DT-Web

DB00082 - Pegvisomant


Identification
Name Pegvisomant
Accession Number DB00082 (BIOD00044, BTD00044)
Type biotech
Description Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 22129.0000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.
Mechanism of action Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Dihydrocodeine Opioids may diminish the therapeutic effect of pegvisomant. It is recommended to monitor therapy.
Food Interactions Not Available

Targets


Growth hormone receptor
Name Growth hormone receptor
Gene Name GHR
Pharmacological action yes
Actions antagonist
References
  • Moller L, Norrelund H, Jessen N, Flyvbjerg A, Pedersen SB, Gaylinn BD, Liu J, Thorner MO, Moller N, Lunde Jorgensen JO: Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. J Clin Endocrinol Metab. 2009 Nov;94(11):4524-32. Epub 2009 Oct 9. - Pubmed
  • Paisley AN, Hayden K, Ellis A, Anderson J, Wieringa G, Trainer PJ: Pegvisomant interference in GH assays results in underestimation of GH levels. Eur J Endocrinol. 2007 Mar;156(3):315-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • De Martino MC, Auriemma RS, Brevetti G, Vitale G, Schiano V, Galdiero M, Grasso L, Lombardi G, Colao A, Pivonello R: THE TREATMENT WITH GROWTH HORMONE RECEPTOR ANTAGONIST IN ACROMEGALY: EFFECT ON VASCULAR STRUCTURE AND FUNCTION IN PATIENTS RESISTANT TO SOMATOSTATIN ANALOGUES. J Endocrinol Invest. 2010 Jul 1. - Pubmed
DTHybrid score 0.7655

Enzymes


Cytochrome P450 27, mitochondrial
Name Cytochrome P450 27, mitochondrial
Gene Name CYP27A1
Actions inducer
References
  • Araya Z, Tang W, Wikvall K: Hormonal regulation of the human sterol 27-hydroxylase gene CYP27A1. Biochem J. 2003 Jun 1;372(Pt 2):529-34. - Pubmed
DTHybrid score 0.4319
Glutamine synthetase
Name Glutamine synthetase
Gene Name GLUL
Actions inhibitor
References
  • Nolan EM, Masters JN, Dunn A: Growth hormone regulation of hepatic glutamine synthetase mRNA levels in rats. Mol Cell Endocrinol. 1990 Mar 5;69(2-3):101-10. - Pubmed
DTHybrid score 0.4551
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions inhibitor
References
  • Lofgren S, Baldwin RM, Carleros M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M: Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. Drug Metab Dispos. 2009 Jul;37(7):1505-12. Epub 2009 Apr 1. - Pubmed
DTHybrid score 0.2949
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Liddle C, Goodwin BJ, George J, Tapner M, Farrell GC: Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab. 1998 Jul;83(7):2411-6. - Pubmed
  • Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ: Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34. Epub 2005 Nov 16. - Pubmed
DTHybrid score 0.5159
Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Lamartiniere CA: Growth hormone modulates serum cholinesterase. Endocrinology. 1986 Mar;118(3):1252-4. - Pubmed
DTHybrid score 0.6669
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Lofgren S, Baldwin RM, Carleros M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M: Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. Drug Metab Dispos. 2009 Jul;37(7):1505-12. Epub 2009 Apr 1. - Pubmed
DTHybrid score 0.3625
Cytochrome P450 4A11
Name Cytochrome P450 4A11
Gene Name CYP4A11
Actions inhibitor
References
  • Savas U, Machemer DE, Hsu MH, Gaynor P, Lasker JM, Tukey RH, Johnson EF: Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. J Biol Chem. 2009 Jun 12;284(24):16541-52. Epub 2009 Apr 14. - Pubmed
DTHybrid score 0.2424

Predictions


Id Partner name Gene Name Score
3426 Glutamine synthetase glnA 0.4551
381 Prolactin receptor PRLR 0.4259
4757 Cytochrome P450 2C9 CYP2C9 0.2042
4119 Cytochrome P450 2D6 CYP2D6 0.1688
4924 Cytochrome P450 2C8 CYP2C8 0.1505
4200 Cytochrome P450 1A2 CYP1A2 0.1437
1588 Multidrug resistance protein 1 ABCB1 0.1393
6030 Cytochrome P450 2B6 CYP2B6 0.1364
4118 Cytochrome P450 3A5 CYP3A5 0.1217
581 Cytochrome P450 2R1 CYP2R1 0.1079
6024 Cytochrome P450 1A1 CYP1A1 0.1046
474 Acetylcholinesterase ACHE 0.0971
3233 Bile acid receptor NR1H4 0.0945
6013 Cytochrome P450 2E1 CYP2E1 0.0889
6107 Cytochrome P450 3A7 CYP3A7 0.087
856 Vitamin D3 receptor VDR 0.0762
5718 Cytochrome P450 2A6 CYP2A6 0.0726
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.0659
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0654
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0633
587 Serum albumin ALB 0.0575
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.053
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0495
20 Prostaglandin G/H synthase 1 PTGS1 0.0472
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0415
556 Alpha-1A adrenergic receptor ADRA1A 0.0385
1898 Cytochrome P450 1B1 CYP1B1 0.0359
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0353
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0352
1729 Solute carrier family 22 member 6 SLC22A6 0.0351
766 Beta-2 adrenergic receptor ADRB2 0.0351
