DT-Web: DB00674

Identification

Name

Galantamine

Accession Number

DB00674 (APRD00206, EXPT01628)

Type

small molecule

Description

A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Galantamine is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimer's disease and other central nervous system disorders. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

287.3535

Groups

approved

Monoisotopic Weight

287.152143543

Pharmacology

Indication

For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease.

Mechanism of action

Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor. It is not structurally related to other acetylcholinesterase inhibitors. Galantamine's proposed mechanism of action involves the reversible inhibition of acetylcholinesterase, which prevents the hydrolysis of acetycholine, leading to an increased concentration of acetylcholine at cholinergic synapses. Galantamine also binds allosterically with nicotinic acetylcholine receptors and may possibly potentiate the action of agonists (such as acetylcholine) at these receptors.

Absorption

Not Available

Protein binding

18%

Biotransformation

Not Available

Route of elimination

Galantamine is metabolized by hepatic cytochrome P450 enzymes, glucuronidated, and excreted unchanged in the urine.

Toxicity

LD₅₀=75 mg/kg (rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acepromazine	Possible antagonism of action
Aceprometazine	Possible antagonism of action
Alverine	Possible antagonism of action
Amantadine	Possible antagonism of action
Amitriptyline	Possible antagonism of action
Amoxapine	Possible antagonism of action
Atropine	Possible antagonism of action
Azatadine	Possible antagonism of action
Benzatropine	Possible antagonism of action
Biperiden	Possible antagonism of action
Brompheniramine	Possible antagonism of action
Carbinoxamine	Possible antagonism of action
Chlorpheniramine	Possible antagonism of action
Chlorpromazine	Possible antagonism of action
Chlorprothixene	Possible antagonism of action
Cimetidine	Possible antagonism of action
Clemastine	Possible antagonism of action
Clidinium	Possible antagonism of action
Clomipramine	Possible antagonism of action
Clozapine	Possible antagonism of action
Cyclizine	Possible antagonism of action
Cyclobenzaprine	Possible antagonism of action
Cyproheptadine	Possible antagonism of action
Darifenacin	Possible antagonism of action
Desipramine	Possible antagonism of action
Dexbrompheniramine	Possible antagonism of action
Dicyclomine	Possible antagonism of action
Dimenhydrinate	Possible antagonism of action
Diphenhydramine	Possible antagonism of action
Diphenoxylate	Possible antagonism of action
Diphenylpyraline	Possible antagonism of action
Disopyramide	Possible antagonism of action
Doxepin	Possible antagonism of action
Doxylamine	Possible antagonism of action
Ethopropazine	Possible antagonism of action
Flavoxate	Possible antagonism of action
Flupenthixol	Possible antagonism of action
Glutethimide	Possible antagonism of action
