DT-Web

DB00805 - Minaprine


Identification
Name Minaprine
Accession Number DB00805 (APRD00735)
Type small molecule
Description Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 298.3828
Groups approved
Monoisotopic Weight 298.179361346
Pharmacology
Indication For the treatment of depression
Mechanism of action Minaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties. It also acts as a reversible inhibitor of MAO-A (RIMA).It has also been found to inhibit acetylcholinesterase.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Pharmacological action yes
Actions inhibitor
References
  • Kan JP, Mouget-Goniot C, Worms P, Biziere K: Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8. - Pubmed
DTHybrid score 0.4471
5-hydroxytryptamine 2B receptor
Name 5-hydroxytryptamine 2B receptor
Gene Name HTR2B
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kodama K, Shibata S, Ueki S: Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia. Jpn J Pharmacol. 1992 Sep;60(1):33-8. - Pubmed
  • Muramatsu M, Tamaki-Ohashi J, Usuki C, Araki H, Chaki S, Aihara H: 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices. Eur J Pharmacol. 1988 Aug 9;153(1):89-95. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2972
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Kodama K, Shibata S, Ueki S: Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia. Jpn J Pharmacol. 1992 Sep;60(1):33-8. - Pubmed
  • Nabeshima T, Kawashima K, Kameyama T: Effect of minaprine on cycloheximide-induced amnesia in mice. Eur J Pharmacol. 1989 Oct 10;169(2-3):249-57. - Pubmed
  • Muramatsu M, Tamaki-Ohashi J, Usuki C, Araki H, Chaki S, Aihara H: 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices. Eur J Pharmacol. 1988 Aug 9;153(1):89-95. - Pubmed
  • Biziere K, Worms P, Kan JP, Mandel P, Garattini S, Roncucci R: Minaprine, a new drug with antidepressant properties. Drugs Exp Clin Res. 1985;11(12):831-40. - Pubmed
DTHybrid score 0.5005
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kodama K, Shibata S, Ueki S: Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia. Jpn J Pharmacol. 1992 Sep;60(1):33-8. - Pubmed
  • Muramatsu M, Tamaki-Ohashi J, Usuki C, Araki H, Chaki S, Aihara H: 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices. Eur J Pharmacol. 1988 Aug 9;153(1):89-95. - Pubmed
DTHybrid score 0.3785
Acetylcholinesterase
Name Acetylcholinesterase
Gene Name ACHE
Pharmacological action yes
Actions inhibitor
References
  • Duarte CD, Barreiro EJ, Fraga CA: Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. - Pubmed
  • Contreras JM, Rival YM, Chayer S, Bourguignon JJ, Wermuth CG: Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41. - Pubmed
DTHybrid score 1.0169
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3809
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4239
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5256
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions agonist
References
  • Duarte CD, Barreiro EJ, Fraga CA: Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. - Pubmed
  • Worms P, Kan JP, Steinberg R, Terranova JP, Perio A, Biziere K: Cholinomimetic activities of minaprine. Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):411-8. - Pubmed
DTHybrid score 0.5067

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5486

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2886
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2382
320 5-hydroxytryptamine 1A receptor HTR1A 0.2363
556 Alpha-1A adrenergic receptor ADRA1A 0.2205
318 Alpha-2A adrenergic receptor ADRA2A 0.2177
4200 Cytochrome P450 1A2 CYP1A2 0.2168
617 Muscarinic acetylcholine receptor M2 CHRM2 0.2167
3939 Amine oxidase [flavin-containing] B MAOB 0.2048
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1941
1588 Multidrug resistance protein 1 ABCB1 0.1848
638 D(3) dopamine receptor DRD3 0.1828
432 D(4) dopamine receptor DRD4 0.1721
492 Histamine H1 receptor HRH1 0.166
713 Sodium-dependent dopamine transporter SLC6A3 0.1565
3923 Cholinesterase BCHE 0.1561
725 5-hydroxytryptamine 1D receptor HTR1D 0.1496
629 Alpha-2B adrenergic receptor ADRA2B 0.1482
163 D(1B) dopamine receptor DRD5 0.1469
378 Alpha-2C adrenergic receptor ADRA2C 0.1457
6016 Cytochrome P450 2C19 CYP2C19 0.1454
885 5-hydroxytryptamine 1B receptor HTR1B 0.1438
4757 Cytochrome P450 2C9 CYP2C9 0.1425
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1356
632 Alpha-1B adrenergic receptor ADRA1B 0.1345
274 Muscarinic acetylcholine receptor M5 CHRM5 0.126
716 5-hydroxytryptamine 7 receptor HTR7 0.1059
6013 Cytochrome P450 2E1 CYP2E1 0.0861