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0343
820 Glycine receptor subunit alpha-2 GLRA2 0.0332
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0326
23 D(1A) dopamine receptor DRD1 0.0318
290 Prostaglandin G/H synthase 2 PTGS2 0.0316
1992 Vitamin D-binding protein GC 0.0314
502 5-hydroxytryptamine 2A receptor HTR2A 0.0309
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0307
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0306
3811 Cytochrome P450 19A1 CYP19A1 0.0305
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0305
824 Sodium-dependent serotonin transporter SLC6A4 0.03
318 Alpha-2A adrenergic receptor ADRA2A 0.0297
6182 Cytochrome P450 2J2 CYP2J2 0.0295
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0293
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0286
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0284
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0282
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0282
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0278
492 Histamine H1 receptor HRH1 0.0277
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0275
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0275
6144 Solute carrier family 22 member 2 SLC22A2 0.0275
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0272
461 Glycine receptor subunit alpha-3 GLRA3 0.0254
6145 Solute carrier family 22 member 1 SLC22A1 0.0247
831 D(2) dopamine receptor DRD2 0.0242
871 Glucocorticoid receptor NR3C1 0.0241
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0235
862 Multidrug resistance-associated protein 1 ABCC1 0.023
6142 Solute carrier family 22 member 8 SLC22A8 0.0224
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0212
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.021
776 Bile salt export pump ABCB11 0.0209
6031 Cytochrome P450 3A43 CYP3A43 0.0196
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0191
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
320 5-hydroxytryptamine 1A receptor HTR1A 0.019
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.019
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0189
3076 Antigen 85-C fbpC 0.0187
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0187
295 Carbonic anhydrase 1 CA1 0.0186
466 Solute carrier family 12 member 3 SLC12A3 0.0184
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0184
118 Organic cation/carnitine transporter 2 SLC22A5 0.018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.018
1024 Solute carrier family 22 member 11 SLC22A11 0.0178
713 Sodium-dependent dopamine transporter SLC6A3 0.0175
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0174
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0172
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.017
136 Estrogen receptor ESR1 0.017
84 Nuclear receptor 0B1 NR0B1 0.0161
260 Cytochrome P450 51 ERG11 0.0161
761 Cytochrome P450 51 ERG11 0.0161
3163 Cytochrome P450 51 cyp51 0.0161
159 Penicillin-binding protein 2B penA 0.016
6121 Penicillin-binding protein 2B penA 0.016
357 Carbonic anhydrase 2 CA2 0.0158
731 HIV-1 protease HIV-1 protease 0.0157
4311 tRNA TRDMT1 0.0156
4325 tRNA trmD 0.0156
4328 tRNA trmD 0.0156
341 5-hydroxytryptamine 3 receptor HTR3A 0.0156
3932 Glutathione S-transferase A2 GSTA2 0.0148
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
847 Mu-type opioid receptor OPRM1 0.0144
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0143
3454 Esterase estA 0.0141
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0139
124 Histamine H2 receptor HRH2 0.0138
467 Delta-type opioid receptor OPRD1 0.0135
317 Methionine-R-sulfoxide reductase SEPX1 0.0135
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0135
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0134
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0134
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0134
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0134
465 Calmodulin CALM1 0.0133
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0131
638 D(3) dopamine receptor DRD3 0.013
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0129
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0128
380 Cytochrome P450 17A1 CYP17A1 0.0126
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0124
232 Corticosteroid-binding globulin SERPINA6 0.0123
6147 Solute carrier family 22 member 3 SLC22A3 0.012
614 Progesterone receptor PGR 0.0119
6151 Monocarboxylate transporter 10 SLC16A10 0.0119
146 Androgen receptor AR 0.0119
275 Arachidonate 5-lipoxygenase ALOX5 0.0117
719 Retinoic acid receptor responder protein 1 RARRES1 0.0116
833 Organic cation/carnitine transporter 1 SLC22A4 0.0116
770 Retinoic acid-induced protein 3 GPRC5A 0.0116
6143 Solute carrier family 22 member 7 SLC22A7 0.0115
6136 Multidrug resistance-associated protein 5 ABCC5 0.0114
191 Peptide methionine sulfoxide reductase MSRA 0.0114
