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Kynurenine--oxoglutarate transaminase 1


Partner ID 301
Name Kynurenine--oxoglutarate transaminase 1
Synonyms 933
Gene name CCBL1
General function Amino acid transport and metabolism
Specific function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kinurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond
Gene sequence + ...

ATGGCCAAACAGCTGCAGGCCCGAAGGCTAGACGGGATCGACTACAACCCCTGGGTGGAGTTTGTGAAACTGGCCAGTGAGCATGACGTCGTGAACTTGGGCCAGGGCTTCCCGGATTTCCCACCACCAGACTTTGCCGTGGAAGCCTTTCAGCACGCTGTCAGTGGAGACTTCATGCTTAACCAGTACACCAAGACATTTGGTTACCCACCACTGACGAAGATCCTGGCAAGTTTCTTTGGGGAGCTGCTGGGTCAGGAGATAGACCCGCTCAGGAATGTGCTGGTGACTGTTGGTGGCTATGGGGCCCTGTTCACAGCCTTCCAGGCCCTGGTGGACGAAGGAGACGAGGTCATCATCATCGAACCCTTTTTTGACTGCTACGAGCCCATGACAATGATGGCAGGGGGTCGTCCTGTGTTTGTGTCCCTGAAGCCGGGTCCCATCCAGAATGGAGAACTGGGTTCCAGCAGCAACTGGCAGCTGGACCCCATGGAGCTGGCCGGCAAATTCACATCACGCACCAAAGCCCTGGTCCTCAACACCCCCAACAACCCCCTGGGCAAGGTGTTCTCCAGGGAAGAGCTGGAGCTGGTGGCCAGCCTTTGCCAGCAGCATGACGTGGTGTGTATCACTGATGAAGTCTACCAGTGGATGGTCTACGACGGGCACCAGCACATCAGCATTGCCAGCCTCCCTGGCATGTGGGAACGGACCCTGACCATCGGCAGCGCCGGCAAGACCTTCAGCGCCACTGGCTGGAAGGTGGGCTGGGTCCTGGGTCCAGATCACATCATGAAGCACCTGCGGACCGTGCACCAGAACTCCGTCTTCCACTGCCCCACGCAGAGCCAGGCTGCAGTAGCCGAGAGCTTTGAACGGGAGCAGCTGCTCTTCCGCCAACCCAGCAGCTACTTTGTGCAGTTCCCGCAGGCCATGCAGCGCTGCCGTGACCACATGATACGTAGCCTACAGTCAGTGGGCCTGAAGCCCATCATCCCTCAGGGCAGCTACTTCCTCATCACAGACATCTCAGACTTCAAGAGGAAGATGCCTGACTTGCCTGGAGCTGTGGATGAGCCCTATGACAGACGCTTCGTCAAGTGGATGATCAAGAACAAGGGCTTGGTGGCCATCCCTGTCTCCATCTTCTATAGTGTGCCACATCAGAAGCACTTTGACCACTATATCCGCTTCTGTTTTGTGAAGGATGAAGCCACGCTCCAGGCCATGGACGAGAAGCTGCGGAAGTGGAAGGTGGAACTCTAG
Protein sequence + ...

MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
GO Classification
function
1-aminocyclopropane-1-carboxylate synthase activity
catalytic activity
lyase activity
transferase activity
transferase activity, transferring nitrogenous groups
carbon-sulfur lyase activity
process
physiological process
metabolism
biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00114 Pyridoxal Phosphate
DB02142 Pyridoxamine-5'-Phosphate
DB02556 D-Phenylalanine
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB07950 1H-INDOL-3-YLACETIC ACID

