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Thymidylate synthase A


Partner ID 3586
Name Thymidylate synthase A
Synonyms 5611
Gene name thyA1
General function Nucleotide transport and metabolism
Specific function Provides the sole de novo source of dTMP for DNA biosynthesis
Gene sequence + ...

ATGACGCAATTCGATAAACAATACAATTCAATTATAAAGGATATTATCAATAATGGAATCTCAGACGAAGAGTTTGATGTAAGAACCAAGTGGGACTCAGATGGAACACCGGCACATACTCTAAGTGTAATCAGTAAGCAAATGAGATTCGACAACTCAGAGGTTCCGATTTTAACGACAAAAAAGGTTGCCTGGAAAACAGCCATTAAAGAGTTGCTCTGGATTTGGCAGCTGAAATCTAATGATGTTAATGATTTAAACATGATGGGCGTCCATATTTGGGATCAGTGGAAACAAGAAGACGGAACCATCGGACATGCATATGGATTTCAGCTGGGGAAGAAAAACAGAAGTCTAAATGGAGAAAAAGTGGATCAGGTAGACTATCTTCTTCATCAATTGAAGAACAATCCATCTTCACGCAGACACATTACAATGCTGTGGAATCCTGATGAATTAGACGCAATGGCCTTAACGCCATGTGTATACGAGACACAATGGTACGTTAAACATGGGAAACTCCACCTTGAGGTAAGAGCACGGAGCAATGATATGGCATTGGGAAATCCATTCAATGTATTCCAGTATAATGTGTTGCAGCGCATGATTGCTCAAGTGACTGGTTATGAGCTTGGTGAATATATCTTTAACATTGGGGATTGCCATGTGTACACACGTCATATAGACAATTTGAAAATTCAAATGGAAAGAGAACAGTTTGAAGCACCTGAACTATGGATCAATCCTGAAGTGAAAGATTTTTATGACTTTACCATTGATGATTTCAAGTTAATCAACTATAAACATGGGGACAAGCTTTTATTTGAGGTAGCGGTTTAA
Protein sequence + ...

MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
GO Classification
function
thymidylate synthase activity
catalytic activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
5,10-methylenetetrahydrofolate-dependent methyltransferase activity
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide metabolism
pyrimidine nucleotide metabolism
pyrimidine nucleotide biosynthesis
physiological process
pyrimidine nucleoside monophosphate biosynthesis
pyrimidine deoxyribonucleoside monophosphate biosynthesis
metabolism
dTMP biosynthesis
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB03761 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate

Associated as Prediction

Id Name
DB01643 Thymidine-5'-Phosphate
DB01903 5-Bromo-2'-Deoxyuridine-5'-Monophosphate
DB02031 (6s)-5,6,7,8-Tetrahydrofolate
DB02223 Ly231514 Tetra Glu
DB02256 2'-Deoxyuridine
DB02301 5,10-Methylene-6-Hydrofolic Acid
DB02467 S-Oxymethionine
DB02752 Tosyl-D-Proline
DB02899 N-Carboxymethionine
DB03038 LY341770
DB03147 Flavin-Adenine Dinucleotide
DB03157 N,O-Didansyl-L-Tyrosine
DB03274 2'-5'dideoxyuridine
DB03541 10-Propargyl-5,8-Dideazafolic Acid
DB03558 Sp-876
DB03685 Uridine-5'-Monophosphate
DB03761 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
DB03798 2'-Deoxycytidine-5'-Monophosphate
DB03800 2'-deoxyuridylic acid
DB03818 N-[Tosyl-D-Prolinyl]Amino-Ethanethiol
DB04447 1,4-Dithiothreitol
DB04457 2'-Deoxyguanosine-5'-Monophosphate
DB04503 Sp-722
DB04530 S,S-(2-Hydroxyethyl)Thiocysteine
DB04586 2-bromophenol
DB04696 4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN
DB06860 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione
DB07507 2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione
DB07511 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile
DB08131 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-3-METHYL-BUTYRIC ACID
DB08204 3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE
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