4118 Cytochrome P450 3A5 CYP3A5 0.0803
6030 Cytochrome P450 2B6 CYP2B6 0.0786
131 Synaptic vesicular amine transporter SLC18A2 0.0771
4924 Cytochrome P450 2C8 CYP2C8 0.077
789 Alpha-1D adrenergic receptor ADRA1D 0.0766
6145 Solute carrier family 22 member 1 SLC22A1 0.0744
6107 Cytochrome P450 3A7 CYP3A7 0.068
1256 5-hydroxytryptamine 6 receptor HTR6 0.0571
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0557
587 Serum albumin ALB 0.0515
193 Beta-1 adrenergic receptor ADRB1 0.0453
5718 Cytochrome P450 2A6 CYP2A6 0.0429
341 5-hydroxytryptamine 3 receptor HTR3A 0.0417
94 5-hydroxytryptamine 4 receptor HTR4 0.0414
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.039
511 5-hydroxytryptamine 1F receptor HTR1F 0.0388
6144 Solute carrier family 22 member 2 SLC22A2 0.038
766 Beta-2 adrenergic receptor ADRB2 0.0368
6024 Cytochrome P450 1A1 CYP1A1 0.0357
5259 Transcriptional regulator ntrC1 0.0327
6699 Transcriptional regulator Cgl2612 0.0327
528 5-hydroxytryptamine 1E receptor HTR1E 0.0317
118 Organic cation/carnitine transporter 2 SLC22A5 0.0317
124 Histamine H2 receptor HRH2 0.0307
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0291
1656 CYP2B protein CYP2B 0.0284
4264 Alpha-L-fucosidase, putative TM_0306 0.0278
465 Calmodulin CALM1 0.027
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0264
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0245
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0245
174 Sigma 1-type opioid receptor SIGMAR1 0.024
6432 Transporter snf 0.0223
696 Kappa-type opioid receptor OPRK1 0.0221
6106 Cytochrome P450 2C18 CYP2C18 0.0215
6794 Uncharacterized lipoprotein ybbD ybbD 0.0213
2662 Glutamate racemase murI 0.0213
6299 Glutamate racemase murI 0.0213
6641 Glutamate racemase murI 0.0213
6771 Glutamate racemase murI 0.0213
6892 Glutamate racemase murI 0.0213
6795 Phosphoenolpyruvate-protein phosphotransferase ptsP 0.0213
435 Kynureninase KYNU 0.0213
4654 Kynureninase kynU 0.0213
3454 Esterase estA 0.0212
6147 Solute carrier family 22 member 3 SLC22A3 0.0206
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.02
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0198
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0195
833 Organic cation/carnitine transporter 1 SLC22A4 0.0195
847 Mu-type opioid receptor OPRM1 0.0182
467 Delta-type opioid receptor OPRD1 0.0179
3810 Catechol O-methyltransferase COMT 0.0177
2517 Subtilisin BPN' apr 0.0155
923 Glutamate receptor 3 GRIA3 0.0149
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0149
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0146
3811 Cytochrome P450 19A1 CYP19A1 0.0143
20 Prostaglandin G/H synthase 1 PTGS1 0.0143
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0141
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0138
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0138
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0124
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0121
904 Glutathione S-transferase P GSTP1 0.012
146 Androgen receptor AR 0.0106
1636 Trace amine-associated receptor 1 TAAR1 0.0106
5698 Riboflavin synthase alpha chain ribE 0.0105
362 Melatonin receptor type 1B MTNR1B 0.0103
571 Melatonin receptor type 1A MTNR1A 0.0103
408 Riboflavin kinase RFK 0.0101
380 Cytochrome P450 17A1 CYP17A1 0.0101
3426 Glutamine synthetase glnA 0.0099
3987 Glutamine synthetase GLUL 0.0099
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0098
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0098
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0098
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0096
1898 Cytochrome P450 1B1 CYP1B1 0.0094
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0094
921 Glutamate receptor 2 GRIA2 0.0092
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0088
3176 Trypsin-1 PRSS1 0.0086
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0086
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0084
1729 Solute carrier family 22 member 6 SLC22A6 0.0081
1517 Beta-3 adrenergic receptor ADRB3 0.0081
6164 POU domain, class 5, transcription factor 1 POU5F1 0.008
6182 Cytochrome P450 2J2 CYP2J2 0.0078
776 Bile salt export pump ABCB11 0.0077
654 Flavin reductase BLVRB 0.0075
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0074
3626 Probable polysaccharide deacetylase pdaA pdaA 0.0071
6031 Cytochrome P450 3A43 CYP3A43 0.007
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.007
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0066
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
862 Multidrug resistance-associated protein 1 ABCC1 0.0066
