DT-Web: DB03800

Identification
Name	2'-deoxyuridylic acid
Accession Number	DB03800 (EXPT03187)
Type	small molecule
Description	Not Available
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)
Molecular Weight	308.1819
Groups	experimental
Monoisotopic Weight	308.040951914
Pharmacology
Indication	Not Available
Mechanism of action	Not Available
Absorption	Not Available
Protein binding	Not Available
Biotransformation	Not Available
Route of elimination	Not Available
Toxicity	Not Available
Affected organisms	Not Available
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Thymidylate synthase
Name	Thymidylate synthase
Gene Name	THYA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9228
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Name	Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene Name	dut
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	Not Available
Thymidylate synthase
Name	Thymidylate synthase
Gene Name	thyA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9228
Thymidylate synthase
Name	Thymidylate synthase
Gene Name	thyA
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.9228
Thymidylate synthase
Name	Thymidylate synthase
Gene Name	TYMS
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.9228
Thymidylate synthase thyX
Name	Thymidylate synthase thyX
Gene Name	thyX
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.0558
Pol polyprotein
Name	Pol polyprotein
Gene Name	pol
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	1.2379
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Name	Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene Name	dut
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	Not Available

Id	Partner name	Gene Name	Score
3242	Pol polyprotein	gag-pol	1.2379
3471	Pol polyprotein	gag-pro-pol	1.2379
5256	Pol polyprotein	pol	1.2379
6469	Pol polyprotein	gag-pol	1.2379
6565	Pol polyprotein	Not Available	1.2379
24	Thymidylate synthase	TMP1	0.9228
2780	Septum formation protein Maf	maf	0.2667
2712	Deoxycytidine triphosphate deaminase	dcd	0.2666
3586	Thymidylate synthase A	thyA1	0.2389
5255	Deoxyuridine triphosphatase	Tcdut	0.225
6322	Periplasmic oligopeptide-binding protein	oppA	0.2029
2223	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	DUT	0.1963
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.1641
5435	Deoxycytidylate 5-hydroxymethyltransferase	42	0.1243
864	Gag-Pol polyprotein	gag-pol	0.0942
2237	Gag-Pol polyprotein	gag-pol	0.0942
2326	Gag-Pol polyprotein	gag-pol	0.0942
2451	Gag-Pol polyprotein	gag-pol	0.0942
2901	Gag-Pol polyprotein	gag-pol	0.0942
3165	Gag-Pol polyprotein	gag-pol	0.0942
3722	Gag-Pol polyprotein	gag-pol	0.0942
6306	Gag-Pol polyprotein	gag-pol	0.0942
6624	Gag-Pol polyprotein	gag-pol	0.0942
2717	Folylpolyglutamate synthase	fgs	0.0934
3639	Thymidine phosphorylase	deoA	0.0784
3936	Thymidine phosphorylase	TYMP	0.0784
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0745
3596	Deoxynucleotide monophosphate kinase	1	0.0625
2617	Nitric oxide synthase oxygenase	nos	0.0577
2701	Nitric oxide synthase oxygenase	nos	0.0577
2590	Galactose-1-phosphate uridylyltransferase	galT	0.047
2257	Uridine phosphorylase	udp	0.0447
5132	Uridine phosphorylase	udp	0.0447
365	Dihydrofolate reductase	DHFR	0.0441
2381	Dihydrofolate reductase	DFR1	0.0441
2833	Dihydrofolate reductase	Not Available	0.0441
2931	Dihydrofolate reductase	folA	0.0441
3544	Dihydrofolate reductase	folA	0.0441
3682	Dihydrofolate reductase	folA	0.0441
6642	Dihydrofolate reductase	folA	0.0441
6756	Dihydrofolate reductase	dfrA	0.0441
4275	PCZA361.16	Not Available	0.0343
4276	DNA polymerase III subunit epsilon	dnaQ	0.0343
3523	Spore coat polysaccharide biosynthesis protein spsA	spsA	0.0338
1353	DNA topoisomerase 1	TOP1	0.0318
