DT-Web

DB01180 - Rescinnamine


Identification
Name Rescinnamine
Accession Number DB01180 (APRD00112)
Type small molecule
Description Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is an alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 634.716
Groups approved
Monoisotopic Weight 634.289030952
Pharmacology
Indication For the treatment of hypertension.
Mechanism of action Rescinnamine Binds to and inhibits the angiotensin converting enzyme. Rescinnamine competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Angiotensin-converting enzyme
Name Angiotensin-converting enzyme
Gene Name ACE
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Azhar I, Mazhar F, Manzar QN, Hussain I, Shamim S: Colorimetric determination of indolic drugs. Pak J Pharm Sci. 2005 Apr;18(2):48-51. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4741

Predictions


Id Partner name Gene Name Score
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1789
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.1375
1385 Angiotensin-converting enzyme 2 ACE2 0.0605
294 Neprilysin MME 0.0432
1588 Multidrug resistance protein 1 ABCB1 0.0349
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0231
6702 Organic hydroperoxide resistance protein, putative VC_A1006 0.0228
4587 Carbapenem-hydrolyzing beta-lactamase blaB-1 blaB1 0.0228
332 Beta-lactamase blaZ 0.0228
2478 Beta-lactamase ampC 0.0228
2613 Beta-lactamase ampC 0.0228
2635 Beta-lactamase ampC 0.0228
2700 Beta-lactamase penP 0.0228
5445 Beta-lactamase blaB 0.0228
6019 Beta-lactamase SHV-7 0.0228
6701 Beta-lactamase cphA 0.0228
4586 FEZ-1 protein blaFEZ-1 0.0228
3923 Cholinesterase BCHE 0.0227
3917 Methylenetetrahydrofolate reductase MTHFR 0.0182
4604 Liver carboxylesterase 1 CES1 0.0158
5754 Metallo-beta-lactamase L1 Not Available 0.0143
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0142
3626 Probable polysaccharide deacetylase pdaA pdaA 0.0138
4787 Envelope glycoprotein gp160 env 0.0125
4820 Envelope glycoprotein gp160 env 0.0125
5727 Envelope glycoprotein gp160 env 0.0125
707 72 kDa type IV collagenase MMP2 0.0119
1373 Glucosylceramidase GBA 0.0114
4666 Fucose-binding lectin PA-IIL lecB 0.0114
1729 Solute carrier family 22 member 6 SLC22A6 0.011
3140 Hemagglutinin-neuraminidase HN 0.0104
3609 Hemagglutinin-neuraminidase HN 0.0104
65 Matrix metalloproteinase-9 Not Available 0.0096
4785 Ig gamma-1 chain C region IGHG1 0.0074
6143 Solute carrier family 22 member 7 SLC22A7 0.0068
474 Acetylcholinesterase ACHE 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
587 Serum albumin ALB 0.0054
4119 Cytochrome P450 2D6 CYP2D6 0.0045
4512 Cytochrome P450 3A4 CYP3A4 0.0041
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