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
1757 Myeloperoxidase MPO 0.0064
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0064
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0064
153 Dopamine beta-hydroxylase DBH 0.0063
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0063
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0061
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0061
144 Hemoglobin subunit alpha HBA1 0.0061
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.006
164 Histamine H4 receptor HRH4 0.006
4787 Envelope glycoprotein gp160 env 0.0059
4820 Envelope glycoprotein gp160 env 0.0059
5727 Envelope glycoprotein gp160 env 0.0059
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0059
1178 Adenosine A2a receptor ADORA2A 0.0058
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0058
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0058
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0058
723 Cytosolic phospholipase A2 PLA2G4A 0.0057
1373 Glucosylceramidase GBA 0.0056
4666 Fucose-binding lectin PA-IIL lecB 0.0056
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0056
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0056
3140 Hemagglutinin-neuraminidase HN 0.0054
3609 Hemagglutinin-neuraminidase HN 0.0054
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0053
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0052
731 HIV-1 protease HIV-1 protease 0.0052
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0051
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0051
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0049
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0049
1360 Sphingomyelin phosphodiesterase SMPD1 0.0049
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0049
6014 Cytochrome P450 2A13 CYP2A13 0.0047
2112 Toll-like receptor 9 TLR9 0.0044
6151 Monocarboxylate transporter 10 SLC16A10 0.0043
2129 Sucrase-isomaltase, intestinal SI 0.0043
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0043
3913 Glutamic acid decarboxylase GAD65 0.0042
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0041
6859 Protein S100-A4 S100A4 0.0041
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0041
3947 Xanthine dehydrogenase/oxidase XDH 0.004
244 Angiotensin-converting enzyme ACE 0.004
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1483 Membrane copper amine oxidase AOC3 0.0039
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0038
4785 Ig gamma-1 chain C region IGHG1 0.0038
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0038
1618 High affinity nerve growth factor receptor NTRK1 0.0038
319 Opioid receptor, sigma 1 OPRS1 0.0038
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0037
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0035
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0035
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0034
427 Substance-P receptor TACR1 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0033
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0033
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0028
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0027
6142 Solute carrier family 22 member 8 SLC22A8 0.0026
327 Glutathione reductase gor 0.0025
5110 Glutathione reductase GR2 0.0025
2164 Multidrug resistance-associated protein 4 ABCC4 0.0025
6143 Solute carrier family 22 member 7 SLC22A7 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0023
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0021
861 Choline kinase alpha CHKA 0.0021
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0021
700 Choline dehydrogenase, mitochondrial CHDH 0.0021
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0021
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0021
1686 Choline transporter-like protein 1 SLC44A1 0.0021
3926 Choline transporter-like protein 2 SLC44A2 0.0021
576 Choline O-acetyltransferase CHAT 0.0021
769 High-affinity choline transporter 1 SLC5A7 0.0021
3922 Phospholipase D2 PLD2 0.0021
3927 Choline transporter-like protein 3 SLC44A3 0.0021
3924 Phospholipase D1 PLD1 0.0021
3925 Choline transporter-like protein 4 SLC44A4 0.0021
6126 Carbonic anhydrase 7 CA7 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0021
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.002
6133 Sodium channel subunit beta-2 SCN2B 0.002
6134 Sodium channel subunit beta-3 SCN3B 0.002
6132 Sodium channel subunit beta-1 SCN1B 0.002
6135 Sodium channel subunit beta-4 SCN4B 0.002
6127 Carbonic anhydrase-related protein CA8 0.002
