DT-Web

DB03685 - Uridine-5'-Monophosphate


Identification
Name Uridine-5'-Monophosphate
Accession Number DB03685 (EXPT03155)
Type small molecule
Description 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 324.1813
Groups experimental
Monoisotopic Weight 324.035866536
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ribosomal small subunit pseudouridine synthase A
Name Ribosomal small subunit pseudouridine synthase A
Gene Name rsuA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1231
Uridine-cytidine kinase-like 1
Name Uridine-cytidine kinase-like 1
Gene Name UCKL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Galactose-1-phosphate uridylyltransferase
Name Galactose-1-phosphate uridylyltransferase
Gene Name galT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.267
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0494
Glycosyltransferase 6 domain-containing protein 1
Name Glycosyltransferase 6 domain-containing protein 1
Gene Name GLT6D1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
U6 snRNA-associated Sm-like protein LSm6
Name U6 snRNA-associated Sm-like protein LSm6
Gene Name LSM6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Uracil phosphoribosyltransferase
Name Uracil phosphoribosyltransferase
Gene Name upp
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.115
Beta-1,4-galactosyltransferase 1
Name Beta-1,4-galactosyltransferase 1
Gene Name B4GALT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3117
Interferon-stimulated gene 20 kDa protein
Name Interferon-stimulated gene 20 kDa protein
Gene Name ISG20
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1119
Orotidine 5'-phosphate decarboxylase
Name Orotidine 5'-phosphate decarboxylase
Gene Name pyrF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase
Name PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase
Gene Name pyrR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2631
Uracil phosphoribosyltransferase
Name Uracil phosphoribosyltransferase
Gene Name upp
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.115
Bifunctional polymyxin resistance protein arnA
Name Bifunctional polymyxin resistance protein arnA
Gene Name arnA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1558

