DT-Web

DB03793 - Benzoic Acid


Identification
Name Benzoic Acid
Accession Number DB03793 (EXPT00675)
Type small molecule
Description A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 122.1213
Groups experimental
Monoisotopic Weight 122.036779436
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Hydrogen peroxide-inducible genes activator
Name Hydrogen peroxide-inducible genes activator
Gene Name oxyR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9613
HTH-type transcriptional regulator malT
Name HTH-type transcriptional regulator malT
Gene Name malT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9606
Probable tautomerase ydcE
Name Probable tautomerase ydcE
Gene Name pptA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8318
D-amino-acid oxidase
Name D-amino-acid oxidase
Gene Name DAO
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.0033
Ribonuclease UK114
Name Ribonuclease UK114
Gene Name HRSP12
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9621
Chlorocatechol 1,2-dioxygenase
Name Chlorocatechol 1,2-dioxygenase
Gene Name clcA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1641
Ras-related protein Rab-9
Name Ras-related protein Rab-9
Gene Name RAB9A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8613
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Name 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Gene Name cumD
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.7378
Non-heme chloroperoxidase
Name Non-heme chloroperoxidase
Gene Name cpo
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0599
Oxygen-insensitive NAD(P)H nitroreductase
Name Oxygen-insensitive NAD(P)H nitroreductase
Gene Name nfnB
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0154
Hydroxyquinol 1,2-dioxygenase
Name Hydroxyquinol 1,2-dioxygenase
Gene Name chqB
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9612
Replication protein
Name Replication protein
Gene Name repA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9613
Peroxiredoxin-5, mitochondrial
Name Peroxiredoxin-5, mitochondrial
Gene Name PRDX5
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.992
Heat-labile enterotoxin B chain
Name Heat-labile enterotoxin B chain
Gene Name eltB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 2.0718
Cocaine esterase
Name Cocaine esterase
Gene Name cocE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8302

Transporters


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions inhibitor
References
  • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther. 2003 Aug;306(2):703-8. Epub 2003 Apr 30. - Pubmed
DTHybrid score 0.5997
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed
DTHybrid score 0.4845
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions Not Available
References
  • Kido Y, Tamai I, Okamoto M, Suzuki F, Tsuji A: Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharm Res. 2000 Jan;17(1):55-62. - Pubmed
DTHybrid score 0.6623

Predictions


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