3552	DNA topoisomerase 1	topA	0.0318
702	UMP-CMP kinase	CMPK1	0.0308
2608	UDP-N-acetylglucosamine 2-epimerase	wecB	0.0295
3408	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	B3GAT3	0.0295
2291	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	B3GAT1	0.0294
3524	DNA beta-glucosyltransferase	bgt	0.0294
4482	UDP-galactose 4-epimerase	galE	0.0294
2251	Thymidylate kinase	tmk	0.0278
2254	Thymidylate kinase	DTYMK	0.0278
3522	Thymidylate kinase	tmk	0.0278
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0276
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0276
2439	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]	otsA	0.0256
4680	Amicyanin	mauC	0.0251
3529	Interferon-stimulated gene 20 kDa protein	ISG20	0.0249
3575	Uracil phosphoribosyltransferase	upp	0.0249
3600	Uracil phosphoribosyltransferase	upp	0.0249
3056	Orotidine 5'-phosphate decarboxylase	pyrF	0.0249
3564	Orotidine 5'-phosphate decarboxylase	pyrF	0.0249
509	Thymidine kinase	TK	0.0234
570	Thymidine kinase	TK	0.0234
2559	Thymidine kinase	TK	0.0234
3430	Thymidine kinase	tdk	0.0234
3518	Thymidine kinase	TK	0.0234
5301	Thymidine kinase	tdk	0.0234
5771	Thymidine kinase	ORF36	0.0234
7009	Thymidine kinase	ORF36	0.0234
3611	Cytidine deaminase	cdd	0.0234
3707	Cytidine deaminase	cdd	0.0234
4211	Cytidine deaminase	CDA	0.0234
3747	Cellulase B precursor	celB	0.0231
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0231
4681	Aminopeptidase	Not Available	0.0231
2320	Thymidine kinase, cytosolic	TK1	0.0231
2762	UDP-glucose 4-epimerase	GALE	0.0229
3461	UDP-glucose 4-epimerase	galE	0.0229
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0222
2344	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0215
3706	Ribosomal small subunit pseudouridine synthase A	rsuA	0.0215
3257	Bifunctional polymyxin resistance protein arnA	arnA	0.0214
6513	Urease subunit gamma	ureA	0.0206
6512	Urease subunit beta	ureB	0.0205
6511	Urease subunit alpha	ureC	0.0205
6514	Probable rRNA methylase	TTHA1387	0.0205
237	Histo-blood group ABO system transferase	ABO	0.0203
2966	PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase	pyrR	0.0198
4773	Deoxycytidine kinase	DCK	0.0196
4272	POSSIBLE CELLULASE CELA1	celA1	0.0192
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0184
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.018
3361	Serpin B5	SERPINB5	0.018
5694	Transcription antiterminator licT	licT	0.018
2164	Multidrug resistance-associated protein 4	ABCC4	0.0172
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.0166
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.0165
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.0165
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0165
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0163
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.016
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0144
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0144
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0144
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0144
2286	Isocitrate dehydrogenase [NADP]	icd	0.0136
2302	Isocitrate dehydrogenase [NADP]	icd	0.0136
2771	Isocitrate dehydrogenase [NADP]	icd	0.0136
4757	Cytochrome P450 2C9	CYP2C9	0.0133
4534	Cytohesin-2	CYTH2	0.013
3668	Maltose-binding periplasmic protein precursor	malE	0.0126
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0125
1729	Solute carrier family 22 member 6	SLC22A6	0.0116
2592	Beta-galactosidase	lacZ	0.0112
1588	Multidrug resistance protein 1	ABCB1	0.0107
315	Arginase-1	ARG1	0.0106
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0106
4604	Liver carboxylesterase 1	CES1	0.0101
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0097