6129 Carbonic anhydrase-related protein 11 CA11 0.002
6128 Carbonic anhydrase-related protein 10 CA10 0.002
6141 Sodium/bile acid cotransporter SLC10A1 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
4203 Histamine N-methyltransferase HNMT 0.0019
295 Carbonic anhydrase 1 CA1 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
6148 Multidrug resistance-associated protein 7 ABCC10 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0018
6130 Carbonic anhydrase 13 CA13 0.0018
844 Epidermal growth factor receptor EGFR 0.0018
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0018
5449 Hypothetical gliding protein mglB 0.0018
5443 UPF0189 protein ymdB ymdB 0.0018
5440 UPF0067 protein yebR yebR 0.0018
5439 33 kDa chaperonin hslO 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0018
2720 Copper-containing nitrite reductase nirK 0.0018
4705 Manganese catalase Not Available 0.0018
332 Beta-lactamase blaZ 0.0018
2478 Beta-lactamase ampC 0.0018
2613 Beta-lactamase ampC 0.0018
2635 Beta-lactamase ampC 0.0018
2700 Beta-lactamase penP 0.0018
5445 Beta-lactamase blaB 0.0018
6019 Beta-lactamase SHV-7 0.0018
6701 Beta-lactamase cphA 0.0018
5448 Ribonuclease Z rnz 0.0018
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0018
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0018
5454 Internalin-A inlA 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
592 Carbonic anhydrase 4 CA4 0.0017
4498 Ornithine cyclodeaminase PP3533 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6131 Carbonic anhydrase 14 CA14 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
6122 Carbonic anhydrase 3 CA3 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
5450 Prolyl endopeptidase Pep pep 0.0016
3356 Diaminopimelate decarboxylase lysA 0.0015
4771 Dissimilatory copper-containing nitrite reductase nir 0.0015
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0015
2714 Chorismate mutase aroH 0.0015
4611 Chorismate mutase aroG 0.0015
3274 Hydroxylamine reductase hcp 0.0015
4804 Hydroxylamine reductase hcp 0.0015
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0015
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0015
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
4604 Liver carboxylesterase 1 CES1 0.0015
756 Sex hormone-binding globulin SHBG 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0014
3399 Limonene-1,2-epoxide hydrolase limA 0.0014
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
3086 Plasmepsin-2 Not Available 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
597 Dihydropteridine reductase QDPR 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
738 Monocarboxylate transporter 1 SLC16A1 0.0014
5180 L(+)-mandelate dehydrogenase mdlB 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
3500 Putative family 31 glucosidase yicI yicI 0.0014
4608 Putative cytochrome P450 SCO1207 0.0013
4963 Putative cytochrome P450 SCO2884 0.0013
6254 Putative cytochrome P450 SCO6998 0.0013
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3404 Exotoxin A eta 0.0013
3480 Mannan endo-1,4-beta-mannosidase manA 0.0013
357 Carbonic anhydrase 2 CA2 0.0013
1615 Chymase CMA1 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
577 Argininosuccinate lyase ASL 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0012
1010 Cytochrome P450 51A1 CYP51A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0011
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0011
6020 Aldehyde oxidase AOX1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
614 Progesterone receptor PGR 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
518 Peroxidase/catalase T katG 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
777 Tumor necrosis factor TNF 0.0009
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
563 Thyroid peroxidase TPO 0.0009
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
4439 Ferredoxin reductase bphA4 0.0009
4486 Phenol 2-hydroxylase component B pheA2 0.0009
4477 Dihydrolipoyl dehydrogenase lpdV 0.0009
5077 Dihydrolipoyl dehydrogenase Not Available 0.0009
5117 Dihydrolipoyl dehydrogenase lpd 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
5078 Amine oxidase, flavin-containing PSPTO1126 0.0009
5095 Putidaredoxin reductase camA 0.0009
5122 Mersacidin decarboxylase mrsD 0.0009
526 Thioredoxin reductase trxB 0.0009
3767 Thioredoxin reductase trxB 0.0009
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0009
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0009
5109 Outer membrane protein p64k or PM-6 m-6 0.0009
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0009
