DT-Web

DB03761 - 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate


Identification
Name 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
Accession Number DB03761 (EXPT03176)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 326.1723
Groups experimental
Monoisotopic Weight 326.031530087
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidylate synthase A
Name Thymidylate synthase A
Gene Name thyA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7389
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1075
Thymidylate synthase
Name Thymidylate synthase
Gene Name thyA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1075
Thymidylate synthase thyX
Name Thymidylate synthase thyX
Gene Name thyX
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1279

Predictions


Id Partner name Gene Name Score
5435 Deoxycytidylate 5-hydroxymethyltransferase 42 0.1243
24 Thymidylate synthase TMP1 0.1075
359 Thymidylate synthase TYMS 0.1075
5352 Thymidylate synthase THYA 0.1075
2717 Folylpolyglutamate synthase fgs 0.0934
2410 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0905
2490 Deoxyuridine 5'-triphosphate nucleotidohydrolase dut 0.0905
2555 Pol polyprotein pol 0.083
3242 Pol polyprotein gag-pol 0.083
3471 Pol polyprotein gag-pro-pol 0.083
5256 Pol polyprotein pol 0.083
6469 Pol polyprotein gag-pol 0.083
6565 Pol polyprotein Not Available 0.083
3596 Deoxynucleotide monophosphate kinase 1 0.0625
2617 Nitric oxide synthase oxygenase nos 0.0577
2701 Nitric oxide synthase oxygenase nos 0.0577
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0451
2257 Uridine phosphorylase udp 0.0447
5132 Uridine phosphorylase udp 0.0447
4680 Amicyanin mauC 0.0251
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0249
3575 Uracil phosphoribosyltransferase upp 0.0249
3600 Uracil phosphoribosyltransferase upp 0.0249
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0249
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0249
3747 Cellulase B precursor celB 0.0231
4681 Aminopeptidase Not Available 0.0231
4276 DNA polymerase III subunit epsilon dnaQ 0.0216
4275 PCZA361.16 Not Available 0.0216
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0215
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0215
3257 Bifunctional polymyxin resistance protein arnA arnA 0.0214
6513 Urease subunit gamma ureA 0.0206
6512 Urease subunit beta ureB 0.0205
6511 Urease subunit alpha ureC 0.0205
6514 Probable rRNA methylase TTHA1387 0.0205
1353 DNA topoisomerase 1 TOP1 0.0204
3552 DNA topoisomerase 1 topA 0.0204
2590 Galactose-1-phosphate uridylyltransferase galT 0.0199
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0198
4272 POSSIBLE CELLULASE CELA1 celA1 0.0192
2251 Thymidylate kinase tmk 0.018
2254 Thymidylate kinase DTYMK 0.018
3522 Thymidylate kinase tmk 0.018
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0179
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0166
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0165
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0165
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.016
509 Thymidine kinase TK 0.015
570 Thymidine kinase TK 0.015
2559 Thymidine kinase TK 0.015
3430 Thymidine kinase tdk 0.015
3518 Thymidine kinase TK 0.015
5301 Thymidine kinase tdk 0.015
5771 Thymidine kinase ORF36 0.015
7009 Thymidine kinase ORF36 0.015
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0096
5694 Transcription antiterminator licT licT 0.0096
3361 Serpin B5 SERPINB5 0.0096
56 Delta-aminolevulinic acid dehydratase ALAD 0.0077
2356 Delta-aminolevulinic acid dehydratase hemB 0.0077
3613 Delta-aminolevulinic acid dehydratase hemB 0.0077
3674 Delta-aminolevulinic acid dehydratase hemB 0.0077
2286 Isocitrate dehydrogenase [NADP] icd 0.0073
2302 Isocitrate dehydrogenase [NADP] icd 0.0073
2771 Isocitrate dehydrogenase [NADP] icd 0.0073
3763 5,10-methylenetetrahydrofolate reductase metF 0.007
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.007
5094 5,10-methylenetetrahydrofolate reductase metF 0.007
5078 Amine oxidase, flavin-containing PSPTO1126 0.007
5122 Mersacidin decarboxylase mrsD 0.007
5115 FkbI fkbI 0.007
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.007
526 Thioredoxin reductase trxB 0.007
3767 Thioredoxin reductase trxB 0.007
5095 Putidaredoxin reductase camA 0.007
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.007
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.007
5081 L-aspartate oxidase nadB 0.007
5111 Phenylacetone monooxygenase pamO 0.007
5109 Outer membrane protein p64k or PM-6 m-6 0.007
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.007
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.007
3133 UDP-galactopyranose mutase glf 0.007
5099 UDP-galactopyranose mutase glf 0.007
