DT-Web

DB04447 - 1,4-Dithiothreitol


Identification
Name 1,4-Dithiothreitol
Accession Number DB04447 (EXPT01291)
Type small molecule
Description A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 154.251
Groups experimental
Monoisotopic Weight 154.012220944
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Protease synthase and sporulation negative regulatory protein PAI 1
Name Protease synthase and sporulation negative regulatory protein PAI 1
Gene Name paiA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9172
Holo-[acyl-carrier-protein] synthase
Name Holo-[acyl-carrier-protein] synthase
Gene Name acpS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9176
Histidinol dehydrogenase
Name Histidinol dehydrogenase
Gene Name hisD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0369
Shikimate dehydrogenase
Name Shikimate dehydrogenase
Gene Name aroE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8877
Galectin-1
Name Galectin-1
Gene Name LGALS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Calcium/calmodulin-dependent protein kinase type II alpha chain
Name Calcium/calmodulin-dependent protein kinase type II alpha chain
Gene Name CAMK2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8073
50S ribosomal protein L27
Name 50S ribosomal protein L27
Gene Name rpmA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0047
Retinal dehydrogenase 1
Name Retinal dehydrogenase 1
Gene Name ALDH1A1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6046
Organic hydroperoxide resistance protein
Name Organic hydroperoxide resistance protein
Gene Name ohr
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.004
3-carboxy-cis,cis-muconate cycloisomerase
Name 3-carboxy-cis,cis-muconate cycloisomerase
Gene Name pcaB
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8857
Transient receptor potential cation channel subfamily M member 7
Name Transient receptor potential cation channel subfamily M member 7
Gene Name TRPM7
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Unsaturated glucuronyl hydrolase
Name Unsaturated glucuronyl hydrolase
Gene Name ugl
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0032
Molybdenum cofactor biosynthesis protein A
Name Molybdenum cofactor biosynthesis protein A
Gene Name moaA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0033
C protein alpha-antigen
Name C protein alpha-antigen
Gene Name bca
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0024
Peptide methionine sulfoxide reductase
Name Peptide methionine sulfoxide reductase
Gene Name MSRA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7837
Chaperone protein torD
Name Chaperone protein torD
Gene Name torD
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0036
Axin-1
Name Axin-1
Gene Name AXIN1
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0026
Peptidyl-prolyl cis-trans isomerase B
Name Peptidyl-prolyl cis-trans isomerase B
Gene Name PPIB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7502
Amylosucrase
Name Amylosucrase
Gene Name ams
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8502
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0254
Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name TPI1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.0561
Maleylacetoacetate isomerase
Name Maleylacetoacetate isomerase
Gene Name GSTZ1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7423
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Gene Name HMGCR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8339
Listeriolysin regulatory protein
Name Listeriolysin regulatory protein
Gene Name prfA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3548

Predictions


Id Partner name Gene Name Score
4381 Holo-[acyl-carrier-protein] synthase acpS 0.9176
2636 Shikimate dehydrogenase aroE 0.8877
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.8339
6580 Serine/threonine-protein kinase PCTAIRE-1 CDK16 0.354
3605 Thermonuclease nuc 0.308
3266 Histidyl-tRNA synthetase hisS 0.2446
3392 Histidyl-tRNA synthetase hisS 0.2446
2333 6,7-dimethyl-8-ribityllumazine synthase ribH 0.1489
2642 6,7-dimethyl-8-ribityllumazine synthase ribH 0.1489
3216 6,7-dimethyl-8-ribityllumazine synthase ribH 0.1489
2320 Thymidine kinase, cytosolic TK1 0.142
2914 Triosephosphate isomerase, glycosomal Not Available 0.103
3705 L-fuculose phosphate aldolase fucA 0.1016
896 Glutathione S-transferase Mu 1 GSTM1 0.0664
3596 Deoxynucleotide monophosphate kinase 1 0.0625
3069 Fructose-bisphosphate aldolase A ALDOA 0.059
2926 Bifunctional PGK/TIM [Includes: Phosphoglycerate kinase pgk/tpi 0.0587
2617 Nitric oxide synthase oxygenase nos 0.0577
2701 Nitric oxide synthase oxygenase nos 0.0577
2314 Triosephosphate isomerase TPI 0.0561
3417 Triosephosphate isomerase tpiA 0.0561
3443 Triosephosphate isomerase tpiA 0.0561
2795 Methionine aminopeptidase 2 METAP2 0.055
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.053
4566 Acyl-CoA hydrolase BC_2038 0.0514
4572 Acyl-CoA hydrolase BH0798 0.0514
4577 4'-phosphopantetheinyl transferase sfp sfp 0.0514
4576 Aac(6')-Ii protein aac(6')-Ii 0.0514
4564 YvbK protein yvbK 0.0514
4567 Putative acyl-CoA thioester hydrolase HI0827 HI_0827 0.0514
2528 Fatty acid metabolism regulator protein fadR 0.0514
6740 Fatty acid metabolism regulator protein fadR 0.0514
4579 Serine acetyltransferase cysE 0.0513
6807 Serine acetyltransferase cysE 0.0513
2262 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI 0.0508
317 Methionine-R-sulfoxide reductase SEPX1 0.0503
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0502