Associated as Enzyme

Id Name
DB00130 L-Glutamine

Associated as Prediction

Id Name
DB00082 Pegvisomant
DB00114 Pyridoxal Phosphate
DB00116 Tetrahydrofolic acid
DB00117 L-Histidine
DB00118 S-Adenosylmethionine
DB00119 Pyruvic acid
DB00120 L-Phenylalanine
DB00123 L-Lysine
DB00125 L-Arginine
DB00127 Spermine
DB00128 L-Aspartic Acid
DB00129 L-Ornithine
DB00130 L-Glutamine
DB00131 Adenosine monophosphate
DB00133 L-Serine
DB00134 L-Methionine
DB00135 L-Tyrosine
DB00138 L-Cystine
DB00142 L-Glutamic Acid
DB00145 Glycine
DB00149 L-Leucine
DB00150 L-Tryptophan
DB00151 L-Cysteine
DB00156 L-Threonine
DB00160 L-Alanine
DB00161 L-Valine
DB00167 L-Isoleucine
DB00171 Adenosine triphosphate
DB00172 L-Proline
DB00174 L-Asparagine
DB00190 Carbidopa
DB00233 Aminosalicylic Acid
DB00260 Cycloserine
DB00279 Liothyronine
DB00313 Valproic Acid
DB00451 Levothyroxine
DB00466 Picrotoxin
DB00509 Dextrothyroxine
DB00544 Fluorouracil
DB00780 Phenelzine
DB00875 Flupenthixol
DB00915 Amantadine
DB00996 Gabapentin
DB01042 Melphalan
DB01055 Mimosine
DB01080 Vigabatrin
DB01119 Diazoxide
DB01212 Ceftriaxone
DB01235 Levodopa
DB01285 Corticotropin
DB01287 Dihydroergotoxine
DB01583 Liotrix
DB01639 N-Methyl-Pyridoxal-5'-Phosphate
DB01696 7,9-Dihydro-1h-Purine-2,6,8(3h)-Trione
DB01699 (4e)-4-Aminohex-4-Enoic Acid
DB01746 D-Leucine
DB01750 Naphthalen-1-Yl-Acetic Acid
DB01786 D-Alanine
DB01813 Pyridoxyl-Glutamic Acid-5'-Monophosphate
DB01823 Beta-D-Glucopyranose Spirohydantoin
DB01839 1,2-Propanediol
DB01843 3-Amino-8,9,10-Trihydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB01864 5'-Guanosine-Diphosphate-Monothiophosphate
DB01917 Putrescine
DB01955 1,4-Butanediol
DB01972 Guanosine-5'-Monophosphate
DB01993 N-(5'-Phosphopyridoxyl)-D-Alanine
DB02007 Alpha-D-Glucose-6-Phosphate
DB02024 3-phenylpropionic acid
DB02054 Gabaculine
DB02067 Triglu-5-Formyl-Tetrahydrofolate
DB02079 (Aminooxy)Acetic Acid
DB02089 CP-526423
DB02142 Pyridoxamine-5'-Phosphate
DB02209 Pyridoxine-5'-Phosphate
DB02274 7-Keto-8-Aminopelargonic Acid
DB02320 1-N-Acetyl-Beta-D-Glucosamine
DB02328 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid
DB02340 N-Acetyl-Serine
DB02348 Fluoro-Phosphite Ion
DB02379 Beta-D-Glucose
DB02447 3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB02448 N-Tridecanoic Acid
DB02471 Nojirimycine Tetrazole
DB02519 Indirubin-5-Sulphonate
DB02556 D-Phenylalanine
DB02604 2-Deoxy-Glucose-6-Phosphate
DB02635 N-[O-Phosphono-Pyridoxyl]-Isoleucine
DB02636 9-Hydroxy-8-Methoxy-6-Nitro-Phenanthrol[3,4-D][1,3]Dioxole-5-Carboxylic Acid
DB02719 C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide
DB02720 Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide
DB02725 2-Amino-4-(4-Amino-Cyclohexa-2,5-Dienyl)-Butyric Acid
DB02750 S-(Methylmercury)-L-Cysteine
DB02758 Indolylpropionic Acid
DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate
DB02795 P-Anisic Acid
DB02800 5-Hydroxymethylene-6-Hydrofolic Acid
DB02821 Canaline
DB02824 N-Pyridoxyl-Glycine-5-Monophosphate
DB02843 Alpha-D-Glucose-1-Phosphate
DB02926 2-Oxo-Glutaric Acid
DB02952 Alpha-Aminoisobutyric Acid
DB02964 8,9,10-Trihydroxy-7-Hydroxymethyl-2-Thioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Decan-4-One
DB02981 Vitamin B6 Complexed with 2-Amino-Hexanoic Acid
DB03014 Heme
DB03067 4-{2,4-Bis[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB03097 Pmp-Hydroxyisoxazole, Pyridoxamine-5-Phosphate-Hydroxyisoxazole
DB03107 Beta-Alanine
DB03133 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole
DB03152 B-2-Octylglucoside
DB03218 N-Acetyl-N'-Beta-D-Glucopyranosyl Urea
DB03225 D-Tryptophan
DB03247 Riboflavin Monophosphate
DB03250 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Benzothiazole
DB03256 5-Formyl-5,6,7,8-Tetrahydrofolate
DB03286 C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide
DB03288 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide
DB03327 {1-[(3-Hydroxy-Methyl-5-Phosphonooxy-Methyl-Pyridin-4-Ylmethyl)-Amino]-Ethyl}-Phosphonic Acid
DB03345 Beta-Mercaptoethanol
DB03354 2-(Beta-D-Glucopyranosyl)-5-Methyl-1,3,4-Oxadiazole