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0112
632 Alpha-1B adrenergic receptor ADRA1B 0.0112
3947 Xanthine dehydrogenase/oxidase XDH 0.0111
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.011
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.011
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.011
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.011
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0108
569 Retinal dehydrogenase 2 ALDH1A2 0.0108
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0107
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0107
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0107
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0107
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0107
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0107
244 Angiotensin-converting enzyme ACE 0.0106
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0106
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0105
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0103
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.01
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.01
611 Retinal dehydrogenase 1 ALDH1A1 0.01
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.01
840 Methionine synthase reductase, mitochondrial MTRR 0.01
696 Kappa-type opioid receptor OPRK1 0.0099
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0099
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0098
5 Glutaminase liver isoform, mitochondrial GLS2 0.0098
917 Glutaminase kidney isoform, mitochondrial GLS 0.0098
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0098
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0098
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0098
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0098
5261 Phosphoribosylformylglycinamidine synthase purL 0.0098
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0098
1757 Myeloperoxidase MPO 0.0098
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
251 Alcohol dehydrogenase 1A ADH1A 0.0096
809 Methionine synthase MTR 0.0094
2935 Methionine synthase metH 0.0094
6137 Multidrug resistance-associated protein 6 ABCC6 0.0094
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0094
780 Retinoic acid receptor RXR-gamma RXRG 0.0092
789 Alpha-1D adrenergic receptor ADRA1D 0.0091
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0091
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.009
590 5-hydroxytryptamine 2C receptor HTR2C 0.009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0089
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0089
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0088
2164 Multidrug resistance-associated protein 4 ABCC4 0.0088
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0087
1656 CYP2B protein CYP2B 0.0087
921 Glutamate receptor 2 GRIA2 0.0085
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0085
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0084
444 Alcohol dehydrogenase 1B ADH1B 0.0084
193 Beta-1 adrenergic receptor ADRB1 0.0083
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0083
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0083
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0083
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0083
1008 CTP synthase 1 CTPS 0.0083
3989 Glutaminyl-tRNA synthetase QARS 0.0083
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0083
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0083
6174 50S ribosomal protein L32 rpmF 0.0083
482 Glycine receptor subunit alpha-1 GLRA1 0.0082
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0081
88 Retinoic acid receptor RXR-beta RXRB 0.0081
3917 Methylenetetrahydrofolate reductase MTHFR 0.0079
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0079
3941 Amine oxidase [flavin-containing] A MAOA 0.0079
284 DNA-directed RNA polymerase beta chain rpoB 0.0079
5773 DNA-directed RNA polymerase beta chain rpoB 0.0079
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
844 Epidermal growth factor receptor EGFR 0.0077
2795 Methionine aminopeptidase 2 METAP2 0.0075
737 Mineralocorticoid receptor NR3C2 0.0074
436 5-hydroxytryptamine 2B receptor HTR2B 0.0074
122 P2Y purinoceptor 12 P2RY12 0.0074
6146 High affinity copper uptake protein 1 SLC31A1 0.0073
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0072
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0072
517 Alcohol dehydrogenase 1C ADH1C 0.0072
818 50S ribosomal protein L10 rplJ 0.0071
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0071
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0071
263 Neutral amino acid transporter B(0) SLC1A5 0.007
162 Retinoic acid receptor gamma-1 RARG 0.007
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.007
904 Glutathione S-transferase P GSTP1 0.007
6102 Arylamine N-acetyltransferase 2 NAT2 0.007
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0069
