Partner ID 2935
Name Methionine synthase
Synonyms 2377
Gene name metH
General function Amino acid transport and metabolism
Specific function Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate
Gene sequence + ...

GTGAGCAGCAAAGTGGAACAACTGCGTGCGCAGTTAAATGAACGTATTCTGGTGCTGGACGGCGGTATGGGCACCATGATCCAGAGTTATCGACTGAACGAAGCCGATTTTCGTGGTGAACGCTTTGCCGACTGGCCATGCGACCTCAAAGGCAACAACGACCTGCTGGTACTCAGTAAACCGGAAGTGATCGCCGCTATCCACAACGCCTACTTTGAAGCGGGCGCGGATATCATCGAAACCAACACCTTCAACTCCACGACCATTGCGATGGCGGATTACCAGATGGAATCCCTGTCGGCGGAAATCAACTTTGCGGCGGCGAAACTGGCGCGACGTTGTGCTGACGAGTGGACCGCGCGCACGCCAGAGAAACCGCGCTACGTTGCCGGTGTTCTCGGCCCGACCAACCGCACGGCGTCTATTTCTCCGGACGTCAACGATCCGGCATTTCGTAATATCACTTTTGACGGGCTGGTGGCGGCTTATCGAGAGTCCACCAAAGCGCTGGTGGAAGGTGGCGCGGATCTGATCCTGATTGAAACCGTTTTCGACACCCTTAACGCCAAAGCGGCGGTATTTGCGGTGAAAACGGAGTTTGAAGCGCTGGGCGTTGAGCTGCCGATTATGATCTCCGGCACCATCACCGACGCCTCCGGGCGCACGCTCTCCGGGCAGACCACCGAAGCATTTTACAACTCATTGCGCCACGCCGAAGCTCTGACCTTTGGCCTGAACTGTGCGCTGGGGCCCGATGAACTGCGCCAGTACGTGCAGGAGCTGTCACGGATTGCGGAATGCTACGTCACCGCGCACCCGAACGCCGGGCTACCCAACGCCTTTGGTGAGTACGATCTCGACGCCGACACGATGGCAAAACAGATACGTGAATGGGCGCAAGCGGGTTTTCTCAATATCGTCGGCGGCTGCTGTGGCACCACGCCACAACATATTGCAGCGATGAGTCGTGCAGTAGAAGGATTAGCGCCGCGCAAACTGCCGGAAATTCCCGTAGCCTGCCGTTTGTCCGGCCTGGAGCCGCTGAACATTGGCGAAGATAGCCTGTTTGTGAACGTGGGTGAACGCACCAACGTCACCGGTTCCGCTAAGTTCAAGCGCCTGATCAAAGAAGAGAAATACAGCGAGGCGCTGGATGTCGCGCGTCAACAGGTGGAAAACGGCGCGCAGATTATCGATATCAACATGGATGAAGGGATGCTCGATGCCGAAGCGGCGATGGTGCGTTTTCTCAATCTGATTGCCGGTGAACCGGATATCGCTCGCGTGCCGATTATGATCGACTCCTCAAAATGGGACGTCATTGAAAAAGGTCTGAAGTGTATCCAGGGCAAAGGCATTGTTAACTCTATCTCGATGAAAGAGGGCGTCGATGCCTTTATCCATCACGCGAAATTGTTGCGTCGCTACGGTGCGGCAGTGGTGGTAATGGCCTTTGACGAACAGGGACAGGCCGATACTCGCGCACGGAAAATCGAGATTTGCCGTCGGGCGTACAAAATCCTCACCGAAGAGGTTGGCTTCCCGCCAGAAGATATCATCTTCGACCCAAACATCTTCGCGGTCGCAACTGGCATTGAAGAGCACAACAACTACGCGCAGGACTTTATCGGCGCGTGTGAAGACATCAAACGCGAACTGCCGCACGCGCTGATTTCCGGCGGCGTATCTAACGTTTCTTTCTCGTTCCGTGGCAACGATCCGGTGCGCGAAGCCATTCACGCAGTGTTCCTCTACTACGCTATTCGCAATGGCATGGATATGGGGATCGTCAACGCCGGGCAACTGGCGATTTACGACGACCTACCCGCTGAACTGCGCGACGCGGTGGAAGATGTGATTCTTAATCGTCGCGACGATGGCACCGAGCGTTTACTGGAGCTTGCCGAGAAATATCGCGGCACGAAAACCGACGACACCGCCAACGCCCAGCAGGCGGAGTGGCGCTCGTGGGAAGTGAATAAACGTCTGGAATACTCGCTGGTCAAAGGCATTACCGAGTTTATCGAGCAGGATACCGAAGAAGCCCGCCAGCAGGCTACGCGCCCGATTGAAGTGATTGAAGGCCCGTTGATGGACGGCATGAATGTGGTCGGCGACCTGTTTGGCGAAGGGAAAATGTTCCTGCCACAGGTGGTCAAATCGGCGCGCGTCATGAAACAGGCGGTGGCCTACCTCGAACCGTTTATTGAAGCCAGCAAAGAGCAGGGCAAAACCAACGGCAAGATGGTGATCGCCACCGTGAAGGGCGACGTCCACGACATCGGTAAAAATATCGTTGGTGTGGTGCTGCAATGTAACAACTACGAAATTGTCGATCTCGGCGTTATGGTGCCTGCGGAAAAAATTCTCCGTACCGCTAAAGAAGTGAATGCTGATCTGATTGGCCTTTCGGGGCTTATCACGCCGTCGCTGGACGAGATGGTTAACGTGGCGAAAGAGATGGAGCGTCAGGGCTTCACTATTCCGTTACTGATTGGCGGCGCGACGACCTCAAAAGCGCACACGGCGGTGAAAATCGAGCAGAACTACAGCGGCCCGACGGTGTATGTGCAGAATGCCTCGCGTACCGTTGGTGTGGTGGCGGCGCTGCTTTCCGATACCCAGCGTGATGATTTTGTCGCTCGTACCCGCAAGGAGTACGAAACCGTACGTATTCAGCACGGGCGCAAGAAACCGCGCACACCACCGGTCACGCTGGAAGCGGCGCGCGATAACGATTTCGCTTTTGACTGGCAGGCTTACACGCCGCCGGTGGCGCACCGTCTCGGCGTGCAGGAAGTCGAAGCCAGCATCGAAACGCTGCGTAATTACATCGACTGGACACCGTTCTTTATGACCTGGTCGCTGGCCGGGAAGTATCCGCGCATTCTGGAAGATGAAGTGGTGGGCGTTGAGGCGCAGCGGCTGTTTAAAGACGCCAACGACATGCTGGATAAATTAAGCGCCGAGAAAACGCTGAATCCGCGTGGCGTGGTGGGCCTGTTCCCGGCAAACCGTGTGGGCGATGACATTGAAATCTACCGTGACGAAACGCGTACCCATGTGATCAACGTCAGCCACCATCTGCGTCAACAGACCGAAAAAACAGGCTTCGCTAACTACTGTCTCGCTGACTTCGTTGCGCCGAAGCTTTCTGGTAAAGCAGATTACATCGGCGCATTTGCCGTGACTGGCGGGCTGGAAGAGGACGCACTGGCTGATGCCTTTGAAGCGCACGACGATGATTACAACAAAATCATGGTGAAAGCGCTTGCCGACCGTTTAGCCGAAGCCTTTGCGGAGTATCTCCATGAGCGTGTGCGTAAAGTCTACTGGGGCTATGCGCCGAACGAGAACCTCAGCAACGAAGAGCTGATCCGCGAAAACTACCAGGGCATCCGTCCGGCACCGGGCTATCCGGCCTGCCCGGAACATACGGAAAAAGCCACCATCTGGGAGCTGCTGGAAGTGGAAAAACACACTGGCATGAAACTCACAGAATCTTTCGCCATGTGGCCCGGTGCATCGGTTTCGGGTTGGTACTTCAGCCACCCGGACAGCAAGTACTACGCTGTAGCACAAACTTCAGCGCGATCAGGTTGA

Protein sequence + ...

MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQAGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDAD

GO Classification
component
cell
intracellular
function
dihydropteroate synthase activity
homocysteine S-methyltransferase activity
transferase activity
cobalamin binding
transferase activity, transferring one-carbon groups
S-methyltransferase activity
binding
methyltransferase activity
methionine synthase activity
cobalt ion binding
vitamin binding
catalytic activity
ion binding
cation binding
transition metal ion binding
transferase activity, transferring alkyl or aryl (other than methyl) groups
process
cellular metabolism
sulfur amino acid metabolism
amino acid metabolism
sulfur amino acid biosynthesis
amino acid and derivative metabolism
physiological process
methionine biosynthesis
aromatic compound metabolism
folic acid and derivative metabolism
folic acid and derivative biosynthesis
metabolism
See more information at   →   www.drugbank.ca
Id Name
DB03614 Co-Methylcobalamin
Id Name
DB00067 Vasopressin
DB00082 Pegvisomant
DB00091 Cyclosporine
DB00114 Pyridoxal Phosphate
DB00115 Cyanocobalamin
DB00116 Tetrahydrofolic acid
DB00117 L-Histidine
DB00118 S-Adenosylmethionine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00128 L-Aspartic Acid
DB00130 L-Glutamine
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00140 Riboflavin
DB00142 L-Glutamic Acid
DB00143 Glutathione
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00157 NADH
DB00158 Folic Acid
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00170 Menadione
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00175 Pravastatin
DB00200 Hydroxocobalamin
DB00206 Reserpine
DB00224 Indinavir
DB00227 Lovastatin
DB00252 Phenytoin
DB00257 Clotrimazole
DB00275 Olmesartan
DB00279 Liothyronine
DB00286 Conjugated Estrogens
DB00300 Tenofovir
DB00328 Indomethacin
DB00345 Aminohippurate
DB00365 Grepafloxacin
DB00398 Sorafenib
DB00421 Spironolactone
DB00439 Cerivastatin
DB00466 Picrotoxin
DB00503 Ritonavir
DB00515 Cisplatin
DB00526 Oxaliplatin
DB00541 Vincristine
DB00542 Benazepril
DB00544 Fluorouracil
DB00563 Methotrexate
DB00564 Carbamazepine
DB00570 Vinblastine
DB00602 Ivermectin
DB00641 Simvastatin