Glycopyrrolate	Possible antagonism of action
Hydroxyzine	Possible antagonism of action
Hyoscyamine	Possible antagonism of action
Imipramine	Possible antagonism of action
Isocarboxazid	Possible antagonism of action
Isopropamide	Possible antagonism of action
Ketoconazole	Ketoconazole increases the effect and toxicity of galantamine
Loxapine	Possible antagonism of action
Maprotiline	Possible antagonism of action
Meclizine	Possible antagonism of action
Meperidine	Possible antagonism of action
Mesoridazine	Possible antagonism of action
Methdilazine	Possible antagonism of action
Methotrimeprazine	Possible antagonism of action
Methylscopolamine	Possible antagonism of action
Mirtazapine	Possible antagonism of action
Moclobemide	Possible antagonism of action
Molindone	Possible antagonism of action
Nortriptyline	Possible antagonism of action
Olanzapine	Possible antagonism of action
Orphenadrine	Possible antagonism of action
Oxybutynin	Possible antagonism of action
Paroxetine	Paroxetine increases the effect and toxicity of galantamine
Perphenazine	Possible antagonism of action
Phenelzine	Possible antagonism of action
Phenindamine	Possible antagonism of action
Pimozide	Possible antagonism of action
Pipotiazine	Possible antagonism of action
Procainamide	Possible antagonism of action
Prochlorperazine	Possible antagonism of action
Procyclidine	Possible antagonism of action
Promazine	Possible antagonism of action
Promethazine	Possible antagonism of action
Propantheline	Possible antagonism of action
Propericiazine	Possible antagonism of action
Protriptyline	Possible antagonism of action
Quetiapine	Possible antagonism of action
Quinidine	Possible antagonism of action
Quinidine barbiturate	Possible antagonism of action
Risperidone	Possible antagonism of action
Scopolamine	Possible antagonism of action
Sertraline	Possible antagonism of action
Solifenacin	Possible antagonism of action
Thioproperazine	Possible antagonism of action
Thioridazine	Possible antagonism of action
Thiothixene	Possible antagonism of action
Tizanidine	Possible antagonism of action
Tolterodine	Possible antagonism of action
Tranylcypromine	Possible antagonism of action
Trazodone	Possible antagonism of action
Trifluoperazine	Possible antagonism of action
Triflupromazine	Possible antagonism of action
Trihexyphenidyl	Possible antagonism of action
Trimeprazine	Possible antagonism of action
Trimethobenzamide	The therapeutic effects of the anticholinergic, Trimethobenzamide, and/or the acetylcholinesterase inhibitor (central), Galantamine, may be reduced due to antagonism. Monitor therapeutic effects of both agents.
Trimipramine	Possible antagonism of action
Tripelennamine	Possible antagonism of action
Triprolidine	Possible antagonism of action
Trospium	The therapeutic effects of the anticholinergic, Trospium, and/or the acetylcholinesterase inhibitor (central), Galantamine, may be reduced due to antagonism. Monitor therapeutic effects of both agents.
Ziprasidone	Possible antagonism of action
Zuclopenthixol	Possible antagonism of action

