Partner ID 1373
Name Glucosylceramidase
Synonyms 3172
Gene name GBA
General function Involved in glucosylceramidase activity
Specific function D-glucosyl-N-acylsphingosine + H(2)O = D- glucose + N-acylsphingosine
Gene sequence + ...

ATGGCTGGCAGCCTCACAGGTTTGCTTCTACTTCAGGCAGTGTCGTGGGCATCAGGTGCCCGCCCCTGCATCCCTAAAAGCTTCGGCTACAGCTCGGTGGTGTGTGTCTGCAATGCCACATACTGTGACTCCTTTGACCCCCCGACCTTTCCTGCCCTTGGTACCTTCAGCCGCTATGAGAGTACACGCAGTGGGCGACGGATGGAGCTGAGTATGGGGCCCATCCAGGCTAATCACACGGGCACAGGCCTGCTACTGACCCTGCAGCCAGAACAGAAGTTCCAGAAAGTGAAGGGATTTGGAGGGGCCATGACAGATGCTGCTGCTCTCAACATCCTTGCCCTGTCACCCCCTGCCCAAAATTTGCTACTTAAATCGTACTTCTCTGAAGAAGGAATCGGATATAACATCATCCGGGTACCCATGGCCAGCTGTGACTTCTCCATCCGCACCTACACCTATGCAGACACCCCTGATGATTTCCAGTTGCACAACTTCAGCCTCCCAGAGGAAGATACCAAGCTCAAGATACCCCTGATTCACCGAGCCCTGCAGTTGGCCCAGCGTCCCGTTTCACTCCTTGCCAGCCCCTGGACATCACCCACTTGGCTCAAGACCAATGGAGCGGTGAATGGGAAGGGGTCACTCAAGGGACAGCCCGGAGACATCTACCACCAGACCTGGGCCAGATACTTTGTGAAGTTCCTGGATGCCTATGCTGAGCACAAGTTACAGTTCTGGGCAGTGACAGCTGAAAATGAGCCTTCTGCTGGGCTGTTGAGTGGATACCCCTTCCAGTGCCTGGGCTTCACCCCTGAACATCAGCGAGACTTCATTGCCCGTGACCTAGGTCCTACCCTCGCCAACAGTACTCACCACAATGTCCGCCTACTCATGCTGGATGACCAACGCTTGCTGCTGCCCCACTGGGCAAAGGTGGTACTGACAGACCCAGAAGCAGCTAAATATGTTCATGGCATTGCTGTACATTGGTACCTGGACTTTCTGGCTCCAGCCAAAGCCACCCTAGGGGAGACACACCGCCTGTTCCCCAACACCATGCTCTTTGCCTCAGAGGCCTGTGTGGGCTCCAAGTTCTGGGAGCAGAGTGTGCGGCTAGGCTCCTGGGATCGAGGGATGCAGTACAGCCACAGCATCATCACGAACCTCCTGTACCATGTGGTCGGCTGGACCGACTGGAACCTTGCCCTGAACCCCGAAGGAGGACCCAATTGGGTGCGTAACTTTGTCGACAGTCCCATCATTGTAGACATCACCAAGGACACGTTTTACAAACAGCCCATGTTCTACCACCTTGGCCACTTCAGCAAGTTCATTCCTGAGGGCTCCCAGAGAGTGGGGCTGGTTGCCAGTCAGAAGAACGACCTGGACGCAGTGGCACTGATGCATCCCGATGGCTCTGCTGTTGTGGTCGTGCTAAACCGCTCCTCTAAGGATGTGCCTCTTACCATCAAGGATCCTGCTGTGGGCTTCCTGGAGACAATCTCACCTGGCTACTCCATTCACACCTACCTGTGGCATCGCCAGTGA

Protein sequence + ...

MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ

GO Classification
component
vacuole
intracellular membrane-bound organelle
lytic vacuole
lysosome
organelle
membrane-bound organelle
function
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing O-glycosyl compounds
catalytic activity
glucosylceramidase activity
hydrolase activity
process
organelle organization and biogenesis
primary metabolism
lipid metabolism
cellular lipid metabolism
physiological process
cellular physiological process
cell organization and biogenesis
membrane lipid metabolism
metabolism
vacuole organization and biogenesis
lysosome organization and biogenesis
sphingolipid metabolism
See more information at   →   www.drugbank.ca
Id Name
DB00122 Choline
DB00178 Ramipril
DB00358 Mefloquine
DB00382 Tacrine
DB00483 Gallamine Triethiodide
DB00492 Fosinopril
DB00519 Trandolapril
DB00542 Benazepril
DB00545 Pyridostigmine
DB00584 Enalapril
DB00616 Candoxatril
DB00674 Galantamine
DB00677 Isoflurophate
DB00691 Moexipril
DB00722 Lisinopril
DB00733 Pralidoxime
DB00790 Perindopril
DB00805 Minaprine
DB00843 Donepezil
DB00881 Quinapril
DB00944 Demecarium
DB00981 Physostigmine
DB00989 Rivastigmine
DB01010 Edrophonium
DB01122 Ambenonium
DB01180 Rescinnamine
DB01197 Captopril
DB01199 Tubocurarine
DB01245 Decamethonium
DB01340 Cilazapril
DB01348 Spirapril
DB01364 Ephedrine
DB01400 Neostigmine
DB01631 Methyl Nonanoate (Ester)
DB01805 Monoisopropylphosphorylserine
DB01928 Huperaine A
DB02032 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid
DB02166 Propidium
DB02226 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium
DB02343 3,6,9,12,15-Pentaoxaheptadecane
DB02379 Beta-D-Glucose
DB02404 1-Deoxy-1-Thio-Heptaethylene Glycol
DB02561 Beta-D-Fructopyranose
DB02673 (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium
DB02687 Beta-D-Mannose
DB02825 Methylphosphonic Acid Ester Group
DB02845 Methylphosphinic Acid
DB02944 Alpha-D-Mannose
DB03005 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
DB03106 Myo-Inositol
DB03128 Acetylcholine
DB03283 beta-L-fucose
DB03359 M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
DB03721 O-Sialic Acid
DB03740 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
DB03779 Glucosaminyl-(Alpha-6)-D-Myo-Inositol
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03991 2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid
DB04021 MF268
DB04114 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine
DB04473 Alpha-L-Fucose
DB04508 Methyl(6s)-1-Thio-L-Manno-Hexodialdo-6,2-Pyranoside
DB04556 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
DB04614 (R)-tacrine(10)-hupyridone
DB04615 (S)-tacrine(10)-hupyridone
DB04616 TACRINE(8)-4-AMINOQUINOLINE
DB04617 (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
DB04639 Biphenylalanine
DB06720 Velaglucerase alfa
DB07371 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID
DB07375 5-BETA-ANDROSTANE-3,17-DIONE
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID
DB07555 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDE
DB07701 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
DB07756 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL
DB07764 FLUORESCIN
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
DB07822 (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE
DB07846 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
DB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE
DB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
DB08167 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM
DB08283 (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
DB08332 [2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE
DB08357 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
DB08377 PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
DB08411 PARA-NITROPHENYL PHOSPHONOBUTANOYL L-ALANINE
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB08615 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
DB08836 Temocapril