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0068
413 Amidophosphoribosyltransferase PPAT 0.0068
2515 Amidophosphoribosyltransferase purF 0.0068
3714 Amidophosphoribosyltransferase purF 0.0068
885 5-hydroxytryptamine 1B receptor HTR1B 0.0068
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0068
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0066
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0066
6 Coagulation factor XIII A chain F13A1 0.0066
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0066
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0065
6163 Copper-transporting ATPase 2 ATP7B 0.0065
6165 Copper-transporting ATPase 1 ATP7A 0.0065
817 DNA topoisomerase 2-alpha TOP2A 0.0065
3808 Dihydropteroate synthase 2 folP2 0.0065
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0065
3601 Dihydropteroate synthase 1 folP1 0.0065
3807 Dihydropteroate synthase 1 folP1 0.0065
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0065
314 System N amino acid transporter 1 SLC38A3 0.0064
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0064
3939 Amine oxidase [flavin-containing] B MAOB 0.0063
908 Glutathione S-transferase theta-1 GSTT1 0.0062
6432 Transporter snf 0.0061
811 Translocator protein TSPO 0.0061
725 5-hydroxytryptamine 1D receptor HTR1D 0.0061
629 Alpha-2B adrenergic receptor ADRA2B 0.006
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.006
469 Annexin A1 ANXA1 0.006
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0059
896 Glutathione S-transferase Mu 1 GSTM1 0.0058
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0058
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0058
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0058
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0057
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0057
131 Synaptic vesicular amine transporter SLC18A2 0.0056
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0056
4604 Liver carboxylesterase 1 CES1 0.0055
592 Carbonic anhydrase 4 CA4 0.0055
161 Tubulin beta chain TUBB 0.0054
312 Tubulin beta chain TUB2 0.0054
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0053
373 Transthyretin TTR 0.0053
49 Endothelin B receptor EDNRB 0.0052
378 Alpha-2C adrenergic receptor ADRA2C 0.0052
6148 Multidrug resistance-associated protein 7 ABCC10 0.0052
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0051
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0051
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.005
1517 Beta-3 adrenergic receptor ADRB3 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
777 Tumor necrosis factor TNF 0.0049
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0048
432 D(4) dopamine receptor DRD4 0.0047
756 Sex hormone-binding globulin SHBG 0.0046
952 Dipeptidyl peptidase 4 DPP4 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
70 Type-1 angiotensin II receptor AGTR1 0.0044
571 Melatonin receptor type 1A MTNR1A 0.0044
362 Melatonin receptor type 1B MTNR1B 0.0044
705 Glutamate receptor 1 GRIA1 0.0044
716 5-hydroxytryptamine 7 receptor HTR7 0.0044
738 Monocarboxylate transporter 1 SLC16A1 0.0044
1178 Adenosine A2a receptor ADORA2A 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
6020 Aldehyde oxidase AOX1 0.0042
7 Nitric oxide synthase, inducible NOS2 0.0042
144 Hemoglobin subunit alpha HBA1 0.0042
407 Vascular endothelial growth factor receptor 2 KDR 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6220 Aryl hydrocarbon receptor AHR 0.0041
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0041
29 Tubulin beta-1 chain TUBB1 0.004
26 Vascular endothelial growth factor receptor 3 FLT4 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
6014 Cytochrome P450 2A13 CYP2A13 0.0039
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0039
6131 Carbonic anhydrase 14 CA14 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
32 Vascular endothelial growth factor receptor 1 FLT1 0.0038
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0038
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0037
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
4120 NADPH--cytochrome P450 reductase POR 0.0037
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0037
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0037
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0036
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0036
3937 Fatty-acid amide hydrolase FAAH 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0036
4237 50S ribosomal protein L22 rplV 0.0035
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
1039 Histone deacetylase 9 HDAC9 0.0035
939 50S ribosomal protein L3 rplC 0.0035
504 Mast/stem cell growth factor receptor KIT 0.0035
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
1360 Sphingomyelin phosphodiesterase SMPD1 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0034
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