Food Interactions

Take with food.

Acetylcholinesterase
Name	Acetylcholinesterase
Gene Name	ACHE
Pharmacological action	yes
Actions	inhibitor
References	Tonkopii VD, Prozorovskii VB, Suslova IM: [Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases] Biull Eksp Biol Med. 1976 Aug;82(8):947-50. - Pubmed Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL: Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. - Pubmed Guillou C, Mary A, Renko DZ, Gras E, Thal C: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts. Bioorg Med Chem Lett. 2000 Apr 3;10(7):637-9. - Pubmed Blesa R: Galantamine: therapeutic effects beyond cognition. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:28-34. - Pubmed Stahl SM: The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different. J Clin Psychiatry. 2000 Oct;61(10):710-1. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.2485
Acetylcholine receptor subunit alpha
Name	Acetylcholine receptor subunit alpha
Gene Name	CHRNA1
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	Not Available
Acetylcholine receptor subunit beta
Name	Acetylcholine receptor subunit beta
Gene Name	CHRNB1
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	Not Available
Acetylcholine receptor subunit delta
Name	Acetylcholine receptor subunit delta
Gene Name	CHRND
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	Not Available
Acetylcholine receptor subunit gamma
Name	Acetylcholine receptor subunit gamma
Gene Name	CHRNG
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	Not Available
Acetylcholine receptor subunit epsilon
Name	Acetylcholine receptor subunit epsilon
Gene Name	CHRNE
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	Not Available
Neuronal acetylcholine receptor subunit alpha-2
Name	Neuronal acetylcholine receptor subunit alpha-2
Gene Name	CHRNA2
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.8287
Neuronal acetylcholine receptor subunit alpha-3
Name	Neuronal acetylcholine receptor subunit alpha-3
Gene Name	CHRNA3
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.8873
Neuronal acetylcholine receptor subunit alpha-4
Name	Neuronal acetylcholine receptor subunit alpha-4
Gene Name	CHRNA4
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.5725
Neuronal acetylcholine receptor subunit alpha-5
Name	Neuronal acetylcholine receptor subunit alpha-5
Gene Name	CHRNA5
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.4396
Neuronal acetylcholine receptor subunit alpha-6
Name	Neuronal acetylcholine receptor subunit alpha-6
Gene Name	CHRNA6
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.6094
Neuronal acetylcholine receptor subunit alpha-7
Name	Neuronal acetylcholine receptor subunit alpha-7
Gene Name	CHRNA7
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.5649
Neuronal acetylcholine receptor subunit alpha-9
Name	Neuronal acetylcholine receptor subunit alpha-9
Gene Name	CHRNA9
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.4358
Neuronal acetylcholine receptor subunit alpha-10
Name	Neuronal acetylcholine receptor subunit alpha-10
Gene Name	CHRNA10
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.715
Neuronal acetylcholine receptor subunit beta-2
Name	Neuronal acetylcholine receptor subunit beta-2
Gene Name	CHRNB2
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.4376
Neuronal acetylcholine receptor subunit beta-3
Name	Neuronal acetylcholine receptor subunit beta-3
Gene Name	CHRNB3
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.4398
Neuronal acetylcholine receptor subunit beta-4
Name	Neuronal acetylcholine receptor subunit beta-4
Gene Name	CHRNB4
Pharmacological action	unknown
Actions	allosteric modulator
References	Scott LJ, Goa KL: Galantamine: a review of its use in Alzheimer's disease. Drugs. 2000 Nov;60(5):1095-122. - Pubmed Lilienfeld S: Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS Drug Rev. 2002 Summer;8(2):159-76. - Pubmed Olin J, Schneider L: Galantamine for Alzheimer's disease. Cochrane Database Syst Rev. 2002;(3):CD001747. - Pubmed Lilienfeld S, Parys W: Galantamine: additional benefits to patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2000 Sep;11 Suppl 1:19-27. - Pubmed Woodruff-Pak DS, Lander C, Geerts H: Nicotinic cholinergic modulation: galantamine as a prototype. CNS Drug Rev. 2002 Winter;8(4):405-26. - Pubmed Hansen RA, Gartlehner G, Kaufer DJ, Lohr KN, Carey T: - Pubmed
DTHybrid score	0.6856
Cholinesterase
Name	Cholinesterase
Gene Name	BCHE
Pharmacological action	unknown
Actions	inhibitor
References	Svoboda Z, Kvetina J, Kunesova G, Herink J, Bajgar J, Bartosova L, Zivny P, Palicka V: Effect of galantamine on acetylcholinesterase and butyrylcholinesterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:183-6. - Pubmed Giacobini E: Selective inhibitors of butyrylcholinesterase: a valid alternative for therapy of Alzheimer's disease? Drugs Aging. 2001;18(12):891-8. - Pubmed Wilkinson DG: Galantamine: a new treatment for Alzheimer's disease. Expert Rev Neurother. 2001 Nov;1(2):153-9. - Pubmed
DTHybrid score	0.9434

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5188
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4469

