DT-Web

3-oxoacyl-[acyl-carrier-protein] synthase 3


Partner ID 4568
Name 3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms 1838
Gene name fabH
General function Involved in 3-oxoacyl-[acyl-carrier-protein] synthase activity
Specific function Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate preference for butyryl-CoA and can tolerate branched substrates. Can also prime acyl-CoA. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. Involved in the biosynthesis of R1128 polyketide
Gene sequence + ...

ATGCCCGGACTTCGGGTTCCCGAGCGGCGTTTCAGCCGTGTTCTCGGGGTCGGTTCGTACCGGCCCCGCCGTGAGGTGAGCAACAAGGAGGTGTGCACCTGGATCGACTCGACGGAGGAGTGGATCGAGACGCGCACCGGGATCAGGTCGCGGCGGATCGCCGAGCCGGACGAGACGATCCAGGTGATGGGGGTGGCCGCGAGCCGCCGCGCGCTGGAGCACGCCGGCGTGGATCCGGCCGAGATCGACCTGGTCGTGGTCTCCACGATGACCAACTTCGTGCACACGCCGCCGCTTTCGGTCGCGATCGCGCACGAGCTGGGTGCCGACAACGCCGGCGGGTTCGACCTGTCGGCGGCGTGCGCGGGGTTCTGCCACGCGTTGTCGATCGCGGCGGACGCGGTGGAGTCCGGCGGTTCGCGGCACGTGCTCGTGGTGGCGACGGAGCGGATGACCGACGTGATCGACCTGGCGGACCGGAGCCTGTCGTTCCTGTTCGGCGACGGCGCCGGCGCGGCCGTGGTCGGCCCGTCCGACGTGCCCGGCATCGGTCCGGTGGTGCGCGGCATCGACGGCACCGGCCTGGGCTCGCTGCACATGAGCAGTTCGTGGGACCAGTACGTCGAGGACCCCTCGGTGGGCCGGCCGGCGCTGGTGATGGACGGCAAGCGGGTGTTCCGCTGGGCGGTCGCGGACGTCGTCCCGGCGGCCCGCGAGGCGCTCGAGGTGGCCGGCCTGACCGTCGGGGACCTGGTGGCGTTCGTCCCGCACCAGGCCAACCTGCGGATCATCGACGTGCTGGTGGACCGGCTCGGCGTGCCGGAGCACGTGGTCGTCTCGCGCGACGCGGAGGACACCGGCAACACCTCGTCGGCGTCGGTGGCCCTGGCCCTGGACCGGCTGGTGCGCTCCGGCGCGGTGCCCGGCGGCGGGCCCGCGCTGATGATCGGTTTCGGCGCCGGGCTGAGCTACGCGGGCCAGGCTCTACTGCTTCCCGACCCGCCGTCCACTCCGGCTTGA
Protein sequence + ...

MPGLRVPERRFSRVLGVGSYRPRREVSNKEVCTWIDSTEEWIETRTGIRSRRIAEPDETIQVMGVAASRRALEHAGVDPAEIDLVVVSTMTNFVHTPPLSVAIAHELGADNAGGFDLSAACAGFCHALSIAADAVESGGSRHVLVVATERMTDVIDLADRSLSFLFGDGAGAAVVGPSDVPGIGPVVRGIDGTGLGSLHMSSSWDQYVEDPSVGRPALVMDGKRVFRWAVADVVPAAREALEVAGLTVGDLVAFVPHQANLRIIDVLVDRLGVPEHVVVSRDAEDTGNTSSASVALALDRLVRSGAVPGGGPALMIGFGAGLSYAGQALLLPDPPSTPA
GO Classification
function
fatty-acid synthase activity
3-oxoacyl-[acyl-carrier protein] synthase activity
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring groups other than amino-acyl groups
acyltransferase activity
process
organic acid metabolism
carboxylic acid metabolism
fatty acid metabolism
fatty acid biosynthesis
physiological process
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01992 Coenzyme A