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0502
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0502
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0502
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0502
3467 Methylglyoxal synthase mgsA 0.0483
4818 Beta-lactamase CTX-M-27 blaCTX-M-27 0.0471
4816 Orange carotenoid-binding protein Not Available 0.0471
4748 Levansucrase sacB 0.0471
4810 Beta-glucosidase bgl3 0.0471
4817 Sucrose porin scrY 0.0471
4565 Aminoglycoside 6'-N-acetyltransferase aac(6')-Iy 0.0447
3024 Crotonobetainyl-CoA:carnitine CoA-transferase caiB 0.0447
4563 Acetyl transferase rimL 0.0447
3560 Gentamicin 3'-acetyltransferase aacC1 0.0447
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0447
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0447
3489 Acetyl-coenzyme A synthetase acs 0.0447
2396 Formyl-coenzyme A transferase frc 0.0447
3457 Formyl-coenzyme A transferase frc 0.0447
2257 Uridine phosphorylase udp 0.0447
5132 Uridine phosphorylase udp 0.0447
3367 GDP-mannose 6-dehydrogenase algD 0.0433
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.0417
3199 Phosphopantetheine adenylyltransferase coaD 0.0412
3543 Phosphopantetheine adenylyltransferase coaD 0.0412
3567 Phosphopantetheine adenylyltransferase coaD 0.0412
5289 Phosphopantetheine adenylyltransferase coaD 0.0412
2560 Galactoside O-acetyltransferase lacA 0.0412
2377 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Not Available 0.0412
2285 Streptogramin A acetyltransferase vatD 0.0412
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0412
4573 Histone acetyltransferase PCAF KAT2B 0.0412
3178 Formate acetyltransferase 1 pflB 0.0411
2248 Malate synthase G glcB 0.0411
3190 Malate synthase G glcB 0.0411
4814 Copper transport protein ATOX1 ATOX1 0.0411
4813 Heme oxygenase hmuO 0.041
5769 Heme oxygenase Not Available 0.041
4812 Extended-spectrum beta-lactamase CTX-M-14 blaCTX-M-14 0.041
2780 Septum formation protein Maf maf 0.041
2567 Thymidylate synthase thyX thyX 0.0409
2371 Pantothenate kinase coaA 0.0401
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0393
6151 Monocarboxylate transporter 10 SLC16A10 0.0391
4404 FcbC1 protein fcbC 0.0389
3419 Rhamnulose-1-phosphate aldolase rhaD 0.0389
3727 Tagatose-1,6-bisphosphate aldolase agaY kbaY 0.0389
3693 Fructose-bisphosphate aldolase class 2 fbaA 0.0389
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0386
569 Retinal dehydrogenase 2 ALDH1A2 0.0384
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0382
2376 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase dapD 0.0372
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0364
551 Carnitine O-acetyltransferase CRAT 0.0364
3586 Thymidylate synthase A thyA1 0.036
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0356
4090 Chromosome 14 open reading frame 149 C14orf149 0.0354
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0353
4082 Proline oxidase, mitochondrial PRODH 0.0353
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0353
797 Sodium-dependent proline transporter SLC6A7 0.0353
4604 Liver carboxylesterase 1 CES1 0.0351
2717 Folylpolyglutamate synthase fgs 0.0347
2596 Acetyl-CoA acetyltransferase phbA 0.0338
615 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0335
3138 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0335
4568 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0335
6370 3-oxoacyl-[acyl-carrier-protein] synthase 3 fabH 0.0335
840 Methionine synthase reductase, mitochondrial MTRR 0.0328
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
5682 Ribonuclease pancreatic RNASE1 0.0317
4388 Aminoglycoside 2'-N-acetyltransferase aac 0.0316
444 Alcohol dehydrogenase 1B ADH1B 0.0311
809 Methionine synthase MTR 0.0305
2935 Methionine synthase metH 0.0305
5328 Prostaglandin F synthase Tb11.02.2310 0.0302
3747 Cellulase B precursor celB 0.0299
4629 Beta-lactamase CTX-M-9a blaCTX-M-9a 0.0297
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0297
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0295
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0295
3822 Actin, alpha skeletal muscle ACTA1 0.0286
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0282
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0269
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0268
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0266
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0266
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0256
24 Thymidylate synthase TMP1 0.0254
359 Thymidylate synthase TYMS 0.0254
2729 Thymidylate synthase thyA 0.0254
5352 Thymidylate synthase THYA 0.0254
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0253
3917 Methylenetetrahydrofolate reductase MTHFR 0.0252
4272 POSSIBLE CELLULASE CELA1 celA1 0.0251
4680 Amicyanin mauC 0.0251
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0247
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0247
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0247
3116 Bacterioferritin bfr 0.0244
4906 Bacterioferritin bfr 0.0244
4965 Bacterioferritin bfr 0.0244
3709 Glycerol uptake facilitator protein glpF 0.0244
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0244
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0244
3238 Multidrug resistance protein mexA mexA 0.0244
3173 Enolase eno 0.0244
3393 TGF-beta receptor type-2 TGFBR2 0.0244
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0244
4757 Cytochrome P450 2C9 CYP2C9 0.0244
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0243
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0243