Id	Partner name	Gene Name	Score
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.1866
4200	Cytochrome P450 1A2	CYP1A2	0.1705
4757	Cytochrome P450 2C9	CYP2C9	0.1695
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1675
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.1647
6016	Cytochrome P450 2C19	CYP2C19	0.1646
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.1632
6145	Solute carrier family 22 member 1	SLC22A1	0.1535
921	Glutamate receptor 2	GRIA2	0.1527
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.1511
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.1505
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.1504
1588	Multidrug resistance protein 1	ABCB1	0.1457
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.1457
6030	Cytochrome P450 2B6	CYP2B6	0.1421
4924	Cytochrome P450 2C8	CYP2C8	0.1399
6144	Solute carrier family 22 member 2	SLC22A2	0.1262
6013	Cytochrome P450 2E1	CYP2E1	0.1252
4118	Cytochrome P450 3A5	CYP3A5	0.1189
6014	Cytochrome P450 2A13	CYP2A13	0.1115
6147	Solute carrier family 22 member 3	SLC22A3	0.1112
833	Organic cation/carnitine transporter 1	SLC22A4	0.1112
118	Organic cation/carnitine transporter 2	SLC22A5	0.1098
5718	Cytochrome P450 2A6	CYP2A6	0.1067
1075	Alkaline phosphatase, placental-like	ALPPL2	0.1024
6107	Cytochrome P450 3A7	CYP3A7	0.1
6024	Cytochrome P450 1A1	CYP1A1	0.0919
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0823
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0813
3941	Amine oxidase [flavin-containing] A	MAOA	0.0808
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0784
3939	Amine oxidase [flavin-containing] B	MAOB	0.075
3811	Cytochrome P450 19A1	CYP19A1	0.0716
847	Mu-type opioid receptor	OPRM1	0.0689
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0639
713	Sodium-dependent dopamine transporter	SLC6A3	0.0629
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0598
2472	Voltage-gated potassium channel	kcsA	0.0515
6366	Voltage-gated potassium channel	kcsA	0.0515
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0477
766	Beta-2 adrenergic receptor	ADRB2	0.0458
492	Histamine H1 receptor	HRH1	0.0395
556	Alpha-1A adrenergic receptor	ADRA1A	0.0388
831	D(2) dopamine receptor	DRD2	0.0377
824	Sodium-dependent serotonin transporter	SLC6A4	0.0372
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0364
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.036
3454	Esterase	estA	0.0353
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0332
5259	Transcriptional regulator	ntrC1	0.0327
6699	Transcriptional regulator	Cgl2612	0.0327
6142	Solute carrier family 22 member 8	SLC22A8	0.0305
20	Prostaglandin G/H synthase 1	PTGS1	0.0298
587	Serum albumin	ALB	0.0286
4264	Alpha-L-fucosidase, putative	TM_0306	0.0278
6106	Cytochrome P450 2C18	CYP2C18	0.0272
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0255
467	Delta-type opioid receptor	OPRD1	0.023
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.023
318	Alpha-2A adrenergic receptor	ADRA2A	0.0226
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.022
871	Glucocorticoid receptor	NR3C1	0.0218
23	D(1A) dopamine receptor	DRD1	0.0218
6794	Uncharacterized lipoprotein ybbD	ybbD	0.0213
2662	Glutamate racemase	murI	0.0213
6299	Glutamate racemase	murI	0.0213
6641	Glutamate racemase	murI	0.0213
6771	Glutamate racemase	murI	0.0213
6892	Glutamate racemase	murI	0.0213
6795	Phosphoenolpyruvate-protein phosphotransferase	ptsP	0.0213
435	Kynureninase	KYNU	0.0213
4654	Kynureninase	kynU	0.0213
2433	Capsid protein P40	UL80	0.0213
3569	Capsid protein P40	BVRF2	0.0213
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0205
193	Beta-1 adrenergic receptor	ADRB1	0.0202
2049	Gastrin/cholecystokinin type B receptor	CCKBR	0.0191
723	Cytosolic phospholipase A2	PLA2G4A	0.0188
862	Multidrug resistance-associated protein 1	ABCC1	0.0187
3076	Antigen 85-C	fbpC	0.0187
638	D(3) dopamine receptor	DRD3	0.0186
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0186
290	Prostaglandin G/H synthase 2	PTGS2	0.0185
131	Synaptic vesicular amine transporter	SLC18A2	0.0174
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0166
632	Alpha-1B adrenergic receptor	ADRA1B	0.0162
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0156
2517	Subtilisin BPN'	apr	0.0155
2796	Parathion hydrolase	opd	0.0147
6539	Parathion hydrolase	opd	0.0147
244	Angiotensin-converting enzyme	ACE	0.0146
1898	Cytochrome P450 1B1	CYP1B1	0.0144
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0142
465	Calmodulin	CALM1	0.014
436	5-hydroxytryptamine 2B receptor	HTR2B	0.014
731	HIV-1 protease	HIV-1 protease	0.0139
696	Kappa-type opioid receptor	OPRK1	0.0139
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0138
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0136
232	Corticosteroid-binding globulin	SERPINA6	0.0135
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0134
776	Bile salt export pump	ABCB11	0.0134
468	Cytochrome P450 4A11	CYP4A11	0.0131
124	Histamine H2 receptor	HRH2	0.0127
