DT-Web

DB04343 - Glyoxalate, Glyoxylate


Identification
Name Glyoxalate, Glyoxylate
Accession Number DB04343 (EXPT01614)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 74.0355
Groups experimental
Monoisotopic Weight 74.00039393
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Malate synthase G
Name Malate synthase G
Gene Name glcB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9764
Isocitrate lyase
Name Isocitrate lyase
Gene Name icl
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0842
Malate synthase G
Name Malate synthase G
Gene Name glcB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9764
Regulator of ribonuclease activity A
Name Regulator of ribonuclease activity A
Gene Name Rv3853
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0845

Transporters


Monocarboxylate transporter 4
Name Monocarboxylate transporter 4
Gene Name SLC16A3
Actions substrate
References
  • Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. - Pubmed
DTHybrid score 0.8541

Predictions


Id Partner name Gene Name Score
2245 Xylose isomerase xylA 0.1866
2253 Xylose isomerase xylA 0.1866
2260 Xylose isomerase xylA 0.1866
2431 Xylose isomerase xylA 0.1866
489 Monocarboxylate transporter 2 SLC16A7 0.1573
738 Monocarboxylate transporter 1 SLC16A1 0.1333
2891 Circadian clock protein kaiB kaiB 0.1233
4384 Capsule biosynthesis protein synC 0.1135
3486 Fumarate hydratase class II fumC 0.1071
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0931
3178 Formate acetyltransferase 1 pflB 0.0398
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0331
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0331
3179 2-isopropylmalate synthase leuA 0.0331
6826 Bacilysin biosynthesis protein bacB bacB 0.0328
6827 Probable chorismate mutase pheA 0.0327
6508 Putative uncharacterized protein srtB 0.0327
6543 Putative uncharacterized protein tcp14 0.0327
6615 Putative uncharacterized protein MT0785 0.0327
6623 Putative uncharacterized protein Not Available 0.0327
6806 Putative uncharacterized protein AGR_C_2535 0.0327
6813 Putative uncharacterized protein SAV4671 0.0327
6815 Putative uncharacterized protein AFE_1514 0.0327
6819 Putative uncharacterized protein RUMGNA_03254 0.0327
6825 Putative uncharacterized protein CV_3270 0.0327
2424 L-lactate dehydrogenase ldh 0.03
2641 L-lactate dehydrogenase Not Available 0.03
4437 L-lactate dehydrogenase ldh 0.03
4442 L-lactate dehydrogenase ldh 0.03
126 D-lactate dehydrogenase dld 0.03
3545 D-lactate dehydrogenase Not Available 0.03
4510 D-lactate dehydrogenase ldhA 0.03
5650 NimA-related protein DR_0842 0.0289
5607 Indole-3-pyruvate decarboxylase ipdC 0.0284
6657 Indole-3-pyruvate decarboxylase ipdC 0.0284
6616 L-phenylalanine dehydrogenase pdh 0.0284
3334 Deacetoxycephalosporin C synthetase cefE 0.0263
77 L-lactate dehydrogenase B chain LDHB 0.0232
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0228
473 L-lactate dehydrogenase A chain LDHA 0.0224
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0213
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.021
6268 Hydroxyacid oxidase 1 HAO1 0.0206
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0198
860 Nicotinamide N-methyltransferase NNMT 0.0192
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0192
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0192
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0192
699 Nicotinic acid receptor 1 GPR109A 0.0192
928 Nicotinic acid receptor 2 GPR109B 0.0192
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0187
6151 Monocarboxylate transporter 10 SLC16A10 0.0174
4576 Aac(6')-Ii protein aac(6')-Ii 0.0173
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0173
4579 Serine acetyltransferase cysE 0.0173
6807 Serine acetyltransferase cysE 0.0173
4566 Acyl-CoA hydrolase BC_2038 0.0173
4572 Acyl-CoA hydrolase BH0798 0.0173
4564 YvbK protein yvbK 0.0172
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0172
2528 Fatty acid metabolism regulator protein fadR 0.0172
6740 Fatty acid metabolism regulator protein fadR 0.0172
3560 Gentamicin 3'-acetyltransferase aacC1 0.015
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.015
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.015
4563 Acetyl transferase rimL 0.015
3317 Holo-[acyl-carrier-protein] synthase acpS 0.015
4381 Holo-[acyl-carrier-protein] synthase acpS 0.015
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.015
3729 Citrate synthase gltA 0.015
4575 Citrate synthase cit 0.015
4580 Citrate synthase gltA 0.015
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.015
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.015
2396 Formyl-coenzyme A transferase frc 0.015
3457 Formyl-coenzyme A transferase frc 0.015
3489 Acetyl-coenzyme A synthetase acs 0.015
2285 Streptogramin A acetyltransferase vatD 0.0138
3199 Phosphopantetheine adenylyltransferase coaD 0.0138
3543 Phosphopantetheine adenylyltransferase coaD 0.0138
3567 Phosphopantetheine adenylyltransferase coaD 0.0138