Associated as Prediction

Id Name
DB00157 NADH
DB00175 Pravastatin
DB00227 Lovastatin
DB00417 Penicillin V
DB00439 Cerivastatin
DB00583 L-Carnitine
DB00641 Simvastatin
DB00684 Tobramycin
DB01034 Cerulenin
DB01076 Atorvastatin
DB01083 Orlistat
DB01095 Fluvastatin
DB01098 Rosuvastatin
DB01133 Tiludronate
DB01172 Kanamycin
DB01669 Virginiamycin M1
DB01734 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid
DB01764 Dalfopristin
DB01769 Double Oxidized Cysteine
DB01783 Pantothenic acid
DB01820 Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide
DB01822 Dithiane Diol
DB01842 3'-Phosphate-Adenosine-5'-Diphosphate
DB01846 Oxidized Coenzyme A
DB01856 Pimelic Acid
DB01862 1-(Isopropylthio)-Beta-Galactopyranside
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01915 S-Hydroxycysteine
DB01992 Coenzyme A
DB02014 Compound 9
DB02039 S-Acetyl-Cysteine
DB02072 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid
DB02160 S-Butyryl-Cystein
DB02175 Malonic acid
DB02259 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide
DB02316 1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid
DB02321 5-(3-Amino-4,4-Dihyroxy-Butylsulfanylmethyl)-Tetrahydro-Furan-2,3,4-Triol
DB02420 [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,
DB02436 2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid
DB02516 O5'-(4-(3-{2-[2-((R)-3-Hydroxy-4-(Trimethylammonio)-1-Oxo-Butyl)Sulfanyl-Ethylcarbamoyl]-Ethylcarbamoyl}-(R)-3-Hydroxy-2,2-Dimethyl-Propyl)-1-Hydroxy-3-Oxido-1,3-Dioxo-2,4-Dioxa-1,3-Diphosphabut-1-Yl) 3'-Phospho-Adenosine
DB02615 Compound 19
DB02620 Sp7343-Sp7964
DB02622 2-(Oxalyl-Amino)-Benzoic Acid
DB02632 1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
DB02648 (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium
DB02651 {[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)
DB02662 Novo Nordisk a/S Compound
DB02784 N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid
DB02827 7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB02977 PNU177836
DB03045 Pantothenyl-Aminoethanol-Acetate Pivalic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03102 2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid
DB03134 2-Aminopimelic Acid
DB03154 {[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid
DB03169 (S)-Hmg-Coa
DB03170 Dephospho Coenzyme A
DB03230 Adenosine-5'-Propylphosphate
DB03264 Dodecyl-Coa
DB03278 D-Treitol
DB03311 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03431 Adenosine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03483 4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid
DB03499 Malate Ion
DB03518 (R)-Mevalonate
DB03557 N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid
DB03566 Spermidine
DB03600 Decanoic Acid
DB03613 4-Hydroxyphenacyl Coenzyme A
DB03615 Ribostamycin
DB03661 Cysteinesulfonic Acid
DB03670 2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
DB03674 Methyl Mercury Ion
DB03699 Succinyl-Coenzyme A
DB03714 4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03905 Succinamide-Coa
DB03912 4'-Phosphopantetheine
DB03940 Oxamic Acid
DB03982 Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
DB04001 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid
DB04067 4-Hydroxybenzyl Coenzyme A
DB04088 N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)
DB04142 3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide
DB04182 (S)-2-Amino-4-[(2s,3r)-2,3,5-Trihydroxy-4-Oxo-Pentyl]Mercapto-Butyric Acid
DB04204 [(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
DB04242 P-Hydroxybenzoic Acid
DB04272 Citric Acid
DB04285 {4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
DB04302 4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One
DB04343 Glyoxalate, Glyoxylate
DB04377 3-Hydroxy-3-Methyl-Glutaric Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB04422 2-Amino-4-Mercapto-Butyric Acid
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04519 Caprylic acid
DB04524 Malonyl-Coenzyme A
DB04525 2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid
DB04800 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID
DB06693 Mevastatin
DB06829 4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID
DB06846 7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
DB06887 3(S)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07130 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
DB07134 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB07197 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID
DB07263 [{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid
DB07289 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID
DB07295 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID
DB07298 3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
DB07429 2-({[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl}amino)benzoic acid
DB07477 BIPHENYL-4-YL-ACETALDEHYDE
DB07480 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
DB07611 DECANE-1-THIOL
DB07650 DECYL FORMATE
DB07651 N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE
DB07719 3(R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
DB07730 5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE
DB08001 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID
DB08003 ISOTHIAZOLIDINONE ANALOG
DB08120 6,8-DIMERCAPTO-OCTANOIC ACID AMIDE
DB08147 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
DB08171 11-MERCAPTOUNDECANOIC ACID
DB08186 (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
DB08291 N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
DB08328 PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID
DB08359 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE
DB08366 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid
DB08371 PARA-(BENZOYL)-PHENYLALANINE
DB08397 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
DB08407 PLATENSIMYCIN
DB08408 (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate
DB08549 (3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
DB08591 5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE
DB08593 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE
DB08627 (5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE
DB08628 (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE
DB08684 O-DECYL HYDROGEN THIOCARBONATE
DB08712 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID
DB08783 (4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
DB08860 Pitavastatin
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