2929	(S)-2-haloacid dehalogenase	dhlB	0.0124
2995	(S)-2-haloacid dehalogenase	Not Available	0.0124
3937	Fatty-acid amide hydrolase	FAAH	0.0118
1729	Solute carrier family 22 member 6	SLC22A6	0.0117
614	Progesterone receptor	PGR	0.0116
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0107
136	Estrogen receptor	ESR1	0.0107
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0107
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0104
629	Alpha-2B adrenergic receptor	ADRA2B	0.0104
144	Hemoglobin subunit alpha	HBA1	0.0103
1178	Adenosine A2a receptor	ADORA2A	0.0101
885	5-hydroxytryptamine 1B receptor	HTR1B	0.01
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0097
378	Alpha-2C adrenergic receptor	ADRA2C	0.0095
4787	Envelope glycoprotein gp160	env	0.0094
4820	Envelope glycoprotein gp160	env	0.0094
5727	Envelope glycoprotein gp160	env	0.0094
275	Arachidonate 5-lipoxygenase	ALOX5	0.0094
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0094
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0092
432	D(4) dopamine receptor	DRD4	0.0092
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0092
789	Alpha-1D adrenergic receptor	ADRA1D	0.0091
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.009
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0088
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0088
1656	CYP2B protein	CYP2B	0.0088
146	Androgen receptor	AR	0.0087
3176	Trypsin-1	PRSS1	0.0086
3947	Xanthine dehydrogenase/oxidase	XDH	0.0085
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0085
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0082
260	Cytochrome P450 51	ERG11	0.0079
761	Cytochrome P450 51	ERG11	0.0079
3163	Cytochrome P450 51	cyp51	0.0079
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0078
85	Growth hormone receptor	GHR	0.0077
737	Mineralocorticoid receptor	NR3C2	0.0077
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0075
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0072
174	Sigma 1-type opioid receptor	SIGMAR1	0.0072
3626	Probable polysaccharide deacetylase pdaA	pdaA	0.0071
319	Opioid receptor, sigma 1	OPRS1	0.0071
6031	Cytochrome P450 3A43	CYP3A43	0.0071
817	DNA topoisomerase 2-alpha	TOP2A	0.007
6182	Cytochrome P450 2J2	CYP2J2	0.0069
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0069
163	D(1B) dopamine receptor	DRD5	0.0068
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0067
952	Dipeptidyl peptidase 4	DPP4	0.0064
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0063
4666	Fucose-binding lectin PA-IIL	lecB	0.0062
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.006
4785	Ig gamma-1 chain C region	IGHG1	0.006
716	5-hydroxytryptamine 7 receptor	HTR7	0.0059
161	Tubulin beta chain	TUBB	0.0058
312	Tubulin beta chain	TUB2	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
1517	Beta-3 adrenergic receptor	ADRB3	0.0057
1373	Glucosylceramidase	GBA	0.0056
4604	Liver carboxylesterase 1	CES1	0.0056
6506	Stathmin-4	STMN4	0.0055
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0054
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0054
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0054
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0054
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0054
2164	Multidrug resistance-associated protein 4	ABCC4	0.0053
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0053
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0053
2112	Toll-like receptor 9	TLR9	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
173	Toll-like receptor 7	TLR7	0.0049
380	Cytochrome P450 17A1	CYP17A1	0.0049
6143	Solute carrier family 22 member 7	SLC22A7	0.0049
565	Extracellular calcium-sensing receptor	CASR	0.0046
4784	Beta-mannosidase	manB	0.0046
6695	Beta-mannosidase	BT_0458	0.0046
504	Mast/stem cell growth factor receptor	KIT	0.0044
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0044
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0044
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0044
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0043
122	P2Y purinoceptor 12	P2RY12	0.0043
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0042
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0042
94	5-hydroxytryptamine 4 receptor	HTR4	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
904	Glutathione S-transferase P	GSTP1	0.0041
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0041
844	Epidermal growth factor receptor	EGFR	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
29	Tubulin beta-1 chain	TUBB1	0.004
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.004
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.004
6137	Multidrug resistance-associated protein 6	ABCC6	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0039
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0039
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0039
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0039
