DT-Web

(S)-2-haloacid dehalogenase


Partner ID 2929
Name (S)-2-haloacid dehalogenase
Synonyms 4935
Gene name dhlB
General function Involved in haloacid dehalogenase activity
Specific function Catalyzes the hydrolytic dehalogenation of small L-2- haloalkanoic acids to yield the corresponding D-2-hydroxyalkanoic acids. Active with 2-halogenated carboxylic acids and converts only the L-isomer of 2-chloropropionic acid with inversion of configuration to produce D-lactate
Gene sequence + ...

ATGATCAAGGCAGTCGTGTTCGACGCTTACGGTACGCTCTTCGACGTCCAGTCGGTGGCCGACGCCACCGAGCGGGCGTATCCAGGCCGGGGCGAGTACATCACGCAGGTCTGGCGGCAGAAGCAGCTGGAATACAGCTGGCTCCGCGCGCTGATGGGGCGCTATGCCGACTTTTGGGGCGTCACGCGGGAAGCGCTGGCCTATACCCTCGGAACGCTGGGGCTGGAGCCGGACGAGTCCTTCCTCGCCGGGATGGCGCAGGCCTACAACCGCCTCACGCCCTATCCGGACGCCGCGCAATGCCTCGCGGAGCTGGCGCCCCTCAAGCGCGCCATCCTCTCCAACGGCGCGCCCGACATGCTGCAGGCGCTCGTGGCCAATGCGGGCCTGACGGACAGCTTCGATGCCGTCATCAGCGTCGATGCCAAGCGCGTGTTCAAGCCTCATCCCGACTCCTACGCGCTGGTGGAGGAGGTACTAGGCGTGACGCCCGCGGAGGTGCTGTTCGTGTCCTCCAACGGCTTCGACGTCGGCGGCGCGAAGAATTTCGGCTTCAGCGTCGCCCGGGTCGCGCGCCTGTCGCAGGAGGCGCTGGCGCGCGAACTCGTCTCGGGTACCATCGCGCCCCTGACCATGTTCAAGGCGCTGAGGATGCGGGAAGAAACCTATGCGGAGGCGCCTGATTTCGTGGTGCCCGCCCTTGGCGACCTGCCGCGGCTGGTTCGCGGGATGGCCGGCGCTCATCTCGCACCAGCGGTGTGA
Protein sequence + ...

MIKAVVFDAYGTLFDVQSVADATERAYPGRGEYITQVWRQKQLEYSWLRALMGRYADFWGVTREALAYTLGTLGLEPDESFLADMAQAYNRLTPYPDAAQCLAELAPLKRAILSNGAPDMLQALVANAGLTDSFDAVISVDAKRVFKPHPDSYALVEEVLGVTPAEVLFVSSNGFDVGGAKNFGFSVARVARLSQEALARELVSGTIAPLTMFKALRMREETYAEAPDFVVPALGDLPRLVRGMAGAHLAPAV
GO Classification
function
catalytic activity
hydrolase activity
hydrolase activity, acting on acid halide bonds
hydrolase activity, acting on acid halide bonds, in C-halide compounds
process
physiological process
metabolism
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Drugs