4118 Cytochrome P450 3A5 CYP3A5 0.0238
4924 Cytochrome P450 2C8 CYP2C8 0.0237
4692 A/G-specific adenine glycosylase mutY 0.0236
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0232
4681 Aminopeptidase Not Available 0.0231
2802 Endoglucanase G celCCG 0.023
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0225
646 Malate dehydrogenase, cytoplasmic MDH1 0.0224
332 Beta-lactamase blaZ 0.0223
2478 Beta-lactamase ampC 0.0223
2613 Beta-lactamase ampC 0.0223
2635 Beta-lactamase ampC 0.0223
2700 Beta-lactamase penP 0.0223
5445 Beta-lactamase blaB 0.0223
6019 Beta-lactamase SHV-7 0.0223
6701 Beta-lactamase cphA 0.0223
2852 DNA mismatch repair protein mutL mutL 0.0213
2904 Phosphatase yniC yniC 0.0212
904 Glutathione S-transferase P GSTP1 0.0206
6513 Urease subunit gamma ureA 0.0206
6512 Urease subunit beta ureB 0.0205
6511 Urease subunit alpha ureC 0.0205
6514 Probable rRNA methylase TTHA1387 0.0205
1588 Multidrug resistance protein 1 ABCB1 0.0202
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0199
6459 Glycodelin PAEP 0.0196
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0196
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0195
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0194
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0194
5322 Oxidoreductase ydhF ydhF 0.0194
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0194
3778 NAD(P) transhydrogenase subunit beta pntB 0.0194
5332 MtdA bifunctional protein mtdA 0.0194
4403 Protein iolS iolS 0.0194
5330 General stress protein 69 yhdN 0.0194
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0194
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0194
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0194
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0194
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0193
719 Retinoic acid receptor responder protein 1 RARRES1 0.0193
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0193
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0193
770 Retinoic acid-induced protein 3 GPRC5A 0.0193
4512 Cytochrome P450 3A4 CYP3A4 0.019
822 Aldose reductase AKR1B1 0.019
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0189
465 Calmodulin CALM1 0.0187
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0187
3221 Cytochrome c4 cc4 0.0185
3309 6-phosphofructokinase pfkA 0.0185
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0185
3192 Glucosamine-6-phosphate deaminase 1 nagB 0.0185
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0181
740 Argininosuccinate synthase ASS1 0.018
865 Argininosuccinate synthase ASS1 0.018
2680 Argininosuccinate synthase argG 0.018
3194 Argininosuccinate synthase argG 0.018
4032 Microsomal glutathione S-transferase 1 MGST1 0.0177
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0177
4034 Glutaredoxin-1 GLRX 0.0177
907 Glutathione peroxidase 2 GPX2 0.0177
4035 Glutathione S-transferase Mu 5 GSTM5 0.0177
903 Glutathione S-transferase A5 GSTA5 0.0177
911 Glutathione peroxidase 3 GPX3 0.0177
4037 Hypothetical protein GPX1 0.0177
4297 Hypothetical protein SP_1951 0.0177
4521 Hypothetical protein BC_2969 0.0177
4540 Hypothetical protein TM_1070 0.0177
4555 Hypothetical protein MT1739 0.0177
4569 Hypothetical protein mshD 0.0177
4578 Hypothetical protein PA3270 0.0177
4747 Hypothetical protein PA3967 0.0177
5177 Hypothetical protein TM_0096 0.0177
5194 Hypothetical protein PA1204 0.0177
5240 Hypothetical protein Rv2991 0.0177
5370 Hypothetical protein TM_1158 0.0177
5710 Hypothetical protein Tb927.5.1360 0.0177
1928 Leukotriene C4 synthase LTC4S 0.0177
4029 Microsomal glutathione S-transferase 3 MGST3 0.0177
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0177
4040 Glutathione peroxidase 7 GPX7 0.0177
4038 Glutathione peroxidase 4 GPX4 0.0177
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0177
906 Glutathione peroxidase 1 GPX1 0.0177
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0177
910 Epididymal secretory glutathione peroxidase GPX5 0.0177
4036 Glutathione peroxidase 6 GPX6 0.0177
900 Glutathione S-transferase A4 GSTA4 0.0177
4042 Glutathione transferase omega-2 GSTO2 0.0177
4033 S-formylglutathione hydrolase ESD 0.0176
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0176
4311 tRNA TRDMT1 0.0176
4325 tRNA trmD 0.0176
4328 tRNA trmD 0.0176
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0176
627 11-cis retinol dehydrogenase RDH5 0.0176
666 NADP-dependent malic enzyme ME1 0.0176
561 Retinol-binding protein II, cellular RBP2 0.0176
589 Retinoid-binding protein 7 RBP7 0.0176
753 Retinol-binding protein III, cellular RBP5 0.0176
1097 Lecithin retinol acyltransferase LRAT 0.0175
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0175
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0175
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0175
863 Cellular retinaldehyde-binding protein RLBP1 0.0175
800 Retinol dehydrogenase 12 RDH12 0.0175
4073 Retinol dehydrogenase 11 RDH11 0.0175
651 Retinol dehydrogenase 13 RDH13 0.0175
4074 Retinol dehydrogenase 14 RDH14 0.0175
4072 All-trans-retinol 13,14-reductase RETSAT 0.0175
282 Interphotoreceptor retinoid-binding protein RBP3 0.0175
6030 Cytochrome P450 2B6 CYP2B6 0.0174
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0173
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0173
6107 Cytochrome P450 3A7 CYP3A7 0.017
897 Glutathione S-transferase kappa 1 GSTK1 0.0169
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0169
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0169
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0169