DB03383 5-Chloro-1h-Indole-2-Carboxylic Acid [1-(4-Fluorobenzyl)-2-(4-Hydroxypiperidin-1yl)-2-Oxoethyl]Amide
DB03392 (3,4,5-Trihydroxy-6-Hydroxymethyl-Tetrahydro-Pyran-2-Yl)-Phosphoramidic Acid Dimethyl Ester
DB03459 N-(Phosphonacetyl)-L-Aspartic Acid
DB03479 8,9,10-Trihydroxy-7-Hydroxymethyl-3-Methyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
DB03496 Flavopiridol
DB03553 Glutaric Acid
DB03576 N-Pyridoxyl-Threonine-5-Monophosphate
DB03579 Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate
DB03585 Oxyphenbutazone
DB03629 Pyridoxal-5'-Phosphate-N-Oxide
DB03657 1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose
DB03662 Vitamin B6 Complexed with 2-Amino-Pentanoic Acid
DB03744 Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate
DB03750 Isovaleric Acid
DB03766 Propanoic Acid
DB03801 Lysine Nz-Carboxylic Acid
DB03835 N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide
DB03839 D-Tyrosine
DB03856 Alpha-Difluoromethylornithine
DB03928 Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol
DB03929 D-Serine
DB03997 Phosphoric Acid Mono-[2-Amino-3-(3h-Imidazol-4-Yl)-Propyl]Ester
DB04013 1-Deoxy-1-Methoxycarbamido-Beta-D-Gluco-2-Heptulopyranosonamide
DB04044 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid
DB04055 2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium
DB04074 Alpha-ketoisovalerate
DB04077 Glycerol
DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate
DB04195 Heptulose-2-Phosphate
DB04217 L-2-amino-3-butynoic acid
DB04235 4-Amino Hexanoic Acid
DB04263 G418
DB04295 N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea
DB04299 Maleic Acid
DB04315 Guanosine-5'-Diphosphate
DB04398 Lactic Acid
DB04467 Pyridoxyl-Alanine-5-Phosphate
DB04522 Phosphonoserine
DB04544 1-Deoxy-1-Acetylamino-Beta-D-Gluco-2-Heptulopyranosonamide
DB04566 Inosinic Acid
DB04642 7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID
DB04643 4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID
DB04644 4-{4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2,3-DIMETHYL-PHENOXY}-BUTYRIC ACID
DB04645 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID
DB04743 Nimesulide
DB04762 N-PYRIDOXYL-D-GLUTAMIC ACID-5'-MONOPHOSPHATE
DB04765 N-PYRIDOXYL-2-METHYL-L-GLUTAMIC ACID-5'-MONOPHOSPHATE
DB06262 Droxidopa
DB06980 (2S)-2-(1H-indol-3-yl)hexanoic acid
DB06981 (2S)-2-(1H-indol-3-yl)pentanoic acid
DB06982 (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
DB06986 2-CHLORO-N-[(1R,2R)-1-HYDROXY-2,3-DIHYDRO-1H-INDEN-2-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB06987 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE
DB07066 2-CHLORO-N-[(3R)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07069 3-Hydroxyhippuric acid
DB07315 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide
DB07395 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid
DB07396 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid
DB07500 (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
DB07544 N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE
DB07792 (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07793 (2S)-N-[(3S)-1-(2-AMINO-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL]-2-CHLORO-2H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE
DB07807 (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL
DB07949 ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID
DB07950 1H-INDOL-3-YLACETIC ACID
DB07958 (2-CARBAMOYLMETHYL-5-PROPYL-OCTAHYDRO-INDOL-7-YL)ACETIC ACID
DB07968 N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
DB08060 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
DB08151 (5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-phenyl-1,6-dioxa-2-azaspiro[4.5]dec-2-ene-8,9,10-triol
DB08322 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID
DB08447 3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL
DB08500 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(2-naphthyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08503 (3S,5R,7R,8S,9S,10R)-7-(hydroxymethyl)-3-(4-methylphenyl)-1,6-dioxa-2-azaspiro[4.5]decane-8,9,10-triol
DB08794 Ethyl biscoumacetate
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