DT-Web

DB02648 - (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium


Identification
Name (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium
Accession Number DB02648 (EXPT00038)
Type small molecule
Description Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 162.2068
Groups experimental
Monoisotopic Weight 162.113018383
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Carnitine O-acetyltransferase
Name Carnitine O-acetyltransferase
Gene Name CRAT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6696
Peroxisomal carnitine O-octanoyltransferase
Name Peroxisomal carnitine O-octanoyltransferase
Gene Name CROT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3051

Predictions


Id Partner name Gene Name Score
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0905
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0905
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0664
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0664
6168 Solute carrier family 22 member 16 SLC22A16 0.0654
4604 Liver carboxylesterase 1 CES1 0.0403
1757 Myeloperoxidase MPO 0.0375
3947 Xanthine dehydrogenase/oxidase XDH 0.0365
833 Organic cation/carnitine transporter 1 SLC22A4 0.0348
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0304
118 Organic cation/carnitine transporter 2 SLC22A5 0.0298
6142 Solute carrier family 22 member 8 SLC22A8 0.0284
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.015
4564 YvbK protein yvbK 0.015
4566 Acyl-CoA hydrolase BC_2038 0.015
4572 Acyl-CoA hydrolase BH0798 0.015
4576 Aac(6')-Ii protein aac(6')-Ii 0.015
4577 4'-phosphopantetheinyl transferase sfp sfp 0.015
2528 Fatty acid metabolism regulator protein fadR 0.015
6740 Fatty acid metabolism regulator protein fadR 0.015
4579 Serine acetyltransferase cysE 0.015
6807 Serine acetyltransferase cysE 0.015
4037 Hypothetical protein GPX1 0.015
4297 Hypothetical protein SP_1951 0.015
4521 Hypothetical protein BC_2969 0.015
4540 Hypothetical protein TM_1070 0.015
4555 Hypothetical protein MT1739 0.015
4569 Hypothetical protein mshD 0.015
4578 Hypothetical protein PA3270 0.015
4747 Hypothetical protein PA3967 0.015
5177 Hypothetical protein TM_0096 0.015
5194 Hypothetical protein PA1204 0.015
5240 Hypothetical protein Rv2991 0.015
5370 Hypothetical protein TM_1158 0.015
5710 Hypothetical protein Tb927.5.1360 0.015
3729 Citrate synthase gltA 0.0134
4575 Citrate synthase cit 0.0134
4580 Citrate synthase gltA 0.0134
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0133
4563 Acetyl transferase rimL 0.0132
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0132
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0132
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0132
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0131
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.013
2396 Formyl-coenzyme A transferase frc 0.013
3457 Formyl-coenzyme A transferase frc 0.013
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.013
3560 Gentamicin 3'-acetyltransferase aacC1 0.013
3489 Acetyl-coenzyme A synthetase acs 0.013
2248 Malate synthase G glcB 0.0123
3190 Malate synthase G glcB 0.0123
3178 Formate acetyltransferase 1 pflB 0.0122
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.012
3199 Phosphopantetheine adenylyltransferase coaD 0.012
3543 Phosphopantetheine adenylyltransferase coaD 0.012
3567 Phosphopantetheine adenylyltransferase coaD 0.012
5289 Phosphopantetheine adenylyltransferase coaD 0.012
2285 Streptogramin A acetyltransferase vatD 0.012
2560 Galactoside O-acetyltransferase lacA 0.012
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.012
4573 Histone acetyltransferase PCAF KAT2B 0.012
2371 Pantothenate kinase coaA 0.0118
4404 FcbC1 protein fcbC 0.0114
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0111
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0101
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0101
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0101
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0101
2596 Acetyl-CoA acetyltransferase phbA 0.01
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0095
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0076
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0076
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