6148	Multidrug resistance-associated protein 7	ABCC10	0.0088
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0087
6171	Solute carrier family 28 member 3	SLC28A3	0.0085
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0085
4924	Cytochrome P450 2C8	CYP2C8	0.0083
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0081
3763	5,10-methylenetetrahydrofolate reductase	metF	0.007
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.007
5094	5,10-methylenetetrahydrofolate reductase	metF	0.007
5078	Amine oxidase, flavin-containing	PSPTO1126	0.007
5122	Mersacidin decarboxylase	mrsD	0.007
5115	FkbI	fkbI	0.007
5114	Putative acyl-CoA dehydrogenase	TT_C0779	0.007
526	Thioredoxin reductase	trxB	0.007
3767	Thioredoxin reductase	trxB	0.007
5095	Putidaredoxin reductase	camA	0.007
5097	PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA	lpdA	0.007
5102	4-cresol dehydrogenase [hydroxylating] flavoprotein subunit	pchF	0.007
5081	L-aspartate oxidase	nadB	0.007
5111	Phenylacetone monooxygenase	pamO	0.007
5109	Outer membrane protein p64k or PM-6	m-6	0.007
1329	Apoptosis-inducing factor 1, mitochondrial	AIFM1	0.007
5112	Benzoate 1,2-dioxygenase electron transfer component	benC	0.007
3133	UDP-galactopyranose mutase	glf	0.007
5099	UDP-galactopyranose mutase	glf	0.007
5083	Cryptochrome DASH	cry	0.007
5100	Gamma-aminobutyrate metabolism dehydratase/isomerase	abfD	0.007
5107	Alkyl hydroperoxide reductase subunit F	ahpF	0.007
5118	Alkyl hydroperoxide reductase subunit F	ahpF	0.007
1410	Oxidoreductase	HSD17B6	0.007
4725	Oxidoreductase	Not Available	0.007
5124	Oxidoreductase	Not Available	0.007
5669	50S ribosomal protein L27	rpmA	0.0065
5670	Organic hydroperoxide resistance protein	ohr	0.0065
5675	Chaperone protein torD	torD	0.0065
5672	Molybdenum cofactor biosynthesis protein A	moaA	0.0065
5410	Unsaturated glucuronyl hydrolase	ugl	0.0065
5676	Axin-1	AXIN1	0.0065
5673	C protein alpha-antigen	bca	0.0065
3594	Deoxyribodipyrimidine photo-lyase	phr	0.0061
5079	Deoxyribodipyrimidine photo-lyase	phrB	0.0061
5080	Deoxyribodipyrimidine photo-lyase	phr	0.0061
4486	Phenol 2-hydroxylase component B	pheA2	0.0061
4439	Ferredoxin reductase	bphA4	0.0061
667	Acyl-CoA dehydrogenase family member 8, mitochondrial	ACAD8	0.0061
3506	Glutaryl-CoA dehydrogenase, mitochondrial	GCDH	0.0061
5073	Ferredoxin--NADP reductase	petH	0.0061
5076	Ferredoxin--NADP reductase	fpr	0.0061
5119	Ferredoxin--NADP reductase	petH	0.0061
5121	Ferredoxin--NADP reductase	fpr	0.0061
2526	NADPH-ferredoxin reductase fprA	fprA	0.0061
3247	2-oxopropyl-CoM reductase, carboxylating	xecC	0.0061
2268	Cholesterol oxidase	choB	0.0061
2822	Cholesterol oxidase	choA	0.0061
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0061
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0061
5117	Dihydrolipoyl dehydrogenase	lpd	0.0061
5075	Sulfite reductase [NADPH] flavoprotein alpha-component	cysJ	0.0061
2470	Pyruvate oxidase	pox5	0.0061
5091	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0061
5093	UDP-N-acetylenolpyruvoylglucosamine reductase	murB	0.0061
6639	Peroxisomal acyl-coenzyme A oxidase 1	ACOX1	0.0061
5003	Acyl-CoA dehydrogenase, short-chain specific	Not Available	0.0061
440	Isovaleryl-CoA dehydrogenase, mitochondrial	IVD	0.0061
5072	N,N-dimethylglycine oxidase	dmg	0.0061
4226	Uridine phosphorylase 2	UPP2	0.0061
3917	Methylenetetrahydrofolate reductase	MTHFR	0.006
4225	Uridine phosphorylase 1	UPP1	0.0059
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0057
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0057
3125	Protease synthase and sporulation negative regulatory protein PAI 1	paiA	0.0057
2636	Shikimate dehydrogenase	aroE	0.0057
3515	Shikimate dehydrogenase	aroE	0.0057
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0057