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0039
861	Choline kinase alpha	CHKA	0.0039
700	Choline dehydrogenase, mitochondrial	CHDH	0.0039
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0039
1686	Choline transporter-like protein 1	SLC44A1	0.0039
3927	Choline transporter-like protein 3	SLC44A3	0.0039
3926	Choline transporter-like protein 2	SLC44A2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
576	Choline O-acetyltransferase	CHAT	0.0039
769	High-affinity choline transporter 1	SLC5A7	0.0039
3925	Choline transporter-like protein 4	SLC44A4	0.0039
3922	Phospholipase D2	PLD2	0.0039
3924	Phospholipase D1	PLD1	0.0039
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0039
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0038
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0038
6220	Aryl hydrocarbon receptor	AHR	0.0038
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0038
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0037
6148	Multidrug resistance-associated protein 7	ABCC10	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
295	Carbonic anhydrase 1	CA1	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0036
407	Vascular endothelial growth factor receptor 2	KDR	0.0036
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0035
6131	Carbonic anhydrase 14	CA14	0.0035
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0035
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0035
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0035
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
811	Translocator protein	TSPO	0.0035
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
2297	Genome polyprotein	Not Available	0.0034
2322	Genome polyprotein	Not Available	0.0034
2694	Genome polyprotein	Not Available	0.0034
2719	Genome polyprotein	Not Available	0.0034
2860	Genome polyprotein	Not Available	0.0034
2928	Genome polyprotein	Not Available	0.0034
3160	Genome polyprotein	Not Available	0.0034
3260	Genome polyprotein	Not Available	0.0034
4783	Genome polyprotein	Not Available	0.0034
5726	Genome polyprotein	Not Available	0.0034
5779	Genome polyprotein	Not Available	0.0034
5867	Genome polyprotein	Not Available	0.0034
6253	Genome polyprotein	Not Available	0.0034
6301	Genome polyprotein	Not Available	0.0034
6380	Genome polyprotein	Not Available	0.0034
6381	Genome polyprotein	Not Available	0.0034
6437	Genome polyprotein	Not Available	0.0034
6520	Genome polyprotein	Not Available	0.0034
6521	Genome polyprotein	Not Available	0.0034
6652	Genome polyprotein	Not Available	0.0034
6734	Genome polyprotein	Not Available	0.0034
6735	Genome polyprotein	Not Available	0.0034
6736	Genome polyprotein	Not Available	0.0034
6737	Genome polyprotein	Not Available	0.0034
6738	Genome polyprotein	Not Available	0.0034
6739	Genome polyprotein	Not Available	0.0034
6744	Genome polyprotein	Not Available	0.0034
6748	Genome polyprotein	Not Available	0.0034
6894	Genome polyprotein	Not Available	0.0034
6898	Genome polyprotein	Not Available	0.0034
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0034
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0033
6020	Aldehyde oxidase	AOX1	0.0033
373	Transthyretin	TTR	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0033
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0033
4120	NADPH--cytochrome P450 reductase	POR	0.0032
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0032
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
777	Tumor necrosis factor	TNF	0.0032
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
365	Dihydrofolate reductase	DHFR	0.0031
2381	Dihydrofolate reductase	DFR1	0.0031
2833	Dihydrofolate reductase	Not Available	0.0031
2931	Dihydrofolate reductase	folA	0.0031
3544	Dihydrofolate reductase	folA	0.0031
3682	Dihydrofolate reductase	folA	0.0031
6642	Dihydrofolate reductase	folA	0.0031
6756	Dihydrofolate reductase	dfrA	0.0031
1629	Transcription factor AP-1	JUN	0.0031
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
70	Type-1 angiotensin II receptor	AGTR1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
3437	Eosinophil lysophospholipase	CLC	0.003
6136	Multidrug resistance-associated protein 5	ABCC5	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
705	Glutamate receptor 1	GRIA1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6102	Arylamine N-acetyltransferase 2	NAT2	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
5449	Hypothetical gliding protein	mglB	0.003
5443	UPF0189 protein ymdB	ymdB	0.003
5440	UPF0067 protein yebR	yebR	0.003
5439	33 kDa chaperonin	hslO	0.003
4705	Manganese catalase	Not Available	0.003
2720	Copper-containing nitrite reductase	nirK	0.003
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.003
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.003
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.003
5448	Ribonuclease Z	rnz	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
332	Beta-lactamase	blaZ	0.003
2478	Beta-lactamase	ampC	0.003
