| Name |
2-isopropylmalate synthase |
| Synonyms |
5214 |
| Gene name |
leuA |
| General function |
Amino acid transport and metabolism |
| Specific function |
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) |
| Gene sequence |
+ ...
GTGACAACTTCTGAATCGCCCGACGCCTATACCGAGTCGTTTGGGGCCCACACCATCGTGAAACCCGCCGGCCCACCTCGCGTCGGTCAGCCCTCGTGGAATCCGCAGCGAGCCTCGTCGATGCCGGTCAACCGCTACCGGCCGTTCGCCGAGGAGGTCGAGCCCATCCGGCTGAGAAACCGCACGTGGCCTGATCGCGTCATCGATCGTGCGCCGCTGTGGTGCGCGGTCGACTTACGCGATGGCAACCAGGCGCTGATCGACCCGATGAGCCCGGCCCGCAAGCGCCGCATGTTCGACCTGCTGGTCCGGATGGGCTACAAGGAGATTGAGGTGGGGTTCCCCTCGGCCAGCCAGACCGACTTCGACTTCGTCAGAGAGATCATCGAGCAGGGCGCCATTCCCGACGACGTCACCATCCAGGTGCTCACCCAATGCCGTCCCGAGCTGATCGAGCGCACCTTCCAGGCGTGTTCGGGCGCACCCCGGGCCATCGTGCACTTCTACAACTCGACGTCAATCCTGCAGCGCCGCGTGGTCTTTCGCGCCAACCGGGCTGAGGTGCAGGCCATCGCGACAGATGGGGCGCGCAAGTGCGTCGAGCAGGCCGCCAAATACCCGGGCACGCAGTGGCGATTCGAGTACTCCCCGGAGTCCTACACCGGCACCGAACTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGCGAGGTCATTGCGCCGACGCCGGAGCGCCCGATCATCTTCAACCTGCCCGCCACGGTGGAGATGACGACGCCCAATGTCTACGCCGACTCGATCGAGTGGATGAGCCGCAACCTAGCCAACCGGGAGTCGGTCATCCTGAGCCTGCACCCGCACAATGACCGCGGAACCGCCGTCGCCGCAGCGGAATTGGGTTTCGCGGCCGGGGCTGATCGGATCGAGGGCTGCCTGTTCGGCAACGGCGAGCGCACCGGCAACGTGTGCCTGGTCACGCTGGGACTCAACCTGTTCTCCCGAGGTGTGGACCCGCAGATCGACTTCTCCAATATTGACGAGATCCGGCGCACGGTGGAGTACTGCAACCAGCTGCCGGTGCACGAACGTCACCCCTATGGCGGCGACCTGGTGTACACCGCGTTCTCCGGTAGCCACCAGGACGCCATCAACAAGGGCCTAGACGCGATGAAGCTGGATGCGGATGCCGCCGACTGTGACGTCGACGACATGCTGTGGCAGGTGCCGTATCTGCCCATCGACCCGCGCGATGTCGGGCGCACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCCGGCAAGGGCGGCGTGGCCTACATCATGAAGACCGACCACGGCCTTTCCCTGCCGCGGCGGCTGCAGATCGAGTTTTCCCAGGTAATCCAGAAGATCGCAGAGGGTACAGCAGGCGAGGGTGGCGAGGTCTCGCCCAAGGAGATGTGGGATGCGTTCGCCGAGGAGTATCTGGCCCCGGTGCGGCCTTTGGAGCGGATAAGGCAACATGTGGACGCTGCCGACGACGACGGCGGCACGACCAGCATCACGGCGACCGTCAAGATCAACGGCGTGGAGACCGAGATCAGCGGGTCCGGTAACGGTCCGTTGGCCGCGTTCGTCCATGCGCTGGCCGATGTCGGGTTTGACGTGGCCGTGCTGGACTACTACGAGCACGCGATGAGCGCCGGCGACGACGCTCAGGCCGCCGCGTATGTGGAGGCCTCCGTGACGATCGCGAGCCCGGCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGATCGCGAGCCCGGCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGAGTAAGACGGTGTGGGGTGTCGGTATCGCACCGTCAATCACCACCGCGTCGCTGCGCGCCGTGGTGTCGGCGGTCAACCGGGCGGCACGCTAG
|
| Protein sequence |
+ ...
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
|
| GO Classification |
| function |
| transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer |
| catalytic activity |
| 2-isopropylmalate synthase activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| process |
| organic acid metabolism |
| carboxylic acid metabolism |
| branched chain family amino acid metabolism |
| leucine metabolism |
| physiological process |
| leucine biosynthesis |
| metabolism |
| cellular metabolism |
| amino acid metabolism |
| amino acid and derivative metabolism |
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