5073 Ferredoxin--NADP reductase petH 0.0169
5076 Ferredoxin--NADP reductase fpr 0.0169
5119 Ferredoxin--NADP reductase petH 0.0169
5121 Ferredoxin--NADP reductase fpr 0.0169
4582 Putative pteridine reductase 2 ptr2 0.0169
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0169
3446 NADP-dependent alcohol dehydrogenase adh 0.0169
2286 Isocitrate dehydrogenase [NADP] icd 0.0169
2302 Isocitrate dehydrogenase [NADP] icd 0.0169
2771 Isocitrate dehydrogenase [NADP] icd 0.0169
989 L-xylulose reductase DCXR 0.0169
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0169
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0169
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0169
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0166
6316 ADP-ribosylation factor 1 ARF1 0.0166
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0165
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0165
898 Glutathione S-transferase A3 GSTA3 0.0164
3319 Hydroxyacylglutathione hydrolase HAGH 0.0164
714 Glutathione reductase, mitochondrial GSR 0.0159
84 Nuclear receptor 0B1 NR0B1 0.0156
6297 Prostaglandin reductase 1 PTGR1 0.0156
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0156
4531 Putative ketoacyl reductase actIII 0.0156
3062 Aspartate-semialdehyde dehydrogenase asd 0.0155
6024 Cytochrome P450 1A1 CYP1A1 0.0155
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0153
5591 Complement component C8 gamma chain C8G 0.0153
2838 Ribose-5-phosphate isomerase A rpiA 0.0153
2952 Ribose-5-phosphate isomerase A rpiA 0.0153
5595 Ribose-5-phosphate isomerase A rpiA 0.0153
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0153
2300 Lysozyme E 0.0153
3633 Lysozyme R 0.0153
5597 Lysozyme 17 0.0153
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0153
5582 Regulator of transcription; stringent starvation protein A sspA 0.0153
4695 UPF0124 protein yfiH yfiH 0.0153
5060 Intron-associated endonuclease 1 ITEVIR 0.0153
5590 N utilization substance protein B homolog nusB 0.0153
5593 Transferase Not Available 0.0153
5588 Cell division protein FtsY TM_0570 0.0153
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0153
5587 Iron(III)-binding periplasmic protein fbpA 0.0153
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0153
5600 Pyruvate decarboxylase pdc 0.0153
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0153
4238 50S ribosomal protein L4 rplD 0.0153
5578 50S ribosomal protein L4 rplD 0.0153
6173 50S ribosomal protein L4 rplD 0.0153
6219 50S ribosomal protein L4 rplD 0.0153
5581 Beta-fructosidase bfrA 0.0153
4375 Glutamine synthetase 1 glnA1 0.0153
5575 Short tail fiber protein 12 0.0153
5580 Hexon protein PII 0.0153
5574 Invasin YPTB1668 0.0153
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0151
52 Pyruvate kinase isozymes R/L PKLR 0.0149
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0149
2165 Glutathione S-transferase Mu 2 GSTM2 0.0149
6016 Cytochrome P450 2C19 CYP2C19 0.0148
2675 Pteridine reductase 1 PTR1 0.0147
1124 Sepiapterin reductase SPR 0.0147
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0147
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0147
331 Retinol-binding protein I, cellular RBP1 0.0144
654 Flavin reductase BLVRB 0.0144
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0141
901 Glutathione S-transferase Mu 4 GSTM4 0.014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.014
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0139
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0139
2159 Quinone oxidoreductase CRYZ 0.0137
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0137
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0136
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0136
899 Glutathione S-transferase Mu 3 GSTM3 0.0135
905 Glutathione transferase omega-1 GSTO1 0.0135
857 Malate dehydrogenase, mitochondrial MDH2 0.0135
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0135
4509 Acetoin(diacetyl) reductase budC 0.0134
4041 Microsomal glutathione S-transferase 2 MGST2 0.0134
4119 Cytochrome P450 2D6 CYP2D6 0.0134
5006 RNASE4 protein RNASE4 0.0133
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0133
4533 Glyoxalase family protein BC_1747 0.0133
3132 Tryptophan synthase alpha chain trpA 0.0133
6568 Tryptophan synthase alpha chain trpA 0.0133
4992 Cytochrome c peroxidase Not Available 0.0133
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0133
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0133
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0132
207 Glutathione synthetase GSS 0.0131
5269 Glutathione synthetase gshB 0.0131
345 Plasma retinol-binding protein RBP4 0.0131
2164 Multidrug resistance-associated protein 4 ABCC4 0.013
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0127
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0127
3668 Maltose-binding periplasmic protein precursor malE 0.0126
2555 Pol polyprotein pol 0.0125
3242 Pol polyprotein gag-pol 0.0125
3471 Pol polyprotein gag-pro-pol 0.0125
5256 Pol polyprotein pol 0.0125
6469 Pol polyprotein gag-pol 0.0125
6565 Pol polyprotein Not Available 0.0125
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0124
862 Multidrug resistance-associated protein 1 ABCC1 0.0124
2149 Angiogenin ANG 0.0123
3583 6-phosphogluconolactonase pgl 0.0123
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0123
2521 Cell division protein ftsZ ftsZ 0.0123
3301 Cell division protein ftsZ ftsZ 0.0123
2603 Beta-lactamase II blm 0.0123
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0123
468 Cytochrome P450 4A11 CYP4A11 0.0123