5289 Phosphopantetheine adenylyltransferase coaD 0.0138
2560 Galactoside O-acetyltransferase lacA 0.0138
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0138
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0138
4573 Histone acetyltransferase PCAF KAT2B 0.0138
4404 FcbC1 protein fcbC 0.0131
2371 Pantothenate kinase coaA 0.0131
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0125
397 Monocarboxylate transporter 3 SLC16A8 0.0125
551 Carnitine O-acetyltransferase CRAT 0.0123
195 Monocarboxylate transporter 7 SLC16A6 0.0122
429 Monocarboxylate transporter 6 SLC16A5 0.0121
218 Monocarboxylate transporter 5 SLC16A4 0.0121
2596 Acetyl-CoA acetyltransferase phbA 0.0114
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0112
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0112
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0112
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0112
52 Pyruvate kinase isozymes R/L PKLR 0.0108
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0105
771 Pyruvate carboxylase, mitochondrial PC 0.0097
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0096
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0093
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0084
118 Organic cation/carnitine transporter 2 SLC22A5 0.0082
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0074
199 Monocarboxylate transporter 8 SLC16A2 0.0074
4119 Cytochrome P450 2D6 CYP2D6 0.0057
4037 Hypothetical protein GPX1 0.0047
4297 Hypothetical protein SP_1951 0.0047
4521 Hypothetical protein BC_2969 0.0047
4540 Hypothetical protein TM_1070 0.0047
4555 Hypothetical protein MT1739 0.0047
4569 Hypothetical protein mshD 0.0047
4578 Hypothetical protein PA3270 0.0047
4747 Hypothetical protein PA3967 0.0047
5177 Hypothetical protein TM_0096 0.0047
5194 Hypothetical protein PA1204 0.0047
5240 Hypothetical protein Rv2991 0.0047
5370 Hypothetical protein TM_1158 0.0047
5710 Hypothetical protein Tb927.5.1360 0.0047
4545 Molybdopterin-converting factor subunit 2 moaE 0.0047
4527 Putative hydrolase ycdX ycdX 0.0047
4106 Guanylate kinase GUK1 0.0047
4516 Guanylate kinase gmk 0.0047
4538 Hypothetical protein VC1899 VC_1899 0.0047
4536 Transcriptional regulator, IclR family TM_0065 0.0047
2501 Protein ygbM ygbM 0.0047
4514 Citrate lyase beta subunit-like protein citE 0.0047
4781 Citrate lyase beta subunit-like protein DR_1240 0.0047
4524 Mannose-6-phosphate isomerase yvyI 0.0047
4522 Arginine N-succinyltransferase subunit alpha astA 0.0047
4547 Iron binding protein FbpA fbpA 0.0047
4529 Oxalate decarboxylase oxdC oxdC 0.0047
4546 Aminotransferase, putative TM_1131 0.0047
658 Para-aminobenzoate synthase component 1 pabB 0.0047
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0047
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0047
4548 Gyrase B gyrB 0.0047
4515 Peripheral plasma membrane protein CASK CASK 0.0047
4496 C-terminal-binding protein 1 CTBP1 0.0043
4532 Gephyrin GPHN 0.0041
56 Delta-aminolevulinic acid dehydratase ALAD 0.0041
2356 Delta-aminolevulinic acid dehydratase hemB 0.0041
3613 Delta-aminolevulinic acid dehydratase hemB 0.0041
3674 Delta-aminolevulinic acid dehydratase hemB 0.0041
4533 Glyoxalase family protein BC_1747 0.0041
3237 Beta-lactamase OXA-2 bla 0.0041
4542 Glutaminase 1 glsA1 0.0041
4544 Glutaminase 1 glsA1 0.0041
2929 (S)-2-haloacid dehalogenase dhlB 0.0041
2995 (S)-2-haloacid dehalogenase Not Available 0.0041
4528 Phenazine biosynthesis protein PhzD phzD1 0.0041
3759 Glutathione S-transferase gst 0.004
4541 Glutathione S-transferase GST 0.004
3261 Signal recognition particle protein ffh 0.004
4517 Probable butyrate kinase 2 buk2 0.004
2230 Catalase CAT 0.0039
3249 Catalase katA 0.0039
3625 Catalase katA 0.0039
4539 Catalase katA 0.0039
4941 Catalase katB 0.0039
3583 6-phosphogluconolactonase pgl 0.0037
3467 Methylglyoxal synthase mgsA 0.0037
2775 Dihydroorotate dehydrogenase pyrD 0.0037
4531 Putative ketoacyl reductase actIII 0.0037
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0035
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0035
2688 Peptide deformylase def 0.0033
2708 Peptide deformylase def 0.0033
3004 Peptide deformylase def 0.0033
4337 Peptide deformylase def 0.0033
4338 Peptide deformylase def 0.0033
5368 Peptide deformylase def 0.0033
5371 Peptide deformylase def 0.0033
6375 Peptide deformylase def 0.0033
6378 Peptide deformylase def 0.0033
6379 Peptide deformylase def 0.0033
6776 Peptide deformylase def 0.0033
6900 Peptide deformylase def 0.0033
4534 Cytohesin-2 CYTH2 0.0033
2548 Subtilisin Carlsberg apr 0.0032
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0032
760 Fibroblast growth factor 1 FGF1 0.0027
810 Heme oxygenase 1 HMOX1 0.0027
3391 Heme oxygenase 1 pbsA1 0.0027
3027 Streptavidin Not Available 0.0027
76 Nitric-oxide synthase, brain NOS1 0.0024
5682 Ribonuclease pancreatic RNASE1 0.0023
357 Carbonic anhydrase 2 CA2 0.0017
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