5115 FkbI fkbI 0.0009
3133 UDP-galactopyranose mutase glf 0.0009
5099 UDP-galactopyranose mutase glf 0.0009
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0009
5083 Cryptochrome DASH cry 0.0009
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0009
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0009
3763 5,10-methylenetetrahydrofolate reductase metF 0.0009
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0009
5094 5,10-methylenetetrahydrofolate reductase metF 0.0009
5081 L-aspartate oxidase nadB 0.0009
5111 Phenylacetone monooxygenase pamO 0.0009
1410 Oxidoreductase HSD17B6 0.0008
4725 Oxidoreductase Not Available 0.0008
5124 Oxidoreductase Not Available 0.0008
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0008
1262 Corticotropin-lipotropin POMC 0.0008
1341 Histamine H3 receptor HRH3 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
482 Glycine receptor subunit alpha-1 GLRA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
4440 NADH peroxidase npr 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0007
3594 Deoxyribodipyrimidine photo-lyase phr 0.0007
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0007
5080 Deoxyribodipyrimidine photo-lyase phr 0.0007
5072 N,N-dimethylglycine oxidase dmg 0.0007
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0007
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
2470 Pyruvate oxidase pox5 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
5073 Ferredoxin--NADP reductase petH 0.0007
5076 Ferredoxin--NADP reductase fpr 0.0007
5119 Ferredoxin--NADP reductase petH 0.0007
5121 Ferredoxin--NADP reductase fpr 0.0007
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0007
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0007
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0007
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0007
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0007
2268 Cholesterol oxidase choB 0.0007
2822 Cholesterol oxidase choA 0.0007
2526 NADPH-ferredoxin reductase fprA fprA 0.0007
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0007
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
126 D-lactate dehydrogenase dld 0.0007
3545 D-lactate dehydrogenase Not Available 0.0007
4510 D-lactate dehydrogenase ldhA 0.0007
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
605 Fumarate reductase flavoprotein subunit frdA 0.0007
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0007
3673 Fumarate reductase flavoprotein subunit fccA 0.0007
4912 Fumarate reductase flavoprotein subunit ifcA 0.0007
6549 Fumarate reductase flavoprotein subunit frdA 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
4773 Deoxycytidine kinase DCK 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0007
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0007
2893 Glycine oxidase thiO 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
737 Mineralocorticoid receptor NR3C2 0.0006
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0006
2769 P-hydroxybenzoate hydroxylase pobA 0.0006
2809 P-hydroxybenzoate hydroxylase pobA 0.0006
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0006
2567 Thymidylate synthase thyX thyX 0.0006
976 Platelet glycoprotein IX GP9 0.0006
2823 Trypanothione reductase TPR 0.0006
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6645 D-amino-acid oxidase DAO 0.0006
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0006
2380 Monomeric sarcosine oxidase soxA 0.0006
6146 High affinity copper uptake protein 1 SLC31A1 0.0006
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
543 Penicillin-binding protein 1B mrcB 0.0005
6186 Penicillin-binding protein 1B ponB 0.0005
6822 Penicillin-binding protein 1b pbp1b 0.0005
6844 Penicillin-binding protein 1b pbp1b 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
645 Penicillin-binding protein 1A mrcA 0.0005
5805 Penicillin-binding protein 1A ponA 0.0005
6185 Penicillin-binding protein 1A mrcA 0.0005
6799 Penicillin-binding protein 1A pbpA 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
159 Penicillin-binding protein 2B penA 0.0005
6121 Penicillin-binding protein 2B penA 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
1024 Solute carrier family 22 member 11 SLC22A11 0.0005
714 Glutathione reductase, mitochondrial GSR 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
136 Estrogen receptor ESR1 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
2207 Rhodopsin RHO 0.0003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
869 Estrogen receptor beta ESR2 0.0002
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