780 Retinoic acid receptor RXR-gamma RXRG 0.0122
1313 Lactoylglutathione lyase GLO1 0.0121
5934 Cytochrome P450 26A1 CYP26A1 0.0119
2697 Uridine-cytidine kinase 2 UCK2 0.0117
3486 Fumarate hydratase class II fumC 0.0116
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0116
2942 Sialidase nanH 0.0116
3546 Sialidase nedA 0.0116
2826 Glucose--fructose oxidoreductase gfo 0.0116
4031 Glutathione S-transferase A1 GSTA1 0.0115
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0111
6136 Multidrug resistance-associated protein 5 ABCC5 0.0109
88 Retinoic acid receptor RXR-beta RXRB 0.0109
365 Dihydrofolate reductase DHFR 0.0107
2381 Dihydrofolate reductase DFR1 0.0107
2833 Dihydrofolate reductase Not Available 0.0107
2931 Dihydrofolate reductase folA 0.0107
3544 Dihydrofolate reductase folA 0.0107
3682 Dihydrofolate reductase folA 0.0107
6642 Dihydrofolate reductase folA 0.0107
6756 Dihydrofolate reductase dfrA 0.0107
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0107
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0107
162 Retinoic acid receptor gamma-1 RARG 0.0107
1123 Eosinophil cationic protein RNASE3 0.0106
2452 Tryptophanyl-tRNA synthetase trpS 0.0105
5579 Carboxypeptidase B CPB1 0.0101
908 Glutathione S-transferase theta-1 GSTT1 0.01
3384 Macrophage migration inhibitory factor MIF 0.0099
76 Nitric-oxide synthase, brain NOS1 0.0098
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0098
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0098
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0096
5694 Transcription antiterminator licT licT 0.0096
3361 Serpin B5 SERPINB5 0.0096
411 Glycine N-methyltransferase GNMT 0.0094
3932 Glutathione S-transferase A2 GSTA2 0.0093
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0088
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0088
816 Biliverdin reductase A BLVRA 0.0088
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0088
4120 NADPH--cytochrome P450 reductase POR 0.0088
3689 Endoglucanase A celA 0.0086
5563 Galectin-2 LGALS2 0.0085
5411 Slt-IIvB stxB2e 0.0085
5046 Ecotin eco 0.0085
3009 Beta-glucanase Not Available 0.0085
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0085
5554 D-galactose-binding periplasmic protein mglB 0.0085
3741 D-galactose-binding periplasmic protein precursor mglB 0.0085
1875 Pulmonary surfactant-associated protein D SFTPD 0.0085
5562 Hexokinase Not Available 0.0085
3793 Aspartate ammonia-lyase aspA 0.0085
4670 Cellulase B celB 0.0085
5569 Endo-1,4-beta glucanase EngF engF 0.0085
5553 Endoglucanase E1 Acel_0614 0.0085
5559 Neopullulanase nplT 0.0085
5568 Endoglucanase C307 celC307 0.0085
4668 Laminarinase TM_0024 0.0085
4671 Endoglucanase C cenC 0.0085
3744 Endoglucanase SS precursor celS 0.0085
5570 Endoglucanase E-4 celD 0.0085
4667 BH0236 protein BH0236 0.0085
6106 Cytochrome P450 2C18 CYP2C18 0.0084
128 Adenine phosphoribosyltransferase APRT 0.0084
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0081
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0081
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0081
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0081
396 Alcohol dehydrogenase 4 ADH4 0.0081
597 Dihydropteridine reductase QDPR 0.008
363 NADP-dependent malic enzyme, mitochondrial ME3 0.008
328 Sorbitol dehydrogenase SORD 0.008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0077
56 Delta-aminolevulinic acid dehydratase ALAD 0.0077
2356 Delta-aminolevulinic acid dehydratase hemB 0.0077
3613 Delta-aminolevulinic acid dehydratase hemB 0.0077
3674 Delta-aminolevulinic acid dehydratase hemB 0.0077
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0076
1630 Integrin beta-2 ITGB2 0.0076
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0076
77 L-lactate dehydrogenase B chain LDHB 0.0076
12 Alcohol dehydrogenase class 3 ADH5 0.0076
1881 Hexokinase-1 HK1 0.0075
1503 Galectin-7 LGALS7 0.0074
1184 Interferon beta IFNB1 0.0074
5176 YtnJ moxC 0.0074
5416 Coat protein VP1 Not Available 0.0074
4622 Amylase Not Available 0.0074
5247 Endo-1,4-beta-xylanase Not Available 0.0074
5248 Endo-1,4-beta-xylanase xlnA 0.0074
5250 Endo-1,4-beta-xylanase xyl 0.0074
5498 Maltoporin lamB 0.0074
5561 Maltoporin lamB 0.0074
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0074
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0074
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0074
2705 Dimethyl sulfoxide reductase dmsA 0.0074
4669 Endo-1,4-beta-xylanase A xynA 0.0074
4715 Endo-1,4-beta-xylanase A xlnA 0.0074
5560 Endo-1,4-beta-xylanase A xynA 0.0074
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0074
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0073
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0073
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0073
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0073
4428 Redox-sensing transcriptional repressor rex rex 0.0073
4449 ADP-ribosyltransferase Not Available 0.0073
4423 Levodione reductase lvr 0.0073
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0073
4435 L-aspartate dehydrogenase nadX 0.0073
4443 Quinate/shikimate dehydrogenase ydiB 0.0073
4472 Glucose 1-dehydrogenase Not Available 0.0073
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0073
4502 Formate dehydrogenase Not Available 0.0073
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0073
2350 3-isopropylmalate dehydrogenase leuB 0.0073
3092 3-isopropylmalate dehydrogenase leuB 0.0073
3729 Citrate synthase gltA 0.0073
4575 Citrate synthase cit 0.0073
4580 Citrate synthase gltA 0.0073
4500 L-lactate dehydrogenase 2 ldh2 0.0073