Associated as Target

Id Name
DB01942 Formic Acid
DB03522 Aspartic Acid-4-Carboxymethyl Ester

Associated as Prediction

Id Name
DB00082 Pegvisomant
DB00119 Pyruvic acid
DB00122 Choline
DB00128 L-Aspartic Acid
DB00142 L-Glutamic Acid
DB00155 L-Citrulline
DB00157 NADH
DB00163 Vitamin E
DB00175 Pravastatin
DB00178 Ramipril
DB00183 Pentagastrin
DB00202 Succinylcholine
DB00232 Methyclothiazide
DB00273 Topiramate
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00345 Aminohippurate
DB00358 Mefloquine
DB00382 Tacrine
DB00391 Sulpiride
DB00392 Ethopropazine
DB00415 Ampicillin
DB00436 Bendroflumethiazide
DB00449 Dipivefrin
DB00477 Chlorpromazine
DB00508 Triflupromazine
DB00515 Cisplatin
DB00527 Dibucaine
DB00529 Foscarnet
DB00536 Guanidine
DB00545 Pyridostigmine
DB00562 Benzthiazide
DB00563 Methotrexate
DB00585 Nizatidine
DB00606 Cyclothiazide
DB00620 Triamcinolone
DB00627 Niacin
DB00674 Galantamine
DB00677 Isoflurophate
DB00686 Pentosan Polysulfate
DB00695 Furosemide
DB00703 Methazolamide
DB00711 Diethylcarbamazine
DB00721 Procaine
DB00731 Nateglinide
DB00733 Pralidoxime
DB00762 Irinotecan
DB00772 Malathion
DB00774 Hydroflumethiazide
DB00790 Perindopril
DB00819 Acetazolamide
DB00856 Chlorphenesin
DB00869 Dorzolamide
DB00871 Terbutaline
DB00880 Chlorothiazide
DB00892 Oxybuprocaine
DB00909 Zonisamide
DB00936 Salicyclic acid
DB00941 Hexafluronium
DB00944 Demecarium
DB00979 Cyclopentolate
DB00989 Rivastigmine
DB00997 Doxorubicin
DB00999 Hydrochlorothiazide
DB01010 Edrophonium
DB01021 Trichlormethiazide
DB01025 Amlexanox
DB01031 Ethinamate
DB01032 Probenecid
DB01035 Procainamide
DB01057 Echothiophate
DB01116 Trimethaphan
DB01119 Diazoxide
DB01122 Ambenonium
DB01135 Doxacurium chloride
DB01144 Dichlorphenamide
DB01161 Chloroprocaine
DB01194 Brinzolamide
DB01226 Mivacurium
DB01245 Decamethonium
DB01325 Quinethazone
DB01337 Pancuronium
DB01338 Pipecuronium
DB01364 Ephedrine
DB01395 Drospirenone
DB01400 Neostigmine
DB01408 Bambuterol
DB01440 Gamma Hydroxybutyric Acid
DB01525 Ecgonine
DB01632 Alpha-Phosphoribosylpyrophosphoric Acid
DB01671 4-(Hydroxymercury)Benzoic Acid
DB01748 N-Benzyl-4-Sulfamoyl-Benzamide
DB01762 Acetoacetic Acid
DB01784 4-Flourobenzenesulfonamide
DB01812 Adenosine-3'-5'-Diphosphate
DB01821 L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01863 Inositol 1,3,4,5-Tetrakisphosphate
DB01901 Sucrose Octasulfate
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01961 Cytidine-3'-Monophosphate
DB01964 AL5424
DB01997 3-Bromo-7-Nitroindazole
DB02027 N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine
DB02044 N-(3-(Aminomethyl)Benzyl)Acetamidine
DB02069 N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide
DB02073 Biliverdine Ix Alpha
DB02077 L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide
DB02087 3,5-Difluorobenzenesulfonamide
DB02098 Adenosine-2'-5'-Diphosphate
DB02143 N-Isopropyl-N'-Hydroxyguanidine
DB02220 Al7089a
DB02221 4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-Benzamide
DB02262 Orotic Acid
DB02264 O2-Sulfo-Glucuronic Acid
DB02276 (S)-2-(Phosphonoxy)Caproyl-L-Leucyl-P-Nitroanilide
DB02292 6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate
DB02363 2'-Monophosphoadenosine-5'-Diphosphate
DB02406 N-Valeric Acid
DB02429 4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-Benzamide
DB02468 12-Phenylheme
DB02479 (R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
DB02531 Isobutyric Acid
DB02535 Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide
DB02560 D-Para-Chlorophenyl-1-Acteamidoboronic Acid Alanine
DB02573 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate
DB02602 AL7182
DB02610 N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-Benzamide
DB02644 N-Omega-Propyl-L-Arginine
DB02674 4-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Butyricacid
DB02677 D-Naphthyl-1-Acetamido Boronic Acid Alanine
DB02679 Cyanamide
DB02687 Beta-D-Mannose
DB02692 (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
DB02714 3'-Uridinemonophosphate
DB02726 2-Phosphoglycolic Acid
DB02727 N-Butyl-N'-Hydroxyguanidine
DB02793 Isochorismic Acid
DB02805 1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB02811 Diethylphosphono Group
DB02828 5-Fluorolevulinic Acid
DB02845 Methylphosphinic Acid
DB02861 4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-Benzamide
DB02866 Dansylamide
DB02894 Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose Ester
DB02944 Alpha-D-Mannose
DB02986 N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide
DB02987 Cysteine-S-Acetamide
DB02991 S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea
DB03014 Heme
DB03026 Phosphoglycolohydroxamic Acid
DB03039 4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide
DB03066 D-Lactic Acid
DB03112 6-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Hexanoic Acid
DB03116 5-(1-Carboxy-1-Phosphonooxy-Ethoxyl)-Shikimate-3-Phosphate
DB03139 6-[5-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Pentanoylamino]-Hexanoic Acid
DB03144 N-Omega-Hydroxy-L-Arginine
DB03147 Flavin-Adenine Dinucleotide
DB03155 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione
DB03166 Acetic acid
DB03186 U-Pi-a-Pi
DB03221 AL7099A
DB03247 Riboflavin Monophosphate
DB03262 Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
DB03270 2,6-Difluorobenzenesulfonamide
DB03290 L-Naphthyl-1-Acetamido Boronic Acid Alanine
DB03294 1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid Amide
DB03316 1,4-Diethylene Dioxide
DB03326 deoxycytidylyl-3',5'-guanosine
DB03333 (4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester
DB03353 2-Iminobiotin
DB03385 4-Methylimidazole
DB03401 D-Myo-Inositol-1,4,5-Triphosphate
DB03431 Adenosine-5'-Diphosphate
DB03447 Uridylyl-2'-5'-Phospho-Adenosine
DB03448 2'-Deoxyuridine 3'-Monophosphate