2613	Beta-lactamase	ampC	0.003
2635	Beta-lactamase	ampC	0.003
2700	Beta-lactamase	penP	0.003
5445	Beta-lactamase	blaB	0.003
6019	Beta-lactamase	SHV-7	0.003
6701	Beta-lactamase	cphA	0.003
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.003
5454	Internalin-A	inlA	0.003
1024	Solute carrier family 22 member 11	SLC22A11	0.0029
4498	Ornithine cyclodeaminase	PP3533	0.0029
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0029
2207	Rhodopsin	RHO	0.0029
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0029
756	Sex hormone-binding globulin	SHBG	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0027
26	Vascular endothelial growth factor receptor 3	FLT4	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0027
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0026
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0026
1010	Cytochrome P450 51A1	CYP51A1	0.0026
5450	Prolyl endopeptidase Pep	pep	0.0026
32	Vascular endothelial growth factor receptor 1	FLT1	0.0026
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0026
3356	Diaminopimelate decarboxylase	lysA	0.0026
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0026
2714	Chorismate mutase	aroH	0.0026
4611	Chorismate mutase	aroG	0.0026
3274	Hydroxylamine reductase	hcp	0.0026
4804	Hydroxylamine reductase	hcp	0.0026
49	Endothelin B receptor	EDNRB	0.0026
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0025
869	Estrogen receptor beta	ESR2	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
597	Dihydropteridine reductase	QDPR	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0024
3399	Limonene-1,2-epoxide hydrolase	limA	0.0024
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
4608	Putative cytochrome P450	SCO1207	0.0023
4963	Putative cytochrome P450	SCO2884	0.0023
6254	Putative cytochrome P450	SCO6998	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
5180	L(+)-mandelate dehydrogenase	mdlB	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0023
3500	Putative family 31 glucosidase yicI	yicI	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
577	Argininosuccinate lyase	ASL	0.0022
4122	Histone deacetylase 2	HDAC2	0.0022
1615	Chymase	CMA1	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
6146	High affinity copper uptake protein 1	SLC31A1	0.0022
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0022
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
1757	Myeloperoxidase	MPO	0.0022
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0022
298	Renin	REN	0.0021
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0021
16	Adenosine A1 receptor	ADORA1	0.0021
738	Monocarboxylate transporter 1	SLC16A1	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
6432	Transporter	snf	0.002
6126	Carbonic anhydrase 7	CA7	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.002
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.002
6141	Sodium/bile acid cotransporter	SLC10A1	0.002
482	Glycine receptor subunit alpha-1	GLRA1	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
896	Glutathione S-transferase Mu 1	GSTM1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
164	Histamine H4 receptor	HRH4	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
165	FL cytokine receptor	FLT3	0.0017
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0017
4311	tRNA	TRDMT1	0.0017
4325	tRNA	trmD	0.0017
4328	tRNA	trmD	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
518	Peroxidase/catalase T	katG	0.0017
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
4773	Deoxycytidine kinase	DCK	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
5787	Angiopoietin-1 receptor	TEK	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0015
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
563	Thyroid peroxidase	TPO	0.0015
427	Substance-P receptor	TACR1	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
1541	Metalloproteinase	mmp20	0.0014
908	Glutathione S-transferase theta-1	GSTT1	0.0014
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0014
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0014
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
183	Vascular endothelial growth factor A	VEGFA	0.0014
1192	Sulfotransferase 1A1	SULT1A1	0.0014
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0013
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0013
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0013
1618	High affinity nerve growth factor receptor	NTRK1	0.0013
153	Dopamine beta-hydroxylase	DBH	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6163	Copper-transporting ATPase 2	ATP7B	0.0013
6165	Copper-transporting ATPase 1	ATP7A	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
239	Coagulation factor X	F10	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
7	Nitric oxide synthase, inducible	NOS2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
4103	Proteasome subunit beta type 2	PSMB2	0.001
4102	Proteasome subunit beta type 5	PSMB5	0.001