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0073
4455 Glycerol dehydrogenase gldA 0.0073
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0073
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0073
4507 Alanine dehydrogenase ald 0.0073
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0073
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0073
3381 Alcohol dehydrogenase Not Available 0.0073
4508 Alcohol dehydrogenase adhA 0.0073
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0073
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0073
4418 AGR_L_3209p AGR_L_3209 0.0073
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0073
4497 Benzyl alcohol dehydrogenase xylB 0.0073
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0073
4414 Dehydrogenase TT_P0035 0.0073
4447 Hypothetical protein yhfP yhfP 0.0073
4451 Vip2Ac vip2Ac 0.0073
4467 Alpha-glucosidase, putative TM_0752 0.0073
4487 Transcriptional regulator nadR nadR 0.0073
473 L-lactate dehydrogenase A chain LDHA 0.0073
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0072
776 Bile salt export pump ABCB11 0.0072
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0071
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0071
5718 Cytochrome P450 2A6 CYP2A6 0.0069
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0069
4534 Cytohesin-2 CYTH2 0.0069
6013 Cytochrome P450 2E1 CYP2E1 0.0069
2683 Mono-ADP-ribosyltransferase C3 C3 0.0069
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0068
2606 Neopullulanase 2 tvaII 0.0068
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0068
2541 Neopullulanase 1 tvaI 0.0068
4819 Hydrolase Not Available 0.0068
5249 Hydrolase Not Available 0.0068
5436 Hydrolase Not Available 0.0068
3547 Enterotoxin type B entB 0.0068
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0068
2531 Alpha-amylase amyE 0.0068
2948 Alpha-amylase amy 0.0068
3169 Alpha-amylase Not Available 0.0068
3091 Maltodextrin phosphorylase malP 0.0068
2324 Botulinum neurotoxin type B botB 0.0068
251 Alcohol dehydrogenase 1A ADH1A 0.0065
587 Serum albumin ALB 0.0065
3225 Shiga toxin B-chain stxB 0.0065
4666 Fucose-binding lectin PA-IIL lecB 0.0065
3365 Beta-amylase spoII 0.0065
4830 Aldose 1-epimerase galM 0.0065
2372 Bifunctional tail protein 9 0.0065
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0063
1675 Glucokinase GCK 0.0062
4662 Glucokinase glk 0.0062
3030 Salivary alpha-amylase AMY1A 0.0062
6614 Lactase-like protein LCTL 0.0062
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0062
2508 Cyclomaltodextrin glucanotransferase cgt 0.0062
2523 Cyclomaltodextrin glucanotransferase cgt 0.0062
3207 Cyclomaltodextrin glucanotransferase amyA 0.0062
4486 Phenol 2-hydroxylase component B pheA2 0.006
4477 Dihydrolipoyl dehydrogenase lpdV 0.006
5077 Dihydrolipoyl dehydrogenase Not Available 0.006
5117 Dihydrolipoyl dehydrogenase lpd 0.006
4439 Ferredoxin reductase bphA4 0.006
4427 TDP-glucose-4,6-dehydratase desIV 0.006
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.006
3177 dTDP-glucose 4,6-dehydratase rfbB 0.006
4499 dTDP-glucose 4,6-dehydratase rmlB 0.006
2967 CDP-paratose 2-epimerase rfbE 0.006
4482 UDP-galactose 4-epimerase galE 0.006
4503 NADPH-flavin oxidoreductase frp 0.006
3081 3-dehydroquinate synthase aroB 0.006
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.006
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.006
2507 Diphtheria toxin Not Available 0.006
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.006
2591 Urocanate hydratase hutU 0.006
2393 Maltose-6'-phosphate glucosidase glvA 0.006
2538 6-phospho-beta-glucosidase bglT bglT 0.006
4450 Iota toxin component Ia Not Available 0.006
2424 L-lactate dehydrogenase ldh 0.006
2641 L-lactate dehydrogenase Not Available 0.006
4437 L-lactate dehydrogenase ldh 0.006
4442 L-lactate dehydrogenase ldh 0.006
126 D-lactate dehydrogenase dld 0.006
3545 D-lactate dehydrogenase Not Available 0.006
4510 D-lactate dehydrogenase ldhA 0.006
3615 Dihydrodipicolinate reductase dapB 0.006
3618 Dihydrodipicolinate reductase dapB 0.006
4462 Dihydrodipicolinate reductase dapB 0.006
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.006
4496 C-terminal-binding protein 1 CTBP1 0.006
4498 Ornithine cyclodeaminase PP3533 0.006
2336 2,3-diketo-L-gulonate reductase dlgD 0.006
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.006
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.006
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.006
2018 Deoxyhypusine synthase DHPS 0.006
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.006
2570 Tetanus toxin tetX 0.0059
6044 Serum paraoxonase/lactonase 3 PON3 0.0059
2592 Beta-galactosidase lacZ 0.0059
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0058
33 Cystine/glutamate transporter SLC7A11 0.0057
315 Arginase-1 ARG1 0.0057
2440 Endoglucanase F celCCF 0.0056
572 Integrin alpha-L ITGAL 0.0056
4476 Mannitol dehydrogenase mtlD 0.0055
2430 Chondroitinase B cslB 0.0055
4504 WbpP Not Available 0.0055
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0055
4440 NADH peroxidase npr 0.0054
4318 Siroheme synthase cysG 0.0054
4343 Alpha-glucosidase aglA 0.0054
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0054
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0054
517 Alcohol dehydrogenase 1C ADH1C 0.0053
63 Malate dehydrogenase mdh 0.0053
2329 Malate dehydrogenase mdh 0.0053
3445 Malate dehydrogenase mdh 0.0053
4420 Malate dehydrogenase mdh 0.0053
4438 Malate dehydrogenase mdh 0.0053
2245 Xylose isomerase xylA 0.0052
2253 Xylose isomerase xylA 0.0052