427 Substance-P receptor TACR1 0.0033
183 Vascular endothelial growth factor A VEGFA 0.0032
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
1010 Cytochrome P450 51A1 CYP51A1 0.0032
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6141 Sodium/bile acid cotransporter SLC10A1 0.0031
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0031
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0031
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
163 D(1B) dopamine receptor DRD5 0.0031
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0031
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
3437 Eosinophil lysophospholipase CLC 0.003
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4026 Aspartyl aminopeptidase DNPEP 0.003
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.003
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.003
1047 Excitatory amino acid transporter 2 SLC1A2 0.003
926 Metabotropic glutamate receptor 7 GRM7 0.003
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.003
4016 Excitatory amino acid transporter 5 SLC1A7 0.003
4019 Excitatory amino acid transporter 4 SLC1A6 0.003
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.003
1912 Excitatory amino acid transporter 1 SLC1A3 0.003
927 Metabotropic glutamate receptor 8 GRM8 0.003
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.003
4017 5-oxoprolinase OPLAH 0.003
922 Glutamate receptor 4 GRIA4 0.003
925 Metabotropic glutamate receptor 4 GRM4 0.003
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.003
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.003
4020 Glutamyl aminopeptidase ENPEP 0.003
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.003
4018 Glutamate receptor delta-2 subunit GRID2 0.003
4027 Glutamate receptor delta-1 subunit GRID1 0.003
664 Glutamate decarboxylase 2 GAD2 0.003
3890 Glutamate decarboxylase 2 GAD2 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.003
228 Beta platelet-derived growth factor receptor PDGFRB 0.003
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.003
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0029
33 Cystine/glutamate transporter SLC7A11 0.0029
891 Dihydropteroate synthase folP 0.0029
5359 Dihydropteroate synthase folP 0.0029
7175 Dihydropteroate synthase sulI 0.0029
869 Estrogen receptor beta ESR2 0.0029
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0028
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0028
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0028
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0028
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0028
528 5-hydroxytryptamine 1E receptor HTR1E 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
365 Dihydrofolate reductase DHFR 0.0026
2381 Dihydrofolate reductase DFR1 0.0026
2833 Dihydrofolate reductase Not Available 0.0026
2931 Dihydrofolate reductase folA 0.0026
3544 Dihydrofolate reductase folA 0.0026
3682 Dihydrofolate reductase folA 0.0026
6642 Dihydrofolate reductase folA 0.0026
6756 Dihydrofolate reductase dfrA 0.0026
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0026
2207 Rhodopsin RHO 0.0026
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0026
518 Peroxidase/catalase T katG 0.0026
1256 5-hydroxytryptamine 6 receptor HTR6 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0025
625 Glutamate carboxypeptidase 2 FOLH1 0.0025
665 Phosphoserine aminotransferase PSAT1 0.0025
4652 Phosphoserine aminotransferase serC 0.0025
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0025
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0025
420 Glutamate decarboxylase 1 GAD1 0.0025
3900 Glutamate decarboxylase 1 GAD1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
2981 Phospholipase A2, membrane associated PLA2G2A 0.0025
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0025
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
916 Metabotropic glutamate receptor 1 GRM1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
1671 Excitatory amino acid transporter 3 SLC1A1 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0023
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0023
3877 Growth-inhibiting protein 18 GIG18 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0023
923 Glutamate receptor 3 GRIA3 0.0023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0023
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0022
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
763 Tyrosine aminotransferase TAT 0.0022
5493 Tyrosine aminotransferase Not Available 0.0022
426 Aspartate aminotransferase, mitochondrial GOT2 0.0022
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0021
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.002
1618 High affinity nerve growth factor receptor NTRK1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
597 Dihydropteridine reductase QDPR 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.002