Predictions


Id Partner name Gene Name Score
2344 Ribosomal small subunit pseudouridine synthase A rsuA 1.1231
3056 Orotidine 5'-phosphate decarboxylase pyrF 1.1117
2865 Ribonuclease Not Available 0.3541
2762 UDP-glucose 4-epimerase GALE 0.3269
3461 UDP-glucose 4-epimerase galE 0.3269
3193 Serine hydroxymethyltransferase glyA 0.1955
3342 Serine hydroxymethyltransferase glyA 0.1955
2916 Chitobiase chb 0.1912
3082 Aminomethyltransferase gcvT 0.1702
5072 N,N-dimethylglycine oxidase dmg 0.1702
5258 Pyrimidine-nucleoside phosphorylase pdp 0.1631
3496 Uracil-DNA glycosylase UL2 0.163
3512 Uracil-DNA glycosylase ung 0.163
5257 Uracil-DNA glycosylase udg 0.163
6272 Uracil-DNA glycosylase UNG 0.163
5435 Deoxycytidylate 5-hydroxymethyltransferase 42 0.1243
914 Formimidoyltransferase-cyclodeaminase FTCD 0.1137
237 Histo-blood group ABO system transferase ABO 0.1119
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0995
2567 Thymidylate synthase thyX thyX 0.0705
2555 Pol polyprotein pol 0.0625
3242 Pol polyprotein gag-pol 0.0625
3471 Pol polyprotein gag-pro-pol 0.0625
5256 Pol polyprotein pol 0.0625
6469 Pol polyprotein gag-pol 0.0625
6565 Pol polyprotein Not Available 0.0625
3586 Thymidylate synthase A thyA1 0.0624
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.059
2717 Folylpolyglutamate synthase fgs 0.0587
2516 GMP reductase 1 GMPR 0.0545
2361 Response regulator pleD pleD 0.0544
3524 DNA beta-glucosyltransferase bgt 0.0513
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.0513
4482 UDP-galactose 4-epimerase galE 0.0513
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0513
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0513
24 Thymidylate synthase TMP1 0.0494
359 Thymidylate synthase TYMS 0.0494
2626 Thymidylate synthase thyA 0.0494
5352 Thymidylate synthase THYA 0.0494
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0475
4106 Guanylate kinase GUK1 0.0474
4516 Guanylate kinase gmk 0.0474
413 Amidophosphoribosyltransferase PPAT 0.0474
2515 Amidophosphoribosyltransferase purF 0.0474
3714 Amidophosphoribosyltransferase purF 0.0474
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0447
338 DNA polymerase UL30 0.0437
379 DNA polymerase UL54 0.0437
697 DNA polymerase ORF28 0.0437
2482 DNA polymerase 43 0.0437
4104 DNA polymerase BALF5 0.0437
3300 Xanthine phosphoribosyltransferase xpt 0.0413
3681 Xanthine phosphoribosyltransferase gpt 0.0413
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0385
702 UMP-CMP kinase CMPK1 0.0374
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0362
4013 Beta-1,4-galactosyltransferase 2 B4GALT2 0.0357
4011 Beta-1,4-galactosyltransferase 3 B4GALT3 0.035
4012 Beta-1,4-galactosyltransferase 4 B4GALT4 0.0349
4014 N-acetylglucosamine kinase NAGK 0.0345
434 Alpha-N-acetylglucosaminidase NAGLU 0.0345
4015 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase NAGPA 0.0345
121 N-acylglucosamine 2-epimerase RENBP 0.0344
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.031
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0273
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.026
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0235
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0235
4276 DNA polymerase III subunit epsilon dnaQ 0.0216
4275 PCZA361.16 Not Available 0.0216
1353 DNA topoisomerase 1 TOP1 0.0204
3552 DNA topoisomerase 1 topA 0.0204
2251 Thymidylate kinase tmk 0.018
2254 Thymidylate kinase DTYMK 0.018
3522 Thymidylate kinase tmk 0.018
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
509 Thymidine kinase TK 0.015
570 Thymidine kinase TK 0.015
2559 Thymidine kinase TK 0.015
3430 Thymidine kinase tdk 0.015
3518 Thymidine kinase TK 0.015
5301 Thymidine kinase tdk 0.015
5771 Thymidine kinase ORF36 0.015
7009 Thymidine kinase ORF36 0.015
5449 Hypothetical gliding protein mglB 0.0105
5443 UPF0189 protein ymdB ymdB 0.0105
332 Beta-lactamase blaZ 0.0105
2478 Beta-lactamase ampC 0.0105
2613 Beta-lactamase ampC 0.0105
2635 Beta-lactamase ampC 0.0105
2700 Beta-lactamase penP 0.0105
5445 Beta-lactamase blaB 0.0105
6019 Beta-lactamase SHV-7 0.0105
6701 Beta-lactamase cphA 0.0105
5439 33 kDa chaperonin hslO 0.0105
5448 Ribonuclease Z rnz 0.0105
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0105
5440 UPF0067 protein yebR yebR 0.0105
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0105
4705 Manganese catalase Not Available 0.0105
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0105
2720 Copper-containing nitrite reductase nirK 0.0105
5454 Internalin-A inlA 0.0105
4498 Ornithine cyclodeaminase PP3533 0.0095
3356 Diaminopimelate decarboxylase lysA 0.0092
5450 Prolyl endopeptidase Pep pep 0.0092
3274 Hydroxylamine reductase hcp 0.0092
4804 Hydroxylamine reductase hcp 0.0092
2714 Chorismate mutase aroH 0.0092
4611 Chorismate mutase aroG 0.0092
4771 Dissimilatory copper-containing nitrite reductase nir 0.0091
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0087
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0085
3399 Limonene-1,2-epoxide hydrolase limA 0.0085
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0084
5180 L(+)-mandelate dehydrogenase mdlB 0.008
3500 Putative family 31 glucosidase yicI yicI 0.008
597 Dihydropteridine reductase QDPR 0.0079
4608 Putative cytochrome P450 SCO1207 0.0077
4963 Putative cytochrome P450 SCO2884 0.0077
6254 Putative cytochrome P450 SCO6998 0.0077
1615 Chymase CMA1 0.0076
3480 Mannan endo-1,4-beta-mannosidase manA 0.0076
577 Argininosuccinate lyase ASL 0.0075
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0074
365 Dihydrofolate reductase DHFR 0.0071
2381 Dihydrofolate reductase DFR1 0.0071
2833 Dihydrofolate reductase Not Available 0.0071
2931 Dihydrofolate reductase folA 0.0071
3544 Dihydrofolate reductase folA 0.0071
3682 Dihydrofolate reductase folA 0.0071
6642 Dihydrofolate reductase folA 0.0071
6756 Dihydrofolate reductase dfrA 0.0071
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0057
904 Glutathione S-transferase P GSTP1 0.0049
474 Acetylcholinesterase ACHE 0.0042
3923 Cholinesterase BCHE 0.0034
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