2260 Xylose isomerase xylA 0.0052
2431 Xylose isomerase xylA 0.0052
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0052
6141 Sodium/bile acid cotransporter SLC10A1 0.0052
2252 Endoglucanase 5A cel5A 0.0052
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0051
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0051
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0051
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0051
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0051
3070 Adenosylhomocysteinase AHCY 0.0051
4424 Adenosylhomocysteinase PFE1050w 0.0051
6278 Adenosylhomocysteinase ahcY 0.0051
327 Glutathione reductase gor 0.005
5110 Glutathione reductase GR2 0.005
4122 Histone deacetylase 2 HDAC2 0.005
2723 Cholera enterotoxin subunit B ctxB 0.005
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0049
10 Glycogen phosphorylase, liver form PYGL 0.0048
2427 Ferrichrome-iron receptor fhuA 0.0048
4513 Pancreatic alpha-amylase AMY2A 0.0047
4491 DNA ligase, NAD-dependent ligA 0.0046
2762 UDP-glucose 4-epimerase GALE 0.0045
3461 UDP-glucose 4-epimerase galE 0.0045
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0045
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0042
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
6220 Aryl hydrocarbon receptor AHR 0.0039
1152 Glycogen phosphorylase, muscle form PYGM 0.0039
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0037
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0037
738 Monocarboxylate transporter 1 SLC16A1 0.0037
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0033
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0033
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0033
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0033
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0033
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0033
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0033
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0033
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0033
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0033
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0033
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0033
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0033
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0032
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0032
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0032
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0032
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0032
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0032
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0032
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0032
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0032
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0032
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0032
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0032
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0032
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0032
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0032
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0032
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0032
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0032
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0032
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0032
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0032
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0032
729 GDP-L-fucose synthetase TSTA3 0.0032
3463 GDP-L-fucose synthetase fcl 0.0032
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0032
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0032
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0032
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0032
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0032
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0032
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0032
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0032
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0032
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0032
167 L-lactate dehydrogenase C chain LDHC 0.0032
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0032
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0032
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0032
206 3-keto-steroid reductase HSD17B7 0.0032
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0032
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0032
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0032
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0032
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0032
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0032
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0032
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0032
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0032
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0032
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0032
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0032
644 Heme oxygenase 2 HMOX2 0.0032
4982 Heme oxygenase 2 pbsA2 0.0032
107 C-4 methylsterol oxidase SC4MOL 0.0032
34 7-dehydrocholesterol reductase DHCR7 0.0032
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0032
3726 D-3-phosphoglycerate dehydrogenase serA 0.0032
4291 D-3-phosphoglycerate dehydrogenase serA 0.0032
711 UDP-glucose 6-dehydrogenase UGDH 0.0032