106 Cannabinoid receptor 2 CNR2 0.002
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
239 Coagulation factor X F10 0.0019
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0019
4122 Histone deacetylase 2 HDAC2 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
1253 Interferon gamma IFNG 0.0018
563 Thyroid peroxidase TPO 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0017
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0017
634 Squalene monooxygenase SQLE 0.0017
7196 Squalene monooxygenase ERG1 0.0017
1050 Bile salt sulfotransferase SULT2A1 0.0017
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
94 5-hydroxytryptamine 4 receptor HTR4 0.0016
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0016
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
173 Toll-like receptor 7 TLR7 0.0016
473 L-lactate dehydrogenase A chain LDHA 0.0016
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
4608 Putative cytochrome P450 SCO1207 0.0015
4963 Putative cytochrome P450 SCO2884 0.0015
6254 Putative cytochrome P450 SCO6998 0.0015
1629 Transcription factor AP-1 JUN 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
153 Dopamine beta-hydroxylase DBH 0.0015
1541 Metalloproteinase mmp20 0.0014
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
165 FL cytokine receptor FLT3 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0013
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0013
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0013
976 Platelet glycoprotein IX GP9 0.0013
1630 Integrin beta-2 ITGB2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
4103 Proteasome subunit beta type 2 PSMB2 0.0012
4102 Proteasome subunit beta type 5 PSMB5 0.0012
4101 Proteasome subunit beta type 1 PSMB1 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
511 5-hydroxytryptamine 1F receptor HTR1F 0.0012
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
810 Heme oxygenase 1 HMOX1 0.0011
3391 Heme oxygenase 1 pbsA1 0.0011
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0011
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0011
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
174 Sigma 1-type opioid receptor SIGMAR1 0.0011
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
273 Apoptosis regulator Bcl-2 BCL2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
936 Ephrin type-A receptor 2 EPHA2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3809 Estrogen-related receptor gamma ESRRG 0.0011
2298 Cytochrome P450-cam camC 0.0011
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0011
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0011
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0011
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0011
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0011
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0011
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0011
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0011
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0011
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0011
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0011
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0011
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0011
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0011
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0011
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0011
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0011
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0011
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0011
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0011
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0011
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0011
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0011
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0011
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0011
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0011
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4947 Bacterial hemoglobin vhb 0.001
4984 Neuroglobin NGB 0.001
4975 Cytochrome c-556 RPA3973 0.001
4943 Cytochrome c6 petJ 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
4936 Cytochrome c2 iso-2 Not Available 0.001
4907 Cytochrome c-L moxG 0.001
6865 Cytochrome c-L moxG 0.001
4916 Cyanoglobin glbN 0.001
4994 Hemoglobin-like protein HbO glbO 0.001
4909 CooA protein cooA 0.001
4942 Diheme cytochrome c napB napB 0.001
4935 Cytochrome c-554 cycA1 0.001
4904 Cytochrome c family protein GSU1996 0.001
4910 Cytoglobin CYGB 0.001
4971 Nonaheme cytochrome c hmcA 0.001
4981 Iron-starvation protein PigA pigA 0.001
4989 Cytochrome c551 peroxidase ccp 0.001
5222 Cytochrome c551 peroxidase ccpA 0.001
4961 Hemophore HasA hasA 0.001
4976 Apocytochrome f petA 0.001
6407 Apocytochrome f petA 0.001
5000 HemO hemO 0.001
