
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0062
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0061
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0061
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0061
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.006
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0059
1353 DNA topoisomerase 1 TOP1 0.0059
3552 DNA topoisomerase 1 topA 0.0059
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
4120 NADPH--cytochrome P450 reductase POR 0.0058
952 Dipeptidyl peptidase 4 DPP4 0.0057
867 Penicillin-binding protein 3 pbpC 0.0057
6119 Penicillin-binding protein 3 pbp3 0.0057
7154 Penicillin-binding protein 3 pbp3 0.0057
7157 Penicillin-binding protein 3 LMHCC_2184 0.0057
7162 Penicillin-binding protein 3 pbpB 0.0057
7172 Penicillin-binding protein 3 pbp3 0.0057
6043 Putative G-protein coupled receptor 44 GPR44 0.0057
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0056
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0056
2112 Toll-like receptor 9 TLR9 0.0055
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
716 5-hydroxytryptamine 7 receptor HTR7 0.0054
459 Retinoic acid receptor RXR-alpha RXRA 0.0053
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0053
5294 Nucleoside diphosphate kinase A NME1 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
1656 CYP2B protein CYP2B 0.0053
260 Cytochrome P450 51 ERG11 0.0053
761 Cytochrome P450 51 ERG11 0.0053
3163 Cytochrome P450 51 cyp51 0.0053
1867 Major prion protein PRNP 0.0052
5482 Sialidase-2 NEU2 0.0052
2183 Fatty acid-binding protein, adipocyte FABP4 0.0052
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
594 Thyroxine-binding globulin SERPINA7 0.0049
1050 Bile salt sulfotransferase SULT2A1 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
1517 Beta-3 adrenergic receptor ADRB3 0.0049
819 Penicillin-binding protein 4 dacB 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6102 Arylamine N-acetyltransferase 2 NAT2 0.0048
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0048
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0047
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0047
6151 Monocarboxylate transporter 10 SLC16A10 0.0047
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0046
758 Thyroid hormone receptor alpha THRA 0.0046
468 Cytochrome P450 4A11 CYP4A11 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0045
6207 30S ribosomal protein S14 rpsN 0.0045
6209 30S ribosomal protein S19 rpsS 0.0045
6712 30S ribosomal protein S19 rpsS 0.0045
6726 30S ribosomal protein S19 rpsS 0.0045
4773 Deoxycytidine kinase DCK 0.0045
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0045
228 Beta platelet-derived growth factor receptor PDGFRB 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0044
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0044
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0044
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0043
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0042
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0042
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0042
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0041
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0041
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
346 Thyroid hormone receptor beta-1 THRB 0.0041
408 Riboflavin kinase RFK 0.0041
365 Dihydrofolate reductase DHFR 0.0041
2381 Dihydrofolate reductase DFR1 0.0041
2833 Dihydrofolate reductase Not Available 0.0041
2931 Dihydrofolate reductase folA 0.0041
3544 Dihydrofolate reductase folA 0.0041
3682 Dihydrofolate reductase folA 0.0041
6642 Dihydrofolate reductase folA 0.0041
6756 Dihydrofolate reductase dfrA 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.004
6033 High affinity interleukin-8 receptor A CXCR1 0.004
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.004
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0039
1198 Serum paraoxonase/arylesterase 1 PON1 0.0039
6223 Penicillin-binding protein 1C pbpC 0.0039
6014 Cytochrome P450 2A13 CYP2A13 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
6677 Myelin P2 protein PMP2 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
1256 5-hydroxytryptamine 6 receptor HTR6 0.0038
6432 Transporter snf 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
768 FK506-binding protein 1A FKBP1A 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
407 Vascular endothelial growth factor receptor 2 KDR 0.0037
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0036
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0036
6167 Organic solute transporter subunit beta OSTB 0.0035
6166 Organic solute transporter subunit alpha OSTA 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
293 Gamma-glutamyl hydrolase GGH 0.0035
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
528 5-hydroxytryptamine 1E receptor HTR1E 0.0035
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0035
811 Translocator protein TSPO 0.0034
3947 Xanthine dehydrogenase/oxidase XDH 0.0034
737 Mineralocorticoid receptor NR3C2 0.0034
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0033
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0033
6506 Stathmin-4 STMN4 0.0033
94 5-hydroxytryptamine 4 receptor HTR4 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
173 Toll-like receptor 7 TLR7 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0033
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0032
4217 Telomerase reverse transcriptase TERT 0.0032
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0032
595 Fibrinogen alpha chain FGA 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
1650 Heme carrier protein 1 SLC46A1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
1525 Heparin-binding growth factor 2 FGF2 0.0031
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.0031
4210 Toll-like receptor 4 TLR4 0.003
1629 Transcription factor AP-1 JUN 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.003
4102 Proteasome subunit beta type 5 PSMB5 0.003
4101 Proteasome subunit beta type 1 PSMB1 0.003
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
4203 Histamine N-methyltransferase HNMT 0.0029
654 Flavin reductase BLVRB 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0029
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0029
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0029
683 Potassium transporter GK0582 0.0029
