DT-Web

DB03615 - Ribostamycin


Identification
Name Ribostamycin
Accession Number DB03615 (EXPT02786)
Type small molecule
Description A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 454.4727
Groups experimental
Monoisotopic Weight 454.227493328
Pharmacology
Indication Not Available
Mechanism of action Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. However, their exact mechanism of action is not fully known.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aminoglycoside 6'-N-acetyltransferase
Name Aminoglycoside 6'-N-acetyltransferase
Gene Name aac(6')-Iy
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score Not Available
Aminoglycoside 2'-N-acetyltransferase
Name Aminoglycoside 2'-N-acetyltransferase
Gene Name aac
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score Not Available
Protein disulfide-isomerase
Name Protein disulfide-isomerase
Gene Name P4HB
Pharmacological action unknown
Actions Not Available
References
  • Horibe T, Nagai H, Sakakibara K, Hagiwara Y, Kikuchi M: Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72. - Pubmed
DTHybrid score 0.896
30S ribosomal protein S12
Name 30S ribosomal protein S12
Gene Name rpsL
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.599

Enzymes


Aminoglycoside 2'-N-acetyltransferase
Name Aminoglycoside 2'-N-acetyltransferase
Gene Name aac
Actions Not Available
References Not Available
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
6704 30S ribosomal protein S12 rpsL 1.599
3390 Aminoglycoside 3'-phosphotransferase aphA 0.1389
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.1389
6028 Kanamycin nucleotidyltransferase knt 0.1388
5682 Ribonuclease pancreatic RNASE1 0.1013
1162 C-X-C chemokine receptor type 4 CXCR4 0.0691
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0525
1729 Solute carrier family 22 member 6 SLC22A6 0.044
4579 Serine acetyltransferase cysE 0.0337
6807 Serine acetyltransferase cysE 0.0337
4576 Aac(6')-Ii protein aac(6')-Ii 0.0337
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0337
4564 YvbK protein yvbK 0.0337
2528 Fatty acid metabolism regulator protein fadR 0.0337
6740 Fatty acid metabolism regulator protein fadR 0.0337
4566 Acyl-CoA hydrolase BC_2038 0.0337
4572 Acyl-CoA hydrolase BH0798 0.0337
4037 Hypothetical protein GPX1 0.0337
4297 Hypothetical protein SP_1951 0.0337
4521 Hypothetical protein BC_2969 0.0337
4540 Hypothetical protein TM_1070 0.0337
4555 Hypothetical protein MT1739 0.0337
4569 Hypothetical protein mshD 0.0337
4578 Hypothetical protein PA3270 0.0337
4747 Hypothetical protein PA3967 0.0337
5177 Hypothetical protein TM_0096 0.0337
5194 Hypothetical protein PA1204 0.0337
5240 Hypothetical protein Rv2991 0.0337
5370 Hypothetical protein TM_1158 0.0337
5710 Hypothetical protein Tb927.5.1360 0.0337
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0336
3560 Gentamicin 3'-acetyltransferase aacC1 0.0293
3489 Acetyl-coenzyme A synthetase acs 0.0293
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0293
2396 Formyl-coenzyme A transferase frc 0.0293
3457 Formyl-coenzyme A transferase frc 0.0293
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0293
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0292
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0292
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0292
4563 Acetyl transferase rimL 0.0292
3729 Citrate synthase gltA 0.0292
4575 Citrate synthase cit 0.0292
4580 Citrate synthase gltA 0.0292
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0292
6208 30S ribosomal protein S13 rpsM 0.0281
6706 30S ribosomal protein S13 rpsM 0.0281
2560 Galactoside O-acetyltransferase lacA 0.0272
3199 Phosphopantetheine adenylyltransferase coaD 0.027
3543 Phosphopantetheine adenylyltransferase coaD 0.027
3567 Phosphopantetheine adenylyltransferase coaD 0.027
5289 Phosphopantetheine adenylyltransferase coaD 0.027
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.027
3178 Formate acetyltransferase 1 pflB 0.027
2285 Streptogramin A acetyltransferase vatD 0.0269
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0269
4573 Histone acetyltransferase PCAF KAT2B 0.0269
2248 Malate synthase G glcB 0.0269
3190 Malate synthase G glcB 0.0269
2371 Pantothenate kinase coaA 0.0258
4404 FcbC1 protein fcbC 0.0255
6209 30S ribosomal protein S19 rpsS 0.0245
6712 30S ribosomal protein S19 rpsS 0.0245
6726 30S ribosomal protein S19 rpsS 0.0245
6207 30S ribosomal protein S14 rpsN 0.0245
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0243
551 Carnitine O-acetyltransferase CRAT 0.0236
2596 Acetyl-CoA acetyltransferase phbA 0.0221
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.022
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.022
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.022
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.022
140 30S ribosomal protein S9 rpsI 0.0185
6719 30S ribosomal protein S9 rpsI 0.0185
6725 30S ribosomal protein S9 rpsI 0.0185
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0161
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0161
↑