4960 Putative cytochrome P450-family protein SCO7417 0.001
4931 Cytochrome P450 167A1 CYP167A1 0.001
4764 Cytochrome P450 165C4 CYP165C4 0.001
4999 Cytochrome P450 165B3 CYP165B3 0.001
4926 Heme-based aerotactic transducer hemAT hemAT 0.001
4993 Hydroxylamine oxidoreductase hao1 0.001
4937 Cytochrome oxidase subunit II rcoxA 0.001
4903 Methyl-accepting chemotaxis protein Tar4 0.001
4972 P450cin cinA 0.001
54 Prothrombin F2 0.001
3093 Catalase HPII katE 0.001
4952 Catalase/peroxidase katA 0.001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.001
4922 Cytochrome c, putative SO_4144 0.001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.001
3356 Diaminopimelate decarboxylase lysA 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
4116 Dihydropteroate synthetase Not Available 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
6044 Serum paraoxonase/lactonase 3 PON3 0.001
1144 Hepatocyte growth factor receptor MET 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
164 Histamine H4 receptor HRH4 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
328 Sorbitol dehydrogenase SORD 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
3810 Catechol O-methyltransferase COMT 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
572 Integrin alpha-L ITGAL 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
4773 Deoxycytidine kinase DCK 0.0009
2320 Thymidine kinase, cytosolic TK1 0.0009
267 Plasminogen activator inhibitor 1 SERPINE1 0.0009
3830 Calreticulin CALR 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
1864 RET proto-oncogene RET 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0009
577 Argininosuccinate lyase ASL 0.0009
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
627 11-cis retinol dehydrogenase RDH5 0.0009
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0009
666 NADP-dependent malic enzyme ME1 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6026 Alcohol dehydrogenase 6 ADH6 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0009
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0009
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
626 Cysteine dioxygenase type 1 CDO1 0.0009
1615 Chymase CMA1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
12 Alcohol dehydrogenase class 3 ADH5 0.0009
77 L-lactate dehydrogenase B chain LDHB 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0008
6218 Pannexin-1 PANX1 0.0008
6221 Steroid hormone receptor ERR1 ESRRA 0.0008
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0008
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0008
5934 Cytochrome P450 26A1 CYP26A1 0.0008
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0008
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0008
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
13 Aminomethyltransferase, mitochondrial AMT 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
279 Tyrosinase TYR 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
4920 Peroxidase/catalase katG 0.0008
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
1025 Aquaporin-1 AQP1 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
4990 PpcA ppcA 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
2091 Endoplasmin HSP90B1 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0007
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0007
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
654 Flavin reductase BLVRB 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
2021 Thrombomodulin THBD 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1830 5'-nucleotidase NT5E 0.0007
1184 Interferon beta IFNB1 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
714 Glutathione reductase, mitochondrial GSR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
3127 Nitrite reductase nirS 0.0006
3284 Nitrite reductase nirS 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
3221 Cytochrome c4 cc4 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
2372 Bifunctional tail protein 9 0.0005
358 Cystathionine beta-synthase CBS 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
822 Aldose reductase AKR1B1 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
489 Monocarboxylate transporter 2 SLC16A7 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
1507 Cytochrome c CYCS 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
693 Hemoglobin subunit beta HBB 0.0005
1243 Cathepsin D CTSD 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
1439 Lactotransferrin LTF 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1275 Estrogen sulfotransferase SULT1E1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
751 Potassium channel subfamily K member 6 KCNK6 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
172 Potassium channel subfamily K member 1 KCNK1 0.0002
3957 Adenosine deaminase ADA 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
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