3672 UDP-glucose 6-dehydrogenase hasB 0.0032
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0032
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0032
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0032
643 Peroxisomal bifunctional enzyme EHHADH 0.0032
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0032
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0032
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0032
1024 Solute carrier family 22 member 11 SLC22A11 0.0031
6143 Solute carrier family 22 member 7 SLC22A7 0.0031
952 Dipeptidyl peptidase 4 DPP4 0.0029
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0027
6026 Alcohol dehydrogenase 6 ADH6 0.0027
626 Cysteine dioxygenase type 1 CDO1 0.0027
6142 Solute carrier family 22 member 8 SLC22A8 0.0027
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0027
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0027
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0027
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0027
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0027
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0027
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0026
13 Aminomethyltransferase, mitochondrial AMT 0.0026
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0025
1729 Solute carrier family 22 member 6 SLC22A6 0.0025
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0025
4200 Cytochrome P450 1A2 CYP1A2 0.0024
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0023
279 Tyrosinase TYR 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
810 Heme oxygenase 1 HMOX1 0.0022
3391 Heme oxygenase 1 pbsA1 0.0022
380 Cytochrome P450 17A1 CYP17A1 0.0021
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.002
6020 Aldehyde oxidase AOX1 0.0018
5288 Shikimate kinase aroK 0.0017
5287 Signaling protein Not Available 0.0017
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0017
5293 Shikimate kinase 2 aroL 0.0017
5304 UPF0166 protein TM_0021 TM_0021 0.0017
4346 Polynucleotide kinase pseT 0.0017
5292 Putative partitioning protein TT_C1605 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
5266 Activator of hgdC 0.0017
5259 Transcriptional regulator ntrC1 0.0017
6699 Transcriptional regulator Cgl2612 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
5264 DNA replication protein REP 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5284 Large T antigen Not Available 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
4106 Guanylate kinase GUK1 0.0013
4516 Guanylate kinase gmk 0.0013
4837 Cag-alfa cag-alfa 0.0013
413 Amidophosphoribosyltransferase PPAT 0.0013
2515 Amidophosphoribosyltransferase purF 0.0013
3714 Amidophosphoribosyltransferase purF 0.0013
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0013
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0013
5646 Galactokinase GALK1 0.0013
4838 PMS1 protein homolog 2 PMS2 0.0013
4839 DNA polymerase III subunit tau dnaX 0.0013
5302 TrwB trwB 0.0013
5265 FtsH ftsH 0.0013
5189 Trimethylamine dehydrogenase tmd 0.0013
4774 NTPase P4 Not Available 0.0013
6277 Heat shock cognate 71 kDa protein HSPA8 0.0013
2270 Dephospho-CoA kinase coaE 0.0013
2284 Adenylate kinase adk 0.0013
2296 Adenylate kinase adk 0.0013
2311 Adenylate kinase adk 0.0013
2312 Adenylate kinase Not Available 0.0013
3470 Hypothetical protein MG245 homolog MPN_348 0.0013
3175 Glutamate--cysteine ligase gshA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0013
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0013
340 Apoptotic protease-activating factor 1 APAF1 0.0012
5300 Antigen peptide transporter 1 TAP1 0.0012
2390 Nonsecretory ribonuclease RNASE2 0.0012
5312 Kinesin-like protein KIF1A KIF1A 0.0012
2922 Glycerol kinase glpK 0.0012
5271 Focal adhesion kinase 1 PTK2 0.0012
2282 Protein recA recA 0.0011
2315 Protein recA recA 0.0011
2332 Protein recA recA 0.0011
5263 Protein recA recA 0.0011
408 Riboflavin kinase RFK 0.0011
2615 Chemotaxis protein cheA cheA 0.0011
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0011
2892 Acetylglutamate kinase argB 0.0011
3550 Acetylglutamate kinase argB 0.0011
3669 Ribokinase rbsK 0.0011
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0011
825 Arsenical pump-driving ATPase ASNA1 0.0011
3435 Arsenical pump-driving ATPase arsA 0.0011
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.001
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.001
788 Creatine kinase M-type CKM 0.001
2727 S-adenosylmethionine synthetase metK 0.001
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.001
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.001
48 Pyridoxal kinase PDXK 0.0009
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0009
702 UMP-CMP kinase CMPK1 0.0009
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0009
2091 Endoplasmin HSP90B1 0.0009
6395 Myosin-14 MYH14 0.0009
2251 Thymidylate kinase tmk 0.0009
2254 Thymidylate kinase DTYMK 0.0009
3522 Thymidylate kinase tmk 0.0009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0008
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
509 Thymidine kinase TK 0.0008
570 Thymidine kinase TK 0.0008
2559 Thymidine kinase TK 0.0008
3430 Thymidine kinase tdk 0.0008
3518 Thymidine kinase TK 0.0008
5301 Thymidine kinase tdk 0.0008
5771 Thymidine kinase ORF36 0.0008
7009 Thymidine kinase ORF36 0.0008
5294 Nucleoside diphosphate kinase A NME1 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
4773 Deoxycytidine kinase DCK 0.0007
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0006
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