DB00642 Pemetrexed
DB00650 Leucovorin
DB00661 Verapamil
DB00675 Tamoxifen
DB00688 Mycophenolate mofetil
DB00694 Daunorubicin
DB00695 Furosemide
DB00709 Lamivudine
DB00762 Irinotecan
DB00773 Etoposide
DB00795 Sulfasalazine
DB00876 Eprosartan
DB00908 Quinidine
DB00957 Norgestimate
DB00958 Carboplatin
DB00966 Telmisartan
DB00973 Ezetimibe
DB00977 Ethinyl Estradiol
DB00978 Lomefloxacin
DB00997 Doxorubicin
DB01016 Glyburide
DB01032 Probenecid
DB01045 Rifampin
DB01055 Mimosine
DB01076 Atorvastatin
DB01115 Nifedipine
DB01119 Diazoxide
DB01138 Sulfinpyrazone
DB01165 Ofloxacin
DB01169 Arsenic trioxide
DB01174 Phenobarbital
DB01202 Levetiracetam
DB01208 Sparfloxacin
DB01212 Ceftriaxone
DB01229 Paclitaxel
DB01232 Saquinavir
DB01234 Dexamethasone
DB01235 Levodopa
DB01248 Docetaxel
DB01268 Sunitinib
DB01287 Dihydroergotoxine
DB01411 Pranlukast
DB01583 Liotrix
DB01586 Ursodeoxycholic acid
DB01700 Aicar
DB01746 D-Leucine
DB01786 D-Alanine
DB01892 Hyperforin
DB01972 Guanosine-5'-Monophosphate
DB02067 Triglu-5-Formyl-Tetrahydrofolate
DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine
DB02310 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium
DB02337 S-(D-Carboxybutyl)-L-Homocysteine
DB02358 LY374571
DB02556 D-Phenylalanine
DB02640 Fumagillin
DB02659 Cholic Acid
DB02703 Fusidic Acid
DB02800 5-Hydroxymethylene-6-Hydrofolic Acid
DB02824 N-Pyridoxyl-Glycine-5-Monophosphate
DB02893 D-Methionine
DB02952 Alpha-Aminoisobutyric Acid
DB03086 N'-(2s,3r)-3-Amino-4-Cyclohexyl-2-Hydroxy-Butano-N-(4-Methylphenyl)Hydrazide
DB03107 Beta-Alanine
DB03191 3-Oxiran-2ylalanine
DB03225 D-Tryptophan
DB03256 5-Formyl-5,6,7,8-Tetrahydrofolate
DB03396 (E)-(2r,3r,4s,5r)-3,4,5-Trihydroxy-2-Methoxy-8,8-Dimethyl-Non-6-Enoic Acid ((3s,6r)-6-Hydroxy-2-Oxo-Azepan-3-Yl)-Amide
DB03431 Adenosine-5'-Diphosphate
DB03442 2-[5-Hydroxy-3-Methyl-1-(2-Methyl-4-Sulfo-Phenyl)-1h-Pyrazol-4-Ylazo]-4-Sulfo-Benzoic Acid
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03611 L-2-Amino-4-Methoxy-Cis-but-3-Enoic Acid
DB03614 Co-Methylcobalamin
DB03839 D-Tyrosine
DB03900 2-Methyl-2-Propanol
DB03929 D-Serine
DB04057 Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor
DB04100 (1,10 Phenanthroline)-(Tri-Carbon Monoxide) Rhenium (I)
DB04108 (2s,3r)-3-Amino-2-Hydroxy-5-(Ethylsulfanyl)Pentanoyl-((S)-(-)-(1-Naphthyl)Ethyl)Amide
DB04216 Quercetin
DB04272 Citric Acid
DB04322 LY249543
DB04324 Ovalicin
DB04348 Taurocholic Acid
DB04398 Lactic Acid
DB04447 1,4-Dithiothreitol
DB04789 5-methyltetrahydrofolate
DB06262 Droxidopa
DB07309 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
DB07313 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
DB07322 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
DB07323 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
DB07377 N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
DB07746 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID
DB08633 (CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER
DB08794 Ethyl biscoumacetate
DB08860 Pitavastatin
DB08884 Gadoxetate
DB08907 Canagliflozin