DB03449 N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03512 Uridine-2',3'-Vanadate
DB03522 Aspartic Acid-4-Carboxymethyl Ester
DB03526 AL5927
DB03533 Glycoluril
DB03549 Biotinyl P-Nitroaniline
DB03568 Butanoic Acid
DB03594 1,2,4-Triazole
DB03596 N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide
DB03598 Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]
DB03607 D-Para-Chlorophenyl-1-Acetamidoboronic Acid Alanine
DB03672 9-N-Phenylmethylamino-Tacrine
DB03674 Methyl Mercury Ion
DB03697 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide
DB03707 S-Ethyl-N-Phenyl-Isothiourea
DB03710 N5-(1-Imino-3-Butenyl)-L-Ornithine
DB03726 Purine Riboside-5'-Monophosphate
DB03741 2-Methylbutanoic Acid
DB03750 Isovaleric Acid
DB03754 Tris(Hydroxymethyl)Aminomethane
DB03765 Cytidine-2'-Monophosphate
DB03766 Propanoic Acid
DB03790 S-Dioxymethionine
DB03792 5-Amino-1h-Pyrimidine-2,4-Dione
DB03793 Benzoic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03822 Ethyl Dihydrogen Phosphate
DB03844 N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide
DB03877 AL4623
DB03884 3-Phenylpyruvic Acid
DB03892 5-N-Allyl-Arginine
DB03900 2-Methyl-2-Propanol
DB03904 Urea
DB03906 2-Phenylheme
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB03940 Oxamic Acid
DB03950 (S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
DB03959 N,O6-Disulfo-Glucosamine
DB03975 Mercuribenzoic Acid
DB04002 4-Sulfonamide-[4-(Thiomethylaminobutane)]Benzamide
DB04074 Alpha-ketoisovalerate
DB04081 (4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-Dioxide
DB04089 AL5300
DB04132 S-Hexylglutathione
DB04180 4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-Benzamide
DB04198 Formycin B
DB04203 3-Mercuri-4-Aminobenzenesulfonamide
DB04216 Quercetin
DB04223 Nitroarginine
DB04250 Butyrylthiocholine
DB04251 Monoisopropyl Ester Phosphonic Acid Group
DB04272 Citric Acid
DB04310 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide
DB04315 Guanosine-5'-Diphosphate
DB04319 6-Deoxyglucose
DB04328 Shikimate-3-Phosphate
DB04343 Glyoxalate, Glyoxylate
DB04348 Taurocholic Acid
DB04368 Bb-3497
DB04371 AL6528
DB04394 3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide
DB04398 Lactic Acid
DB04409 Naphthalene Trisulfonate
DB04464 N-Formylmethionine
DB04514 Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester
DB04522 Phosphonoserine
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04539 Glyphosate
DB04549 4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide
DB04552 Niflumic Acid
DB04566 Inosinic Acid
DB04600 4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
DB04601 4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE
DB04650 5-[(3AS,4R,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOIC ACID
DB04763 1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM
DB04803 Verdoheme
DB04920 Clevidipine
DB06589 Pazopanib
DB06891 5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDE
DB06914 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
DB06954 2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamate
DB07048 N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide
DB07050 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
DB07342 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
DB07348 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE
DB07363 THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)
DB07467 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide
DB07476 N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDE
DB07596 (17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamate
DB07632 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
DB07667 2-((3',5'-DIMETHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB07681 DODECANESULFONATE ION
DB07710 PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDE
DB07715 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
DB07742 N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE
DB07880 2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
DB07940 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
DB08018 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
DB08019 N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
DB08046 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide
DB08083 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide
DB08155 N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE
DB08156 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID
DB08157 ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE
DB08165 indane-5-sulfonamide
DB08181 2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08196 2-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08200 (1R)-MENTHYL HEXYL PHOSPHONATE GROUP
DB08201 (1S)-MENTHYL HEXYL PHOSPHONATE GROUP
DB08202 4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDE
DB08216 2-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
DB08238 5-AMINO-NAPHTALENE-2-MONOSULFONATE
DB08252 2-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACID
DB08301 N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE
DB08329 SULTHIAME
DB08416 (9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATE
DB08418 (4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamate
DB08523 [HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL
DB08596 5'-deoxy-5'-piperidin-1-ylthymidine
DB08645 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
DB08658 ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE
DB08659 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide
DB08661 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
DB08765 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
DB08782 4-(2-AMINOETHYL)BENZENESULFONAMIDE
DB08846 Ellagic Acid
DB08893 Mirabegron
DB08897 Aclidinium
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