904 Glutathione S-transferase P GSTP1 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0028
199 Monocarboxylate transporter 8 SLC16A2 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1025 Aquaporin-1 AQP1 0.0027
1405 Thiopurine S-methyltransferase TPMT 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
702 UMP-CMP kinase CMPK1 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
3685 Catabolite gene activator crp 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
2021 Thrombomodulin THBD 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0026
1992 Vitamin D-binding protein GC 0.0026
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0026
1291 cAMP response element-binding protein CREB1 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
822 Aldose reductase AKR1B1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
130 Prostacyclin synthase PTGIS 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
1010 Cytochrome P450 51A1 CYP51A1 0.0025
229 Retinoic acid receptor beta RARB 0.0025
780 Retinoic acid receptor RXR-gamma RXRG 0.0025
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0025
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
730 Retinoic acid receptor alpha RARA 0.0024
3616 Fatty acid-binding protein, epidermal FABP5 0.0024
5431 Lipid binding protein Not Available 0.0024
5433 UPF0230 protein TM_1468 TM_1468 0.0024
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0024
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0024
3856 Fibroblast growth factor receptor 3 FGFR3 0.0024
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0024
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0024
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0024
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0024
2207 Rhodopsin RHO 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6231 Pepsin A PGA3 0.0024
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0024
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
6459 Glycodelin PAEP 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
88 Retinoic acid receptor RXR-beta RXRB 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
165 FL cytokine receptor FLT3 0.0023
162 Retinoic acid receptor gamma-1 RARG 0.0023
4760 Mll3241 protein mll3241 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
6218 Pannexin-1 PANX1 0.0022
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0021
527 Prostacyclin receptor PTGIR 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.002
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
144 Hemoglobin subunit alpha HBA1 0.002
672 Prostaglandin F2-alpha receptor PTGFR 0.002
283 SEC14-like protein 2 SEC14L2 0.002
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.002
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
6755 Poliovirus receptor PVR 0.002
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
33 Cystine/glutamate transporter SLC7A11 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
5818 Folate receptor alpha FOLR1 0.0019
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0019
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
1864 RET proto-oncogene RET 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0018
634 Squalene monooxygenase SQLE 0.0018
7196 Squalene monooxygenase ERG1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0018
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0017
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0017
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
605 Fumarate reductase flavoprotein subunit frdA 0.0016
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0016
3673 Fumarate reductase flavoprotein subunit fccA 0.0016
4912 Fumarate reductase flavoprotein subunit ifcA 0.0016
6549 Fumarate reductase flavoprotein subunit frdA 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
1313 Lactoylglutathione lyase GLO1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
3587 Gastrotropin FABP6 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
7 Nitric oxide synthase, inducible NOS2 0.0015
4311 tRNA TRDMT1 0.0014
4325 tRNA trmD 0.0014
4328 tRNA trmD 0.0014
469 Annexin A1 ANXA1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
3086 Plasmepsin-2 Not Available 0.0014
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
16 Adenosine A1 receptor ADORA1 0.0014
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0014
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0014
4122 Histone deacetylase 2 HDAC2 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
3404 Exotoxin A eta 0.0013
164 Histamine H4 receptor HRH4 0.0013
3957 Adenosine deaminase ADA 0.0013
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
1630 Integrin beta-2 ITGB2 0.0013
976 Platelet glycoprotein IX GP9 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
823 Fibroblast growth factor receptor 2 FGFR2 0.0012
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
694 Matrix protein 2 M 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
6859 Protein S100-A4 S100A4 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
6020 Aldehyde oxidase AOX1 0.0012
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0012
518 Peroxidase/catalase T katG 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
6048 Troponin C, skeletal muscle TNNC2 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
427 Substance-P receptor TACR1 0.0011
6044 Serum paraoxonase/lactonase 3 PON3 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
997 Protein kinase C beta type PRKCB 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
68 Cannabinoid receptor 1 CNR1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
4192 DNA topoisomerase 2-beta TOP2B 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
6228 Nuclear receptor coactivator 1 NCOA1 0.0009
760 Fibroblast growth factor 1 FGF1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
1341 Histamine H3 receptor HRH3 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
751 Potassium channel subfamily K member 6 KCNK6 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
484 Tyrosine-protein kinase ABL2 ABL2 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0006
1063 Signal transducer and activator of transcription 5B STAT5B 0.0006
3221 Cytochrome c4 cc4 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
153 Dopamine beta-hydroxylase DBH 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
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