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DB01669 - Virginiamycin M1


Identification
Name Virginiamycin M1
Accession Number DB01669 (EXPT03225)
Type small molecule
Description Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA). It is produced by Streptomyces graminofaciens and other bacteria.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 525.5934
Groups experimental
Monoisotopic Weight 525.247500489
Pharmacology
Indication For the treatment of bacterial infections.
Mechanism of action Virginiamycin M1 is a macrocyclic lactone antibiotic that acts syngeristically with the structurally unrelated cyclic depsipeptides more commonly known as the virginiamycins B (ostreogrycin B or streptogramin B) and S to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Virginiamycin M1 has proven to be highly active against Gram positive bacteria, particularly methicillin-resistant S. aureus.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Bacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Streptogramin A acetyltransferase
Name Streptogramin A acetyltransferase
Gene Name vatD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0163

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.0678
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0173
4579 Serine acetyltransferase cysE 0.0173
6807 Serine acetyltransferase cysE 0.0173
4576 Aac(6')-Ii protein aac(6')-Ii 0.0173
4564 YvbK protein yvbK 0.0173
4566 Acyl-CoA hydrolase BC_2038 0.0173
4572 Acyl-CoA hydrolase BH0798 0.0173
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0173
2528 Fatty acid metabolism regulator protein fadR 0.0173
6740 Fatty acid metabolism regulator protein fadR 0.0173
4037 Hypothetical protein GPX1 0.0173
4297 Hypothetical protein SP_1951 0.0173
4521 Hypothetical protein BC_2969 0.0173
4540 Hypothetical protein TM_1070 0.0173
4555 Hypothetical protein MT1739 0.0173
4569 Hypothetical protein mshD 0.0173
4578 Hypothetical protein PA3270 0.0173
4747 Hypothetical protein PA3967 0.0173
5177 Hypothetical protein TM_0096 0.0173
5194 Hypothetical protein PA1204 0.0173
5240 Hypothetical protein Rv2991 0.0173
5370 Hypothetical protein TM_1158 0.0173
5710 Hypothetical protein Tb927.5.1360 0.0173
3317 Holo-[acyl-carrier-protein] synthase acpS 0.015
4381 Holo-[acyl-carrier-protein] synthase acpS 0.015
3729 Citrate synthase gltA 0.015
4575 Citrate synthase cit 0.015
4580 Citrate synthase gltA 0.015
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.015
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.015
3560 Gentamicin 3'-acetyltransferase aacC1 0.015
4563 Acetyl transferase rimL 0.015
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.015
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.015
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.015
3489 Acetyl-coenzyme A synthetase acs 0.015
2396 Formyl-coenzyme A transferase frc 0.015
3457 Formyl-coenzyme A transferase frc 0.015
2560 Galactoside O-acetyltransferase lacA 0.0139
3199 Phosphopantetheine adenylyltransferase coaD 0.0139
3543 Phosphopantetheine adenylyltransferase coaD 0.0139
3567 Phosphopantetheine adenylyltransferase coaD 0.0139
5289 Phosphopantetheine adenylyltransferase coaD 0.0139
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0139
3178 Formate acetyltransferase 1 pflB 0.0139
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0138
4573 Histone acetyltransferase PCAF KAT2B 0.0138
2248 Malate synthase G glcB 0.0138
3190 Malate synthase G glcB 0.0138
4404 FcbC1 protein fcbC 0.0131
2371 Pantothenate kinase coaA 0.0131
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0125
551 Carnitine O-acetyltransferase CRAT 0.012
2596 Acetyl-CoA acetyltransferase phbA 0.0114
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0113
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0113
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0113
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0113
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0106
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.008
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