5083 Cryptochrome DASH cry 0.007
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.007
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.007
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.007
1410 Oxidoreductase HSD17B6 0.007
4725 Oxidoreductase Not Available 0.007
5124 Oxidoreductase Not Available 0.007
4534 Cytohesin-2 CYTH2 0.0069
3668 Maltose-binding periplasmic protein precursor malE 0.0067
5669 50S ribosomal protein L27 rpmA 0.0065
5670 Organic hydroperoxide resistance protein ohr 0.0065
5675 Chaperone protein torD torD 0.0065
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0065
5410 Unsaturated glucuronyl hydrolase ugl 0.0065
5676 Axin-1 AXIN1 0.0065
5673 C protein alpha-antigen bca 0.0065
3594 Deoxyribodipyrimidine photo-lyase phr 0.0061
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0061
5080 Deoxyribodipyrimidine photo-lyase phr 0.0061
4486 Phenol 2-hydroxylase component B pheA2 0.0061
4439 Ferredoxin reductase bphA4 0.0061
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0061
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0061
5073 Ferredoxin--NADP reductase petH 0.0061
5076 Ferredoxin--NADP reductase fpr 0.0061
5119 Ferredoxin--NADP reductase petH 0.0061
5121 Ferredoxin--NADP reductase fpr 0.0061
2526 NADPH-ferredoxin reductase fprA fprA 0.0061
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0061
2268 Cholesterol oxidase choB 0.0061
2822 Cholesterol oxidase choA 0.0061
4477 Dihydrolipoyl dehydrogenase lpdV 0.0061
5077 Dihydrolipoyl dehydrogenase Not Available 0.0061
5117 Dihydrolipoyl dehydrogenase lpd 0.0061
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0061
2470 Pyruvate oxidase pox5 0.0061
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0061
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0061
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0061
5072 N,N-dimethylglycine oxidase dmg 0.0061
2592 Beta-galactosidase lacZ 0.0059
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0057
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0057
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0057
2636 Shikimate dehydrogenase aroE 0.0057
3515 Shikimate dehydrogenase aroE 0.0057
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0057
315 Arginase-1 ARG1 0.0057
4440 NADH peroxidase npr 0.0056
2893 Glycine oxidase thiO 0.0056
3102 Flavohemoprotein hmp 0.0056
4969 Flavohemoprotein hmp 0.0056
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0056
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0056
2823 Trypanothione reductase TPR 0.0053
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0053
2280 Listeriolysin regulatory protein prfA 0.0052
4811 Amylosucrase ams 0.0052
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0052
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0052
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0052
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0051
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0051
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0051
2769 P-hydroxybenzoate hydroxylase pobA 0.0051
2809 P-hydroxybenzoate hydroxylase pobA 0.0051
3191 Histidinol dehydrogenase hisD 0.0049
126 D-lactate dehydrogenase dld 0.0049
3545 D-lactate dehydrogenase Not Available 0.0049
4510 D-lactate dehydrogenase ldhA 0.0049
2380 Monomeric sarcosine oxidase soxA 0.0049
327 Glutathione reductase gor 0.0049
5110 Glutathione reductase GR2 0.0049
605 Fumarate reductase flavoprotein subunit frdA 0.0048
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0048
3673 Fumarate reductase flavoprotein subunit fccA 0.0048
4912 Fumarate reductase flavoprotein subunit ifcA 0.0048
6549 Fumarate reductase flavoprotein subunit frdA 0.0048
191 Peptide methionine sulfoxide reductase MSRA 0.0047
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0047
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0047
6645 D-amino-acid oxidase DAO 0.0046
909 Maleylacetoacetate isomerase GSTZ1 0.0046
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0045
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
2314 Triosephosphate isomerase TPI 0.004
3417 Triosephosphate isomerase tpiA 0.004
3443 Triosephosphate isomerase tpiA 0.004
6346 Triosephosphate isomerase TPI1 0.004
714 Glutathione reductase, mitochondrial GSR 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
76 Nitric-oxide synthase, brain NOS1 0.0035
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
4120 NADPH--cytochrome P450 reductase POR 0.0031
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
3939 Amine oxidase [flavin-containing] B MAOB 0.0027
3947 Xanthine dehydrogenase/oxidase XDH 0.0026
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
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