4440	NADH peroxidase	npr	0.0056
2893	Glycine oxidase	thiO	0.0056
3102	Flavohemoprotein	hmp	0.0056
4969	Flavohemoprotein	hmp	0.0056
3185	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADM	0.0056
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0056
2823	Trypanothione reductase	TPR	0.0053
3573	2,4-dienoyl-CoA reductase [NADPH]	fadH	0.0053
2280	Listeriolysin regulatory protein	prfA	0.0052
4811	Amylosucrase	ams	0.0052
6579	Calcium/calmodulin-dependent protein kinase type II alpha chain	CAMK2A	0.0052
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0052
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0051
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0051
2769	P-hydroxybenzoate hydroxylase	pobA	0.0051
2809	P-hydroxybenzoate hydroxylase	pobA	0.0051
413	Amidophosphoribosyltransferase	PPAT	0.0051
2515	Amidophosphoribosyltransferase	purF	0.0051
3714	Amidophosphoribosyltransferase	purF	0.0051
4512	Cytochrome P450 3A4	CYP3A4	0.005
3191	Histidinol dehydrogenase	hisD	0.0049
126	D-lactate dehydrogenase	dld	0.0049
3545	D-lactate dehydrogenase	Not Available	0.0049
4510	D-lactate dehydrogenase	ldhA	0.0049
2380	Monomeric sarcosine oxidase	soxA	0.0049
327	Glutathione reductase	gor	0.0049
5110	Glutathione reductase	GR2	0.0049
605	Fumarate reductase flavoprotein subunit	frdA	0.0048
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0048
3673	Fumarate reductase flavoprotein subunit	fccA	0.0048
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0048
6549	Fumarate reductase flavoprotein subunit	frdA	0.0048
191	Peptide methionine sulfoxide reductase	MSRA	0.0047
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0047
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0047
6645	D-amino-acid oxidase	DAO	0.0046
909	Maleylacetoacetate isomerase	GSTZ1	0.0046
6143	Solute carrier family 22 member 7	SLC22A7	0.0045
2314	Triosephosphate isomerase	TPI	0.004
3417	Triosephosphate isomerase	tpiA	0.004
3443	Triosephosphate isomerase	tpiA	0.004
6346	Triosephosphate isomerase	TPI1	0.004
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.004
714	Glutathione reductase, mitochondrial	GSR	0.0037
5818	Folate receptor alpha	FOLR1	0.0037
611	Retinal dehydrogenase 1	ALDH1A1	0.0036
587	Serum albumin	ALB	0.0036
76	Nitric-oxide synthase, brain	NOS1	0.0035
6136	Multidrug resistance-associated protein 5	ABCC5	0.0033
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0033
293	Gamma-glutamyl hydrolase	GGH	0.0032
4120	NADPH--cytochrome P450 reductase	POR	0.0031
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.003
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.003
1650	Heme carrier protein 1	SLC46A1	0.0029
3939	Amine oxidase [flavin-containing] B	MAOB	0.0027
3947	Xanthine dehydrogenase/oxidase	XDH	0.0026
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0025
5718	Cytochrome P450 2A6	CYP2A6	0.0025
3941	Amine oxidase [flavin-containing] A	MAOA	0.0024
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0023
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0023
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0022
6020	Aldehyde oxidase	AOX1	0.0021
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.002
738	Monocarboxylate transporter 1	SLC16A1	0.002
4200	Cytochrome P450 1A2	CYP1A2	0.002
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0018
1024	Solute carrier family 22 member 11	SLC22A11	0.0017
862	Multidrug resistance-associated protein 1	ABCC1	0.0016
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0016
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0015
6142	Solute carrier family 22 member 8	SLC22A8	0.0015

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB03800 - 2'-deoxyuridylic acid

Targets

Predictions