4101	Proteasome subunit beta type 1	PSMB1	0.001
976	Platelet glycoprotein IX	GP9	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1630	Integrin beta-2	ITGB2	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
469	Annexin A1	ANXA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
511	5-hydroxytryptamine 1F receptor	HTR1F	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
823	Fibroblast growth factor receptor 2	FGFR2	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
4878	Glycoprotein hormones alpha chain	CGA	0.0009
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0009
1072	Granzyme B	GZMB	0.0009
4889	Ig epsilon chain C region	IGHE	0.0009
4877	Beta-mannanase	man	0.0009
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0009
4189	Alpha-galactosidase A	GLA	0.0009
4850	Beta-2-glycoprotein 1	APOH	0.0009
4880	Membrane cofactor protein	CD46	0.0009
4856	CD209 antigen	CD209	0.0009
1354	Beta-glucuronidase	GUSB	0.0009
757	Fusion glycoprotein F0	F	0.0009
4875	Fusion glycoprotein F0	F	0.0009
4869	Major capsid protein	A430L	0.0009
4852	Reticulon-4 receptor	RTN4R	0.0009
4845	ADAM 33	ADAM33	0.0009
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0009
442	Envelope glycoprotein	gp41	0.0009
4859	Envelope glycoprotein	env	0.0009
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0009
4721	Beta-1,4-mannanase	manA	0.0009
3352	Structural polyprotein	Not Available	0.0009
3628	Structural polyprotein	Not Available	0.0009
4892	Structural polyprotein	Not Available	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
6044	Serum paraoxonase/lactonase 3	PON3	0.0008
3810	Catechol O-methyltransferase	COMT	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
1867	Major prion protein	PRNP	0.0008
572	Integrin alpha-L	ITGAL	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4861	Interleukin-6 receptor alpha chain	IL6R	0.0008
793	T-cell surface antigen CD2	CD2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0008
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0008
3837	Cytokine receptor common beta chain	CSF2RB	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
1864	RET proto-oncogene	RET	0.0008
1025	Aquaporin-1	AQP1	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
1275	Estrogen sulfotransferase	SULT1E1	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
5934	Cytochrome P450 26A1	CYP26A1	0.0007
4890	Hemagglutinin	HA	0.0007
6566	Hemagglutinin	Not Available	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
1379	Interleukin-12 subunit beta	IL12B	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
2298	Cytochrome P450-cam	camC	0.0007
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
751	Potassium channel subfamily K member 6	KCNK6	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6858	Inactive carboxylesterase 4	CES1P1	0.0007
1830	5'-nucleotidase	NT5E	0.0007
1184	Interferon beta	IFNB1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0006
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0006
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
554	Low-density lipoprotein receptor	LDLR	0.0006
852	Heparin cofactor 2	SERPIND1	0.0006
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
172	Potassium channel subfamily K member 1	KCNK1	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
6085	Fatty acid-binding protein, intestinal	FABP2	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
1859	Prostatic acid phosphatase	ACPP	0.0006
3444	Cyanovirin-N	Not Available	0.0006
3140	Hemagglutinin-neuraminidase	HN	0.0006
3609	Hemagglutinin-neuraminidase	HN	0.0006
595	Fibrinogen alpha chain	FGA	0.0006
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
3957	Adenosine deaminase	ADA	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0006
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0005
4210	Toll-like receptor 4	TLR4	0.0005
2372	Bifunctional tail protein	9	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0005
958	Insulin-like growth factor 1 receptor	IGF1R	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0005
3814	Complement C1r subcomponent	C1R	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
64	Neuraminidase	NA	0.0005
641	Neuraminidase	NA	0.0005
2676	Neuraminidase	NA	0.0005
3026	Neuraminidase	NA	0.0005
3519	Neuraminidase	NA	0.0005
6007	Neuraminidase	NA	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
1243	Cathepsin D	CTSD	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
1439	Lactotransferrin	LTF	0.0005
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0005
309	Antithrombin-III	SERPINC1	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
2430	Chondroitinase B	cslB	0.0004
6307	Ig gamma-2 chain C region	IGHG2	0.0004
2581	Chondroitinase AC	cslA	0.0004
6847	Lactase-phlorizin hydrolase	LCT	0.0004
6500	Phospholipase A2	PLA2G1B	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
33	Cystine/glutamate transporter	SLC7A11	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00674 - Galantamine

Targets

Enzymes

Predictions